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Protein

Calcium-binding protein 1

Gene

CABP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).By similarity5 Publications

Caution

The interaction with CACNA1A is described as calcium independent in PubMed:11865310 while it is shown to be acutely calcium dependent in PubMed:14570872. PubMed:12032348 describes a stimulatory effect of CABP1 during agonist-induced intracellular calcium signaling while PubMed:14570872 and PubMed:11865310 show an inhibitory effect.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi238Magnesium1 Publication1
Metal bindingi240Magnesium1 Publication1
Metal bindingi242Magnesium1 Publication1
Metal bindingi244Magnesium; via carbonyl oxygen1 Publication1
Metal bindingi315Calcium 11 Publication1
Metal bindingi317Calcium 11 Publication1
Metal bindingi319Calcium 11 Publication1
Metal bindingi321Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi326Calcium 11 Publication1
Metal bindingi352Calcium 21 Publication1
Metal bindingi353Calcium 2; via amide nitrogen1 Publication1
Metal bindingi354Calcium 21 Publication1
Metal bindingi356Calcium 21 Publication1
Metal bindingi357Calcium 2; via amide nitrogen1 Publication1
Metal bindingi358Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi360Calcium 21 Publication1
Metal bindingi363Calcium 21 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi238 – 2491Add BLAST12
Calcium bindingi315 – 3262Add BLAST12
Calcium bindingi352 – 3633Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: ProtInc
  • enzyme inhibitor activity Source: ProtInc
  • nuclear localization sequence binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction, Vision
LigandCalcium, Magnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding protein 1
Short name:
CaBP1
Alternative name(s):
Calbrain
Caldendrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CABP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157782.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1384 CABP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605563 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZU7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi238D → A: Loss of magnesium-binding. Loss of binding to ITPRs; when associated with A-240; A-315; A-317; A-352 and A-354. 2 Publications1
Mutagenesisi240D → A: Loss of magnesium-binding. Loss of binding to ITPRs; when associated with A-238; A-315; A-317; A-352 and A-354. 2 Publications1
Mutagenesisi242D → A: Loss of magnesium-binding. 1 Publication1
Mutagenesisi249D → A: No effect on magnesium-binding. 1 Publication1
Mutagenesisi315D → A: Loss of binding to ITPRs; when associated with A-238; A-240; A-317; A-352 and A-354. 1 Publication1
Mutagenesisi317N → A: Loss of binding to ITPRs; when associated with A-238; A-240; A-315; A-352 and A-354. 1 Publication1
Mutagenesisi323S → A: Loss of phosphorylation and loss of calcium release by InsP(3). 1 Publication1
Mutagenesisi352D → A: Loss of binding to ITPRs; when associated with A-238; A-240; A-315; A-317 and A-354. 1 Publication1
Mutagenesisi354N → A: Loss of binding to ITPRs; when associated with A-238; A-240; A-315; A-317 and A-352. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000157782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26000

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CABP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
334302962

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000735132 – 370Calcium-binding protein 1Add BLAST369
Isoform L-CaBP1 (identifier: Q9NZU7-1)
Initiator methionineiRemoved1 Publication1 Publication
Isoform S-CaBP1 (identifier: Q9NZU7-2)
Initiator methionineiRemoved1 Publication1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei323Phosphoserine1 Publication1
Isoform L-CaBP1 (identifier: Q9NZU7-1)
Lipidationi2N-myristoyl glycine1 Publication1 Publication1
Lipidationi4S-palmitoyl cysteine1 Publication1 Publication1
Isoform S-CaBP1 (identifier: Q9NZU7-2)
Lipidationi2N-myristoyl glycine1 Publication1 Publication1
Lipidationi4S-palmitoyl cysteine1 Publication1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. The phosphorylation regulates the activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZU7

PeptideAtlas

More...
PeptideAtlasi
Q9NZU7

PRoteomics IDEntifications database

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PRIDEi
Q9NZU7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83512
83513 [Q9NZU7-1]
83514 [Q9NZU7-2]
83515 [Q9NZU7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157782 Expressed in 165 organ(s), highest expression level in anterior cingulate cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_CABP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NZU7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NZU7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; when bound to calcium or magnesium. Interacts (via C-terminus) with ITPR1, ITPR2 and ITPR3. This binding is calcium dependent and the interaction correlates with calcium concentration. An additional calcium-independent interaction with the N-terminus of ITPR1 results in a decreased InsP3 binding to the receptor. Interacts with CACNA1A (via C-terminal CDB motif) in the pre- and postsynaptic membranes. Interacts with CACNA1C (via C-terminal C and IQ motifs). The binding to the C motif is calcium independent whereas the binding to IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. Interacts with CACNA1D (By similarity). Interacts with TRPC5 (via C-terminus). Interacts (via EF-hands 1 and 2) at microtubules with MAP1LC3B. Interacts with MYO1C (By similarity). Interacts (via EF-hands 1 and 2) with NSMF (via the central NLS-containing motif region), the interaction occurs in a calcium dependent manner after synaptic NMDA receptor stimulation and prevents nuclear import of NSMF. Interacts with SPACA9 (By similarity).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114863, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-35477N

Protein interaction database and analysis system

More...
IntActi
Q9NZU7, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000317310

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1370
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NZU7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NZU7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NZU7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini225 – 260EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini261 – 296EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini302 – 337EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini339 – 370EF-hand 4PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 48Poly-Pro4
Compositional biasi74 – 79Poly-Ala6
Compositional biasi86 – 164Pro-richAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0027 Eukaryota
COG5126 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158555

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233018

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG012180

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NZU7

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PB4

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NZU7

TreeFam database of animal gene trees

More...
TreeFami
TF334804

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Caldendrin (identifier: Q9NZU7-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGGDGAAFK RPGDGARLQR VLGLGSRREP RSLPAGGPAP RRTAPPPPGH
60 70 80 90 100
ASAGPAAMSS HIAKSESKTS LLKAAAAAAS GGSRAPRHGP ARDPGLPSRR
110 120 130 140 150
LPGSCPATPQ SSGDPSSRRP LCRPAPREEG ARGSQRVLPQ AHCRPREALP
160 170 180 190 200
AAASRPSPSS PLPPARGRDG EERGLSPALG LRGSLRARGR GDSVPAAASE
210 220 230 240 250
ADPFLHRLRP MLSSAFGQDR SLRPEEIEEL REAFREFDKD KDGYINCRDL
260 270 280 290 300
GNCMRTMGYM PTEMELIELS QQINMNLGGH VDFDDFVELM GPKLLAETAD
310 320 330 340 350
MIGVKELRDA FREFDTNGDG EISTSELREA MRKLLGHQVG HRDIEEIIRD
360 370
VDLNGDGRVD FEEFVRMMSR
Length:370
Mass (Da):39,838
Last modified:May 31, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3444721152E01AA7
GO
Isoform L-CaBP1 (identifier: Q9NZU7-1) [UniParc]FASTAAdd to basket
Also known as: Caldendrin-S2

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-218: RPREALPAAA...RPMLSSAFGQ → MGNCVKYPLR...RKGFAENRQP

Show »
Length:227
Mass (Da):25,979
Checksum:iFF3F7A9B575486AB
GO
Isoform S-CaBP1 (identifier: Q9NZU7-2) [UniParc]FASTAAdd to basket
Also known as: Caldendrin-S1

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-218: FLHRLRPMLSSAFGQ → MGNCVKYPLRNLSRK

Show »
Length:167
Mass (Da):19,430
Checksum:iB8C19D9E24D384FD
GO
Isoform Calbrain (identifier: Q9NZU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.

Note: It is currently uncertain whether calbrain represent a spliced isoform.
Show »
Length:70
Mass (Da):8,139
Checksum:i2807BEB35ADCDA48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8G2C9J8G2_HUMAN
Calcium-binding protein 1
CABP1
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140Q → R in AAH30201 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379361 – 300Missing in isoform Calbrain. 1 PublicationAdd BLAST300
Alternative sequenceiVSP_0379371 – 203Missing in isoform S-CaBP1. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_0379381 – 143Missing in isoform L-CaBP1. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_037939144 – 218RPREA…SAFGQ → MGNCVKYPLRNLSRKMCQEE QTSYMVVQTSEEGLAADAEL PGPLLMLAQNCAVMHNLLGP ACIFLRKGFAENRQP in isoform L-CaBP1. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_037940204 – 218FLHRL…SAFGQ → MGNCVKYPLRNLSRK in isoform S-CaBP1. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X94700 mRNA Translation: CAA64361.1
AF169148 mRNA Translation: AAF25782.1
AF169149 mRNA Translation: AAF25783.1
AC069234 Genomic DNA No translation available.
BC030201 mRNA Translation: AAH30201.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS31913.1 [Q9NZU7-4]
CCDS9204.1 [Q9NZU7-2]
CCDS9205.1 [Q9NZU7-1]

NCBI Reference Sequences

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RefSeqi
NP_001028849.1, NM_001033677.1 [Q9NZU7-4]
NP_004267.2, NM_004276.4 [Q9NZU7-2]
NP_112482.1, NM_031205.3 [Q9NZU7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458482

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000288616; ENSP00000288616; ENSG00000157782 [Q9NZU7-1]
ENST00000316803; ENSP00000317310; ENSG00000157782 [Q9NZU7-4]
ENST00000351200; ENSP00000288615; ENSG00000157782 [Q9NZU7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9478

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9478

UCSC genome browser

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UCSCi
uc001tyu.4 human [Q9NZU7-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94700 mRNA Translation: CAA64361.1
AF169148 mRNA Translation: AAF25782.1
AF169149 mRNA Translation: AAF25783.1
AC069234 Genomic DNA No translation available.
BC030201 mRNA Translation: AAH30201.2
CCDSiCCDS31913.1 [Q9NZU7-4]
CCDS9204.1 [Q9NZU7-2]
CCDS9205.1 [Q9NZU7-1]
RefSeqiNP_001028849.1, NM_001033677.1 [Q9NZU7-4]
NP_004267.2, NM_004276.4 [Q9NZU7-2]
NP_112482.1, NM_031205.3 [Q9NZU7-1]
UniGeneiHs.458482

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K7BNMR-A219-294[»]
2K7CNMR-A299-370[»]
2K7DNMR-A299-370[»]
2LANNMR-A219-370[»]
2LAPNMR-A219-370[»]
3OX5X-ray2.90A/B/C/D/E/F219-370[»]
3OX6X-ray2.40A/B/C/D/E/F219-370[»]
ProteinModelPortaliQ9NZU7
SMRiQ9NZU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114863, 8 interactors
DIPiDIP-35477N
IntActiQ9NZU7, 4 interactors
STRINGi9606.ENSP00000317310

PTM databases

iPTMnetiQ9NZU7
PhosphoSitePlusiQ9NZU7

Polymorphism and mutation databases

BioMutaiCABP1
DMDMi334302962

Proteomic databases

PaxDbiQ9NZU7
PeptideAtlasiQ9NZU7
PRIDEiQ9NZU7
ProteomicsDBi83512
83513 [Q9NZU7-1]
83514 [Q9NZU7-2]
83515 [Q9NZU7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9478
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288616; ENSP00000288616; ENSG00000157782 [Q9NZU7-1]
ENST00000316803; ENSP00000317310; ENSG00000157782 [Q9NZU7-4]
ENST00000351200; ENSP00000288615; ENSG00000157782 [Q9NZU7-2]
GeneIDi9478
KEGGihsa:9478
UCSCiuc001tyu.4 human [Q9NZU7-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9478
EuPathDBiHostDB:ENSG00000157782.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CABP1
HGNCiHGNC:1384 CABP1
HPAiHPA051438
MIMi605563 gene
neXtProtiNX_Q9NZU7
OpenTargetsiENSG00000157782
PharmGKBiPA26000

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00940000158555
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9NZU7
OrthoDBiEOG091G0PB4
PhylomeDBiQ9NZU7
TreeFamiTF334804

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CABP1 human
EvolutionaryTraceiQ9NZU7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9478

Protein Ontology

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PROi
PR:Q9NZU7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157782 Expressed in 165 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CABP1
ExpressionAtlasiQ9NZU7 baseline and differential
GenevisibleiQ9NZU7 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCABP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZU7
Secondary accession number(s): O95663, Q8N6H5, Q9NZU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 31, 2011
Last modified: December 5, 2018
This is version 157 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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