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Entry version 154 (16 Oct 2019)
Sequence version 2 (13 Jun 2006)
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Protein

Ankycorbin

Gene

RAI14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankycorbin
Alternative name(s):
Ankyrin repeat and coiled-coil structure-containing protein
Novel retinal pigment epithelial cell protein
Retinoic acid-induced protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAI14
Synonyms:KIAA1334, NORPEG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14873 RAI14

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606586 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0K7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26064

Open Targets

More...
OpenTargetsi
ENSG00000039560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34189

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P0K7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAI14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108860920

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002396301 – 980AnkycorbinAdd BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei249PhosphothreonineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphothreonineCombined sources1
Modified residuei297PhosphothreonineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei915PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P0K7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0K7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P0K7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0K7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0K7

PeptideAtlas

More...
PeptideAtlasi
Q9P0K7

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0K7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19863
83561 [Q9P0K7-1]
83562 [Q9P0K7-2]
83563 [Q9P0K7-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9P0K7

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0K7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9P0K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000039560 Expressed in 209 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0K7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P0K7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036949
HPA036950

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PALLD. Associates with actin. However, does not bind F-actin directly.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
YWHAZP631042EBI-1023749,EBI-347088

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117526, 83 interactors

Protein interaction database and analysis system

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IntActi
Q9P0K7, 76 interactors

Molecular INTeraction database

More...
MINTi
Q9P0K7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427123

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P0K7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 51ANK 1Add BLAST34
Repeati52 – 81ANK 2Add BLAST30
Repeati85 – 114ANK 3Add BLAST30
Repeati118 – 147ANK 4Add BLAST30
Repeati151 – 180ANK 5Add BLAST30
Repeati184 – 213ANK 6Add BLAST30
Repeati217 – 247ANK 7Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili349 – 374Sequence analysisAdd BLAST26
Coiled coili425 – 947Sequence analysisAdd BLAST523

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi270 – 276Nuclear localization signal1 Publication7

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEWD Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154070

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0K7

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHHECVK

Database of Orthologous Groups

More...
OrthoDBi
876605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0K7

TreeFam database of animal gene trees

More...
TreeFami
TF331274

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR042420 RAI14

The PANTHER Classification System

More...
PANTHERi
PTHR24129 PTHR24129, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSLKAKFRK SDTNEWNKND DRLLQAVENG DAEKVASLLG KKGASATKHD
60 70 80 90 100
SEGKTAFHLA AAKGHVECLR VMITHGVDVT AQDTTGHSAL HLAAKNSHHE
110 120 130 140 150
CIRKLLQSKC PAESVDSSGK TALHYAAAQG CLQAVQILCE HKSPINLKDL
160 170 180 190 200
DGNIPLLLAV QNGHSEICHF LLDHGADVNS RNKSGRTALM LACEIGSSNA
210 220 230 240 250
VEALIKKGAD LNLVDSLGYN ALHYSKLSEN AGIQSLLLSK ISQDADLKTP
260 270 280 290 300
TKPKQHDQVS KISSERSGTP KKRKAPPPPI SPTQLSDVSS PRSITSTPLS
310 320 330 340 350
GKESVFFAEP PFKAEISSIR ENKDRLSDST TGADSLLDIS SEADQQDLLS
360 370 380 390 400
LLQAKVASLT LHNKELQDKL QAKSPKEAEA DLSFDSYHST QTDLGPSLGK
410 420 430 440 450
PGETSPPDSK SSPSVLIHSL GKSTTDNDVR IQQLQEILQD LQKRLESSEA
460 470 480 490 500
ERKQLQVELQ SRRAELVCLN NTEISENSSD LSQKLKETQS KYEEAMKEVL
510 520 530 540 550
SVQKQMKLGL VSPESMDNYS HFHELRVTEE EINVLKQDLQ NALEESERNK
560 570 580 590 600
EKVRELEEKL VEREKGTVIK PPVEEYEEMK SSYCSVIENM NKEKAFLFEK
610 620 630 640 650
YQEAQEEIMK LKDTLKSQMT QEASDEAEDM KEAMNRMIDE LNKQVSELSQ
660 670 680 690 700
LYKEAQAELE DYRKRKSLED VTAEYIHKAE HEKLMQLTNV SRAKAEDALS
710 720 730 740 750
EMKSQYSKVL NELTQLKQLV DAQKENSVSI TEHLQVITTL RTAAKEMEEK
760 770 780 790 800
ISNLKEHLAS KEVEVAKLEK QLLEEKAAMT DAMVPRSSYE KLQSSLESEV
810 820 830 840 850
SVLASKLKES VKEKEKVHSE VVQIRSEVSQ VKREKENIQT LLKSKEQEVN
860 870 880 890 900
ELLQKFQQAQ EELAEMKRYA ESSSKLEEDK DKKINEMSKE VTKLKEALNS
910 920 930 940 950
LSQLSYSTSS SKRQSQQLEA LQQQVKQLQN QLAECKKQHQ EVISVYRMHL
960 970 980
LYAVQGQMDE DVQKVLKQIL TMCKNQSQKK
Length:980
Mass (Da):110,041
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFCF4B7913B30B69
GO
Isoform 2 (identifier: Q9P0K7-2) [UniParc]FASTAAdd to basket
Also known as: sNORPEG

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLKAKFRKSD → MQPTYLPWLSAKEKK

Show »
Length:983
Mass (Da):110,423
Checksum:i9B18E2F9DBFF5A6D
GO
Isoform 3 (identifier: Q9P0K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLKAKFRKSD → MEAK

Show »
Length:972
Mass (Da):109,080
Checksum:i5862375423E1C605
GO
Isoform 4 (identifier: Q9P0K7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-283: Missing.

Note: No experimental confirmation available.
Show »
Length:951
Mass (Da):106,905
Checksum:iF5CB369061C23BB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REL2D6REL2_HUMAN
Ankycorbin
RAI14
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9G4D6R9G4_HUMAN
Ankycorbin
RAI14
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9G6D6R9G6_HUMAN
Ankycorbin
RAI14
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB27D6RB27_HUMAN
Ankycorbin
RAI14
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBY4D6RBY4_HUMAN
Ankycorbin
RAI14
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE17D6RE17_HUMAN
Ankycorbin
RAI14
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF74D6RF74_HUMAN
Ankycorbin
RAI14
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB25D6RB25_HUMAN
Ankycorbin
RAI14
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBW6D6RBW6_HUMAN
Ankycorbin
RAI14
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDL2D6RDL2_HUMAN
Ankycorbin
RAI14
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43236 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104K → R in AAF44722 (PubMed:11042181).Curated1
Sequence conflicti272K → T in AAF44722 (PubMed:11042181).Curated1
Sequence conflicti272K → T in AAQ63889 (Ref. 3) Curated1
Sequence conflicti434L → P in AAQ63889 (Ref. 3) Curated1
Sequence conflicti491K → Q in AAQ63889 (Ref. 3) Curated1
Sequence conflicti602Q → P in AAQ63889 (Ref. 3) Curated1
Sequence conflicti607E → G in AAQ63889 (Ref. 3) Curated1
Sequence conflicti610K → E in AAQ63889 (Ref. 3) Curated1
Sequence conflicti636R → G in CAB43236 (PubMed:17974005).Curated1
Sequence conflicti766A → L in AAQ63889 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02667344A → T. Corresponds to variant dbSNP:rs17521570Ensembl.1
Natural variantiVAR_05551745S → N. Corresponds to variant dbSNP:rs35941954Ensembl.1
Natural variantiVAR_055518499V → L. Corresponds to variant dbSNP:rs10472941Ensembl.1
Natural variantiVAR_055519870A → S2 PublicationsCorresponds to variant dbSNP:rs1048944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0192481 – 12MKSLK…FRKSD → MQPTYLPWLSAKEKK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0192491 – 12MKSLK…FRKSD → MEAK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_045814255 – 283Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF155135 mRNA Translation: AAF44722.1
AY317139 mRNA Translation: AAP84319.1
AY354204 mRNA Translation: AAQ63889.2
AB037755 mRNA Translation: BAA92572.1 Different initiation.
AK314379 mRNA No translation available.
AC016602 Genomic DNA No translation available.
AC025754 Genomic DNA No translation available.
AC026801 Genomic DNA No translation available.
BC052988 mRNA Translation: AAH52988.1
AL050011 mRNA Translation: CAB43236.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34142.1 [Q9P0K7-1]
CCDS54837.1 [Q9P0K7-4]
CCDS54838.1 [Q9P0K7-3]
CCDS54839.1 [Q9P0K7-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08700

NCBI Reference Sequences

More...
RefSeqi
NP_001138992.1, NM_001145520.1 [Q9P0K7-1]
NP_001138993.1, NM_001145521.1 [Q9P0K7-1]
NP_001138994.1, NM_001145522.1 [Q9P0K7-4]
NP_001138995.1, NM_001145523.1 [Q9P0K7-3]
NP_001138997.1, NM_001145525.1 [Q9P0K7-2]
NP_056392.2, NM_015577.2 [Q9P0K7-1]
XP_006714532.1, XM_006714469.2 [Q9P0K7-1]
XP_011512319.1, XM_011514017.2 [Q9P0K7-1]
XP_011512320.1, XM_011514018.1 [Q9P0K7-1]
XP_011512321.1, XM_011514019.1 [Q9P0K7-1]
XP_011512322.1, XM_011514020.1 [Q9P0K7-1]
XP_011512323.1, XM_011514021.1 [Q9P0K7-1]
XP_011512324.1, XM_011514022.1 [Q9P0K7-1]
XP_016864824.1, XM_017009335.1 [Q9P0K7-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265109; ENSP00000265109; ENSG00000039560 [Q9P0K7-1]
ENST00000428746; ENSP00000388725; ENSG00000039560 [Q9P0K7-1]
ENST00000503673; ENSP00000422942; ENSG00000039560 [Q9P0K7-1]
ENST00000506376; ENSP00000423854; ENSG00000039560 [Q9P0K7-3]
ENST00000512629; ENSP00000422377; ENSG00000039560 [Q9P0K7-4]
ENST00000515799; ENSP00000427123; ENSG00000039560 [Q9P0K7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26064

UCSC genome browser

More...
UCSCi
uc003jir.4 human [Q9P0K7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155135 mRNA Translation: AAF44722.1
AY317139 mRNA Translation: AAP84319.1
AY354204 mRNA Translation: AAQ63889.2
AB037755 mRNA Translation: BAA92572.1 Different initiation.
AK314379 mRNA No translation available.
AC016602 Genomic DNA No translation available.
AC025754 Genomic DNA No translation available.
AC026801 Genomic DNA No translation available.
BC052988 mRNA Translation: AAH52988.1
AL050011 mRNA Translation: CAB43236.2 Different initiation.
CCDSiCCDS34142.1 [Q9P0K7-1]
CCDS54837.1 [Q9P0K7-4]
CCDS54838.1 [Q9P0K7-3]
CCDS54839.1 [Q9P0K7-2]
PIRiT08700
RefSeqiNP_001138992.1, NM_001145520.1 [Q9P0K7-1]
NP_001138993.1, NM_001145521.1 [Q9P0K7-1]
NP_001138994.1, NM_001145522.1 [Q9P0K7-4]
NP_001138995.1, NM_001145523.1 [Q9P0K7-3]
NP_001138997.1, NM_001145525.1 [Q9P0K7-2]
NP_056392.2, NM_015577.2 [Q9P0K7-1]
XP_006714532.1, XM_006714469.2 [Q9P0K7-1]
XP_011512319.1, XM_011514017.2 [Q9P0K7-1]
XP_011512320.1, XM_011514018.1 [Q9P0K7-1]
XP_011512321.1, XM_011514019.1 [Q9P0K7-1]
XP_011512322.1, XM_011514020.1 [Q9P0K7-1]
XP_011512323.1, XM_011514021.1 [Q9P0K7-1]
XP_011512324.1, XM_011514022.1 [Q9P0K7-1]
XP_016864824.1, XM_017009335.1 [Q9P0K7-4]

3D structure databases

SMRiQ9P0K7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117526, 83 interactors
IntActiQ9P0K7, 76 interactors
MINTiQ9P0K7
STRINGi9606.ENSP00000427123

PTM databases

CarbonylDBiQ9P0K7
iPTMnetiQ9P0K7
PhosphoSitePlusiQ9P0K7
SwissPalmiQ9P0K7

Polymorphism and mutation databases

BioMutaiRAI14
DMDMi108860920

Proteomic databases

EPDiQ9P0K7
jPOSTiQ9P0K7
MassIVEiQ9P0K7
MaxQBiQ9P0K7
PaxDbiQ9P0K7
PeptideAtlasiQ9P0K7
PRIDEiQ9P0K7
ProteomicsDBi19863
83561 [Q9P0K7-1]
83562 [Q9P0K7-2]
83563 [Q9P0K7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26064

Genome annotation databases

EnsembliENST00000265109; ENSP00000265109; ENSG00000039560 [Q9P0K7-1]
ENST00000428746; ENSP00000388725; ENSG00000039560 [Q9P0K7-1]
ENST00000503673; ENSP00000422942; ENSG00000039560 [Q9P0K7-1]
ENST00000506376; ENSP00000423854; ENSG00000039560 [Q9P0K7-3]
ENST00000512629; ENSP00000422377; ENSG00000039560 [Q9P0K7-4]
ENST00000515799; ENSP00000427123; ENSG00000039560 [Q9P0K7-2]
GeneIDi26064
KEGGihsa:26064
UCSCiuc003jir.4 human [Q9P0K7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26064
DisGeNETi26064

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAI14
HGNCiHGNC:14873 RAI14
HPAiHPA036949
HPA036950
MIMi606586 gene
neXtProtiNX_Q9P0K7
OpenTargetsiENSG00000039560
PharmGKBiPA34189

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEWD Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000157400
HOGENOMiHOG000154070
InParanoidiQ9P0K7
OMAiSHHECVK
OrthoDBi876605at2759
PhylomeDBiQ9P0K7
TreeFamiTF331274

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAI14 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAI14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26064
PharosiQ9P0K7

Protein Ontology

More...
PROi
PR:Q9P0K7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000039560 Expressed in 209 organ(s), highest expression level in testis
ExpressionAtlasiQ9P0K7 baseline and differential
GenevisibleiQ9P0K7 HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR042420 RAI14
PANTHERiPTHR24129 PTHR24129, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAI14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0K7
Secondary accession number(s): E9PED3
, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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