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Protein

E3 ubiquitin-protein ligase RNF181

Gene

RNF181

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 117RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.2.B10 2681
6.3.2.19 2681
ReactomeiR-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF181 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 181
RING-type E3 ubiquitin transferase RNF181Curated
Gene namesi
Name:RNF181
ORF Names:HSPC238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168894.9
HGNCiHGNC:28037 RNF181
MIMi612490 gene
neXtProtiNX_Q9P0P0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168894
PharmGKBiPA162401586

Polymorphism and mutation databases

BioMutaiRNF181
DMDMi74761852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951741 – 153E3 ubiquitin-protein ligase RNF181Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphothreonineCombined sources1

Post-translational modificationi

Auto-ubiquitinated as part of the enzymatic reaction.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9P0P0
MaxQBiQ9P0P0
PaxDbiQ9P0P0
PeptideAtlasiQ9P0P0
PRIDEiQ9P0P0
ProteomicsDBi83589

PTM databases

iPTMnetiQ9P0P0
PhosphoSitePlusiQ9P0P0

Expressioni

Tissue specificityi

Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000168894
CleanExiHS_RNF181
ExpressionAtlasiQ9P0P0 baseline and differential
GenevisibleiQ9P0P0 HS

Organism-specific databases

HPAiHPA046112
HPA062121

Interactioni

Subunit structurei

Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119411, 71 interactors
IntActiQ9P0P0, 21 interactors
MINTiQ9P0P0
STRINGi9606.ENSP00000306906

Structurei

3D structure databases

ProteinModelPortaliQ9P0P0
SMRiQ9P0P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNF181 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 117RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00530000062967
HOGENOMiHOG000031081
HOVERGENiHBG108412
InParanoidiQ9P0P0
KOiK22378
OMAiDEHNCEP
PhylomeDBiQ9P0P0
TreeFamiTF332127

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P0P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYFDEHDC EPSDPEQETR TNMLLELARS LFNRMDFEDL GLVVDWDHHL
60 70 80 90 100
PPPAAKTVVE NLPRTVIRGS QAELKCPVCL LEFEEEETAI EMPCHHLFHS
110 120 130 140 150
SCILPWLSKT NSCPLCRYEL PTDDDTYEEH RRDKARKQQQ QHRLENLHGA

MYT
Length:153
Mass (Da):17,909
Last modified:October 1, 2000 - v1
Checksum:iAF0CEC8D438FF0AB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033323118Y → H1 PublicationCorresponds to variant dbSNP:rs6643Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151072 mRNA Translation: AAF36158.1
CR457165 mRNA Translation: CAG33446.1
AK222700 mRNA Translation: BAD96420.1
AC016753 Genomic DNA Translation: AAY24343.1
BC002803 mRNA Translation: AAH02803.1
CCDSiCCDS1981.1
RefSeqiNP_057578.1, NM_016494.3
UniGeneiHs.356187

Genome annotation databases

EnsembliENST00000306368; ENSP00000306906; ENSG00000168894
GeneIDi51255
KEGGihsa:51255
UCSCiuc002spv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRN181_HUMAN
AccessioniPrimary (citable) accession number: Q9P0P0
Secondary accession number(s): Q53H81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

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