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Protein

Thyroid transcription factor 1-associated protein 26

Gene

CCDC59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism
R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid transcription factor 1-associated protein 26
Short name:
TTF-1-associated protein 26
Alternative name(s):
Coiled-coil domain-containing protein 59
TTF-1-associated protein BR2
Gene namesi
Name:CCDC59
Synonyms:BR22, TAP26
ORF Names:HSPC128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000133773.11
HGNCiHGNC:25005 CCDC59
neXtProtiNX_Q9P031

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133773
PharmGKBiPA143485412

Polymorphism and mutation databases

BioMutaiCCDC59
DMDMi156633647

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989411 – 241Thyroid transcription factor 1-associated protein 26Add BLAST241

Proteomic databases

EPDiQ9P031
MaxQBiQ9P031
PaxDbiQ9P031
PeptideAtlasiQ9P031
PRIDEiQ9P031
ProteomicsDBi83538

PTM databases

iPTMnetiQ9P031
PhosphoSitePlusiQ9P031

Expressioni

Tissue specificityi

Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000133773
CleanExiHS_CCDC59
ExpressionAtlasiQ9P031 baseline and differential
GenevisibleiQ9P031 HS

Organism-specific databases

HPAiHPA038555

Interactioni

Subunit structurei

Interacts with NKX2-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NKX2-1P436994EBI-1047110,EBI-1391923

Protein-protein interaction databases

BioGridi118850, 65 interactors
IntActiQ9P031, 21 interactors
MINTiQ9P031
STRINGi9606.ENSP00000256151

Structurei

3D structure databases

ProteinModelPortaliQ9P031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAP26 family.Curated

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
KOG4819 Eukaryota
ENOG4111ZBH LUCA
GeneTreeiENSGT00390000006546
HOGENOMiHOG000154507
HOVERGENiHBG108545
InParanoidiQ9P031
OMAiKIQQNYK
OrthoDBiEOG091G0QX3
PhylomeDBiQ9P031
TreeFamiTF324429

Family and domain databases

InterProiView protein in InterPro
IPR013730 Fyv7/TAP26
PANTHERiPTHR15657 PTHR15657, 1 hit
PfamiView protein in Pfam
PF08524 rRNA_processing, 1 hit
PRINTSiPR01854 BR22PROTEIN

Sequencei

Sequence statusi: Complete.

Q9P031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR
60 70 80 90 100
EGQGFAFRRK LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE
110 120 130 140 150
EERHRKQARK VDHPLSEQVH QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC
160 170 180 190 200
IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ AKRAAKKQEF ERRKQEREEA
210 220 230 240
QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C
Length:241
Mass (Da):28,670
Last modified:August 21, 2007 - v2
Checksum:iA9012048D32A87AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136E → G in BAA91524 (PubMed:14702039).Curated1
Sequence conflicti160P → S in AAF29092 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213377 mRNA Translation: AAG43569.1
AF161477 mRNA Translation: AAF29092.1
BC020647 mRNA Translation: AAH20647.1
AK001156 mRNA Translation: BAA91524.1
CCDSiCCDS9023.1
RefSeqiNP_054886.2, NM_014167.4
UniGeneiHs.582627

Genome annotation databases

EnsembliENST00000256151; ENSP00000256151; ENSG00000133773
GeneIDi29080
KEGGihsa:29080
UCSCiuc001szp.5 human

Similar proteinsi

Entry informationi

Entry nameiTAP26_HUMAN
AccessioniPrimary (citable) accession number: Q9P031
Secondary accession number(s): Q9H2V5, Q9NW62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 18, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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