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Protein

COMM domain-containing protein 9

Gene

COMMD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).1 Publication2 Publications

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 9
Gene namesi
Name:COMMD9
ORF Names:HSPC166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110442.11
HGNCiHGNC:25014 COMMD9
MIMi612299 gene
neXtProtiNX_Q9P000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110442
PharmGKBiPA134930445

Polymorphism and mutation databases

BioMutaiCOMMD9
DMDMi124056492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000774032 – 198COMM domain-containing protein 9Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P000
MaxQBiQ9P000
PaxDbiQ9P000
PeptideAtlasiQ9P000
PRIDEiQ9P000
ProteomicsDBi83528
83529 [Q9P000-2]

PTM databases

iPTMnetiQ9P000
PhosphoSitePlusiQ9P000
SwissPalmiQ9P000

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000110442 Expressed in 225 organ(s), highest expression level in leukocyte
CleanExiHS_COMMD9
ExpressionAtlasiQ9P000 baseline and differential
GenevisibleiQ9P000 HS

Organism-specific databases

HPAiHPA009142

Interactioni

Subunit structurei

Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi118867, 23 interactors
CORUMiQ9P000
IntActiQ9P000, 10 interactors
STRINGi9606.ENSP00000263401

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P000
SMRiQ9P000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 196COMMPROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410II5T Eukaryota
ENOG4111H94 LUCA
GeneTreeiENSGT00390000006218
HOGENOMiHOG000232004
HOVERGENiHBG080522
InParanoidiQ9P000
KOiK22565
OMAiHISTWRA
OrthoDBiEOG091G1AK9
PhylomeDBiQ9P000
TreeFamiTF323880

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037360 COMMD9
PANTHERiPTHR15663 PTHR15663, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL
60 70 80 90 100
SVTQEEAEEL LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK
110 120 130 140 150
IILEHVSTWR TEAQANQISL PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ
160 170 180 190
MKIQEDPSLC GDKPSISAVT VELSKETLDT MLDGLGRIRD QLSAVASK
Length:198
Mass (Da):21,819
Last modified:January 23, 2007 - v2
Checksum:i54DA2FE525C3A24F
GO
Isoform 2 (identifier: Q9P000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-59: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,333
Checksum:i9AF5728847F609AC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ95E9PJ95_HUMAN
COMM domain-containing protein 9
COMMD9
185Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45V → F in CAB66623 (PubMed:11230166).Curated1
Sequence conflicti161G → R in AAS22246 (PubMed:15799966).Curated1
Sequence conflicti161G → R in AAF29130 (PubMed:11042152).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04149918 – 59Missing in isoform 2. CuratedAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542164 mRNA Translation: AAS22246.1
AF161515 mRNA Translation: AAF29130.1
AL136688 mRNA Translation: CAB66623.1
AC087277 Genomic DNA No translation available.
BC010892 mRNA Translation: AAH10892.1
CCDSiCCDS44571.1 [Q9P000-2]
CCDS7900.1 [Q9P000-1]
RefSeqiNP_001294866.1, NM_001307937.1
NP_054905.2, NM_014186.3 [Q9P000-1]
UniGeneiHs.279836
Hs.99443

Genome annotation databases

EnsembliENST00000263401; ENSP00000263401; ENSG00000110442 [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442 [Q9P000-2]
GeneIDi29099
KEGGihsa:29099
UCSCiuc001mwn.5 human [Q9P000-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542164 mRNA Translation: AAS22246.1
AF161515 mRNA Translation: AAF29130.1
AL136688 mRNA Translation: CAB66623.1
AC087277 Genomic DNA No translation available.
BC010892 mRNA Translation: AAH10892.1
CCDSiCCDS44571.1 [Q9P000-2]
CCDS7900.1 [Q9P000-1]
RefSeqiNP_001294866.1, NM_001307937.1
NP_054905.2, NM_014186.3 [Q9P000-1]
UniGeneiHs.279836
Hs.99443

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NKNX-ray2.79A/B/C/D/E/F1-116[»]
4OE9X-ray1.55A/B1-117[»]
6BP6X-ray2.17A/B115-198[»]
ProteinModelPortaliQ9P000
SMRiQ9P000
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118867, 23 interactors
CORUMiQ9P000
IntActiQ9P000, 10 interactors
STRINGi9606.ENSP00000263401

PTM databases

iPTMnetiQ9P000
PhosphoSitePlusiQ9P000
SwissPalmiQ9P000

Polymorphism and mutation databases

BioMutaiCOMMD9
DMDMi124056492

Proteomic databases

EPDiQ9P000
MaxQBiQ9P000
PaxDbiQ9P000
PeptideAtlasiQ9P000
PRIDEiQ9P000
ProteomicsDBi83528
83529 [Q9P000-2]

Protocols and materials databases

DNASUi29099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263401; ENSP00000263401; ENSG00000110442 [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442 [Q9P000-2]
GeneIDi29099
KEGGihsa:29099
UCSCiuc001mwn.5 human [Q9P000-1]

Organism-specific databases

CTDi29099
EuPathDBiHostDB:ENSG00000110442.11
GeneCardsiCOMMD9
HGNCiHGNC:25014 COMMD9
HPAiHPA009142
MIMi612299 gene
neXtProtiNX_Q9P000
OpenTargetsiENSG00000110442
PharmGKBiPA134930445
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5T Eukaryota
ENOG4111H94 LUCA
GeneTreeiENSGT00390000006218
HOGENOMiHOG000232004
HOVERGENiHBG080522
InParanoidiQ9P000
KOiK22565
OMAiHISTWRA
OrthoDBiEOG091G1AK9
PhylomeDBiQ9P000
TreeFamiTF323880

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiCOMMD9 human
GeneWikiiCOMMD9
GenomeRNAii29099
PROiPR:Q9P000
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110442 Expressed in 225 organ(s), highest expression level in leukocyte
CleanExiHS_COMMD9
ExpressionAtlasiQ9P000 baseline and differential
GenevisibleiQ9P000 HS

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037360 COMMD9
PANTHERiPTHR15663 PTHR15663, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD9_HUMAN
AccessioniPrimary (citable) accession number: Q9P000
Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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