UniProtKB - Q9P013 (CWC15_HUMAN)
Protein
Spliceosome-associated protein CWC15 homolog
Gene
CWC15
Organism
Homo sapiens (Human)
Status
Functioni
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.3 Publications
Caution
Has been termed C11orf5, but is not the official C11orf5 as defined by HGNC.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA cis splicing, via spliceosome Source: GO_Central
- mRNA splicing, via spliceosome Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q9P013 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Spliceosome-associated protein CWC15 homolog |
Gene namesi | Name:CWC15 Synonyms:C11orf5 ORF Names:AD-002, HSPC148 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26939, CWC15 |
neXtProti | NX_Q9P013 |
VEuPathDBi | HostDB:ENSG00000150316.11 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB
- U2-type catalytic step 2 spliceosome Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 51503 |
OpenTargetsi | ENSG00000150316 |
PharmGKBi | PA162383026 |
Miscellaneous databases
Pharosi | Q9P013, Tdark |
Genetic variation databases
BioMutai | CWC15 |
DMDMi | 150438891 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000291543 | 2 – 229 | Spliceosome-associated protein CWC15 homologAdd BLAST | 228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonine1 Publication | 1 | |
Modified residuei | 18 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 47 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 110 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 121 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9P013 |
jPOSTi | Q9P013 |
MassIVEi | Q9P013 |
MaxQBi | Q9P013 |
PeptideAtlasi | Q9P013 |
PRIDEi | Q9P013 |
ProteomicsDBi | 83532 |
TopDownProteomicsi | Q9P013 |
PTM databases
iPTMneti | Q9P013 |
MetOSitei | Q9P013 |
PhosphoSitePlusi | Q9P013 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150316, Expressed in quadriceps femoris and 221 other tissues |
Genevisiblei | Q9P013, HS |
Organism-specific databases
HPAi | ENSG00000150316, Low tissue specificity |
Interactioni
Subunit structurei
Identified in the spliceosome C complex (PubMed:28502770, PubMed:28076346).
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:20176811).
Interacts directly with CTNNBL1 in the complex (PubMed:20176811).
3 PublicationsProtein-protein interaction databases
BioGRIDi | 119575, 41 interactors |
ComplexPortali | CPX-5824, PRP19-CDC5L complex |
CORUMi | Q9P013 |
IntActi | Q9P013, 33 interactors |
MINTi | Q9P013 |
STRINGi | 9606.ENSP00000475615 |
Miscellaneous databases
RNActi | Q9P013, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9P013 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 123 – 165 | Sequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the CWC15 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3228, Eukaryota |
GeneTreei | ENSGT00390000012084 |
HOGENOMi | CLU_068312_0_1_1 |
InParanoidi | Q9P013 |
OMAi | FKNCARS |
OrthoDBi | 1576404at2759 |
PhylomeDBi | Q9P013 |
Family and domain databases
InterProi | View protein in InterPro IPR006973, Cwf_Cwc_15 |
PANTHERi | PTHR12718, PTHR12718, 1 hit |
Pfami | View protein in Pfam PF04889, Cwf_Cwc_15, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9P013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA
60 70 80 90 100
PEEVRNRDFR RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA
110 120 130 140 150
ANLDADDPLT DEEDEDFEEE SDDDDTAALL AELEKIKKER AEEQARKEQE
160 170 180 190 200
QKAEEERIRM ENILSGNPLL NLTGPSQPQA NFKVKRRWDD DVVFKNCAKG
210 220
VDDQKKDKRF VNDTLRSEFH KKFMEKYIK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 148 | E → D in AAF29112 (PubMed:11042152).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250393 mRNA Translation: CAB96541.1 AF161497 mRNA Translation: AAF29112.1 AF110775 mRNA Translation: AAF14858.1 AK314900 mRNA Translation: BAG37414.1 BC006975 mRNA Translation: AAH06975.1 Different termination. BC032629 mRNA Translation: AAH32629.1 Different termination. BC040946 mRNA Translation: AAH40946.1 |
CCDSi | CCDS73369.1 |
RefSeqi | NP_057487.2, NM_016403.3 XP_011541170.1, XM_011542868.2 XP_016873405.1, XM_017017916.1 |
Genome annotation databases
Ensembli | ENST00000279839; ENSP00000475615; ENSG00000150316 |
GeneIDi | 51503 |
KEGGi | hsa:51503 |
UCSCi | uc031ybh.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250393 mRNA Translation: CAB96541.1 AF161497 mRNA Translation: AAF29112.1 AF110775 mRNA Translation: AAF14858.1 AK314900 mRNA Translation: BAG37414.1 BC006975 mRNA Translation: AAH06975.1 Different termination. BC032629 mRNA Translation: AAH32629.1 Different termination. BC040946 mRNA Translation: AAH40946.1 |
CCDSi | CCDS73369.1 |
RefSeqi | NP_057487.2, NM_016403.3 XP_011541170.1, XM_011542868.2 XP_016873405.1, XM_017017916.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MQF | electron microscopy | 5.90 | R | 1-229 | [»] | |
5XJC | electron microscopy | 3.60 | P | 1-229 | [»] | |
5YZG | electron microscopy | 4.10 | P | 1-229 | [»] | |
5Z56 | electron microscopy | 5.10 | P | 1-229 | [»] | |
5Z57 | electron microscopy | 6.50 | P | 1-229 | [»] | |
5Z58 | electron microscopy | 4.90 | P | 1-229 | [»] | |
6FF4 | electron microscopy | 16.00 | R | 1-229 | [»] | |
6FF7 | electron microscopy | 4.50 | R | 1-229 | [»] | |
6ICZ | electron microscopy | 3.00 | P | 1-229 | [»] | |
6ID0 | electron microscopy | 2.90 | P | 1-229 | [»] | |
6ID1 | electron microscopy | 2.86 | P | 1-229 | [»] | |
6QDV | electron microscopy | 3.30 | P | 1-229 | [»] | |
6ZYM | electron microscopy | 3.40 | R | 1-229 | [»] | |
SMRi | Q9P013 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119575, 41 interactors |
ComplexPortali | CPX-5824, PRP19-CDC5L complex |
CORUMi | Q9P013 |
IntActi | Q9P013, 33 interactors |
MINTi | Q9P013 |
STRINGi | 9606.ENSP00000475615 |
PTM databases
iPTMneti | Q9P013 |
MetOSitei | Q9P013 |
PhosphoSitePlusi | Q9P013 |
Genetic variation databases
BioMutai | CWC15 |
DMDMi | 150438891 |
Proteomic databases
EPDi | Q9P013 |
jPOSTi | Q9P013 |
MassIVEi | Q9P013 |
MaxQBi | Q9P013 |
PeptideAtlasi | Q9P013 |
PRIDEi | Q9P013 |
ProteomicsDBi | 83532 |
TopDownProteomicsi | Q9P013 |
Protocols and materials databases
Antibodypediai | 70625, 73 antibodies |
DNASUi | 51503 |
Genome annotation databases
Ensembli | ENST00000279839; ENSP00000475615; ENSG00000150316 |
GeneIDi | 51503 |
KEGGi | hsa:51503 |
UCSCi | uc031ybh.1, human |
Organism-specific databases
CTDi | 51503 |
DisGeNETi | 51503 |
GeneCardsi | CWC15 |
HGNCi | HGNC:26939, CWC15 |
HPAi | ENSG00000150316, Low tissue specificity |
neXtProti | NX_Q9P013 |
OpenTargetsi | ENSG00000150316 |
PharmGKBi | PA162383026 |
VEuPathDBi | HostDB:ENSG00000150316.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3228, Eukaryota |
GeneTreei | ENSGT00390000012084 |
HOGENOMi | CLU_068312_0_1_1 |
InParanoidi | Q9P013 |
OMAi | FKNCARS |
OrthoDBi | 1576404at2759 |
PhylomeDBi | Q9P013 |
Enzyme and pathway databases
PathwayCommonsi | Q9P013 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 51503, 26 hits in 124 CRISPR screens |
ChiTaRSi | CWC15, human |
GeneWikii | CWC15 |
GenomeRNAii | 51503 |
Pharosi | Q9P013, Tdark |
PROi | PR:Q9P013 |
RNActi | Q9P013, protein |
Gene expression databases
Bgeei | ENSG00000150316, Expressed in quadriceps femoris and 221 other tissues |
Genevisiblei | Q9P013, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006973, Cwf_Cwc_15 |
PANTHERi | PTHR12718, PTHR12718, 1 hit |
Pfami | View protein in Pfam PF04889, Cwf_Cwc_15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CWC15_HUMAN | |
Accessioni | Q9P013Primary (citable) accession number: Q9P013 Secondary accession number(s): B2RC17 Q9UI29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 26, 2007 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM