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Protein

Protein cornichon homolog 4

Gene

CNIH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).1 Publication

GO - Molecular functioni

  • CCR5 chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 4
Short name:
CNIH-4
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 4
Gene namesi
Name:CNIH4
ORF Names:HSPC163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143771.11
HGNCiHGNC:25013 CNIH4
MIMi617483 gene
neXtProtiNX_Q9P003

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29097
OpenTargetsiENSG00000143771
PharmGKBiPA142672091

Polymorphism and mutation databases

DMDMi12229837

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001222301 – 139Protein cornichon homolog 4Add BLAST139

Proteomic databases

EPDiQ9P003
MaxQBiQ9P003
PaxDbiQ9P003
PeptideAtlasiQ9P003
PRIDEiQ9P003
ProteomicsDBi83530
83531 [Q9P003-2]

PTM databases

SwissPalmiQ9P003

Expressioni

Gene expression databases

BgeeiENSG00000143771 Expressed in 231 organ(s), highest expression level in bone marrow
CleanExiHS_CNIH4
ExpressionAtlasiQ9P003 baseline and differential
GenevisibleiQ9P003 HS

Organism-specific databases

HPAiHPA044268

Interactioni

Subunit structurei

Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118865, 8 interactors
IntActiQ9P003, 6 interactors
STRINGi9606.ENSP00000420443

Structurei

3D structure databases

ProteinModelPortaliQ9P003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiQ9P003
KOiK20368
OMAiAWNIYRY
OrthoDBiEOG091G0U69
PhylomeDBiQ9P003
TreeFamiTF300083

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP
60 70 80 90 100
ELIGHTIVTV LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE
110 120 130
IHNRGQLKSH MKEAMIKLGF HLLCFFMYLY SMILALIND
Length:139
Mass (Da):16,093
Last modified:October 1, 2000 - v1
Checksum:i9452E9BDEC2A8DEF
GO
Isoform 2 (identifier: Q9P003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-131: Missing.

Show »
Length:92
Mass (Da):10,615
Checksum:iA99857E36401B352
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NLH6A6NLH6_HUMAN
Protein cornichon homolog 4
CNIH4
137Annotation score:
A6NJ96A6NJ96_HUMAN
Protein cornichon homolog 4
CNIH4
90Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0488303A → G. Corresponds to variant dbSNP:rs12123896Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01346685 – 131Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161512 mRNA Translation: AAF29127.1
AL136930 mRNA Translation: CAB66864.1
AK289973 mRNA Translation: BAF82662.1
AK312064 mRNA Translation: BAG35000.1
CH471098 Genomic DNA Translation: EAW69717.1
CH471098 Genomic DNA Translation: EAW69719.1
BC000573 mRNA Translation: AAH00573.1
CCDSiCCDS1543.1 [Q9P003-1]
CCDS60430.1 [Q9P003-2]
RefSeqiNP_001264126.1, NM_001277197.1 [Q9P003-2]
NP_054903.1, NM_014184.3 [Q9P003-1]
UniGeneiHs.445890

Genome annotation databases

EnsembliENST00000366857; ENSP00000355822; ENSG00000143771 [Q9P003-2]
ENST00000465271; ENSP00000420443; ENSG00000143771 [Q9P003-1]
GeneIDi29097
KEGGihsa:29097
UCSCiuc001hom.3 human [Q9P003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161512 mRNA Translation: AAF29127.1
AL136930 mRNA Translation: CAB66864.1
AK289973 mRNA Translation: BAF82662.1
AK312064 mRNA Translation: BAG35000.1
CH471098 Genomic DNA Translation: EAW69717.1
CH471098 Genomic DNA Translation: EAW69719.1
BC000573 mRNA Translation: AAH00573.1
CCDSiCCDS1543.1 [Q9P003-1]
CCDS60430.1 [Q9P003-2]
RefSeqiNP_001264126.1, NM_001277197.1 [Q9P003-2]
NP_054903.1, NM_014184.3 [Q9P003-1]
UniGeneiHs.445890

3D structure databases

ProteinModelPortaliQ9P003
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118865, 8 interactors
IntActiQ9P003, 6 interactors
STRINGi9606.ENSP00000420443

PTM databases

SwissPalmiQ9P003

Polymorphism and mutation databases

DMDMi12229837

Proteomic databases

EPDiQ9P003
MaxQBiQ9P003
PaxDbiQ9P003
PeptideAtlasiQ9P003
PRIDEiQ9P003
ProteomicsDBi83530
83531 [Q9P003-2]

Protocols and materials databases

DNASUi29097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366857; ENSP00000355822; ENSG00000143771 [Q9P003-2]
ENST00000465271; ENSP00000420443; ENSG00000143771 [Q9P003-1]
GeneIDi29097
KEGGihsa:29097
UCSCiuc001hom.3 human [Q9P003-1]

Organism-specific databases

CTDi29097
DisGeNETi29097
EuPathDBiHostDB:ENSG00000143771.11
GeneCardsiCNIH4
HGNCiHGNC:25013 CNIH4
HPAiHPA044268
MIMi617483 gene
neXtProtiNX_Q9P003
OpenTargetsiENSG00000143771
PharmGKBiPA142672091
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2729 Eukaryota
ENOG4111MWH LUCA
GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
HOVERGENiHBG003814
InParanoidiQ9P003
KOiK20368
OMAiAWNIYRY
OrthoDBiEOG091G0U69
PhylomeDBiQ9P003
TreeFamiTF300083

Miscellaneous databases

ChiTaRSiCNIH4 human
GeneWikiiCNIH4
GenomeRNAii29097
PROiPR:Q9P003
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143771 Expressed in 231 organ(s), highest expression level in bone marrow
CleanExiHS_CNIH4
ExpressionAtlasiQ9P003 baseline and differential
GenevisibleiQ9P003 HS

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNIH4_HUMAN
AccessioniPrimary (citable) accession number: Q9P003
Secondary accession number(s): A8K1Q8, B2R553, Q9H0X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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