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Protein

MAGUK p55 subfamily member 6

Gene

MPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • protein-containing complex assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 6
Alternative name(s):
Veli-associated MAGUK 1
Short name:
VAM-1
Gene namesi
Name:MPP6
Synonyms:VAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105926.15
HGNCiHGNC:18167 MPP6
MIMi606959 gene
neXtProtiNX_Q9NZW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105926
PharmGKBiPA38511

Polymorphism and mutation databases

BioMutaiMPP6
DMDMi42560556

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945841 – 540MAGUK p55 subfamily member 6Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei500PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZW5
MaxQBiQ9NZW5
PaxDbiQ9NZW5
PeptideAtlasiQ9NZW5
PRIDEiQ9NZW5
ProteomicsDBi83523

PTM databases

iPTMnetiQ9NZW5
PhosphoSitePlusiQ9NZW5
SwissPalmiQ9NZW5

Expressioni

Tissue specificityi

Abundant in testis, brain, and kidney with lower levels detectable in other tissues.

Gene expression databases

BgeeiENSG00000105926 Expressed in 136 organ(s), highest expression level in testis
CleanExiHS_MPP6
ExpressionAtlasiQ9NZW5 baseline and differential
GenevisibleiQ9NZW5 HS

Organism-specific databases

HPAiHPA019085
HPA020456

Interactioni

Subunit structurei

Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LIN7AO149103EBI-2683764,EBI-2513988

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119675, 41 interactors
CORUMiQ9NZW5
IntActiQ9NZW5, 7 interactors
STRINGi9606.ENSP00000222644

Structurei

3D structure databases

ProteinModelPortaliQ9NZW5
SMRiQ9NZW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48L27 1PROSITE-ProRule annotationAdd BLAST48
Domaini49 – 107L27 2PROSITE-ProRule annotationAdd BLAST59
Domaini130 – 209PDZPROSITE-ProRule annotationAdd BLAST80
Domaini215 – 284SH3PROSITE-ProRule annotationAdd BLAST70
Domaini338 – 525Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ9NZW5
OMAiDTIIPQQ
OrthoDBiEOG091G065I
PhylomeDBiQ9NZW5
TreeFamiTF314263

Family and domain databases

CDDicd12038 SH3_MPP6, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035603 MPP6_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9NZW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE
60 70 80 90 100
AVSDNNLELV NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA
110 120 130 140 150
SKCYDSPPSS PEMNNSSINN QLLPVDAIRI LGIHKRAGEP LGVTFRVENN
160 170 180 190 200
DLVIARILHG GMIDRQGLLH VGDIIKEVNG HEVGNNPKEL QELLKNISGS
210 220 230 240 250
VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG LKFSKGEILQ
260 270 280 290 300
IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT
310 320 330 340 350
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG
360 370 380 390 400
RRSLKNRFIV LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK
410 420 430 440 450
AGKYLEHGEY EGNLYGTKID SILEVVQTGR TCILDVNPQA LKVLRTSEFM
460 470 480 490 500
PYVVFIAAPE LETLRAMHKA VVDAGITTKL LTDSDLKKTV DESARIQRAY
510 520 530 540
NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY
Length:540
Mass (Da):61,117
Last modified:February 16, 2004 - v2
Checksum:i86310E4F6AF632BD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZG1B8ZZG1_HUMAN
Membrane protein, palmitoylated 6 (...
MPP6 hCG_38837
428Annotation score:
C9J4Q3C9J4Q3_HUMAN
MAGUK p55 subfamily member 6
MPP6
307Annotation score:
C9JGI8C9JGI8_HUMAN
MAGUK p55 subfamily member 6
MPP6
217Annotation score:
F8WCD2F8WCD2_HUMAN
MAGUK p55 subfamily member 6
MPP6
41Annotation score:
R4GNA8R4GNA8_HUMAN
MAGUK p55 subfamily member 6
MPP6
64Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41H → R in AAD45919 (PubMed:11311936).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162130 mRNA Translation: AAD45919.2
AL136836 mRNA Translation: CAB66770.1
AC005084 Genomic DNA Translation: AAQ96847.1
CH236948 Genomic DNA Translation: EAL24247.1
CH471073 Genomic DNA Translation: EAW93810.1
BC023638 mRNA Translation: AAH23638.1
CCDSiCCDS5388.1
RefSeqiNP_001289966.1, NM_001303037.1
NP_057531.2, NM_016447.3
XP_006715801.1, XM_006715738.3
XP_006715802.1, XM_006715739.3
XP_006715803.1, XM_006715740.3
XP_011513727.1, XM_011515425.2
XP_016867804.1, XM_017012315.1
XP_016867805.1, XM_017012316.1
XP_016867806.1, XM_017012317.1
UniGeneiHs.533355
Hs.563501
Hs.594275

Genome annotation databases

EnsembliENST00000222644; ENSP00000222644; ENSG00000105926
ENST00000396475; ENSP00000379737; ENSG00000105926
GeneIDi51678
KEGGihsa:51678
UCSCiuc003swx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162130 mRNA Translation: AAD45919.2
AL136836 mRNA Translation: CAB66770.1
AC005084 Genomic DNA Translation: AAQ96847.1
CH236948 Genomic DNA Translation: EAL24247.1
CH471073 Genomic DNA Translation: EAW93810.1
BC023638 mRNA Translation: AAH23638.1
CCDSiCCDS5388.1
RefSeqiNP_001289966.1, NM_001303037.1
NP_057531.2, NM_016447.3
XP_006715801.1, XM_006715738.3
XP_006715802.1, XM_006715739.3
XP_006715803.1, XM_006715740.3
XP_011513727.1, XM_011515425.2
XP_016867804.1, XM_017012315.1
XP_016867805.1, XM_017012316.1
XP_016867806.1, XM_017012317.1
UniGeneiHs.533355
Hs.563501
Hs.594275

3D structure databases

ProteinModelPortaliQ9NZW5
SMRiQ9NZW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119675, 41 interactors
CORUMiQ9NZW5
IntActiQ9NZW5, 7 interactors
STRINGi9606.ENSP00000222644

PTM databases

iPTMnetiQ9NZW5
PhosphoSitePlusiQ9NZW5
SwissPalmiQ9NZW5

Polymorphism and mutation databases

BioMutaiMPP6
DMDMi42560556

Proteomic databases

EPDiQ9NZW5
MaxQBiQ9NZW5
PaxDbiQ9NZW5
PeptideAtlasiQ9NZW5
PRIDEiQ9NZW5
ProteomicsDBi83523

Protocols and materials databases

DNASUi51678
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222644; ENSP00000222644; ENSG00000105926
ENST00000396475; ENSP00000379737; ENSG00000105926
GeneIDi51678
KEGGihsa:51678
UCSCiuc003swx.4 human

Organism-specific databases

CTDi51678
EuPathDBiHostDB:ENSG00000105926.15
GeneCardsiMPP6
HGNCiHGNC:18167 MPP6
HPAiHPA019085
HPA020456
MIMi606959 gene
neXtProtiNX_Q9NZW5
OpenTargetsiENSG00000105926
PharmGKBiPA38511
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ9NZW5
OMAiDTIIPQQ
OrthoDBiEOG091G065I
PhylomeDBiQ9NZW5
TreeFamiTF314263

Miscellaneous databases

ChiTaRSiMPP6 human
GeneWikiiMPP6
GenomeRNAii51678
PROiPR:Q9NZW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105926 Expressed in 136 organ(s), highest expression level in testis
CleanExiHS_MPP6
ExpressionAtlasiQ9NZW5 baseline and differential
GenevisibleiQ9NZW5 HS

Family and domain databases

CDDicd12038 SH3_MPP6, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035603 MPP6_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPP6_HUMAN
AccessioniPrimary (citable) accession number: Q9NZW5
Secondary accession number(s): A4D157, Q9H0E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 16, 2004
Last modified: September 12, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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