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Protein

JNK1/MAPK8-associated membrane protein

Gene

JKAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).By similarity

Miscellaneous

Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • response to unfolded protein Source: UniProtKB-KW
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
JNK1/MAPK8-associated membrane protein
Short name:
JKAMP
Alternative name(s):
JNK1-associated membrane protein
Short name:
JAMP
Medulloblastoma antigen MU-MB-50.4
Gene namesi
Name:JKAMP
Synonyms:C14orf100, JAMP
ORF Names:CDA06, HSPC213, HSPC327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000050130.17
HGNCiHGNC:20184 JKAMP
MIMi611176 gene
neXtProtiNX_Q9P055

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65LumenalSequence analysisAdd BLAST65
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 157LumenalSequence analysisAdd BLAST41
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 196CytoplasmicSequence analysisAdd BLAST18
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218LumenalSequence analysis1
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 258CytoplasmicSequence analysisAdd BLAST19
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 285LumenalSequence analysis6
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 319CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51528
OpenTargetsiENSG00000050130
PharmGKBiPA165479069

Polymorphism and mutation databases

DMDMi38257782

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899031 – 319JNK1/MAPK8-associated membrane proteinAdd BLAST319

Post-translational modificationi

Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9P055
PeptideAtlasiQ9P055
PRIDEiQ9P055
ProteomicsDBi83541
83542 [Q9P055-2]
83543 [Q9P055-3]
83544 [Q9P055-4]
83545 [Q9P055-5]

PTM databases

iPTMnetiQ9P055
PhosphoSitePlusiQ9P055

Expressioni

Gene expression databases

BgeeiENSG00000050130 Expressed in 203 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ9P055 baseline and differential
GenevisibleiQ9P055 HS

Organism-specific databases

HPAiHPA031172
HPA071650

Interactioni

Subunit structurei

Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119590, 8 interactors
IntActiQ9P055, 1 interactor
STRINGi9606.ENSP00000261247

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3744 Eukaryota
ENOG410XSIG LUCA
GeneTreeiENSGT00390000018097
HOVERGENiHBG051016
InParanoidiQ9P055
PhylomeDBiQ9P055
TreeFamiTF314201

Family and domain databases

InterProiView protein in InterPro
IPR008485 JAMP
PANTHERiPTHR12740 PTHR12740, 1 hit
PfamiView protein in Pfam
PF05571 DUF766, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 5 (identifier: Q9P055-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGEIQQSLG AWVLLTCLGL YCGKTLLFKN GSTEIYGECG VCPRGQRTNA
60 70 80 90 100
QKYCQPCTES PELYDWLYLG FMAMLPLVLH WFFIEWYSGK KSSSALFQHI
110 120 130 140 150
TALFECSMAA IITLLVSDPV GVLYIRSCRV LMLSDWYTML YNPSPDYVTT
160 170 180 190 200
VHCTHEAVYP LYTIVFIYYA FCLVLMMLLR PLLVKKIACG LGKSDRFKSI
210 220 230 240 250
YAALYFFPIL TVLQAVGGGL LYYAFPYIIL VLSLVTLAVY MSASEIENCY
260 270 280 290 300
DLLVRKKRLI VLFSHWLLHA YGIISISRVD KLEQDLPLLA LVPTPALFYL
310
FTAKFTEPSR ILSEGANGH
Length:319
Mass (Da):36,169
Last modified:September 12, 2018 - v3
Checksum:i91D42D3746B15413
GO
Isoform 2 (identifier: Q9P055-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:248
Mass (Da):28,212
Checksum:i6918AC0A6414F401
GO
Isoform 3 (identifier: Q9P055-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MKGEIQQSLGAWVLLT → MA

Show »
Length:305
Mass (Da):34,615
Checksum:i1047E4068BAC541A
GO
Isoform 4 (identifier: Q9P055-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MKGEIQQSLGAWVLLT → MAVDIQPA

Show »
Length:311
Mass (Da):35,239
Checksum:iF294B4CAFDDCECE4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2M4G3V2M4_HUMAN
Chromosome 14 open reading frame 10...
JKAMP C14orf100, hCG_20984
325Annotation score:
A0A087WVY6A0A087WVY6_HUMAN
JNK1/MAPK8-associated membrane prot...
JKAMP
213Annotation score:
G3V4D0G3V4D0_HUMAN
JNK1/MAPK8-associated membrane prot...
JKAMP
140Annotation score:
G3V2R2G3V2R2_HUMAN
JNK1/MAPK8-associated membrane prot...
JKAMP
247Annotation score:
G3V372G3V372_HUMAN
JNK1/MAPK8-associated membrane prot...
JKAMP
153Annotation score:

Sequence cautioni

The sequence AAF29005 differs from that shown. Reason: Frameshift at position 2.Curated
The sequence AAF36133 differs from that shown. Reason: Frameshift at positions 98 and 117.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78V → A in BAB13874 (PubMed:14702039).Curated1
Sequence conflicti134S → P in AAF36133 (PubMed:11042152).Curated1
Sequence conflicti142N → S in AAF36133 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0597621 – 71Missing in isoform 2. 2 PublicationsAdd BLAST71
Alternative sequenceiVSP_0597631 – 16MKGEI…WVLLT → MA in isoform 3. 5 PublicationsAdd BLAST16
Alternative sequenceiVSP_0597641 – 16MKGEI…WVLLT → MAVDIQPA in isoform 4. 4 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529304 mRNA Translation: AAP85636.1
AF151047 mRNA Translation: AAF36133.1 Frameshift.
AF161445 mRNA Translation: AAF29005.1 Sequence problems.
AL136696 mRNA Translation: CAB66631.1
AK021683 mRNA Translation: BAB13874.1
AK027591 mRNA Translation: BAB55216.1
AK298209 mRNA Translation: BAG60479.1
AF212245 mRNA Translation: AAG41781.1
BX161501 mRNA Translation: CAD61945.1
CR457163 mRNA Translation: CAG33444.1
CR533510 mRNA Translation: CAG38541.1
CH471061 Genomic DNA Translation: EAW80753.1
BC005198 mRNA Translation: AAH05198.1
BC010359 mRNA Translation: AAH10359.1
CCDSiCCDS45116.1 [Q9P055-4]
CCDS45117.1 [Q9P055-3]
CCDS61463.1 [Q9P055-5]
RefSeqiNP_001092095.1, NM_001098625.2 [Q9P055-3]
NP_001271130.1, NM_001284201.1
NP_001271131.1, NM_001284202.1 [Q9P055-5]
NP_001271132.1, NM_001284203.1 [Q9P055-2]
NP_001271133.1, NM_001284204.1
NP_057559.2, NM_016475.4 [Q9P055-4]
UniGeneiHs.446850

Genome annotation databases

EnsembliENST00000261247; ENSP00000261247; ENSG00000050130 [Q9P055-4]
ENST00000356057; ENSP00000348351; ENSG00000050130 [Q9P055-5]
ENST00000425728; ENSP00000389699; ENSG00000050130 [Q9P055-3]
GeneIDi51528
KEGGihsa:51528
UCSCiuc001xef.6 human [Q9P055-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529304 mRNA Translation: AAP85636.1
AF151047 mRNA Translation: AAF36133.1 Frameshift.
AF161445 mRNA Translation: AAF29005.1 Sequence problems.
AL136696 mRNA Translation: CAB66631.1
AK021683 mRNA Translation: BAB13874.1
AK027591 mRNA Translation: BAB55216.1
AK298209 mRNA Translation: BAG60479.1
AF212245 mRNA Translation: AAG41781.1
BX161501 mRNA Translation: CAD61945.1
CR457163 mRNA Translation: CAG33444.1
CR533510 mRNA Translation: CAG38541.1
CH471061 Genomic DNA Translation: EAW80753.1
BC005198 mRNA Translation: AAH05198.1
BC010359 mRNA Translation: AAH10359.1
CCDSiCCDS45116.1 [Q9P055-4]
CCDS45117.1 [Q9P055-3]
CCDS61463.1 [Q9P055-5]
RefSeqiNP_001092095.1, NM_001098625.2 [Q9P055-3]
NP_001271130.1, NM_001284201.1
NP_001271131.1, NM_001284202.1 [Q9P055-5]
NP_001271132.1, NM_001284203.1 [Q9P055-2]
NP_001271133.1, NM_001284204.1
NP_057559.2, NM_016475.4 [Q9P055-4]
UniGeneiHs.446850

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119590, 8 interactors
IntActiQ9P055, 1 interactor
STRINGi9606.ENSP00000261247

PTM databases

iPTMnetiQ9P055
PhosphoSitePlusiQ9P055

Polymorphism and mutation databases

DMDMi38257782

Proteomic databases

PaxDbiQ9P055
PeptideAtlasiQ9P055
PRIDEiQ9P055
ProteomicsDBi83541
83542 [Q9P055-2]
83543 [Q9P055-3]
83544 [Q9P055-4]
83545 [Q9P055-5]

Protocols and materials databases

DNASUi51528
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261247; ENSP00000261247; ENSG00000050130 [Q9P055-4]
ENST00000356057; ENSP00000348351; ENSG00000050130 [Q9P055-5]
ENST00000425728; ENSP00000389699; ENSG00000050130 [Q9P055-3]
GeneIDi51528
KEGGihsa:51528
UCSCiuc001xef.6 human [Q9P055-5]

Organism-specific databases

CTDi51528
DisGeNETi51528
EuPathDBiHostDB:ENSG00000050130.17
GeneCardsiJKAMP
H-InvDBiHIX0011705
HGNCiHGNC:20184 JKAMP
HPAiHPA031172
HPA071650
MIMi611176 gene
neXtProtiNX_Q9P055
OpenTargetsiENSG00000050130
PharmGKBiPA165479069
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3744 Eukaryota
ENOG410XSIG LUCA
GeneTreeiENSGT00390000018097
HOVERGENiHBG051016
InParanoidiQ9P055
PhylomeDBiQ9P055
TreeFamiTF314201

Miscellaneous databases

ChiTaRSiJKAMP human
GeneWikiiJKAMP
GenomeRNAii51528
PROiPR:Q9P055
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000050130 Expressed in 203 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ9P055 baseline and differential
GenevisibleiQ9P055 HS

Family and domain databases

InterProiView protein in InterPro
IPR008485 JAMP
PANTHERiPTHR12740 PTHR12740, 1 hit
PfamiView protein in Pfam
PF05571 DUF766, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJKAMP_HUMAN
AccessioniPrimary (citable) accession number: Q9P055
Secondary accession number(s): B4DP67
, Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P0R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: September 12, 2018
Last modified: October 10, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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