IL17C

Functionⁱ

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.1 Publication

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 10639155

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 10639155
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10639155
inflammatory response
Source: ProtInc
Traceable author statementⁱ
- 10639155
interleukin-17-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-448424 Interleukin-17 signaling

Reactomeⁱ

R-HSA-448424 Interleukin-17 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-17C Short name: IL-17C Alternative name(s): Cytokine CX2
Gene namesⁱ	Name:IL17C ORF Names:UNQ561/PRO1122
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124391.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5983 IL17C
MIMⁱ	604628 gene
neXtProtⁱ	NX_Q9P0M4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27189
Open Targets More...OpenTargetsⁱ	ENSG00000124391
PharmGKBⁱ	PA29797

Polymorphism and mutation databases

BioMutaⁱ	IL17C
DMDMⁱ	20138769

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000015429	19 – 197	Interleukin-17CAdd BLAST		179

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	129 ↔ 189	By similarity
Disulfide bondⁱ	134 ↔ 191	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q9P0M4
PeptideAtlas More...PeptideAtlasⁱ	Q9P0M4
PRIDEⁱ	Q9P0M4
ProteomicsDBⁱ	83579

Expressionⁱ

Inductionⁱ

Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000124391 Expressed in 151 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_IL17C
Genevisibleⁱ	Q9P0M4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065051

HPAⁱ

HPA065051

Interactionⁱ

Subunit structureⁱ

Binds to a heterodimer formed by IL17RA and IL17RE.

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 10639155

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000244241

STRINGⁱ

9606.ENSP00000244241

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P0M4
SMRⁱ	Q9P0M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-17 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IZ2K Eukaryota ENOG4111VTD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150940
HOGENOMⁱ	HOG000113031
HOVERGENⁱ	HBG052096
InParanoidⁱ	Q9P0M4
KEGG Orthology (KO) More...KOⁱ	K05491
OMAⁱ	GQAPPHL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17O0
PhylomeDBⁱ	Q9P0M4
TreeFamⁱ	TF314701

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020440 IL-17_chr IPR010345 IL-17_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06083 IL17, 1 hit
PRINTSⁱ	PR01932 INTRLEUKIN17
SUPFAMⁱ	SSF57501 SSF57501, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9P0M4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH 
        60         70         80         90        100
LLARGAKWGQ ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD 
       110        120        130        140        150
THQRSISPWR YRVDTDEDRY PQKLAFAECL CRGCIDARTG RETAALNSVR 
       160        170        180        190 
LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT EFIHVPVGCT CVLPRSV

Length:197

Mass (Da):21,765

Last modified:October 1, 2000 - v1

Checksum:ⁱBAE0152E18DE7D08

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	50	H → R in AAG27921 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049598	25	R → G. Corresponds to variant dbSNP:rs11465492Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF152099 mRNA Translation: AAF28105.1 AF142410 mRNA Translation: AAG27921.1 AY358471 mRNA Translation: AAQ88835.1 BC069152 mRNA Translation: AAH69152.1 BC101835 mRNA Translation: AAI01836.1 BC112196 mRNA Translation: AAI12197.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42217.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037410.1, NM_013278.3
UniGeneⁱ	Hs.278911

Genome annotation databases

Ensemblⁱ	ENST00000244241; ENSP00000244241; ENSG00000124391
GeneIDⁱ	27189
KEGGⁱ	hsa:27189
UCSC genome browser More...UCSCⁱ	uc002fla.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P0M4	Uncharacterized protein		MACMU		197	UniRef90_Q9P0M4
Uncharacterized protein		MACFA		197
Uncharacterized protein		MACNE		197
Uncharacterized protein		NOMLE		197
Uncharacterized protein		CERAT		197
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9P0M4	IL17C isoform 2		PANTR		197	UniRef50_Q9P0M4
Uncharacterized protein		PANPA		197
IL17C isoform 1		PONAB		197
Uncharacterized protein		NOMLE		197
Uncharacterized protein		MANLE		197
+22

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF152099 mRNA Translation: AAF28105.1 AF142410 mRNA Translation: AAG27921.1 AY358471 mRNA Translation: AAQ88835.1 BC069152 mRNA Translation: AAH69152.1 BC101835 mRNA Translation: AAI01836.1 BC112196 mRNA Translation: AAI12197.1
CCDSⁱ	CCDS42217.1
RefSeqⁱ	NP_037410.1, NM_013278.3
UniGeneⁱ	Hs.278911

3D structure databases

ProteinModelPortalⁱ	Q9P0M4
SMRⁱ	Q9P0M4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000244241

STRINGⁱ

9606.ENSP00000244241

Polymorphism and mutation databases

BioMutaⁱ	IL17C
DMDMⁱ	20138769

Proteomic databases

PaxDbⁱ	Q9P0M4
PeptideAtlasⁱ	Q9P0M4
PRIDEⁱ	Q9P0M4
ProteomicsDBⁱ	83579

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000244241; ENSP00000244241; ENSG00000124391
GeneIDⁱ	27189
KEGGⁱ	hsa:27189
UCSCⁱ	uc002fla.4 human

Organism-specific databases

CTDⁱ	27189
DisGeNETⁱ	27189
EuPathDBⁱ	HostDB:ENSG00000124391.4
GeneCardsⁱ	IL17C
HGNCⁱ	HGNC:5983 IL17C
HPAⁱ	HPA065051
MIMⁱ	604628 gene
neXtProtⁱ	NX_Q9P0M4
OpenTargetsⁱ	ENSG00000124391
PharmGKBⁱ	PA29797
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZ2K Eukaryota ENOG4111VTD LUCA
GeneTreeⁱ	ENSGT00930000150940
HOGENOMⁱ	HOG000113031
HOVERGENⁱ	HBG052096
InParanoidⁱ	Q9P0M4
KOⁱ	K05491
OMAⁱ	GQAPPHL
OrthoDBⁱ	EOG091G17O0
PhylomeDBⁱ	Q9P0M4
TreeFamⁱ	TF314701

Enzyme and pathway databases

Reactomeⁱ	R-HSA-448424 Interleukin-17 signaling

Reactomeⁱ

R-HSA-448424 Interleukin-17 signaling

Miscellaneous databases

GenomeRNAiⁱ	27189
Protein Ontology More...PROⁱ	PR:Q9P0M4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124391 Expressed in 151 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_IL17C
Genevisibleⁱ	Q9P0M4 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020440 IL-17_chr IPR010345 IL-17_fam
Pfamⁱ	View protein in Pfam PF06083 IL17, 1 hit
PRINTSⁱ	PR01932 INTRLEUKIN17
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL17C_HUMAN
Accessionⁱ	Q9P0M4Primary (citable) accession number: Q9P0M4 Secondary accession number(s): Q3MIG8, Q9HC75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9P0M4 (IL17C_HUMAN)

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Interleukin-17C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ