Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM and cysteine-rich domains protein 1

Gene

LMCD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and cysteine-rich domains protein 1
Alternative name(s):
Dyxin
Gene namesi
Name:LMCD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000071282.11
HGNCiHGNC:6633 LMCD1
MIMi604859 gene
neXtProtiNX_Q9NZU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29995
OpenTargetsiENSG00000071282
PharmGKBiPA30401

Polymorphism and mutation databases

DMDMi20978521

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758151 – 365LIM and cysteine-rich domains protein 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZU5
MaxQBiQ9NZU5
PaxDbiQ9NZU5
PeptideAtlasiQ9NZU5
PRIDEiQ9NZU5
ProteomicsDBi83511

PTM databases

iPTMnetiQ9NZU5
PhosphoSitePlusiQ9NZU5

Expressioni

Tissue specificityi

Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000071282 Expressed in 202 organ(s), highest expression level in left coronary artery
CleanExiHS_LMCD1
ExpressionAtlasiQ9NZU5 baseline and differential
GenevisibleiQ9NZU5 HS

Organism-specific databases

HPAiHPA024059

Interactioni

Subunit structurei

Interacts with GATA1 and GATA4 (By similarity). Interacts with beta-dystroglycan. Interacts with GATA6.By similarity1 Publication

Protein-protein interaction databases

BioGridi119020, 8 interactors
IntActiQ9NZU5, 7 interactors
MINTiQ9NZU5
STRINGi9606.ENSP00000157600

Structurei

3D structure databases

ProteinModelPortaliQ9NZU5
SMRiQ9NZU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 206PETPROSITE-ProRule annotationAdd BLAST108
Domaini241 – 306LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST66
Domaini307 – 365LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 58Cys-richAdd BLAST31

Domaini

The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.By similarity

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410INGI Eukaryota
ENOG410ZPX3 LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000231628
HOVERGENiHBG001038
InParanoidiQ9NZU5
OMAiAGYSKQW
OrthoDBiEOG091G07C5
PhylomeDBiQ9NZU5
TreeFamiTF313265

Family and domain databases

CDDicd09829 PET_testin, 1 hit
InterProiView protein in InterPro
IPR010442 PET_domain
IPR033724 PET_testin
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
PS51303 PET, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC
60 70 80 90 100
KCSQEDHCLT SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI
110 120 130 140 150
MTNPIATGKD PTFDTITYEW APPGVTQKLG LQYMELIPKE KQPVTGTEGA
160 170 180 190 200
FYRRRQLMHQ LPIYDQDPSR CRGLLENELK LMEEFVKQYK SEALGVGEVA
210 220 230 240 250
LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE YVCELCKGAA
260 270 280 290 300
PPDSPVVYSD RAGYNKQWHP TCFVCAKCSE PLVDLIYFWK DGAPWCGRHY
310 320 330 340 350
CESLRPRCSG CDEIIFAEDY QRVEDLAWHR KHFVCEGCEQ LLSGRAYIVT
360
KGQLLCPTCS KSKRS
Length:365
Mass (Da):40,833
Last modified:October 1, 2000 - v1
Checksum:iD84BFD53C43D2DD7
GO
Isoform 2 (identifier: Q9NZU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):32,882
Checksum:iD19CF028814D51FD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DEY6B4DEY6_HUMAN
cDNA FLJ52480, highly similar to LI...
LMCD1
253Annotation score:
H7C3D2H7C3D2_HUMAN
LIM and cysteine-rich domains prote...
LMCD1
247Annotation score:
C9IYS1C9IYS1_HUMAN
LIM and cysteine-rich domains prote...
LMCD1
233Annotation score:
F8WB09F8WB09_HUMAN
LIM and cysteine-rich domains prote...
LMCD1
58Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538951 – 73Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169284 mRNA Translation: AAF34411.1
AF216709 mRNA Translation: AAG36778.1
AK022176 mRNA Translation: BAB13976.1
AK294455 mRNA Translation: BAG57691.1
AC087859 Genomic DNA No translation available.
BC000646 mRNA Translation: AAH00646.1
CCDSiCCDS33688.1 [Q9NZU5-1]
CCDS63534.1 [Q9NZU5-2]
RefSeqiNP_001265162.1, NM_001278233.1 [Q9NZU5-2]
NP_001265163.1, NM_001278234.1
NP_001265164.1, NM_001278235.1
NP_055398.1, NM_014583.3 [Q9NZU5-1]
UniGeneiHs.475353
Hs.732705

Genome annotation databases

EnsembliENST00000157600; ENSP00000157600; ENSG00000071282 [Q9NZU5-1]
ENST00000454244; ENSP00000396515; ENSG00000071282 [Q9NZU5-2]
GeneIDi29995
KEGGihsa:29995
UCSCiuc010hci.4 human [Q9NZU5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169284 mRNA Translation: AAF34411.1
AF216709 mRNA Translation: AAG36778.1
AK022176 mRNA Translation: BAB13976.1
AK294455 mRNA Translation: BAG57691.1
AC087859 Genomic DNA No translation available.
BC000646 mRNA Translation: AAH00646.1
CCDSiCCDS33688.1 [Q9NZU5-1]
CCDS63534.1 [Q9NZU5-2]
RefSeqiNP_001265162.1, NM_001278233.1 [Q9NZU5-2]
NP_001265163.1, NM_001278234.1
NP_001265164.1, NM_001278235.1
NP_055398.1, NM_014583.3 [Q9NZU5-1]
UniGeneiHs.475353
Hs.732705

3D structure databases

ProteinModelPortaliQ9NZU5
SMRiQ9NZU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119020, 8 interactors
IntActiQ9NZU5, 7 interactors
MINTiQ9NZU5
STRINGi9606.ENSP00000157600

PTM databases

iPTMnetiQ9NZU5
PhosphoSitePlusiQ9NZU5

Polymorphism and mutation databases

DMDMi20978521

Proteomic databases

EPDiQ9NZU5
MaxQBiQ9NZU5
PaxDbiQ9NZU5
PeptideAtlasiQ9NZU5
PRIDEiQ9NZU5
ProteomicsDBi83511

Protocols and materials databases

DNASUi29995
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000157600; ENSP00000157600; ENSG00000071282 [Q9NZU5-1]
ENST00000454244; ENSP00000396515; ENSG00000071282 [Q9NZU5-2]
GeneIDi29995
KEGGihsa:29995
UCSCiuc010hci.4 human [Q9NZU5-1]

Organism-specific databases

CTDi29995
DisGeNETi29995
EuPathDBiHostDB:ENSG00000071282.11
GeneCardsiLMCD1
HGNCiHGNC:6633 LMCD1
HPAiHPA024059
MIMi604859 gene
neXtProtiNX_Q9NZU5
OpenTargetsiENSG00000071282
PharmGKBiPA30401
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGI Eukaryota
ENOG410ZPX3 LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000231628
HOVERGENiHBG001038
InParanoidiQ9NZU5
OMAiAGYSKQW
OrthoDBiEOG091G07C5
PhylomeDBiQ9NZU5
TreeFamiTF313265

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism

Miscellaneous databases

ChiTaRSiLMCD1 human
GenomeRNAii29995
PROiPR:Q9NZU5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000071282 Expressed in 202 organ(s), highest expression level in left coronary artery
CleanExiHS_LMCD1
ExpressionAtlasiQ9NZU5 baseline and differential
GenevisibleiQ9NZU5 HS

Family and domain databases

CDDicd09829 PET_testin, 1 hit
InterProiView protein in InterPro
IPR010442 PET_domain
IPR033724 PET_testin
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
PS51303 PET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMCD1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU5
Secondary accession number(s): B4DG80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again