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Protein

39S ribosomal protein L27, mitochondrial

Gene

MRPL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L27, mitochondrial
Short name:
L27mt
Short name:
MRP-L27
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL27m1 Publication
Gene namesi
Name:MRPL27
ORF Names:HSPC250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108826.15
HGNCiHGNC:14483 MRPL27
MIMi611837 gene
neXtProtiNX_Q9P0M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108826
PharmGKBiPA30957

Polymorphism and mutation databases

BioMutaiMRPL27
DMDMi20139806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000018122931 – 14839S ribosomal protein L27, mitochondrialAdd BLAST118

Proteomic databases

EPDiQ9P0M9
MaxQBiQ9P0M9
PaxDbiQ9P0M9
PeptideAtlasiQ9P0M9
PRIDEiQ9P0M9
ProteomicsDBi83581
TopDownProteomicsiQ9P0M9

PTM databases

iPTMnetiQ9P0M9
PhosphoSitePlusiQ9P0M9

Expressioni

Gene expression databases

BgeeiENSG00000108826
CleanExiHS_MRPL27
ExpressionAtlasiQ9P0M9 baseline and differential
GenevisibleiQ9P0M9 HS

Organism-specific databases

HPAiHPA021416

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136435EBI-5325236,EBI-741101

Protein-protein interaction databases

BioGridi119418, 50 interactors
CORUMiQ9P0M9
IntActiQ9P0M9, 11 interactors
MINTiQ9P0M9
STRINGi9606.ENSP00000225969

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 55Combined sources4
Beta strandi66 – 69Combined sources4
Beta strandi74 – 77Combined sources4
Beta strandi81 – 83Combined sources3
Beta strandi88 – 103Combined sources16
Helixi111 – 117Combined sources7
Beta strandi120 – 123Combined sources4
Beta strandi127 – 135Combined sources9
Beta strandi141 – 148Combined sources8

3D structure databases

ProteinModelPortaliQ9P0M9
SMRiQ9P0M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4600 Eukaryota
COG0211 LUCA
GeneTreeiENSGT00390000014660
HOGENOMiHOG000111610
HOVERGENiHBG018255
InParanoidiQ9P0M9
KOiK02899
OMAiHQRFRLV
OrthoDBiEOG091G17I3
PhylomeDBiQ9P0M9
TreeFamiTF323523

Family and domain databases

InterProiView protein in InterPro
IPR001684 Ribosomal_L27
PANTHERiPTHR15893 PTHR15893, 1 hit
PfamiView protein in Pfam
PF01016 Ribosomal_L27, 1 hit
PRINTSiPR00063 RIBOSOMALL27
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003114 Ribosomal_L27, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR
60 70 80 90 100
QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT
110 120 130 140
KEVYVPHPRN TEAVDLITRL PKGAVLYKTF VHVVPAKPEG TFKLVAML
Length:148
Mass (Da):16,073
Last modified:October 1, 2000 - v1
Checksum:i90945F471E80EFB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202324T → A. Corresponds to variant dbSNP:rs17776919Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049647 mRNA Translation: BAB40852.1
AF151084 mRNA Translation: AAF36170.1
AK315758 mRNA Translation: BAG38111.1
CH471109 Genomic DNA Translation: EAW94623.1
BC001066 mRNA Translation: AAH01066.1
BC021986 mRNA Translation: AAH21986.1
CCDSiCCDS11564.1
RefSeqiNP_057588.1, NM_016504.2
UniGeneiHs.7736

Genome annotation databases

EnsembliENST00000225969; ENSP00000225969; ENSG00000108826
GeneIDi51264
KEGGihsa:51264
UCSCiuc002iqq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM27_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M9
Secondary accession number(s): B2RE14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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