UniProtKB - Q9P0M4 (IL17C_HUMAN)
Interleukin-17C
IL17C
Functioni
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
1 PublicationGO - Molecular functioni
- cytokine activity Source: ProtInc
GO - Biological processi
- cell-cell signaling Source: ProtInc
- cell surface receptor signaling pathway Source: ProtInc
- inflammatory response Source: ProtInc
Keywordsi
Molecular function | Cytokine |
Biological process | Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | Q9P0M4 |
Reactomei | R-HSA-448424, Interleukin-17 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-17CShort name: IL-17C Alternative name(s): Cytokine CX2 |
Gene namesi | Name:IL17C ORF Names:UNQ561/PRO1122 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5983, IL17C |
MIMi | 604628, gene |
neXtProti | NX_Q9P0M4 |
VEuPathDBi | HostDB:ENSG00000124391 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: ProtInc
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 27189 |
OpenTargetsi | ENSG00000124391 |
PharmGKBi | PA29797 |
Miscellaneous databases
Pharosi | Q9P0M4, Tbio |
Genetic variation databases
BioMutai | IL17C |
DMDMi | 20138769 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000015429 | 19 – 197 | Interleukin-17CAdd BLAST | 179 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 129 ↔ 189 | By similarity | ||
Disulfide bondi | 134 ↔ 191 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q9P0M4 |
PaxDbi | Q9P0M4 |
PeptideAtlasi | Q9P0M4 |
PRIDEi | Q9P0M4 |
ProteomicsDBi | 83579 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000124391, Expressed in quadriceps femoris and 158 other tissues |
Genevisiblei | Q9P0M4, HS |
Organism-specific databases
HPAi | ENSG00000124391, Tissue enhanced (endometrium, urinary bladder) |
Interactioni
Subunit structurei
Binds to a heterodimer formed by IL17RA and IL17RE.
GO - Molecular functioni
- cytokine activity Source: ProtInc
Protein-protein interaction databases
STRINGi | 9606.ENSP00000244241 |
Miscellaneous databases
RNActi | Q9P0M4, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2UJ, Eukaryota |
GeneTreei | ENSGT00940000161887 |
HOGENOMi | CLU_121730_0_0_1 |
InParanoidi | Q9P0M4 |
OMAi | YPQKLAV |
OrthoDBi | 1298853at2759 |
PhylomeDBi | Q9P0M4 |
TreeFami | TF314701 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH
60 70 80 90 100
LLARGAKWGQ ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD
110 120 130 140 150
THQRSISPWR YRVDTDEDRY PQKLAFAECL CRGCIDARTG RETAALNSVR
160 170 180 190
LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT EFIHVPVGCT CVLPRSV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | H → R in AAG27921 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049598 | 25 | R → G. Corresponds to variant dbSNP:rs11465492Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152099 mRNA Translation: AAF28105.1 AF142410 mRNA Translation: AAG27921.1 AY358471 mRNA Translation: AAQ88835.1 BC069152 mRNA Translation: AAH69152.1 BC101835 mRNA Translation: AAI01836.1 BC112196 mRNA Translation: AAI12197.1 |
CCDSi | CCDS42217.1 |
RefSeqi | NP_037410.1, NM_013278.3 |
Genome annotation databases
Ensembli | ENST00000244241; ENSP00000244241; ENSG00000124391 |
GeneIDi | 27189 |
KEGGi | hsa:27189 |
MANE-Selecti | ENST00000244241.5; ENSP00000244241.4; NM_013278.4; NP_037410.1 |
UCSCi | uc002fla.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Interleukin-17 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF152099 mRNA Translation: AAF28105.1 AF142410 mRNA Translation: AAG27921.1 AY358471 mRNA Translation: AAQ88835.1 BC069152 mRNA Translation: AAH69152.1 BC101835 mRNA Translation: AAI01836.1 BC112196 mRNA Translation: AAI12197.1 |
CCDSi | CCDS42217.1 |
RefSeqi | NP_037410.1, NM_013278.3 |
3D structure databases
SMRi | Q9P0M4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000244241 |
Genetic variation databases
BioMutai | IL17C |
DMDMi | 20138769 |
Proteomic databases
MassIVEi | Q9P0M4 |
PaxDbi | Q9P0M4 |
PeptideAtlasi | Q9P0M4 |
PRIDEi | Q9P0M4 |
ProteomicsDBi | 83579 |
Protocols and materials databases
Antibodypediai | 30734, 327 antibodies from 26 providers |
DNASUi | 27189 |
Genome annotation databases
Ensembli | ENST00000244241; ENSP00000244241; ENSG00000124391 |
GeneIDi | 27189 |
KEGGi | hsa:27189 |
MANE-Selecti | ENST00000244241.5; ENSP00000244241.4; NM_013278.4; NP_037410.1 |
UCSCi | uc002fla.4, human |
Organism-specific databases
CTDi | 27189 |
DisGeNETi | 27189 |
GeneCardsi | IL17C |
HGNCi | HGNC:5983, IL17C |
HPAi | ENSG00000124391, Tissue enhanced (endometrium, urinary bladder) |
MIMi | 604628, gene |
neXtProti | NX_Q9P0M4 |
OpenTargetsi | ENSG00000124391 |
PharmGKBi | PA29797 |
VEuPathDBi | HostDB:ENSG00000124391 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S2UJ, Eukaryota |
GeneTreei | ENSGT00940000161887 |
HOGENOMi | CLU_121730_0_0_1 |
InParanoidi | Q9P0M4 |
OMAi | YPQKLAV |
OrthoDBi | 1298853at2759 |
PhylomeDBi | Q9P0M4 |
TreeFami | TF314701 |
Enzyme and pathway databases
PathwayCommonsi | Q9P0M4 |
Reactomei | R-HSA-448424, Interleukin-17 signaling |
Miscellaneous databases
BioGRID-ORCSi | 27189, 7 hits in 1032 CRISPR screens |
GenomeRNAii | 27189 |
Pharosi | Q9P0M4, Tbio |
PROi | PR:Q9P0M4 |
RNActi | Q9P0M4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124391, Expressed in quadriceps femoris and 158 other tissues |
Genevisiblei | Q9P0M4, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL17C_HUMAN | |
Accessioni | Q9P0M4Primary (citable) accession number: Q9P0M4 Secondary accession number(s): Q3MIG8, Q9HC75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families