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Protein

Leucine-rich repeat transmembrane protein FLRT1

Gene

FLRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: Ensembl
  • protein binding, bridging Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-5654687 Downstream signaling of activated FGFR1

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT1
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 1
Gene namesi
Name:FLRT1
ORF Names:UNQ752/PRO1483
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000126500.3
HGNCiHGNC:3760 FLRT1
MIMi604806 gene
neXtProtiNX_Q9NZU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 524ExtracellularSequence analysisAdd BLAST504
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 646CytoplasmicSequence analysisAdd BLAST101

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

MalaCardsiFLRT1
Orphaneti401825 Autosomal recessive spastic paraplegia type 68
PharmGKBiPA28177

Polymorphism and mutation databases

BioMutaiFLRT1
DMDMi215274159

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002127821 – 646Leucine-rich repeat transmembrane protein FLRT1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi30 ↔ 39By similarity
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 329By similarity

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.By similarity
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NZU1
PaxDbiQ9NZU1
PeptideAtlasiQ9NZU1
PRIDEiQ9NZU1
ProteomicsDBi83510

PTM databases

iPTMnetiQ9NZU1
PhosphoSitePlusiQ9NZU1

Expressioni

Tissue specificityi

Expressed in kidney and brain.1 Publication

Gene expression databases

BgeeiENSG00000126500 Expressed in 147 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_FLRT1
GenevisibleiQ9NZU1 HS

Organism-specific databases

HPAiHPA054589

Interactioni

Subunit structurei

Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and ADGRL3 (via olfactomedin-like domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117269, 18 interactors
IntActiQ9NZU1, 2 interactors
MINTiQ9NZU1
STRINGi9606.ENSP00000246841

Structurei

3D structure databases

ProteinModelPortaliQ9NZU1
SMRiQ9NZU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 53LRRNTAdd BLAST33
Repeati54 – 75LRR 1Add BLAST22
Repeati79 – 99LRR 2Add BLAST21
Repeati100 – 121LRR 3Add BLAST22
Repeati124 – 145LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati172 – 192LRR 6Add BLAST21
Repeati195 – 218LRR 7Add BLAST24
Repeati221 – 241LRR 8Add BLAST21
Repeati243 – 264LRR 9Add BLAST22
Repeati267 – 288LRR 10Add BLAST22
Domaini300 – 352LRRCTAdd BLAST53
Domaini409 – 504Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEA Eukaryota
COG4886 LUCA
HOGENOMiHOG000290188
HOVERGENiHBG051629
InParanoidiQ9NZU1
KOiK16362
OrthoDBiEOG091G05YU
PhylomeDBiQ9NZU1
TreeFamiTF331598

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLRDWLFLC YGLIAFLTEV IDSTTCPSVC RCDNGFIYCN DRGLTSIPAD
60 70 80 90 100
IPDDATTLYL QNNQINNAGI PQDLKTKVNV QVIYLYENDL DEFPINLPRS
110 120 130 140 150
LRELHLQDNN VRTIARDSLA RIPLLEKLHL DDNSVSTVSI EEDAFADSKQ
160 170 180 190 200
LKLLFLSRNH LSSIPSGLPH TLEELRLDDN RISTIPLHAF KGLNSLRRLV
210 220 230 240 250
LDGNLLANQR IADDTFSRLQ NLTELSLVRN SLAAPPLNLP SAHLQKLYLQ
260 270 280 290 300
DNAISHIPYN TLAKMRELER LDLSNNNLTT LPRGLFDDLG NLAQLLLRNN
310 320 330 340 350
PWFCGCNLMW LRDWVKARAA VVNVRGLMCQ GPEKVRGMAI KDITSEMDEC
360 370 380 390 400
FETGPQGGVA NAAAKTTASN HASATTPQGS LFTLKAKRPG LRLPDSNIDY
410 420 430 440 450
PMATGDGAKT LAIHVKALTA DSIRITWKAT LPASSFRLSW LRLGHSPAVG
460 470 480 490 500
SITETLVQGD KTEYLLTALE PKSTYIICMV TMETSNAYVA DETPVCAKAE
510 520 530 540 550
TADSYGPTTT LNQEQNAGPM ASLPLAGIIG GAVALVFLFL VLGAICWYVH
560 570 580 590 600
QAGELLTRER AYNRGSRKKD DYMESGTKKD NSILEIRGPG LQMLPINPYR
610 620 630 640
AKEEYVVHTI FPSNGSSLCK ATHTIGYGTT RGYRDGGIPD IDYSYT
Length:646
Mass (Da):71,358
Last modified:November 25, 2008 - v3
Checksum:i0F81FF7C9CA13129
GO

Sequence cautioni

The sequence AAF28459 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH18370 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88675 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF82620 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW74194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti568K → E in AAF28459 (PubMed:10644439).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169675 mRNA Translation: AAF28459.1 Different initiation.
AY358308 mRNA Translation: AAQ88675.1 Different initiation.
AK289931 mRNA Translation: BAF82620.1 Different initiation.
AP006333 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74194.1 Different initiation.
BC018370 mRNA Translation: AAH18370.1 Different initiation.
RefSeqiNP_037412.2, NM_013280.4
XP_005273918.1, XM_005273861.1
XP_011543185.1, XM_011544883.1
UniGeneiHs.584876

Genome annotation databases

EnsembliENST00000246841; ENSP00000246841; ENSG00000126500
GeneIDi23769
KEGGihsa:23769
UCSCiuc001nyi.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169675 mRNA Translation: AAF28459.1 Different initiation.
AY358308 mRNA Translation: AAQ88675.1 Different initiation.
AK289931 mRNA Translation: BAF82620.1 Different initiation.
AP006333 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74194.1 Different initiation.
BC018370 mRNA Translation: AAH18370.1 Different initiation.
RefSeqiNP_037412.2, NM_013280.4
XP_005273918.1, XM_005273861.1
XP_011543185.1, XM_011544883.1
UniGeneiHs.584876

3D structure databases

ProteinModelPortaliQ9NZU1
SMRiQ9NZU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117269, 18 interactors
IntActiQ9NZU1, 2 interactors
MINTiQ9NZU1
STRINGi9606.ENSP00000246841

PTM databases

iPTMnetiQ9NZU1
PhosphoSitePlusiQ9NZU1

Polymorphism and mutation databases

BioMutaiFLRT1
DMDMi215274159

Proteomic databases

MaxQBiQ9NZU1
PaxDbiQ9NZU1
PeptideAtlasiQ9NZU1
PRIDEiQ9NZU1
ProteomicsDBi83510

Protocols and materials databases

DNASUi23769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246841; ENSP00000246841; ENSG00000126500
GeneIDi23769
KEGGihsa:23769
UCSCiuc001nyi.2 human

Organism-specific databases

CTDi23769
EuPathDBiHostDB:ENSG00000126500.3
GeneCardsiFLRT1
HGNCiHGNC:3760 FLRT1
HPAiHPA054589
MalaCardsiFLRT1
MIMi604806 gene
neXtProtiNX_Q9NZU1
Orphaneti401825 Autosomal recessive spastic paraplegia type 68
PharmGKBiPA28177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEA Eukaryota
COG4886 LUCA
HOGENOMiHOG000290188
HOVERGENiHBG051629
InParanoidiQ9NZU1
KOiK16362
OrthoDBiEOG091G05YU
PhylomeDBiQ9NZU1
TreeFamiTF331598

Enzyme and pathway databases

ReactomeiR-HSA-5654687 Downstream signaling of activated FGFR1

Miscellaneous databases

GenomeRNAii23769
PROiPR:Q9NZU1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126500 Expressed in 147 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_FLRT1
GenevisibleiQ9NZU1 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFLRT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU1
Secondary accession number(s): Q8WVA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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