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Protein

39S ribosomal protein L15, mitochondrial

Gene

MRPL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL15m1 Publication
Gene namesi
Name:MRPL15
ORF Names:HSPC145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000137547.8
HGNCiHGNC:14054 MRPL15
MIMi611828 gene
neXtProtiNX_Q9P015

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137547
PharmGKBiPA30944

Polymorphism and mutation databases

BioMutaiMRPL15
DMDMi74734761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionBy similarityAdd BLAST21
ChainiPRO_000025783822 – 29639S ribosomal protein L15, mitochondrialAdd BLAST275

Proteomic databases

EPDiQ9P015
MaxQBiQ9P015
PaxDbiQ9P015
PeptideAtlasiQ9P015
PRIDEiQ9P015
ProteomicsDBi83533

PTM databases

iPTMnetiQ9P015
PhosphoSitePlusiQ9P015
SwissPalmiQ9P015

Expressioni

Gene expression databases

BgeeiENSG00000137547 Expressed in 224 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL15
ExpressionAtlasiQ9P015 baseline and differential
GenevisibleiQ9P015 HS

Organism-specific databases

HPAiHPA044425

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi118857, 80 interactors
CORUMiQ9P015
IntActiQ9P015, 22 interactors
MINTiQ9P015
STRINGi9606.ENSP00000260102

Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P015
SMRiQ9P015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 64Arg-richAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0846 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000009040
HOGENOMiHOG000231264
HOVERGENiHBG088294
InParanoidiQ9P015
KOiK02876
OMAiYEPYYKG
OrthoDBiEOG091G0VT9
PhylomeDBiQ9P015
TreeFamiTF105918

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR005749 Ribosomal_L15_bac-type
IPR021131 Ribosomal_L18e/L15P
PANTHERiPTHR12934 PTHR12934, 1 hit
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9P015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG
60 70 80 90 100
RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR
110 120 130 140 150
LQYLIDLGRV DPSQPIDLTQ LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA
160 170 180 190 200
KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD PRSLDIVCKP VPFFLRGQPI
210 220 230 240 250
PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY GYILPDITKD
260 270 280 290
ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS
Length:296
Mass (Da):33,420
Last modified:October 1, 2000 - v1
Checksum:iD7396086F808A72C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHF4E5RHF4_HUMAN
39S ribosomal protein L15, mitochon...
MRPL15
198Annotation score:
E5RIZ4E5RIZ4_HUMAN
39S ribosomal protein L15, mitochon...
MRPL15
237Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96L → M in CAB66600 (PubMed:11230166).Curated1
Sequence conflicti96L → M in CAG38562 (Ref. 3) Curated1
Sequence conflicti137G → D in CAB66600 (PubMed:11230166).Curated1
Sequence conflicti137G → D in CAG38562 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161494 mRNA Translation: AAF29109.1
AL136665 mRNA Translation: CAB66600.1
CR533531 mRNA Translation: CAG38562.1
BC000891 mRNA Translation: AAH00891.1
AB051619 Genomic DNA Translation: BAB54947.1
CCDSiCCDS6158.1
RefSeqiNP_054894.1, NM_014175.3
UniGeneiHs.18349

Genome annotation databases

EnsembliENST00000260102; ENSP00000260102; ENSG00000137547
GeneIDi29088
KEGGihsa:29088
UCSCiuc003xsa.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161494 mRNA Translation: AAF29109.1
AL136665 mRNA Translation: CAB66600.1
CR533531 mRNA Translation: CAG38562.1
BC000891 mRNA Translation: AAH00891.1
AB051619 Genomic DNA Translation: BAB54947.1
CCDSiCCDS6158.1
RefSeqiNP_054894.1, NM_014175.3
UniGeneiHs.18349

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40M1-296[»]
3J9Melectron microscopy3.50M1-296[»]
5OOLelectron microscopy3.06M1-296[»]
5OOMelectron microscopy3.03M1-296[»]
ProteinModelPortaliQ9P015
SMRiQ9P015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118857, 80 interactors
CORUMiQ9P015
IntActiQ9P015, 22 interactors
MINTiQ9P015
STRINGi9606.ENSP00000260102

PTM databases

iPTMnetiQ9P015
PhosphoSitePlusiQ9P015
SwissPalmiQ9P015

Polymorphism and mutation databases

BioMutaiMRPL15
DMDMi74734761

Proteomic databases

EPDiQ9P015
MaxQBiQ9P015
PaxDbiQ9P015
PeptideAtlasiQ9P015
PRIDEiQ9P015
ProteomicsDBi83533

Protocols and materials databases

DNASUi29088
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260102; ENSP00000260102; ENSG00000137547
GeneIDi29088
KEGGihsa:29088
UCSCiuc003xsa.3 human

Organism-specific databases

CTDi29088
EuPathDBiHostDB:ENSG00000137547.8
GeneCardsiMRPL15
HGNCiHGNC:14054 MRPL15
HPAiHPA044425
MIMi611828 gene
neXtProtiNX_Q9P015
OpenTargetsiENSG00000137547
PharmGKBiPA30944
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0846 Eukaryota
COG0200 LUCA
GeneTreeiENSGT00390000009040
HOGENOMiHOG000231264
HOVERGENiHBG088294
InParanoidiQ9P015
KOiK02876
OMAiYEPYYKG
OrthoDBiEOG091G0VT9
PhylomeDBiQ9P015
TreeFamiTF105918

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL15 human
GeneWikiiMRPL15
GenomeRNAii29088
PROiPR:Q9P015
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137547 Expressed in 224 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL15
ExpressionAtlasiQ9P015 baseline and differential
GenevisibleiQ9P015 HS

Family and domain databases

HAMAPiMF_01341 Ribosomal_L15, 1 hit
InterProiView protein in InterPro
IPR036227 L18e/L15P_sf
IPR030878 Ribosomal_L15
IPR005749 Ribosomal_L15_bac-type
IPR021131 Ribosomal_L18e/L15P
PANTHERiPTHR12934 PTHR12934, 1 hit
PfamiView protein in Pfam
PF00828 Ribosomal_L27A, 1 hit
SUPFAMiSSF52080 SSF52080, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM15_HUMAN
AccessioniPrimary (citable) accession number: Q9P015
Secondary accession number(s): Q96Q54, Q9H0Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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