UniProtKB - Q9P0K8 (FOXJ2_HUMAN)
Protein
Forkhead box protein J2
Gene
FOXJ2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity).By similarity2 Publications
Transcriptional activator.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 66 – 143 | Fork-headPROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: IntAct
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- male meiosis I Source: UniProtKB
- negative regulation of angiogenesis Source: BHF-UCL
- negative regulation of blood vessel endothelial cell differentiation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Meiosis, Spermatogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9P0K8 |
SignaLinki | Q9P0K8 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein J2Alternative name(s): Fork head homologous X |
Gene namesi | Name:FOXJ2 Synonyms:FHX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24818, FOXJ2 |
neXtProti | NX_Q9P0K8 |
VEuPathDBi | HostDB:ENSG00000065970.8 |
Subcellular locationi
Nucleus
Nucleus
- fibrillar center Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55810 |
OpenTargetsi | ENSG00000065970 |
PharmGKBi | PA134982817 |
Miscellaneous databases
Pharosi | Q9P0K8, Tbio |
Genetic variation databases
BioMutai | FOXJ2 |
DMDMi | 13626933 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000091853 | 2 – 574 | Forkhead box protein J2Add BLAST | 573 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 | |
Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 164 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9P0K8 |
MassIVEi | Q9P0K8 |
MaxQBi | Q9P0K8 |
PaxDbi | Q9P0K8 |
PeptideAtlasi | Q9P0K8 |
PRIDEi | Q9P0K8 |
ProteomicsDBi | 83564 [Q9P0K8-1] 83565 [Q9P0K8-2] |
PTM databases
iPTMneti | Q9P0K8 |
PhosphoSitePlusi | Q9P0K8 |
Expressioni
Tissue specificityi
Widely expressed.
Gene expression databases
Bgeei | ENSG00000065970, Expressed in cerebellum and 249 other tissues |
Genevisiblei | Q9P0K8, HS |
Organism-specific databases
HPAi | ENSG00000065970, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9P0K8
With | #Exp. | IntAct |
---|---|---|
CSTF2T [Q9H0L4] | 3 | EBI-2869608,EBI-747012 |
EGLN3 [Q9H6Z9] | 6 | EBI-2869608,EBI-1175354 |
itself | 2 | EBI-2869608,EBI-2869608 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 120920, 79 interactors |
IntActi | Q9P0K8, 74 interactors |
MINTi | Q9P0K8 |
STRINGi | 9606.ENSP00000162391 |
Miscellaneous databases
RNActi | Q9P0K8, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 266 – 270 | Poly-Ser | 5 | |
Compositional biasi | 291 – 294 | Poly-Gln | 4 | |
Compositional biasi | 295 – 298 | Poly-Pro | 4 | |
Compositional biasi | 299 – 306 | Poly-Gln | 8 | |
Compositional biasi | 313 – 321 | Poly-Gln | 9 | |
Compositional biasi | 390 – 395 | Poly-Pro | 6 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000161053 |
HOGENOMi | CLU_034661_0_0_1 |
InParanoidi | Q9P0K8 |
OMAi | SVMAMHP |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9P0K8 |
TreeFami | TF333250 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform FOXJ2.L (identifier: Q9P0K8-1) [UniParc]FASTAAdd to basket
Also known as: FHX.L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP
60 70 80 90 100
NATLSKDEAA VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF
110 120 130 140 150
PYYKNAGIGW KNSIRHNLSL NKCFRKVPRP RDDPGKGSYW TIDTCPDISR
160 170 180 190 200
KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS GEASLPPEGN PQMSLQSPTS
210 220 230 240 250
IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK FSYSEINFQD
260 270 280 290 300
LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ
310 320 330 340 350
QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK
360 370 380 390 400
QAGAEGYGPP PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ
410 420 430 440 450
APINNTGFAF PSDWCSNIDS LKESFKMVNR LNWSSIEQSQ FSELMESLRQ
460 470 480 490 500
AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV PPQGGTHRPP APARIADSCA
510 520 530 540 550
LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA GYNRPAHHMV
560 570
PRPSVPPPGA NEEIPDDFDW DLIT
Isoform FOXJ2.S (identifier: Q9P0K8-2) [UniParc]FASTAAdd to basket
Also known as: FHX.S
The sequence of this isoform differs from the canonical sequence as follows:
513-574: VNSYGHPQAP...PDDFDWDLIT → GTAPSQLPWRWRLC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049162 | 229 | P → R. Corresponds to variant dbSNP:rs35642012Ensembl. | 1 | |
Natural variantiVAR_021842 | 310 | P → S. Corresponds to variant dbSNP:rs2277415Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001544 | 513 – 574 | VNSYG…WDLIT → GTAPSQLPWRWRLC in isoform FOXJ2.S. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155132 mRNA Translation: AAF65927.1 AF155133 mRNA Translation: AAK49016.1 BC126396 mRNA Translation: AAI26397.1 BC136305 mRNA Translation: AAI36306.1 AL161978 mRNA Translation: CAB82315.1 |
CCDSi | CCDS8587.1 [Q9P0K8-1] |
PIRi | T47161 |
RefSeqi | NP_060886.1, NM_018416.2 [Q9P0K8-1] |
Genome annotation databases
Ensembli | ENST00000162391; ENSP00000162391; ENSG00000065970 [Q9P0K8-1] ENST00000428177; ENSP00000403411; ENSG00000065970 [Q9P0K8-2] |
GeneIDi | 55810 |
KEGGi | hsa:55810 |
UCSCi | uc001qtt.2, human [Q9P0K8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF155132 mRNA Translation: AAF65927.1 AF155133 mRNA Translation: AAK49016.1 BC126396 mRNA Translation: AAI26397.1 BC136305 mRNA Translation: AAI36306.1 AL161978 mRNA Translation: CAB82315.1 |
CCDSi | CCDS8587.1 [Q9P0K8-1] |
PIRi | T47161 |
RefSeqi | NP_060886.1, NM_018416.2 [Q9P0K8-1] |
3D structure databases
SMRi | Q9P0K8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120920, 79 interactors |
IntActi | Q9P0K8, 74 interactors |
MINTi | Q9P0K8 |
STRINGi | 9606.ENSP00000162391 |
PTM databases
iPTMneti | Q9P0K8 |
PhosphoSitePlusi | Q9P0K8 |
Genetic variation databases
BioMutai | FOXJ2 |
DMDMi | 13626933 |
Proteomic databases
jPOSTi | Q9P0K8 |
MassIVEi | Q9P0K8 |
MaxQBi | Q9P0K8 |
PaxDbi | Q9P0K8 |
PeptideAtlasi | Q9P0K8 |
PRIDEi | Q9P0K8 |
ProteomicsDBi | 83564 [Q9P0K8-1] 83565 [Q9P0K8-2] |
Protocols and materials databases
Antibodypediai | 1748, 168 antibodies |
DNASUi | 55810 |
Genome annotation databases
Ensembli | ENST00000162391; ENSP00000162391; ENSG00000065970 [Q9P0K8-1] ENST00000428177; ENSP00000403411; ENSG00000065970 [Q9P0K8-2] |
GeneIDi | 55810 |
KEGGi | hsa:55810 |
UCSCi | uc001qtt.2, human [Q9P0K8-1] |
Organism-specific databases
CTDi | 55810 |
DisGeNETi | 55810 |
GeneCardsi | FOXJ2 |
HGNCi | HGNC:24818, FOXJ2 |
HPAi | ENSG00000065970, Low tissue specificity |
neXtProti | NX_Q9P0K8 |
OpenTargetsi | ENSG00000065970 |
PharmGKBi | PA134982817 |
VEuPathDBi | HostDB:ENSG00000065970.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000161053 |
HOGENOMi | CLU_034661_0_0_1 |
InParanoidi | Q9P0K8 |
OMAi | SVMAMHP |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q9P0K8 |
TreeFami | TF333250 |
Enzyme and pathway databases
PathwayCommonsi | Q9P0K8 |
SignaLinki | Q9P0K8 |
Miscellaneous databases
BioGRID-ORCSi | 55810, 8 hits in 1017 CRISPR screens |
ChiTaRSi | FOXJ2, human |
GeneWikii | FOXJ2 |
GenomeRNAii | 55810 |
Pharosi | Q9P0K8, Tbio |
PROi | PR:Q9P0K8 |
RNActi | Q9P0K8, protein |
Gene expression databases
Bgeei | ENSG00000065970, Expressed in cerebellum and 249 other tissues |
Genevisiblei | Q9P0K8, HS |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXJ2_HUMAN | |
Accessioni | Q9P0K8Primary (citable) accession number: Q9P0K8 Secondary accession number(s): A0AVK4 Q9NSN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports