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Entry version 132 (13 Feb 2019)
Sequence version 3 (23 Jan 2007)
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Protein

ER membrane protein complex subunit 3

Gene

EMC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • protein folding in endoplasmic reticulum Source: GO_Central

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ER membrane protein complex subunit 3
Alternative name(s):
Transmembrane protein 111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EMC3
Synonyms:TMEM111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125037.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23999 EMC3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0I2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55831

Open Targets

More...
OpenTargetsi
ENSG00000125037

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670762

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EMC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153383

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114062 – 261ER membrane protein complex subunit 3Add BLAST260

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0I2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0I2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0I2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0I2

PeptideAtlas

More...
PeptideAtlasi
Q9P0I2

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0I2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83550
83551 [Q9P0I2-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9P0I2-1 [Q9P0I2-1]
Q9P0I2-2 [Q9P0I2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0I2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0I2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125037 Expressed in 226 organ(s), highest expression level in biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0I2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0I2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042372

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120936, 52 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P0I2, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000245046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9P0I2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P0I2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EMC3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3188 Eukaryota
ENOG410XQK6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158234

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0I2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNIRGWV

Database of Orthologous Groups

More...
OrthoDBi
1482782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0I2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008568 EMC3
IPR002809 EMC3/TMCO1

The PANTHER Classification System

More...
PANTHERi
PTHR13116 PTHR13116, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01956 EMC3_TMCO1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010045 DUF850_TM_euk, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01415 DUF106, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPELLLDS NIRLWVVLPI VIITFFVGMI RHYVSILLQS DKKLTQEQVS
60 70 80 90 100
DSQVLIRSRV LRENGKYIPK QSFLTRKYYF NNPEDGFFKK TKRKVVPPSP
110 120 130 140 150
MTDPTMLTDM MKGNVTNVLP MILIGGWINM TFSGFVTTKV PFPLTLRFKP
160 170 180 190 200
MLQQGIELLT LDASWVSSAS WYFLNVFGLR SIYSLILGQD NAADQSRMMQ
210 220 230 240 250
EQMTGAAMAM PADTNKAFKT EWEALELTDH QWALDDVEEE LMAKDLHFEG
260
MFKKELQTSI F
Length:261
Mass (Da):29,952
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FB279E54D6C1FCC
GO
Isoform 2 (identifier: Q9P0I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-261: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,915
Checksum:i2591071C7822CBBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JLM9C9JLM9_HUMAN
ER membrane protein complex subunit...
EMC3
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U9S4R3U9_HUMAN
ER membrane protein complex subunit...
EMC3
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18807 differs from that shown. Reason: Erroneous termination at position 222. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29M → T in BAD18807 (PubMed:14702039).Curated1
Sequence conflicti60V → I in BAD96673 (Ref. 3) Curated1
Sequence conflicti172Y → H in BAD18807 (PubMed:14702039).Curated1
Sequence conflicti250G → D in BAD18807 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014886220 – 261Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF157321 mRNA Translation: AAF67487.1
AK172843 mRNA Translation: BAD18807.1 Sequence problems.
AK222953 mRNA Translation: BAD96673.1
AK312008 mRNA Translation: BAG34946.1
CH471055 Genomic DNA Translation: EAW64047.1
BC022807 mRNA Translation: AAH22807.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2594.1 [Q9P0I2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060917.1, NM_018447.3 [Q9P0I2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.475392
Hs.633578
Hs.662766

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000245046; ENSP00000245046; ENSG00000125037 [Q9P0I2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55831

UCSC genome browser

More...
UCSCi
uc003bun.4 human [Q9P0I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF157321 mRNA Translation: AAF67487.1
AK172843 mRNA Translation: BAD18807.1 Sequence problems.
AK222953 mRNA Translation: BAD96673.1
AK312008 mRNA Translation: BAG34946.1
CH471055 Genomic DNA Translation: EAW64047.1
BC022807 mRNA Translation: AAH22807.1
CCDSiCCDS2594.1 [Q9P0I2-1]
RefSeqiNP_060917.1, NM_018447.3 [Q9P0I2-1]
UniGeneiHs.475392
Hs.633578
Hs.662766

3D structure databases

ProteinModelPortaliQ9P0I2
SMRiQ9P0I2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120936, 52 interactors
IntActiQ9P0I2, 16 interactors
STRINGi9606.ENSP00000245046

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

PTM databases

iPTMnetiQ9P0I2
PhosphoSitePlusiQ9P0I2

Polymorphism and mutation databases

BioMutaiEMC3
DMDMi71153383

Proteomic databases

EPDiQ9P0I2
jPOSTiQ9P0I2
MaxQBiQ9P0I2
PaxDbiQ9P0I2
PeptideAtlasiQ9P0I2
PRIDEiQ9P0I2
ProteomicsDBi83550
83551 [Q9P0I2-2]
TopDownProteomicsiQ9P0I2-1 [Q9P0I2-1]
Q9P0I2-2 [Q9P0I2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55831
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245046; ENSP00000245046; ENSG00000125037 [Q9P0I2-1]
GeneIDi55831
KEGGihsa:55831
UCSCiuc003bun.4 human [Q9P0I2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55831
DisGeNETi55831
EuPathDBiHostDB:ENSG00000125037.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EMC3
HGNCiHGNC:23999 EMC3
HPAiHPA042372
neXtProtiNX_Q9P0I2
OpenTargetsiENSG00000125037
PharmGKBiPA142670762

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3188 Eukaryota
ENOG410XQK6 LUCA
GeneTreeiENSGT00390000005780
HOGENOMiHOG000158234
HOVERGENiHBG056099
InParanoidiQ9P0I2
OMAiPNIRGWV
OrthoDBi1482782at2759
PhylomeDBiQ9P0I2

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55831

Protein Ontology

More...
PROi
PR:Q9P0I2

Gene expression databases

BgeeiENSG00000125037 Expressed in 226 organ(s), highest expression level in biceps brachii
ExpressionAtlasiQ9P0I2 baseline and differential
GenevisibleiQ9P0I2 HS

Family and domain databases

InterProiView protein in InterPro
IPR008568 EMC3
IPR002809 EMC3/TMCO1
PANTHERiPTHR13116 PTHR13116, 1 hit
PfamiView protein in Pfam
PF01956 EMC3_TMCO1, 1 hit
PIRSFiPIRSF010045 DUF850_TM_euk, 1 hit
SMARTiView protein in SMART
SM01415 DUF106, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0I2
Secondary accession number(s): B2R4Z9, Q53GH8, Q6ZMC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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