CWC15

Functionⁱ

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.3 Publications

Caution

Has been termed C11orf5, but is not the official C11orf5 as defined by HGNC.1 Publication

GO - Molecular functionⁱ

RNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 28076346

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Spliceosome-associated protein CWC15 homolog
Gene namesⁱ	Name:CWC15 Synonyms:C11orf5 ORF Names:AD-002, HSPC148
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000150316.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26939 CWC15
neXtProtⁱ	NX_Q9P013

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51503
Open Targets More...OpenTargetsⁱ	ENSG00000150316
PharmGKBⁱ	PA162383026

Polymorphism and mutation databases

BioMutaⁱ	CWC15
DMDMⁱ	150438891

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000291543	2 – 229	Spliceosome-associated protein CWC15 homologAdd BLAST		228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonine1 Publication	1
Modified residueⁱ	18	N6-acetyllysineBy similarity	1
Modified residueⁱ	47	PhosphothreonineCombined sources	1
Modified residueⁱ	110	PhosphothreonineCombined sources	1
Modified residueⁱ	121	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P013
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P013
PeptideAtlas More...PeptideAtlasⁱ	Q9P013
PRIDEⁱ	Q9P013
ProteomicsDBⁱ	83532
TopDownProteomicsⁱ	Q9P013

PTM databases

iPTMnetⁱ	Q9P013
PhosphoSitePlusⁱ	Q9P013

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000150316
CleanExⁱ	HS_CWC15
Genevisibleⁱ	Q9P013 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039878

HPAⁱ

HPA039878

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:20176811). Interacts directly with CTNNBL1 in the complex (PubMed:20176811).3 Publications

Protein-protein interaction databases

BioGridⁱ	119575, 28 interactors
CORUMⁱ	Q9P013
IntActⁱ	Q9P013, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q9P013

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5MQF	electron microscopy	5.90	R	1-229	[»]
	5XJC	electron microscopy	3.60	P	1-229	[»]
ProteinModelPortalⁱ	Q9P013
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	123 – 165	Sequence analysisAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the CWC15 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012084
HOGENOMⁱ	HOG000214250
HOVERGENⁱ	HBG107412
InParanoidⁱ	Q9P013
KEGG Orthology (KO) More...KOⁱ	K12863
OMAⁱ	FKNCARS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TA6
PhylomeDBⁱ	Q9P013

Family and domain databases

InterProⁱ	View protein in InterPro IPR006973 Cwf_Cwc_15
PANTHERⁱ	PTHR12718 PTHR12718, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04889 Cwf_Cwc_15, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9P013-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA 
        60         70         80         90        100
PEEVRNRDFR RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA 
       110        120        130        140        150
ANLDADDPLT DEEDEDFEEE SDDDDTAALL AELEKIKKER AEEQARKEQE 
       160        170        180        190        200
QKAEEERIRM ENILSGNPLL NLTGPSQPQA NFKVKRRWDD DVVFKNCAKG 
       210        220 
VDDQKKDKRF VNDTLRSEFH KKFMEKYIK

Length:229

Mass (Da):26,624

Last modified:June 26, 2007 - v2

Checksum:ⁱB21E6EEF46C4427C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	148	E → D in AAF29112 (PubMed:11042152).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ250393 mRNA Translation: CAB96541.1 AF161497 mRNA Translation: AAF29112.1 AF110775 mRNA Translation: AAF14858.1 AK314900 mRNA Translation: BAG37414.1 BC006975 mRNA Translation: AAH06975.1 Different termination. BC032629 mRNA Translation: AAH32629.1 Different termination. BC040946 mRNA Translation: AAH40946.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73369.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057487.2, NM_016403.3 XP_011541170.1, XM_011542868.2 XP_016873405.1, XM_017017916.1
UniGeneⁱ	Hs.503597

Genome annotation databases

Ensemblⁱ	ENST00000279839; ENSP00000475615; ENSG00000150316
GeneIDⁱ	51503
KEGGⁱ	hsa:51503
UCSC genome browser More...UCSCⁱ	uc031ybh.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9P013	Spliceosome-associated protein CWC15 homolog		PONAB		229
CWC15 spliceosome associated protein homolog		CALJA		229
CWC15 spliceosome associated protein homolog		MACMU		229
spliceosome-associated protein CWC15 homolog		TARSY		229
CWC15 spliceosome associated protein homolog		PAPAN		229
+159

Protein	Similar proteins		Species	Score	Length
Q9P013	Spliceosome-associated protein CWC15 homolog		PONAB		229
CWC15 spliceosome associated protein homolog		CALJA		229
CWC15 spliceosome associated protein homolog		MACMU		229
spliceosome-associated protein CWC15 homolog		TARSY		229
CWC15 spliceosome associated protein homolog		PAPAN		229
+163

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ250393 mRNA Translation: CAB96541.1 AF161497 mRNA Translation: AAF29112.1 AF110775 mRNA Translation: AAF14858.1 AK314900 mRNA Translation: BAG37414.1 BC006975 mRNA Translation: AAH06975.1 Different termination. BC032629 mRNA Translation: AAH32629.1 Different termination. BC040946 mRNA Translation: AAH40946.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73369.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057487.2, NM_016403.3 XP_011541170.1, XM_011542868.2 XP_016873405.1, XM_017017916.1
UniGeneⁱ	Hs.503597

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5MQF	electron microscopy	5.90	R	1-229	[»]
	5XJC	electron microscopy	3.60	P	1-229	[»]
ProteinModelPortalⁱ	Q9P013
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119575, 28 interactors
CORUMⁱ	Q9P013
IntActⁱ	Q9P013, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q9P013

PTM databases

iPTMnetⁱ	Q9P013
PhosphoSitePlusⁱ	Q9P013

Polymorphism and mutation databases

BioMutaⁱ	CWC15
DMDMⁱ	150438891

Proteomic databases

EPDⁱ	Q9P013
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P013
PeptideAtlas More...PeptideAtlasⁱ	Q9P013
PRIDEⁱ	Q9P013
ProteomicsDBⁱ	83532
TopDownProteomicsⁱ	Q9P013

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51503
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000279839; ENSP00000475615; ENSG00000150316
GeneIDⁱ	51503
KEGGⁱ	hsa:51503
UCSC genome browser More...UCSCⁱ	uc031ybh.1 human

Organism-specific databases

CTDⁱ	51503
DisGeNET More...DisGeNETⁱ	51503
EuPathDBⁱ	HostDB:ENSG00000150316.11
GeneCardsⁱ	CWC15
H-InvDBⁱ	HIX0010036
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26939 CWC15
Human Protein Atlas More...HPAⁱ	HPA039878
neXtProtⁱ	NX_Q9P013
Open Targets More...OpenTargetsⁱ	ENSG00000150316
PharmGKBⁱ	PA162383026
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012084
HOGENOMⁱ	HOG000214250
HOVERGENⁱ	HBG107412
InParanoidⁱ	Q9P013
KEGG Orthology (KO) More...KOⁱ	K12863
OMAⁱ	FKNCARS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TA6
PhylomeDBⁱ	Q9P013

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

GeneWikiⁱ	CWC15
GenomeRNAiⁱ	51503
Protein Ontology More...PROⁱ	PR:Q9P013

Gene expression databases

Bgeeⁱ	ENSG00000150316
CleanExⁱ	HS_CWC15
Genevisibleⁱ	Q9P013 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006973 Cwf_Cwc_15
PANTHERⁱ	PTHR12718 PTHR12718, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04889 Cwf_Cwc_15, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CWC15_HUMAN
Accessionⁱ	Q9P013Primary (citable) accession number: Q9P013 Secondary accession number(s): B2RC17 , Q05BV9, Q05DM1, Q9UI29
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	June 26, 2007
	Last modified:	June 20, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Help

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Supporting data

UniProtKB - Q9P013 (CWC15_HUMAN)

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Spliceosome-associated protein CWC15 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ