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Entry version 123 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Uncharacterized protein C6orf203

Gene

C6orf203

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf203
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:HSPC230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17971 C6orf203

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0P8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000130349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134898244

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf203

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152388

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895591 – 240Uncharacterized protein C6orf203Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0P8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0P8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P0P8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0P8

PeptideAtlas

More...
PeptideAtlasi
Q9P0P8

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0P8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83590

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9P0P8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9P0P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130349 Expressed in 198 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0P8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0P8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049535

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119407, 37 interactors

Protein interaction database and analysis system

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IntActi
Q9P0P8, 33 interactors

Molecular INTeraction database

More...
MINTi
Q9P0P8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384867

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4837 Eukaryota
ENOG4111QEK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009366

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000294127

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P0P8

Database of Orthologous Groups

More...
OrthoDBi
1440120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0P8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039167 C6orf203

The PANTHER Classification System

More...
PANTHERi
PTHR13633 PTHR13633, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9P0P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMASVKLLA GVLRKPDAWI GLWGVLRGTP SSYKLCTSWN RYLYFSSTKL
60 70 80 90 100
RAPNYKTLFY NIFSLRLPGL LLSPECIFPF SVRLKSNIRS TKSTKKSLQK
110 120 130 140 150
VDEEDSDEES HHDEMSEQEE ELEDDPTVVK NYKDLEKAVQ SFRYDVVLKT
160 170 180 190 200
GLDIGRNKVE DAFYKGELRL NEEKLWKKSR TVKVGDTLDL LIGEDKEAGT
210 220 230 240
ETVMRILLKK VFEEKTESEK YRVVLRRWKS LKLPKKRMSK
Length:240
Mass (Da):27,941
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01E2DBCB11537275
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEI0A0A0D9SEI0_HUMAN
Uncharacterized protein C6orf203
C6orf203
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF151064 mRNA Translation: AAF36150.1
AK091564 mRNA Translation: BAG52381.1
AL355586 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48402.1
BC010899 mRNA Translation: AAH10899.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5058.1

NCBI Reference Sequences

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RefSeqi
NP_001135940.1, NM_001142468.2
NP_001135942.1, NM_001142470.2
NP_057571.1, NM_016487.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311381; ENSP00000310951; ENSG00000130349
ENST00000405204; ENSP00000384867; ENSG00000130349

Database of genes from NCBI RefSeq genomes

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GeneIDi
51250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51250

UCSC genome browser

More...
UCSCi
uc003prq.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151064 mRNA Translation: AAF36150.1
AK091564 mRNA Translation: BAG52381.1
AL355586 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48402.1
BC010899 mRNA Translation: AAH10899.1
CCDSiCCDS5058.1
RefSeqiNP_001135940.1, NM_001142468.2
NP_001135942.1, NM_001142470.2
NP_057571.1, NM_016487.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119407, 37 interactors
IntActiQ9P0P8, 33 interactors
MINTiQ9P0P8
STRINGi9606.ENSP00000384867

PTM databases

iPTMnetiQ9P0P8
PhosphoSitePlusiQ9P0P8

Polymorphism and mutation databases

BioMutaiC6orf203
DMDMi71152388

Proteomic databases

EPDiQ9P0P8
jPOSTiQ9P0P8
MaxQBiQ9P0P8
PaxDbiQ9P0P8
PeptideAtlasiQ9P0P8
PRIDEiQ9P0P8
ProteomicsDBi83590
TopDownProteomicsiQ9P0P8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51250
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311381; ENSP00000310951; ENSG00000130349
ENST00000405204; ENSP00000384867; ENSG00000130349
GeneIDi51250
KEGGihsa:51250
UCSCiuc003prq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51250

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf203
HGNCiHGNC:17971 C6orf203
HPAiHPA049535
neXtProtiNX_Q9P0P8
OpenTargetsiENSG00000130349
PharmGKBiPA134898244

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4837 Eukaryota
ENOG4111QEK LUCA
GeneTreeiENSGT00390000009366
HOGENOMiHOG000294127
InParanoidiQ9P0P8
OrthoDBi1440120at2759
PhylomeDBiQ9P0P8

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51250

Protein Ontology

More...
PROi
PR:Q9P0P8

Gene expression databases

BgeeiENSG00000130349 Expressed in 198 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9P0P8 baseline and differential
GenevisibleiQ9P0P8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039167 C6orf203
PANTHERiPTHR13633 PTHR13633, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF203_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0P8
Secondary accession number(s): B3KRG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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