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Protein

Kallikrein-14

Gene

KLK14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.6 Publications

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a higher catalytic efficiency for the trypsin-like enzyme substrates S-2288, S-2222 and S-2302 compared to S-2586 a chymotrypsin-like enzyme substrate. Has a lower catalytic activity compared to trypsin towards S-2288, S-2222 and S-2302. Cleaves preferentially after Arg residues.
  1. KM=0.3 mM for S-22882 Publications
  2. KM=0.2 mM for S-22222 Publications
  3. KM=0.2 mM for S-23022 Publications
  4. KM=0.7 mM for S-25862 Publications
  5. KM=0.045 mM for Gln-Ala-Arg synthetic peptide2 Publications
  6. KM=0.043 mM for Val-Pro-Arg synthetic peptide2 Publications
  7. KM=0.09 mM for Pro-Phe-Arg synthetic peptide2 Publications
  8. KM=0.278 mM for Phe-Ser-Arg synthetic peptide2 Publications
  9. KM=0.0577 mM for Leu-Gly-Arg synthetic peptide2 Publications
  10. KM=0.139 mM for Gln-Gly-Arg synthetic peptide2 Publications
  11. KM=0.173 mM for Gly-Pro-Arg synthetic peptide2 Publications
  12. KM=0.0268 mM for Gln-Arg-Arg synthetic peptide2 Publications
  13. KM=0.130 mM for Gly-Gly-Arg synthetic peptide2 Publications
  14. KM=0.578 mM for Val-Leu-Lys synthetic peptide2 Publications

    pH dependencei

    Optimum pH is 8.0.2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei83Charge relay systemBy similarity1
    Active sitei127Charge relay systemBy similarity1
    Active sitei220Charge relay systemBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.21.B45 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6809371 Formation of the cornified envelope

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    S01.029

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Kallikrein-14 (EC:3.4.21.-)
    Short name:
    hK14
    Alternative name(s):
    Kallikrein-like protein 6
    Short name:
    KLK-L6
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:KLK14
    Synonyms:KLKL6
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000129437.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:6362 KLK14

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606135 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9P0G3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    43847

    Open Targets

    More...
    OpenTargetsi
    ENSG00000129437

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30151

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2641

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2866

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    KLK14

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    251757292

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Add BLAST34
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002795835 – 40Activation peptide1 Publication6
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002795941 – 267Kallikrein-14Add BLAST227

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 180PROSITE-ProRule annotation
    Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
    Disulfide bondi159 ↔ 226PROSITE-ProRule annotation
    Disulfide bondi191 ↔ 205PROSITE-ProRule annotation
    Disulfide bondi216 ↔ 241PROSITE-ProRule annotation

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Proteolytic cleavage of the activation peptide produces the active enzyme.1 Publication

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Zymogen

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9P0G3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9P0G3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9P0G3

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    83548

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9P0G3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9P0G3

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    Q9P0G3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level).6 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by steroid hormone.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000129437 Expressed in 83 organ(s), highest expression level in ectocervix

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_KLK14

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9P0G3 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9P0G3 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB026228

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119063, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000156499

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9P0G3

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9P0G3

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9P0G3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 265Peptidase S1PROSITE-ProRule annotationAdd BLAST225

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3627 Eukaryota
    COG5640 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153621

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000251820

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG013304

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9P0G3

    KEGG Orthology (KO)

    More...
    KOi
    K09622

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SAPKMFL

    Database of Orthologous Groups

    More...
    OrthoDBi
    1129026at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9P0G3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF331065

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00190 Tryp_SPc, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00089 Trypsin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00722 CHYMOTRYPSIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00020 Tryp_SPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50494 SSF50494, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9P0G3-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSLRVLGSGT WPSAPKMFLL LTALQVLAIA MTQSQEDENK IIGGHTCTRS
    60 70 80 90 100
    SQPWQAALLA GPRRRFLCGG ALLSGQWVIT AAHCGRPILQ VALGKHNLRR
    110 120 130 140 150
    WEATQQVLRV VRQVTHPNYN SRTHDNDLML LQLQQPARIG RAVRPIEVTQ
    160 170 180 190 200
    ACASPGTSCR VSGWGTISSP IARYPASLQC VNINISPDEV CQKAYPRTIT
    210 220 230 240 250
    PGMVCAGVPQ GGKDSCQGDS GGPLVCRGQL QGLVSWGMER CALPGYPGVY
    260
    TNLCKYRSWI EETMRDK
    Length:267
    Mass (Da):29,122
    Last modified:July 7, 2009 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CE085DA7BD1D92B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1R3UHJ7A0A1R3UHJ7_HUMAN
    Kallikrein M
    KLK14 KLNM
    251Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAD50773 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAG23260 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAK48523 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence AAK48524 differs from that shown. Reason: Erroneous initiation.Curated
    The sequence ABU63131 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05801833Q → R1 PublicationCorresponds to variant dbSNP:rs35287116Ensembl.1
    Natural variantiVAR_05801945H → Y1 PublicationCorresponds to variant dbSNP:rs2569491Ensembl.1
    Natural variantiVAR_05802064R → H. Corresponds to variant dbSNP:rs2569490Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF161221 Genomic DNA Translation: AAD50773.2 Sequence problems.
    AF283669 Genomic DNA Translation: AAK48523.1 Sequence problems.
    AF283670 mRNA Translation: AAK48524.1 Different initiation.
    EU091477 Genomic DNA Translation: ABU63131.1 Sequence problems.
    AC011473 Genomic DNA Translation: AAG23260.1 Sequence problems.
    CH471135 Genomic DNA Translation: EAW71982.1
    BC074904 mRNA Translation: AAH74904.2
    BC074905 mRNA Translation: AAH74905.2
    BC114614 mRNA Translation: AAI14615.2

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001298111.1, NM_001311182.1
    NP_071329.2, NM_022046.5

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.283925

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000391802; ENSP00000375678; ENSG00000129437

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    43847

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:43847

    UCSC genome browser

    More...
    UCSCi
    uc002pvs.1 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF161221 Genomic DNA Translation: AAD50773.2 Sequence problems.
    AF283669 Genomic DNA Translation: AAK48523.1 Sequence problems.
    AF283670 mRNA Translation: AAK48524.1 Different initiation.
    EU091477 Genomic DNA Translation: ABU63131.1 Sequence problems.
    AC011473 Genomic DNA Translation: AAG23260.1 Sequence problems.
    CH471135 Genomic DNA Translation: EAW71982.1
    BC074904 mRNA Translation: AAH74904.2
    BC074905 mRNA Translation: AAH74905.2
    BC114614 mRNA Translation: AAI14615.2
    RefSeqiNP_001298111.1, NM_001311182.1
    NP_071329.2, NM_022046.5
    UniGeneiHs.283925

    3D structure databases

    ProteinModelPortaliQ9P0G3
    SMRiQ9P0G3
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119063, 2 interactors
    STRINGi9606.ENSP00000156499

    Chemistry databases

    BindingDBiQ9P0G3
    ChEMBLiCHEMBL2641
    GuidetoPHARMACOLOGYi2866

    Protein family/group databases

    MEROPSiS01.029

    PTM databases

    iPTMnetiQ9P0G3
    PhosphoSitePlusiQ9P0G3

    Polymorphism and mutation databases

    BioMutaiKLK14
    DMDMi251757292

    Proteomic databases

    PaxDbiQ9P0G3
    PeptideAtlasiQ9P0G3
    PRIDEiQ9P0G3
    ProteomicsDBi83548

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000391802; ENSP00000375678; ENSG00000129437
    GeneIDi43847
    KEGGihsa:43847
    UCSCiuc002pvs.1 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    43847
    DisGeNETi43847
    EuPathDBiHostDB:ENSG00000129437.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    KLK14
    HGNCiHGNC:6362 KLK14
    HPAiCAB026228
    MIMi606135 gene
    neXtProtiNX_Q9P0G3
    OpenTargetsiENSG00000129437
    PharmGKBiPA30151

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3627 Eukaryota
    COG5640 LUCA
    GeneTreeiENSGT00940000153621
    HOGENOMiHOG000251820
    HOVERGENiHBG013304
    InParanoidiQ9P0G3
    KOiK09622
    OMAiSAPKMFL
    OrthoDBi1129026at2759
    PhylomeDBiQ9P0G3
    TreeFamiTF331065

    Enzyme and pathway databases

    BRENDAi3.4.21.B45 2681
    ReactomeiR-HSA-6809371 Formation of the cornified envelope

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    KLK14

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    43847
    PMAP-CutDBiQ9P0G3

    Protein Ontology

    More...
    PROi
    PR:Q9P0G3

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000129437 Expressed in 83 organ(s), highest expression level in ectocervix
    CleanExiHS_KLK14
    ExpressionAtlasiQ9P0G3 baseline and differential
    GenevisibleiQ9P0G3 HS

    Family and domain databases

    CDDicd00190 Tryp_SPc, 1 hit
    InterProiView protein in InterPro
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER
    PfamiView protein in Pfam
    PF00089 Trypsin, 1 hit
    PRINTSiPR00722 CHYMOTRYPSIN
    SMARTiView protein in SMART
    SM00020 Tryp_SPc, 1 hit
    SUPFAMiSSF50494 SSF50494, 1 hit
    PROSITEiView protein in PROSITE
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLK14_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0G3
    Secondary accession number(s): A7UNK5, Q1RMZ2, Q6B089
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 7, 2009
    Last modified: January 16, 2019
    This is version 150 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
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