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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:MED11
ORF Names:HSPC296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161920.9
HGNCiHGNC:32687 MED11
MIMi612383 gene
neXtProtiNX_Q9P086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161920
PharmGKBiPA144596413

Polymorphism and mutation databases

BioMutaiMED11
DMDMi158564056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003043082 – 117Mediator of RNA polymerase II transcription subunit 11Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P086
MaxQBiQ9P086
PaxDbiQ9P086
PeptideAtlasiQ9P086
PRIDEiQ9P086
ProteomicsDBi83546
TopDownProteomicsiQ9P086

PTM databases

iPTMnetiQ9P086
PhosphoSitePlusiQ9P086

Expressioni

Gene expression databases

BgeeiENSG00000161920 Expressed in 198 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MED11
ExpressionAtlasiQ9P086 baseline and differential
GenevisibleiQ9P086 HS

Organism-specific databases

HPAiHPA056669

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MED22Q155283EBI-394704,EBI-394687

Protein-protein interaction databases

BioGridi134637, 32 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9P086
IntActiQ9P086, 23 interactors
MINTiQ9P086
STRINGi9606.ENSP00000293777

Structurei

3D structure databases

ProteinModelPortaliQ9P086
SMRiQ9P086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.Curated

Phylogenomic databases

eggNOGiKOG4057 Eukaryota
ENOG4111SCB LUCA
GeneTreeiENSGT00390000010184
HOGENOMiHOG000006725
HOVERGENiHBG108126
InParanoidiQ9P086
KOiK15131
OMAiMTPPMER
OrthoDBiEOG091G0YZ0
PhylomeDBiQ9P086
TreeFamiTF318328

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PANTHERiPTHR22890 PTHR22890, 1 hit
PfamiView protein in Pfam
PF10280 Med11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9P086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTASVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKLSDVART CEQMLEN
Length:117
Mass (Da):13,129
Last modified:September 11, 2007 - v2
Checksum:iD01CAA8D211D6FC7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3E8I3L3E8_HUMAN
Mediator of RNA polymerase II trans...
MED11
85Annotation score:
I3L2Q0I3L2Q0_HUMAN
Mediator of RNA polymerase II trans...
MED11
93Annotation score:

Sequence cautioni

The sequence AAF28974 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112E → G in AAF28974 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161414 mRNA Translation: AAF28974.1 Different initiation.
CH471108 Genomic DNA Translation: EAW90417.1
BC070377 mRNA Translation: AAH70377.1
CCDSiCCDS32533.1
RefSeqiNP_001001683.1, NM_001001683.3
NP_001291929.1, NM_001305000.1
UniGeneiHs.513885

Genome annotation databases

EnsembliENST00000293777; ENSP00000293777; ENSG00000161920
GeneIDi400569
KEGGihsa:400569
UCSCiuc002fyp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161414 mRNA Translation: AAF28974.1 Different initiation.
CH471108 Genomic DNA Translation: EAW90417.1
BC070377 mRNA Translation: AAH70377.1
CCDSiCCDS32533.1
RefSeqiNP_001001683.1, NM_001001683.3
NP_001291929.1, NM_001305000.1
UniGeneiHs.513885

3D structure databases

ProteinModelPortaliQ9P086
SMRiQ9P086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134637, 32 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9P086
IntActiQ9P086, 23 interactors
MINTiQ9P086
STRINGi9606.ENSP00000293777

PTM databases

iPTMnetiQ9P086
PhosphoSitePlusiQ9P086

Polymorphism and mutation databases

BioMutaiMED11
DMDMi158564056

Proteomic databases

EPDiQ9P086
MaxQBiQ9P086
PaxDbiQ9P086
PeptideAtlasiQ9P086
PRIDEiQ9P086
ProteomicsDBi83546
TopDownProteomicsiQ9P086

Protocols and materials databases

DNASUi400569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293777; ENSP00000293777; ENSG00000161920
GeneIDi400569
KEGGihsa:400569
UCSCiuc002fyp.4 human

Organism-specific databases

CTDi400569
EuPathDBiHostDB:ENSG00000161920.9
GeneCardsiMED11
HGNCiHGNC:32687 MED11
HPAiHPA056669
MIMi612383 gene
neXtProtiNX_Q9P086
OpenTargetsiENSG00000161920
PharmGKBiPA144596413
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4057 Eukaryota
ENOG4111SCB LUCA
GeneTreeiENSGT00390000010184
HOGENOMiHOG000006725
HOVERGENiHBG108126
InParanoidiQ9P086
KOiK15131
OMAiMTPPMER
OrthoDBiEOG091G0YZ0
PhylomeDBiQ9P086
TreeFamiTF318328

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRSiMED11 human
GenomeRNAii400569
PROiPR:Q9P086
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161920 Expressed in 198 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MED11
ExpressionAtlasiQ9P086 baseline and differential
GenevisibleiQ9P086 HS

Family and domain databases

InterProiView protein in InterPro
IPR019404 Mediator_Med11
PANTHERiPTHR22890 PTHR22890, 1 hit
PfamiView protein in Pfam
PF10280 Med11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMED11_HUMAN
AccessioniPrimary (citable) accession number: Q9P086
Secondary accession number(s): Q6NS89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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