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Protein

Cysteine-rich motor neuron 1 protein

Gene

CRIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.2 Publications

GO - Molecular functioni

  • insulin-like growth factor-activated receptor activity Source: ProtInc
  • insulin-like growth factor binding Source: InterPro
  • PDZ domain binding Source: MGI
  • serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Alternative name(s):
Cysteine-rich repeat-containing protein S52
Cleaved into the following chain:
Gene namesi
Name:CRIM1
Synonyms:S52
ORF Names:UNQ1886/PRO4330
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000150938.9
HGNCiHGNC:2359 CRIM1
MIMi606189 gene
neXtProtiNX_Q9NZV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 939ExtracellularSequence analysisAdd BLAST905
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 1036CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51232
MalaCardsiCRIM1
OpenTargetsiENSG00000150938
Orphaneti468672 Colobomatous macrophthalmia-microcornea syndrome
PharmGKBiPA26877

Polymorphism and mutation databases

BioMutaiCRIM1
DMDMi67460590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000296243? – 1036Processed cysteine-rich motor neuron 1 protein
Signal peptidei1 – 342 PublicationsAdd BLAST34
ChainiPRO_000002100135 – 1036Cysteine-rich motor neuron 1 proteinAdd BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1035PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NZV1
MaxQBiQ9NZV1
PaxDbiQ9NZV1
PeptideAtlasiQ9NZV1
PRIDEiQ9NZV1
ProteomicsDBi83516

PTM databases

iPTMnetiQ9NZV1
PhosphoSitePlusiQ9NZV1
SwissPalmiQ9NZV1

Miscellaneous databases

PMAP-CutDBiQ9NZV1

Expressioni

Tissue specificityi

Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000150938 Expressed in 237 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_CRIM1
ExpressionAtlasiQ9NZV1 baseline and differential
GenevisibleiQ9NZV1 HS

Organism-specific databases

HPAiHPA000556

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119395, 3 interactors
DIPiDIP-58932N
IntActiQ9NZV1, 9 interactors
MINTiQ9NZV1
STRINGi9606.ENSP00000280527

Structurei

3D structure databases

ProteinModelPortaliQ9NZV1
SMRiQ9NZV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 112IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini334 – 391VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini401 – 457VWFC 2PROSITE-ProRule annotationAdd BLAST57
Domaini469 – 498Antistasin-like 1PROSITE-ProRule annotationAdd BLAST30
Domaini505 – 532Antistasin-like 2PROSITE-ProRule annotationAdd BLAST28
Domaini539 – 564Antistasin-like 3PROSITE-ProRule annotationAdd BLAST26
Domaini567 – 592Antistasin-like 4PROSITE-ProRule annotationAdd BLAST26
Domaini606 – 663VWFC 3PROSITE-ProRule annotationAdd BLAST58
Domaini677 – 735VWFC 4PROSITE-ProRule annotationAdd BLAST59
Domaini751 – 809VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini817 – 874VWFC 6PROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi314 – 316Cell attachment siteSequence analysis3

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR8F Eukaryota
ENOG410Z6K0 LUCA
GeneTreeiENSGT00840000129763
HOGENOMiHOG000063671
HOVERGENiHBG081345
InParanoidiQ9NZV1
OMAiCSTVECP
OrthoDBiEOG091G01IV
PhylomeDBiQ9NZV1
TreeFamiTF106451

Family and domain databases

InterProiView protein in InterPro
IPR004094 Antistasin-like
IPR009030 Growth_fac_rcpt_cys_sf
IPR011061 Hirudin/antistatin
IPR000867 IGFBP-like
IPR001007 VWF_dom
PfamiView protein in Pfam
PF02822 Antistasin, 4 hits
PF00219 IGFBP, 1 hit
PF00093 VWC, 6 hits
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00214 VWC, 6 hits
SM00215 VWC_out, 4 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57262 SSF57262, 3 hits
PROSITEiView protein in PROSITE
PS51252 ANTISTASIN, 4 hits
PS51323 IGFBP_N_2, 1 hit
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9NZV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN
60 70 80 90 100
CPGSIVQGVC GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS
110 120 130 140 150
LTEYEAGVCE DENWTDDQLL GFKPCNENLI AGCNIINGKC ECNTIRTCSN
160 170 180 190 200
PFEFPSQDMC LSALKRIEEE KPDCSKARCE VQFSPRCPED SVLIEGYAPP
210 220 230 240 250
GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE CCDLYECKPV
260 270 280 290 300
FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF
310 320 330 340 350
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR
360 370 380 390 400
MDNCRFCRCQ GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP
410 420 430 440 450
AGCYANGLIL AHGDRWREDD CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG
460 470 480 490 500
ECCPVCEEPT IITVDPPACG ELSNCTLTGK DCINGFKRDH NGCRTCQCIN
510 520 530 540 550
TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR PIICDKYCPL
560 570 580 590 600
GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG
610 620 630 640 650
PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN
660 670 680 690 700
PTIHPGQCCP SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ
710 720 730 740 750
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP
760 770 780 790 800
NYCKNDEGDI FLAAESWKPD VCTSCICIDS VISCFSESCP SVSCERPVLR
810 820 830 840 850
KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC YCLQGQTLCS
860 870 880 890 900
TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP
910 920 930 940 950
LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC
960 970 980 990 1000
LSIIIAFLFI NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD
1010 1020 1030
SSQRMLRIAE PDARFSGFYS MQKQNHLQAD NFYQTV
Length:1,036
Mass (Da):113,738
Last modified:October 1, 2000 - v1
Checksum:i10CBF02A5C579C27
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53TH9Q53TH9_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
110Annotation score:
H7C2T6H7C2T6_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
222Annotation score:
H7C458H7C458_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
55Annotation score:
A0A0G2JN95A0A0G2JN95_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
60Annotation score:
A0A0G2JN98A0A0G2JN98_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
51Annotation score:
H7C1Z0H7C1Z0_HUMAN
Cysteine-rich motor neuron 1 protei...
CRIM1
175Annotation score:

Sequence cautioni

The sequence BAD92376 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433C → F in BAD92376 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050907502E → K. Corresponds to variant dbSNP:rs12997487Ensembl.1
Natural variantiVAR_061625781V → I. Corresponds to variant dbSNP:rs59929305Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167706 mRNA Translation: AAF34409.1
AF168681 Genomic DNA Translation: AAG37011.1
AB209139 mRNA Translation: BAD92376.1 Different initiation.
AY358371 mRNA Translation: AAQ88737.1
BC111989 mRNA Translation: AAI11990.1
BC113371 mRNA Translation: AAI13372.1
CCDSiCCDS1783.1
RefSeqiNP_057525.1, NM_016441.2
UniGeneiHs.699247

Genome annotation databases

EnsembliENST00000280527; ENSP00000280527; ENSG00000150938
GeneIDi51232
KEGGihsa:51232
UCSCiuc002rpd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167706 mRNA Translation: AAF34409.1
AF168681 Genomic DNA Translation: AAG37011.1
AB209139 mRNA Translation: BAD92376.1 Different initiation.
AY358371 mRNA Translation: AAQ88737.1
BC111989 mRNA Translation: AAI11990.1
BC113371 mRNA Translation: AAI13372.1
CCDSiCCDS1783.1
RefSeqiNP_057525.1, NM_016441.2
UniGeneiHs.699247

3D structure databases

ProteinModelPortaliQ9NZV1
SMRiQ9NZV1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119395, 3 interactors
DIPiDIP-58932N
IntActiQ9NZV1, 9 interactors
MINTiQ9NZV1
STRINGi9606.ENSP00000280527

PTM databases

iPTMnetiQ9NZV1
PhosphoSitePlusiQ9NZV1
SwissPalmiQ9NZV1

Polymorphism and mutation databases

BioMutaiCRIM1
DMDMi67460590

Proteomic databases

EPDiQ9NZV1
MaxQBiQ9NZV1
PaxDbiQ9NZV1
PeptideAtlasiQ9NZV1
PRIDEiQ9NZV1
ProteomicsDBi83516

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280527; ENSP00000280527; ENSG00000150938
GeneIDi51232
KEGGihsa:51232
UCSCiuc002rpd.4 human

Organism-specific databases

CTDi51232
DisGeNETi51232
EuPathDBiHostDB:ENSG00000150938.9
GeneCardsiCRIM1
H-InvDBiHIX0030218
HGNCiHGNC:2359 CRIM1
HPAiHPA000556
MalaCardsiCRIM1
MIMi606189 gene
neXtProtiNX_Q9NZV1
OpenTargetsiENSG00000150938
Orphaneti468672 Colobomatous macrophthalmia-microcornea syndrome
PharmGKBiPA26877
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8F Eukaryota
ENOG410Z6K0 LUCA
GeneTreeiENSGT00840000129763
HOGENOMiHOG000063671
HOVERGENiHBG081345
InParanoidiQ9NZV1
OMAiCSTVECP
OrthoDBiEOG091G01IV
PhylomeDBiQ9NZV1
TreeFamiTF106451

Miscellaneous databases

ChiTaRSiCRIM1 human
GeneWikiiCRIM1
GenomeRNAii51232
PMAP-CutDBiQ9NZV1
PROiPR:Q9NZV1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150938 Expressed in 237 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_CRIM1
ExpressionAtlasiQ9NZV1 baseline and differential
GenevisibleiQ9NZV1 HS

Family and domain databases

InterProiView protein in InterPro
IPR004094 Antistasin-like
IPR009030 Growth_fac_rcpt_cys_sf
IPR011061 Hirudin/antistatin
IPR000867 IGFBP-like
IPR001007 VWF_dom
PfamiView protein in Pfam
PF02822 Antistasin, 4 hits
PF00219 IGFBP, 1 hit
PF00093 VWC, 6 hits
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00214 VWC, 6 hits
SM00215 VWC_out, 4 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57262 SSF57262, 3 hits
PROSITEiView protein in PROSITE
PS51252 ANTISTASIN, 4 hits
PS51323 IGFBP_N_2, 1 hit
PS01208 VWFC_1, 6 hits
PS50184 VWFC_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCRIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV1
Secondary accession number(s): Q2M2G4
, Q59GH0, Q7LCQ5, Q9H318
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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