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UniProtKB - Q9P0L1 (ZKSC7_HUMAN)
Protein
Zinc finger protein with KRAB and SCAN domains 7
Gene
ZKSCAN7
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 383 – 405 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9P0L1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9P0L1 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein with KRAB and SCAN domains 7Alternative name(s): Zinc finger protein 167 Zinc finger protein 448 Zinc finger protein 64 |
Gene namesi | Name:ZKSCAN7 Synonyms:ZNF167, ZNF448, ZNF64 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12955, ZKSCAN7 |
neXtProti | NX_Q9P0L1 |
VEuPathDBi | HostDB:ENSG00000196345 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55888 |
OpenTargetsi | ENSG00000196345 |
PharmGKBi | PA37537 |
Miscellaneous databases
Pharosi | Q9P0L1, Tbio |
Genetic variation databases
BioMutai | ZKSCAN7 |
DMDMi | 124078992 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047437 | 1 – 754 | Zinc finger protein with KRAB and SCAN domains 7Add BLAST | 754 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 28 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q9P0L1 |
MassIVEi | Q9P0L1 |
MaxQBi | Q9P0L1 |
PaxDbi | Q9P0L1 |
PeptideAtlasi | Q9P0L1 |
PRIDEi | Q9P0L1 |
ProteomicsDBi | 83569 [Q9P0L1-1] |
PTM databases
iPTMneti | Q9P0L1 |
PhosphoSitePlusi | Q9P0L1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196345, Expressed in forebrain and 187 other tissues |
ExpressionAtlasi | Q9P0L1, baseline and differential |
Genevisiblei | Q9P0L1, HS |
Organism-specific databases
HPAi | ENSG00000196345, Low tissue specificity |
Interactioni
Binary interactionsi
Q9P0L1
Isoform 2 [Q9P0L1-2]
Protein-protein interaction databases
BioGRIDi | 120978, 18 interactors |
IntActi | Q9P0L1, 16 interactors |
STRINGi | 9606.ENSP00000273320 |
Miscellaneous databases
RNActi | Q9P0L1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 136 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 231 – 306 | KRABPROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 215 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 735 – 754 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 172 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 195 – 215 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 383 – 405 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162985 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q9P0L1 |
OMAi | EPASQTW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9P0L1 |
TreeFami | TF350837 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC
60 70 80 90 100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE
110 120 130 140 150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE
160 170 180 190 200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC
210 220 230 240 250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL
260 270 280 290 300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
310 320 330 340 350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST
360 370 380 390 400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG
410 420 430 440 450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH
460 470 480 490 500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC
510 520 530 540 550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP
560 570 580 590 600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
610 620 630 640 650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL
660 670 680 690 700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF
710 720 730 740 750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA
WSVS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J6L6 | C9J6L6_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN7 | 373 | Annotation score: | ||
E7EMM9 | E7EMM9_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN7 | 202 | Annotation score: | ||
H7BZE7 | H7BZE7_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN7 | 121 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 665 | C → Y in AAF72104 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052782 | 24 | R → C. Corresponds to variant dbSNP:rs35696191Ensembl. | 1 | |
Natural variantiVAR_052783 | 153 | F → S. Corresponds to variant dbSNP:rs13081859Ensembl. | 1 | |
Natural variantiVAR_052784 | 342 | T → I. Corresponds to variant dbSNP:rs34396823Ensembl. | 1 | |
Natural variantiVAR_052785 | 359 | E → K. Corresponds to variant dbSNP:rs34181686Ensembl. | 1 | |
Natural variantiVAR_052786 | 432 | T → A. Corresponds to variant dbSNP:rs9835485Ensembl. | 1 | |
Natural variantiVAR_052787 | 483 | T → I2 PublicationsCorresponds to variant dbSNP:rs9873604Ensembl. | 1 | |
Natural variantiVAR_052788 | 746 | S → F. Corresponds to variant dbSNP:rs34437520Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011955 | 271 – 276 | AGENMM → GWSTMA in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_011956 | 277 – 754 | Missing in isoform 2. 1 PublicationAdd BLAST | 478 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154846 mRNA Translation: AAF72104.1 AY280798 mRNA Translation: AAQ16302.1 AK291285 mRNA Translation: BAF83974.1 BC010555 mRNA Translation: AAH10555.1 BC063020 mRNA Translation: AAH63020.1 BC127640 mRNA Translation: AAI27641.1 |
CCDSi | CCDS2714.1 [Q9P0L1-2] CCDS2715.1 [Q9P0L1-1] |
PIRi | G45193 |
RefSeqi | NP_001275519.1, NM_001288590.1 [Q9P0L1-1] NP_001275520.1, NM_001288591.1 [Q9P0L1-2] NP_001275521.1, NM_001288592.1 NP_061121.2, NM_018651.3 [Q9P0L1-1] NP_079445.1, NM_025169.2 [Q9P0L1-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154846 mRNA Translation: AAF72104.1 AY280798 mRNA Translation: AAQ16302.1 AK291285 mRNA Translation: BAF83974.1 BC010555 mRNA Translation: AAH10555.1 BC063020 mRNA Translation: AAH63020.1 BC127640 mRNA Translation: AAI27641.1 |
CCDSi | CCDS2714.1 [Q9P0L1-2] CCDS2715.1 [Q9P0L1-1] |
PIRi | G45193 |
RefSeqi | NP_001275519.1, NM_001288590.1 [Q9P0L1-1] NP_001275520.1, NM_001288591.1 [Q9P0L1-2] NP_001275521.1, NM_001288592.1 NP_061121.2, NM_018651.3 [Q9P0L1-1] NP_079445.1, NM_025169.2 [Q9P0L1-2] |
3D structure databases
SMRi | Q9P0L1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120978, 18 interactors |
IntActi | Q9P0L1, 16 interactors |
STRINGi | 9606.ENSP00000273320 |
PTM databases
iPTMneti | Q9P0L1 |
PhosphoSitePlusi | Q9P0L1 |
Genetic variation databases
BioMutai | ZKSCAN7 |
DMDMi | 124078992 |
Proteomic databases
jPOSTi | Q9P0L1 |
MassIVEi | Q9P0L1 |
MaxQBi | Q9P0L1 |
PaxDbi | Q9P0L1 |
PeptideAtlasi | Q9P0L1 |
PRIDEi | Q9P0L1 |
ProteomicsDBi | 83569 [Q9P0L1-1] |
Protocols and materials databases
Antibodypediai | 12496, 90 antibodies from 21 providers |
DNASUi | 55888 |
Genome annotation databases
Organism-specific databases
CTDi | 55888 |
DisGeNETi | 55888 |
GeneCardsi | ZKSCAN7 |
HGNCi | HGNC:12955, ZKSCAN7 |
HPAi | ENSG00000196345, Low tissue specificity |
neXtProti | NX_Q9P0L1 |
OpenTargetsi | ENSG00000196345 |
PharmGKBi | PA37537 |
VEuPathDBi | HostDB:ENSG00000196345 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162985 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q9P0L1 |
OMAi | EPASQTW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9P0L1 |
TreeFami | TF350837 |
Enzyme and pathway databases
PathwayCommonsi | Q9P0L1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9P0L1 |
Miscellaneous databases
BioGRID-ORCSi | 55888, 4 hits in 1056 CRISPR screens |
ChiTaRSi | ZKSCAN7, human |
GenomeRNAii | 55888 |
Pharosi | Q9P0L1, Tbio |
PROi | PR:Q9P0L1 |
RNActi | Q9P0L1, protein |
Gene expression databases
Bgeei | ENSG00000196345, Expressed in forebrain and 187 other tissues |
ExpressionAtlasi | Q9P0L1, baseline and differential |
Genevisiblei | Q9P0L1, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZKSC7_HUMAN | |
Accessioni | Q9P0L1Primary (citable) accession number: Q9P0L1 Secondary accession number(s): A0PJV3 Q96FQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families