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Entry version 108 (17 Jun 2020)
Sequence version 2 (23 Oct 2007)
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Protein

Coiled-coil domain-containing protein 167

Gene

CCDC167

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 167
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC167
Synonyms:C6orf129
ORF Names:HSPC265
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198937.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21239 CCDC167

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0B6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei78 – 95HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
154467

Open Targets

More...
OpenTargetsi
ENSG00000198937

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134900129

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P0B6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC167

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160017504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003085501 – 97Coiled-coil domain-containing protein 167Add BLAST97

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0B6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0B6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P0B6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0B6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0B6

PeptideAtlas

More...
PeptideAtlasi
Q9P0B6

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0B6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83547

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198937 Expressed in heart left ventricle and 185 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0B6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198937 Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9P0B6
With#Exp.IntAct
APPBP2 [Q92624]3EBI-9083477,EBI-743771
AQP6 [Q13520]3EBI-9083477,EBI-13059134
AQP9 [O43315]3EBI-9083477,EBI-17444777
ARL13B [Q3SXY8]3EBI-9083477,EBI-11343438
CD79A [P11912]3EBI-9083477,EBI-7797864
CLDN5 [O00501]3EBI-9083477,EBI-18400628
CX3CR1 - isoform 4 [P49238-4]3EBI-9083477,EBI-13049264
EBP [Q15125]3EBI-9083477,EBI-3915253
ELOVL4 [Q9GZR5]3EBI-9083477,EBI-18535450
ERGIC3 [Q9Y282]3EBI-9083477,EBI-781551
FAM174A [Q8TBP5]3EBI-9083477,EBI-18636064
FAM210B [Q96KR6]3EBI-9083477,EBI-18938272
FFAR2 [O15552]3EBI-9083477,EBI-2833872
GJA8 [P48165]3EBI-9083477,EBI-17458373
GOLT1A [Q6ZVE7]3EBI-9083477,EBI-17231387
GPR152 [Q8TDT2]3EBI-9083477,EBI-13345167
GPR42 [O15529]3EBI-9083477,EBI-18076404
HSD17B13 [Q7Z5P4]3EBI-9083477,EBI-18053395
MS4A3 [Q96HJ5]3EBI-9083477,EBI-12806656
MUC1 - isoform Y-LSP [P15941-11]3EBI-9083477,EBI-17263240
NIPA1 [Q7RTP0]3EBI-9083477,EBI-17702144
OPRM1 - isoform 10 [P35372-10]3EBI-9083477,EBI-12807478
RETREG3 [Q86VR2]3EBI-9083477,EBI-10192441
SLC10A6 [Q3KNW5]3EBI-9083477,EBI-18159983
SLC18A3 [Q16572]3EBI-9083477,EBI-17598000
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-9083477,EBI-17295964
SLC7A14 [Q8TBB6]3EBI-9083477,EBI-5235586
SYT2 [Q8N9I0]3EBI-9083477,EBI-8032987
TACR1 [P25103]3EBI-9083477,EBI-6655287
TLCD4 [Q96MV1]3EBI-9083477,EBI-12947623
TM4SF19 [Q96DZ7]3EBI-9083477,EBI-6448756
TMEM179B [Q7Z7N9]3EBI-9083477,EBI-11724423
TMEM237 - isoform 2 [Q96Q45-2]3EBI-9083477,EBI-10982110
TMEM51 [Q9NW97]3EBI-9083477,EBI-726044
TMEM80 [Q96HE8]3EBI-9083477,EBI-11742770
TMEM86B [Q8N661]3EBI-9083477,EBI-2548832
TMX2 [Q9Y320]3EBI-9083477,EBI-6447886

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127548, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P0B6, 42 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362507

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P0B6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P0B6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili10 – 79Sequence analysisAdd BLAST70

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J3GR Eukaryota
ENOG410Y5E9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_152032_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0B6

Identification of Orthologs from Complete Genome Data

More...
OMAi
GENRKNM

Database of Orthologous Groups

More...
OrthoDBi
1588154at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0B6

TreeFam database of animal gene trees

More...
TreeFami
TF336097

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028194 CCDC-167

The PANTHER Classification System

More...
PANTHERi
PTHR31759 PTHR31759, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15188 CCDC-167, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P0B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKKKRENLG VALEIDGLEE KLSQCRRDLE AVNSRLHSRE LSPEARRSLE
60 70 80 90
KEKNSLMNKA SNYEKELKFL RQENRKNMLL SVAIFILLTL VYAYWTM
Length:97
Mass (Da):11,459
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B68E89EFEEB782C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28943 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH03515 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161383 mRNA Translation: AAF28943.1 Different initiation.
AL353597 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03947.1
BC003515 mRNA Translation: AAH03515.1 Different initiation.
BC104835 mRNA Translation: AAI04836.1
BC108655 mRNA Translation: AAI08656.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34441.1

NCBI Reference Sequences

More...
RefSeqi
NP_612502.1, NM_138493.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373408; ENSP00000362507; ENSG00000198937

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154467

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154467

UCSC genome browser

More...
UCSCi
uc003ont.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161383 mRNA Translation: AAF28943.1 Different initiation.
AL353597 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03947.1
BC003515 mRNA Translation: AAH03515.1 Different initiation.
BC104835 mRNA Translation: AAI04836.1
BC108655 mRNA Translation: AAI08656.1
CCDSiCCDS34441.1
RefSeqiNP_612502.1, NM_138493.2

3D structure databases

SMRiQ9P0B6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127548, 7 interactors
IntActiQ9P0B6, 42 interactors
STRINGi9606.ENSP00000362507

PTM databases

iPTMnetiQ9P0B6
PhosphoSitePlusiQ9P0B6

Polymorphism and mutation databases

BioMutaiCCDC167
DMDMi160017504

Proteomic databases

EPDiQ9P0B6
jPOSTiQ9P0B6
MassIVEiQ9P0B6
MaxQBiQ9P0B6
PaxDbiQ9P0B6
PeptideAtlasiQ9P0B6
PRIDEiQ9P0B6
ProteomicsDBi83547

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50913 50 antibodies

Genome annotation databases

EnsembliENST00000373408; ENSP00000362507; ENSG00000198937
GeneIDi154467
KEGGihsa:154467
UCSCiuc003ont.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154467
DisGeNETi154467
EuPathDBiHostDB:ENSG00000198937.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC167
HGNCiHGNC:21239 CCDC167
HPAiENSG00000198937 Tissue enhanced (blood)
neXtProtiNX_Q9P0B6
OpenTargetsiENSG00000198937
PharmGKBiPA134900129

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J3GR Eukaryota
ENOG410Y5E9 LUCA
GeneTreeiENSGT00390000010210
HOGENOMiCLU_152032_0_0_1
InParanoidiQ9P0B6
OMAiGENRKNM
OrthoDBi1588154at2759
PhylomeDBiQ9P0B6
TreeFamiTF336097

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
154467 1 hit in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC167 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
154467
PharosiQ9P0B6 Tdark

Protein Ontology

More...
PROi
PR:Q9P0B6
RNActiQ9P0B6 protein

Gene expression databases

BgeeiENSG00000198937 Expressed in heart left ventricle and 185 other tissues
GenevisibleiQ9P0B6 HS

Family and domain databases

InterProiView protein in InterPro
IPR028194 CCDC-167
PANTHERiPTHR31759 PTHR31759, 1 hit
PfamiView protein in Pfam
PF15188 CCDC-167, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC167_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0B6
Secondary accession number(s): Q5T7F7, Q9BTQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 17, 2020
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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