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Entry version 165 (13 Nov 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12955 ZKSCAN7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0L1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55888

Open Targets

More...
OpenTargetsi
ENSG00000196345

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37537

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P0L1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZKSCAN7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124078992

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474371 – 754Zinc finger protein with KRAB and SCAN domains 7Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0L1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9P0L1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0L1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0L1

PeptideAtlas

More...
PeptideAtlasi
Q9P0L1

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0L1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83569 [Q9P0L1-1]
83570 [Q9P0L1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196345 Expressed in 170 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P0L1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P0L1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048312
HPA049906
HPA071850

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120978, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P0L1, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273320

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P0L1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 136SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini231 – 306KRABPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162985

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234619

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0L1

KEGG Orthology (KO)

More...
KOi
K09229

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPASQTW

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0L1

TreeFam database of animal gene trees

More...
TreeFami
TF350837

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC
60 70 80 90 100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE
110 120 130 140 150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE
160 170 180 190 200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC
210 220 230 240 250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL
260 270 280 290 300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
310 320 330 340 350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST
360 370 380 390 400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG
410 420 430 440 450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH
460 470 480 490 500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC
510 520 530 540 550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP
560 570 580 590 600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
610 620 630 640 650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL
660 670 680 690 700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF
710 720 730 740 750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA

WSVS
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6L6C9J6L6_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMM9E7EMM9_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZE7H7BZE7_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti665C → Y in AAF72104 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05278224R → C. Corresponds to variant dbSNP:rs35696191Ensembl.1
Natural variantiVAR_052783153F → S. Corresponds to variant dbSNP:rs13081859Ensembl.1
Natural variantiVAR_052784342T → I. Corresponds to variant dbSNP:rs34396823Ensembl.1
Natural variantiVAR_052785359E → K. Corresponds to variant dbSNP:rs34181686Ensembl.1
Natural variantiVAR_052786432T → A. Corresponds to variant dbSNP:rs9835485Ensembl.1
Natural variantiVAR_052787483T → I2 PublicationsCorresponds to variant dbSNP:rs9873604Ensembl.1
Natural variantiVAR_052788746S → F. Corresponds to variant dbSNP:rs34437520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011955271 – 276AGENMM → GWSTMA in isoform 2. 1 Publication6
Alternative sequenceiVSP_011956277 – 754Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF154846 mRNA Translation: AAF72104.1
AY280798 mRNA Translation: AAQ16302.1
AK291285 mRNA Translation: BAF83974.1
BC010555 mRNA Translation: AAH10555.1
BC063020 mRNA Translation: AAH63020.1
BC127640 mRNA Translation: AAI27641.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2714.1 [Q9P0L1-2]
CCDS2715.1 [Q9P0L1-1]

Protein sequence database of the Protein Information Resource

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PIRi
G45193

NCBI Reference Sequences

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RefSeqi
NP_001275519.1, NM_001288590.1 [Q9P0L1-1]
NP_001275520.1, NM_001288591.1 [Q9P0L1-2]
NP_001275521.1, NM_001288592.1
NP_061121.2, NM_018651.3 [Q9P0L1-1]
NP_079445.1, NM_025169.2 [Q9P0L1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273320; ENSP00000273320; ENSG00000196345 [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345 [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345 [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345 [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894 [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894 [Q9P0L1-1]
ENST00000629379; ENSP00000485948; ENSG00000281894 [Q9P0L1-1]
ENST00000629459; ENSP00000486642; ENSG00000281894 [Q9P0L1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55888

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55888

UCSC genome browser

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UCSCi
uc003cni.5 human [Q9P0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA Translation: AAF72104.1
AY280798 mRNA Translation: AAQ16302.1
AK291285 mRNA Translation: BAF83974.1
BC010555 mRNA Translation: AAH10555.1
BC063020 mRNA Translation: AAH63020.1
BC127640 mRNA Translation: AAI27641.1
CCDSiCCDS2714.1 [Q9P0L1-2]
CCDS2715.1 [Q9P0L1-1]
PIRiG45193
RefSeqiNP_001275519.1, NM_001288590.1 [Q9P0L1-1]
NP_001275520.1, NM_001288591.1 [Q9P0L1-2]
NP_001275521.1, NM_001288592.1
NP_061121.2, NM_018651.3 [Q9P0L1-1]
NP_079445.1, NM_025169.2 [Q9P0L1-2]

3D structure databases

SMRiQ9P0L1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120978, 14 interactors
IntActiQ9P0L1, 16 interactors
STRINGi9606.ENSP00000273320

PTM databases

iPTMnetiQ9P0L1
PhosphoSitePlusiQ9P0L1

Polymorphism and mutation databases

BioMutaiZKSCAN7
DMDMi124078992

Proteomic databases

jPOSTiQ9P0L1
MassIVEiQ9P0L1
MaxQBiQ9P0L1
PaxDbiQ9P0L1
PeptideAtlasiQ9P0L1
PRIDEiQ9P0L1
ProteomicsDBi83569 [Q9P0L1-1]
83570 [Q9P0L1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55888

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345 [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345 [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345 [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345 [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894 [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894 [Q9P0L1-1]
ENST00000629379; ENSP00000485948; ENSG00000281894 [Q9P0L1-1]
ENST00000629459; ENSP00000486642; ENSG00000281894 [Q9P0L1-2]
GeneIDi55888
KEGGihsa:55888
UCSCiuc003cni.5 human [Q9P0L1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55888
DisGeNETi55888

GeneCards: human genes, protein and diseases

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GeneCardsi
ZKSCAN7
HGNCiHGNC:12955 ZKSCAN7
HPAiHPA048312
HPA049906
HPA071850
neXtProtiNX_Q9P0L1
OpenTargetsiENSG00000196345
PharmGKBiPA37537

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162985
HOGENOMiHOG000234619
InParanoidiQ9P0L1
KOiK09229
OMAiEPASQTW
OrthoDBi1318335at2759
PhylomeDBiQ9P0L1
TreeFamiTF350837

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZKSCAN7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55888
PharosiQ9P0L1

Protein Ontology

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PROi
PR:Q9P0L1

Gene expression databases

BgeeiENSG00000196345 Expressed in 170 organ(s), highest expression level in forebrain
ExpressionAtlasiQ9P0L1 baseline and differential
GenevisibleiQ9P0L1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZKSC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 13, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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