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Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196345.12
HGNCiHGNC:12955 ZKSCAN7
neXtProtiNX_Q9P0L1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55888
OpenTargetsiENSG00000196345
PharmGKBiPA37537

Polymorphism and mutation databases

BioMutaiZKSCAN7
DMDMi124078992

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474371 – 754Zinc finger protein with KRAB and SCAN domains 7Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9P0L1
MaxQBiQ9P0L1
PaxDbiQ9P0L1
PeptideAtlasiQ9P0L1
PRIDEiQ9P0L1
ProteomicsDBi83569
83570 [Q9P0L1-2]

PTM databases

iPTMnetiQ9P0L1
PhosphoSitePlusiQ9P0L1

Expressioni

Gene expression databases

BgeeiENSG00000196345 Expressed in 170 organ(s), highest expression level in forebrain
CleanExiHS_ZNF167
ExpressionAtlasiQ9P0L1 baseline and differential
GenevisibleiQ9P0L1 HS

Organism-specific databases

HPAiHPA048312
HPA049906
HPA071850

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120978, 14 interactors
IntActiQ9P0L1, 15 interactors
STRINGi9606.ENSP00000273320

Structurei

3D structure databases

ProteinModelPortaliQ9P0L1
SMRiQ9P0L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 136SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini231 – 306KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148943
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ9P0L1
KOiK09229
OMAiDKYKEVG
OrthoDBiEOG091G02KC
PhylomeDBiQ9P0L1
TreeFamiTF350837

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC
60 70 80 90 100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE
110 120 130 140 150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE
160 170 180 190 200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC
210 220 230 240 250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL
260 270 280 290 300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
310 320 330 340 350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST
360 370 380 390 400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG
410 420 430 440 450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH
460 470 480 490 500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC
510 520 530 540 550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP
560 570 580 590 600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
610 620 630 640 650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL
660 670 680 690 700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF
710 720 730 740 750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA

WSVS
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6L6C9J6L6_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
373Annotation score:
H7BZE7H7BZE7_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
121Annotation score:
E7EMM9E7EMM9_HUMAN
Zinc finger protein with KRAB and S...
ZKSCAN7
202Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti665C → Y in AAF72104 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05278224R → C. Corresponds to variant dbSNP:rs35696191Ensembl.1
Natural variantiVAR_052783153F → S. Corresponds to variant dbSNP:rs13081859Ensembl.1
Natural variantiVAR_052784342T → I. Corresponds to variant dbSNP:rs34396823Ensembl.1
Natural variantiVAR_052785359E → K. Corresponds to variant dbSNP:rs34181686Ensembl.1
Natural variantiVAR_052786432T → A. Corresponds to variant dbSNP:rs9835485Ensembl.1
Natural variantiVAR_052787483T → I2 PublicationsCorresponds to variant dbSNP:rs9873604Ensembl.1
Natural variantiVAR_052788746S → F. Corresponds to variant dbSNP:rs34437520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011955271 – 276AGENMM → GWSTMA in isoform 2. 1 Publication6
Alternative sequenceiVSP_011956277 – 754Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA Translation: AAF72104.1
AY280798 mRNA Translation: AAQ16302.1
AK291285 mRNA Translation: BAF83974.1
BC010555 mRNA Translation: AAH10555.1
BC063020 mRNA Translation: AAH63020.1
BC127640 mRNA Translation: AAI27641.1
CCDSiCCDS2714.1 [Q9P0L1-2]
CCDS2715.1 [Q9P0L1-1]
PIRiG45193
RefSeqiNP_001275519.1, NM_001288590.1 [Q9P0L1-1]
NP_001275520.1, NM_001288591.1 [Q9P0L1-2]
NP_001275521.1, NM_001288592.1
NP_061121.2, NM_018651.3 [Q9P0L1-1]
NP_079445.1, NM_025169.2 [Q9P0L1-2]
UniGeneiHs.529512
Hs.696570

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345 [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345 [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345 [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345 [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894 [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894 [Q9P0L1-1]
ENST00000629379; ENSP00000485948; ENSG00000281894 [Q9P0L1-1]
ENST00000629459; ENSP00000486642; ENSG00000281894 [Q9P0L1-2]
GeneIDi55888
KEGGihsa:55888
UCSCiuc003cni.5 human [Q9P0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZKSC7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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