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Protein

Forkhead box protein J2

Gene

FOXJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 143Fork-headPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9P0K8

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J2
Alternative name(s):
Fork head homologous X
Gene namesi
Name:FOXJ2
Synonyms:FHX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000065970.8
HGNCiHGNC:24818 FOXJ2
neXtProtiNX_Q9P0K8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55810
OpenTargetsiENSG00000065970
PharmGKBiPA134982817

Polymorphism and mutation databases

BioMutaiFOXJ2
DMDMi13626933

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000918532 – 574Forkhead box protein J2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P0K8
MaxQBiQ9P0K8
PaxDbiQ9P0K8
PeptideAtlasiQ9P0K8
PRIDEiQ9P0K8
ProteomicsDBi83564
83565 [Q9P0K8-2]

PTM databases

iPTMnetiQ9P0K8
PhosphoSitePlusiQ9P0K8

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000065970 Expressed in 235 organ(s), highest expression level in cerebellum
CleanExiHS_FOXJ2
GenevisibleiQ9P0K8 HS

Organism-specific databases

HPAiHPA008723

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120920, 76 interactors
IntActiQ9P0K8, 74 interactors
MINTiQ9P0K8

Structurei

3D structure databases

ProteinModelPortaliQ9P0K8
SMRiQ9P0K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 270Poly-Ser5
Compositional biasi291 – 294Poly-Gln4
Compositional biasi295 – 298Poly-Pro4
Compositional biasi299 – 306Poly-Gln8
Compositional biasi313 – 321Poly-Gln9
Compositional biasi390 – 395Poly-Pro6

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000231184
HOVERGENiHBG051648
InParanoidiQ9P0K8
KOiK09403
OMAiPSPMYPI
OrthoDBiEOG091G0U7S
PhylomeDBiQ9P0K8
TreeFamiTF333250

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform FOXJ2.L (identifier: Q9P0K8-1) [UniParc]FASTAAdd to basket
Also known as: FHX.L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP
60 70 80 90 100
NATLSKDEAA VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF
110 120 130 140 150
PYYKNAGIGW KNSIRHNLSL NKCFRKVPRP RDDPGKGSYW TIDTCPDISR
160 170 180 190 200
KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS GEASLPPEGN PQMSLQSPTS
210 220 230 240 250
IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK FSYSEINFQD
260 270 280 290 300
LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ
310 320 330 340 350
QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK
360 370 380 390 400
QAGAEGYGPP PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ
410 420 430 440 450
APINNTGFAF PSDWCSNIDS LKESFKMVNR LNWSSIEQSQ FSELMESLRQ
460 470 480 490 500
AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV PPQGGTHRPP APARIADSCA
510 520 530 540 550
LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA GYNRPAHHMV
560 570
PRPSVPPPGA NEEIPDDFDW DLIT
Length:574
Mass (Da):62,395
Last modified:October 1, 2000 - v1
Checksum:i258120EDAE4B11EB
GO
Isoform FOXJ2.S (identifier: Q9P0K8-2) [UniParc]FASTAAdd to basket
Also known as: FHX.S

The sequence of this isoform differs from the canonical sequence as follows:
     513-574: VNSYGHPQAP...PDDFDWDLIT → GTAPSQLPWRWRLC

Show »
Length:526
Mass (Da):57,220
Checksum:i666CFE383030805D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049162229P → R. Corresponds to variant dbSNP:rs35642012Ensembl.1
Natural variantiVAR_021842310P → S. Corresponds to variant dbSNP:rs2277415Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001544513 – 574VNSYG…WDLIT → GTAPSQLPWRWRLC in isoform FOXJ2.S. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155132 mRNA Translation: AAF65927.1
AF155133 mRNA Translation: AAK49016.1
BC126396 mRNA Translation: AAI26397.1
BC136305 mRNA Translation: AAI36306.1
AL161978 mRNA Translation: CAB82315.1
CCDSiCCDS8587.1 [Q9P0K8-1]
PIRiT47161
RefSeqiNP_060886.1, NM_018416.2 [Q9P0K8-1]
UniGeneiHs.120844

Genome annotation databases

EnsembliENST00000162391; ENSP00000162391; ENSG00000065970 [Q9P0K8-1]
ENST00000428177; ENSP00000403411; ENSG00000065970 [Q9P0K8-2]
GeneIDi55810
KEGGihsa:55810
UCSCiuc001qtt.2 human [Q9P0K8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155132 mRNA Translation: AAF65927.1
AF155133 mRNA Translation: AAK49016.1
BC126396 mRNA Translation: AAI26397.1
BC136305 mRNA Translation: AAI36306.1
AL161978 mRNA Translation: CAB82315.1
CCDSiCCDS8587.1 [Q9P0K8-1]
PIRiT47161
RefSeqiNP_060886.1, NM_018416.2 [Q9P0K8-1]
UniGeneiHs.120844

3D structure databases

ProteinModelPortaliQ9P0K8
SMRiQ9P0K8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120920, 76 interactors
IntActiQ9P0K8, 74 interactors
MINTiQ9P0K8

PTM databases

iPTMnetiQ9P0K8
PhosphoSitePlusiQ9P0K8

Polymorphism and mutation databases

BioMutaiFOXJ2
DMDMi13626933

Proteomic databases

EPDiQ9P0K8
MaxQBiQ9P0K8
PaxDbiQ9P0K8
PeptideAtlasiQ9P0K8
PRIDEiQ9P0K8
ProteomicsDBi83564
83565 [Q9P0K8-2]

Protocols and materials databases

DNASUi55810
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000162391; ENSP00000162391; ENSG00000065970 [Q9P0K8-1]
ENST00000428177; ENSP00000403411; ENSG00000065970 [Q9P0K8-2]
GeneIDi55810
KEGGihsa:55810
UCSCiuc001qtt.2 human [Q9P0K8-1]

Organism-specific databases

CTDi55810
DisGeNETi55810
EuPathDBiHostDB:ENSG00000065970.8
GeneCardsiFOXJ2
HGNCiHGNC:24818 FOXJ2
HPAiHPA008723
neXtProtiNX_Q9P0K8
OpenTargetsiENSG00000065970
PharmGKBiPA134982817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000231184
HOVERGENiHBG051648
InParanoidiQ9P0K8
KOiK09403
OMAiPSPMYPI
OrthoDBiEOG091G0U7S
PhylomeDBiQ9P0K8
TreeFamiTF333250

Enzyme and pathway databases

SignaLinkiQ9P0K8

Miscellaneous databases

ChiTaRSiFOXJ2 human
GeneWikiiFOXJ2
GenomeRNAii55810
PROiPR:Q9P0K8

Gene expression databases

BgeeiENSG00000065970 Expressed in 235 organ(s), highest expression level in cerebellum
CleanExiHS_FOXJ2
GenevisibleiQ9P0K8 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXJ2_HUMAN
AccessioniPrimary (citable) accession number: Q9P0K8
Secondary accession number(s): A0AVK4
, B2RMP3, Q96PS9, Q9NSN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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