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UniProtKB - Q9P0L1 (ZKSC7_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P0L1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9P0L1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12955, ZKSCAN7

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P0L1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196345

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55888

Open Targets

More...OpenTargetsi		ENSG00000196345

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37537

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P0L1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZKSCAN7

Domain mapping of disease mutations (DMDM)

More...DMDMi		124078992

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474371 – 754Zinc finger protein with KRAB and SCAN domains 7Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P0L1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P0L1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P0L1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P0L1

PeptideAtlas

More...PeptideAtlasi		Q9P0L1

PRoteomics IDEntifications database

More...PRIDEi		Q9P0L1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83569 [Q9P0L1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P0L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P0L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196345, Expressed in forebrain and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P0L1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P0L1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196345, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120978, 18 interactors

Protein interaction database and analysis system

More...IntActi		Q9P0L1, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000273320

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P0L1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P0L1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 136SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini231 – 306KRABPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 215DisorderedSequence analysisAdd BLAST59
Regioni735 – 754DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi157 – 172Polar residuesSequence analysisAdd BLAST16
Compositional biasi195 – 215Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162985

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P0L1

Identification of Orthologs from Complete Genome Data

More...OMAi		EPASQTW

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P0L1

TreeFam database of animal gene trees

More...TreeFami		TF350837

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC 
        60         70         80         90        100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE 
       110        120        130        140        150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE 
       160        170        180        190        200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC 
       210        220        230        240        250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL 
       260        270        280        290        300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG 
       310        320        330        340        350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST 
       360        370        380        390        400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG 
       410        420        430        440        450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH 
       460        470        480        490        500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC 
       510        520        530        540        550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP 
       560        570        580        590        600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI 
       610        620        630        640        650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL 
       660        670        680        690        700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF 
       710        720        730        740        750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA 

WSVS
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6L6C9J6L6_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMM9E7EMM9_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZE7H7BZE7_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti665C → Y in AAF72104 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05278224R → C. Corresponds to variant dbSNP:rs35696191Ensembl.1
Natural variantiVAR_052783153F → S. Corresponds to variant dbSNP:rs13081859Ensembl.1
Natural variantiVAR_052784342T → I. Corresponds to variant dbSNP:rs34396823Ensembl.1
Natural variantiVAR_052785359E → K. Corresponds to variant dbSNP:rs34181686Ensembl.1
Natural variantiVAR_052786432T → A. Corresponds to variant dbSNP:rs9835485Ensembl.1
Natural variantiVAR_052787483T → I2 PublicationsCorresponds to variant dbSNP:rs9873604Ensembl.1
Natural variantiVAR_052788746S → F. Corresponds to variant dbSNP:rs34437520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011955271 – 276AGENMM → GWSTMA in isoform 2. 1 Publication6
Alternative sequenceiVSP_011956277 – 754Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF154846 mRNA Translation: AAF72104.1
AY280798 mRNA Translation: AAQ16302.1
AK291285 mRNA Translation: BAF83974.1
BC010555 mRNA Translation: AAH10555.1
BC063020 mRNA Translation: AAH63020.1
BC127640 mRNA Translation: AAI27641.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2714.1 [Q9P0L1-2]
CCDS2715.1 [Q9P0L1-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G45193

NCBI Reference Sequences

More...RefSeqi		NP_001275519.1, NM_001288590.1 [Q9P0L1-1]
NP_001275520.1, NM_001288591.1 [Q9P0L1-2]
NP_001275521.1, NM_001288592.1
NP_061121.2, NM_018651.3 [Q9P0L1-1]
NP_079445.1, NM_025169.2 [Q9P0L1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000273320; ENSP00000273320; ENSG00000196345
ENST00000341840; ENSP00000345404; ENSG00000196345 [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345
ENST00000431636; ENSP00000416681; ENSG00000196345 [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894 [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894
ENST00000629379; ENSP00000485948; ENSG00000281894
ENST00000629459; ENSP00000486642; ENSG00000281894 [Q9P0L1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55888

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55888

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000426540.6; ENSP00000395524.1; NM_001288590.2; NP_001275519.1

UCSC genome browser

More...UCSCi		uc003cni.5, human [Q9P0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA Translation: AAF72104.1
AY280798 mRNA Translation: AAQ16302.1
AK291285 mRNA Translation: BAF83974.1
BC010555 mRNA Translation: AAH10555.1
BC063020 mRNA Translation: AAH63020.1
BC127640 mRNA Translation: AAI27641.1
CCDSiCCDS2714.1 [Q9P0L1-2]
CCDS2715.1 [Q9P0L1-1]
PIRiG45193
RefSeqiNP_001275519.1, NM_001288590.1 [Q9P0L1-1]
NP_001275520.1, NM_001288591.1 [Q9P0L1-2]
NP_001275521.1, NM_001288592.1
NP_061121.2, NM_018651.3 [Q9P0L1-1]
NP_079445.1, NM_025169.2 [Q9P0L1-2]

3D structure databases

SMRiQ9P0L1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120978, 18 interactors
IntActiQ9P0L1, 16 interactors
STRINGi9606.ENSP00000273320

PTM databases

iPTMnetiQ9P0L1
PhosphoSitePlusiQ9P0L1

Genetic variation databases

BioMutaiZKSCAN7
DMDMi124078992

Proteomic databases

jPOSTiQ9P0L1
MassIVEiQ9P0L1
MaxQBiQ9P0L1
PaxDbiQ9P0L1
PeptideAtlasiQ9P0L1
PRIDEiQ9P0L1
ProteomicsDBi83569 [Q9P0L1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12496, 90 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		55888

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345
ENST00000341840; ENSP00000345404; ENSG00000196345 [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345
ENST00000431636; ENSP00000416681; ENSG00000196345 [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894 [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894
ENST00000629379; ENSP00000485948; ENSG00000281894
ENST00000629459; ENSP00000486642; ENSG00000281894 [Q9P0L1-2]
GeneIDi55888
KEGGihsa:55888
MANE-SelectiENST00000426540.6; ENSP00000395524.1; NM_001288590.2; NP_001275519.1
UCSCiuc003cni.5, human [Q9P0L1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55888
DisGeNETi55888

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZKSCAN7
HGNCiHGNC:12955, ZKSCAN7
HPAiENSG00000196345, Low tissue specificity
neXtProtiNX_Q9P0L1
OpenTargetsiENSG00000196345
PharmGKBiPA37537
VEuPathDBiHostDB:ENSG00000196345

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162985
HOGENOMiCLU_002678_49_8_1
InParanoidiQ9P0L1
OMAiEPASQTW
OrthoDBi1318335at2759
PhylomeDBiQ9P0L1
TreeFamiTF350837

Enzyme and pathway databases

PathwayCommonsiQ9P0L1
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiQ9P0L1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55888, 4 hits in 1056 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZKSCAN7, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55888
PharosiQ9P0L1, Tbio

Protein Ontology

More...PROi		PR:Q9P0L1
RNActiQ9P0L1, protein

Gene expression databases

BgeeiENSG00000196345, Expressed in forebrain and 187 other tissues
ExpressionAtlasiQ9P0L1, baseline and differential
GenevisibleiQ9P0L1, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZKSC7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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