NDUFA13

Functionⁱ

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).4 Publications

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10924506
NADH dehydrogenase (ubiquinone) activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12611891
NADH dehydrogenase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10924506
cellular response to interferon-beta
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443
cellular response to retinoic acid
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443
extrinsic apoptotic signaling pathway Source: Ensembl
mitochondrial respiratory chain complex I assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25901006
- 27626371
negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 10924506
negative regulation of intrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12867595
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 17297443
positive regulation of peptidase activity
Source: ParkinsonsUK-UCL
Inferred by curatorⁱ
- 17297443
positive regulation of protein catabolic process
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 17297443
protein import into mitochondrial inner membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 23271731
reactive oxygen species metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16826196

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Electron transport, Respiratory chain, Transport

Biological process

Apoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Alternative name(s): Cell death regulatory protein GRIM-19 Complex I-B16.6 Short name: CI-B16.6 Gene associated with retinoic and interferon-induced mortality 19 protein Short name: GRIM-19 Short name: Gene associated with retinoic and IFN-induced mortality 19 protein NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesⁱ	Name:NDUFA13 Synonyms:GRIM19 ORF Names:CDA016, CGI-39
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186010.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17194 NDUFA13
MIMⁱ	609435 gene
neXtProtⁱ	NX_Q9P0J0

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	30 – 51	HelicalSequence analysisAdd BLAST		22

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hurthle cell thyroid carcinoma (HCTC)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.

Keywords - Diseaseⁱ

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51079
MalaCards human disease database More...MalaCardsⁱ	NDUFA13
MIMⁱ	607464 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000186010
Orphanetⁱ	146 Papillary or follicular thyroid carcinoma
PharmGKBⁱ	PA142671270

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
Drug and drug target database More...DrugBankⁱ	DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	NDUFA13
DMDMⁱ	20139242

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000118804	2 – 144	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Add BLAST		143

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9P0J0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P0J0
PaxDbⁱ	Q9P0J0
PeptideAtlas More...PeptideAtlasⁱ	Q9P0J0
PRIDEⁱ	Q9P0J0
ProteomicsDBⁱ	83552
TopDownProteomicsⁱ	Q9P0J0-1 [Q9P0J0-1]

PTM databases

iPTMnetⁱ	Q9P0J0
PhosphoSitePlusⁱ	Q9P0J0

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.1 Publication

Developmental stageⁱ

Expressed in numerous fetal tissues.

Inductionⁱ

By IFNB1/IFN-beta combined with all-trans-retinoic acid (ATRA).

Gene expression databases

Bgeeⁱ	ENSG00000186010 Expressed in 224 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_NDUFA13
ExpressionAtlasⁱ	Q9P0J0 baseline and differential
Genevisibleⁱ	Q9P0J0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041213

HPAⁱ

HPA041213

Interactionⁱ

Subunit structureⁱ

Complex I is composed of 45 different subunits (PubMed:27626371). Interacts with CARD15, but not with CARD4 (PubMed:12611891, PubMed:15753091). Interacts with STAT3, but not with STAT1, STAT2 and STAT5A (PubMed:12628925, PubMed:12867595). Interacts with OLFM4 (PubMed:15059901).7 Publications

(Microbial infection) Interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 and SV40 LT (PubMed:12163600).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HTRA2	O43464	6	EBI-372742,EBI-517086
NOD2	Q9HC29	6	EBI-372742,EBI-7445625

Protein-protein interaction databases

BioGridⁱ	119270, 78 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	Q9P0J0
Database of interacting proteins More...DIPⁱ	DIP-31180N
IntActⁱ	Q9P0J0, 68 interactors
Molecular INTeraction database More...MINTⁱ	Q9P0J0
STRINGⁱ	9606.ENSP00000423673

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P0J0
SMRⁱ	Q9P0J0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	102 – 144	Important for inducing cell deathAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3300 Eukaryota ENOG4111KIB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000719
HOGENOMⁱ	HOG000206566
HOVERGENⁱ	HBG019074
InParanoidⁱ	Q9P0J0
KEGG Orthology (KO) More...KOⁱ	K11353
OMAⁱ	SGYSMFG
PhylomeDBⁱ	Q9P0J0
TreeFamⁱ	TF315182

Family and domain databases

InterProⁱ	View protein in InterPro IPR009346 GRIM-19
PANTHERⁱ	PTHR12966 PTHR12966, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06212 GRIM-19, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P0J0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI 
        60         70         80         90        100
MKWNRERRRL QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD 
       110        120        130        140 
VPDWKVGESV FHTTRWVPPL IGELYGLRTT EEALHASHGF MWYT

Length:144

Mass (Da):16,698

Last modified:January 23, 2007 - v3

Checksum:ⁱ058F608B235FF856

GO

Isoform 2 (identifier: Q9P0J0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
143-144: YT → ALELQPPLAD...AAARGAVRSC

« Hide

        10         20         30         40         50
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI 
        60         70         80         90        100
MKWNRERRRL QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD 
       110        120        130        140        150
VPDWKVGESV FHTTRWVPPL IGELYGLRTT EEALHASHGF MWALELQPPL 
       160        170        180        190        200
ADMGRAELSS NATTSLVQRR KQAWGRQSWL EQIWNAGPVC QRLHRGGSRP 
       210        220 
GAGAAGGLSL WAAAARGAVR SC

Note: No experimental confirmation available.

Show »

Length:222

Mass (Da):24,882

Checksum:ⁱDE2128E0367CD4D9

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJE1	K7EJE1_HUMAN	NADH dehydrogenase [ubiquinone] 1 a... NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	150	Annotation score:
B4DEZ3	B4DEZ3_HUMAN	NADH dehydrogenase [ubiquinone] 1 a... NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (cDNA FLJ57958, highly similar to NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13)	NDUFA13	120	Annotation score:
U3KQP3	U3KQP3_HUMAN	NADH dehydrogenase [ubiquinone] 1 a... NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	75	Annotation score:
K7EP87	K7EP87_HUMAN	NADH dehydrogenase [ubiquinone] 1 a... NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	107	Annotation score:

Sequence cautionⁱ

The sequence AAD27748 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAG44670 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH00589 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2	A → P (PubMed:10810093).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_045984	5	K → N in a Hurthle cell variant of papillary carcinoma sample. 1 PublicationCorresponds to variant dbSNP:rs137852869EnsemblClinVar.	1
Natural variantⁱVAR_078938	57	R → H Probable disease-associated mutation found in patients with mitochondrial complex I deficiency. 1 PublicationCorresponds to variant dbSNP:rs752513525EnsemblClinVar.	1
Natural variantⁱVAR_045985	115	R → P in a Hurthle cell variant of papillary carcinoma sample. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056644	143 – 144	YT → ALELQPPLADMGRAELSSNA TTSLVQRRKQAWGRQSWLEQ IWNAGPVCQRLHRGGSRPGA GAAGGLSLWAAAARGAVRSC in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF286697 mRNA Translation: AAG28167.1 AF155662 mRNA Translation: AAF67481.1 AF132973 mRNA Translation: AAD27748.1 Different initiation. AF261134 mRNA Translation: AAG44670.1 Different initiation. AK293965 mRNA Translation: BAG57337.1 AC011448 Genomic DNA No translation available. BC000589 mRNA Translation: AAH00589.2 Different initiation. BC009189 mRNA Translation: AAH09189.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12404.2 [Q9P0J0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_057049.5, NM_015965.6 [Q9P0J0-1]
UniGeneⁱ	Hs.534453

Genome annotation databases

Ensemblⁱ	ENST00000507754; ENSP00000423673; ENSG00000186010 [Q9P0J0-1]
GeneIDⁱ	51079
KEGGⁱ	hsa:51079
UCSC genome browser More...UCSCⁱ	uc021uqu.2 human [Q9P0J0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P0J0	NADH dehydrogenase		GORGO		163	UniRef100_Q9P0J0
UPI000BA4E5FC		HUMAN		116
UPI000BA4E5D1		HUMAN		138

Protein	Similar proteins		Species	Score	Length	Source
Q9P0J0	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		MACFA		163	UniRef90_Q9P0J0
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		GORGO		144
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		PANTR		144
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		PONPY		144
Uncharacterized protein		CERAT		163
+11
Q9P0J0-2	NADH:ubiquinone oxidoreductase subunit A13		CHLSB		222	UniRef90_Q9P0J0-2

Protein	Similar proteins		Species	Score	Length	Source
Q9P0J0	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		MACFA		163	UniRef50_Q9P0J0
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		GORGO		144
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		PANTR		144
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		PONPY		144
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	)	BOVIN		144
+126
Q9P0J0-2	NADH:ubiquinone oxidoreductase subunit A13		CHLSB		222	UniRef50_Q9P0J0-2
Uncharacterized protein		SHEEP		259
NADH:ubiquinone oxidoreductase subunit A13		MYOLU		227
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13		MYOBR		144
Uncharacterized protein		AILME		257
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF286697 mRNA Translation: AAG28167.1 AF155662 mRNA Translation: AAF67481.1 AF132973 mRNA Translation: AAD27748.1 Different initiation. AF261134 mRNA Translation: AAG44670.1 Different initiation. AK293965 mRNA Translation: BAG57337.1 AC011448 Genomic DNA No translation available. BC000589 mRNA Translation: AAH00589.2 Different initiation. BC009189 mRNA Translation: AAH09189.1
CCDSⁱ	CCDS12404.2 [Q9P0J0-1]
RefSeqⁱ	NP_057049.5, NM_015965.6 [Q9P0J0-1]
UniGeneⁱ	Hs.534453

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XTB	electron microscopy	3.40	W	7-28	[»]
	5XTC	electron microscopy	3.70	W	29-144	[»]
	5XTD	electron microscopy	3.70	W	7-144	[»]
	5XTH	electron microscopy	3.90	W	7-144	[»]
	5XTI	electron microscopy	17.40	BW/W	7-144	[»]
ProteinModelPortalⁱ	Q9P0J0
SMRⁱ	Q9P0J0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119270, 78 interactors
ComplexPortalⁱ	CPX-577 Mitochondrial respiratory chain complex I
CORUMⁱ	Q9P0J0
DIPⁱ	DIP-31180N
IntActⁱ	Q9P0J0, 68 interactors
MINTⁱ	Q9P0J0
STRINGⁱ	9606.ENSP00000423673

Chemistry databases

ChEMBLⁱ	CHEMBL2363065
DrugBankⁱ	DB00157 NADH

PTM databases

iPTMnetⁱ	Q9P0J0
PhosphoSitePlusⁱ	Q9P0J0

Polymorphism and mutation databases

BioMutaⁱ	NDUFA13
DMDMⁱ	20139242

Proteomic databases

EPDⁱ	Q9P0J0
MaxQBⁱ	Q9P0J0
PaxDbⁱ	Q9P0J0
PeptideAtlasⁱ	Q9P0J0
PRIDEⁱ	Q9P0J0
ProteomicsDBⁱ	83552
TopDownProteomicsⁱ	Q9P0J0-1 [Q9P0J0-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000507754; ENSP00000423673; ENSG00000186010 [Q9P0J0-1]
GeneIDⁱ	51079
KEGGⁱ	hsa:51079
UCSCⁱ	uc021uqu.2 human [Q9P0J0-1]

Organism-specific databases

CTDⁱ	51079
DisGeNETⁱ	51079
EuPathDBⁱ	HostDB:ENSG00000186010.18
GeneCardsⁱ	NDUFA13
H-InvDBⁱ	HIX0213010
HGNCⁱ	HGNC:17194 NDUFA13
HPAⁱ	HPA041213
MalaCardsⁱ	NDUFA13
MIMⁱ	607464 phenotype 609435 gene
neXtProtⁱ	NX_Q9P0J0
OpenTargetsⁱ	ENSG00000186010
Orphanetⁱ	146 Papillary or follicular thyroid carcinoma
PharmGKBⁱ	PA142671270
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3300 Eukaryota ENOG4111KIB LUCA
GeneTreeⁱ	ENSGT00390000000719
HOGENOMⁱ	HOG000206566
HOVERGENⁱ	HBG019074
InParanoidⁱ	Q9P0J0
KOⁱ	K11353
OMAⁱ	SGYSMFG
PhylomeDBⁱ	Q9P0J0
TreeFamⁱ	TF315182

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport R-HSA-6799198 Complex I biogenesis

Reactomeⁱ

R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSⁱ	NDUFA13 human
GeneWikiⁱ	NDUFA13
GenomeRNAiⁱ	51079
Protein Ontology More...PROⁱ	PR:Q9P0J0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186010 Expressed in 224 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_NDUFA13
ExpressionAtlasⁱ	Q9P0J0 baseline and differential
Genevisibleⁱ	Q9P0J0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009346 GRIM-19
PANTHERⁱ	PTHR12966 PTHR12966, 1 hit
Pfamⁱ	View protein in Pfam PF06212 GRIM-19, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDUAD_HUMAN
Accessionⁱ	Q9P0J0Primary (citable) accession number: Q9P0J0 Secondary accession number(s): B4DF76 , K7EK58, Q6PKI0, Q9H2L3, Q9Y327
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9P0J0 (NDUAD_HUMAN)

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ