UniProtKB - Q9NZU0 (FLRT3_HUMAN)
Leucine-rich repeat transmembrane protein FLRT3
FLRT3
Functioni
GO - Molecular functioni
- chemorepellent activity Source: Ensembl
- fibroblast growth factor receptor binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
GO - Biological processi
- axon guidance Source: Ensembl
- cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
- embryonic morphogenesis Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- head development Source: UniProtKB
- heart development Source: UniProtKB
- neuron projection development Source: UniProtKB
- neuron projection extension Source: UniProtKB
- positive regulation of synapse assembly Source: Ensembl
- proepicardium cell migration involved in pericardium morphogenesis Source: UniProtKB
- response to axon injury Source: UniProtKB
- synapse assembly Source: UniProtKB
- synaptic membrane adhesion Source: Ensembl
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q9NZU0 |
Reactomei | R-HSA-376176, Signaling by ROBO receptors R-HSA-5654687, Downstream signaling of activated FGFR1 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat transmembrane protein FLRT3Alternative name(s): Fibronectin-like domain-containing leucine-rich transmembrane protein 3 |
Gene namesi | Name:FLRT3 Synonyms:KIAA1469 ORF Names:UNQ856/PRO1865 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3762, FLRT3 |
MIMi | 604808, gene |
neXtProti | NX_Q9NZU0 |
VEuPathDBi | HostDB:ENSG00000125848.9 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass membrane protein By similarity
- growth cone membrane By similarity
Extracellular region or secreted
- Secreted By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Other locations
- focal adhesion By similarity
- axon By similarity
Note: Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain.By similarity
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- growth cone membrane Source: UniProtKB-SubCell
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic membrane Source: Ensembl
- plasma membrane Source: HPA
- synaptic membrane Source: UniProtKB
Other locations
- axon terminus Source: UniProtKB
- axonal growth cone Source: UniProtKB
- cell junction Source: HPA
- cell-cell junction Source: Ensembl
- extracellular matrix Source: UniProtKB
- focal adhesion Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 528 | ExtracellularSequence analysisAdd BLAST | 500 | |
Transmembranei | 529 – 549 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 550 – 649 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069950 | 69 | Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398124653EnsemblClinVar. | 1 | |
Natural variantiVAR_069951 | 97 | E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124651EnsemblClinVar. | 1 | |
Natural variantiVAR_069952 | 144 | S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124652EnsemblClinVar. | 1 | |
Natural variantiVAR_069953 | 339 | K → R in HH21. 1 PublicationCorresponds to variant dbSNP:rs398124654EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | D → A: Abolishes ADGRL3 binding; when associated with A-43; A-45 and A-47. 1 Publication | 1 | |
Mutagenesisi | 43 | Y → A: Abolishes ADGRL3 binding; when associated with A-64. Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication | 1 | |
Mutagenesisi | 45 | N → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication | 1 | |
Mutagenesisi | 47 | R → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-45. 1 Publication | 1 | |
Mutagenesisi | 64 | Y → A: Abolishes ADGRL3 binding; when associated with A-43. 1 Publication | 1 | |
Mutagenesisi | 89 | Y → A: Abolishes ADGRL3 binding; when associated with A-91. 1 Publication | 1 | |
Mutagenesisi | 91 | Y → A: Abolishes ADGRL3 binding; when associated with A-89. 1 Publication | 1 | |
Mutagenesisi | 181 | R → A: No effect on homodimerization; when associated with A-183. 1 Publication | 1 | |
Mutagenesisi | 181 | R → N: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication | 1 | |
Mutagenesisi | 183 | D → A: No effect on homodimerization; when associated with A-181. 1 Publication | 1 | |
Mutagenesisi | 183 | D → T: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Hypogonadotropic hypogonadism, Kallmann syndromeOrganism-specific databases
DisGeNETi | 23767 |
GeneReviewsi | FLRT3 |
MalaCardsi | FLRT3 |
MIMi | 615271, phenotype |
OpenTargetsi | ENSG00000125848 |
Orphaneti | 478, Kallmann syndrome |
PharmGKBi | PA28179 |
Miscellaneous databases
Pharosi | Q9NZU0, Tbio |
Genetic variation databases
BioMutai | FLRT3 |
DMDMi | 20138400 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000021280 | 29 – 649 | Leucine-rich repeat transmembrane protein FLRT3Add BLAST | 621 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 37 | 1 Publication | ||
Disulfide bondi | 35 ↔ 44 | 1 Publication | ||
Glycosylationi | 226 | N-linked (GlcNAc...) asparagineSequence analysis1 Publication | 1 | |
Glycosylationi | 282 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 309 ↔ 334 | 1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9NZU0 |
jPOSTi | Q9NZU0 |
MassIVEi | Q9NZU0 |
MaxQBi | Q9NZU0 |
PaxDbi | Q9NZU0 |
PeptideAtlasi | Q9NZU0 |
PRIDEi | Q9NZU0 |
ProteomicsDBi | 83509 |
PTM databases
GlyConnecti | 1454, 2 N-Linked glycans (1 site) |
GlyGeni | Q9NZU0, 3 sites |
iPTMneti | Q9NZU0 |
PhosphoSitePlusi | Q9NZU0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000125848, Expressed in metanephros and 213 other tissues |
Genevisiblei | Q9NZU0, HS |
Organism-specific databases
HPAi | ENSG00000125848, Tissue enhanced (kidney) |
Interactioni
Subunit structurei
Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030).
Interacts with FGFR1.
Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity).
Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030).
Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C.
Interacts (via cytoplasmic domain) with ROBO1 (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsQ9NZU0
With | #Exp. | IntAct |
---|---|---|
ADGRL3 [Q9HAR2] | 4 | EBI-1057092,EBI-2689295 |
APP - isoform APP695 [P05067-4] | 3 | EBI-1057092,EBI-302641 |
GO - Molecular functioni
- chemorepellent activity Source: Ensembl
- fibroblast growth factor receptor binding Source: Ensembl
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117267, 11 interactors |
CORUMi | Q9NZU0 |
DIPi | DIP-50407N |
IntActi | Q9NZU0, 9 interactors |
STRINGi | 9606.ENSP00000367292 |
Miscellaneous databases
RNActi | Q9NZU0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZU0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 58 | LRRNTSequence analysisAdd BLAST | 30 | |
Repeati | 59 – 80 | LRR 1Sequence analysisAdd BLAST | 22 | |
Repeati | 84 – 104 | LRR 2Sequence analysisAdd BLAST | 21 | |
Repeati | 105 – 126 | LRR 3Sequence analysisAdd BLAST | 22 | |
Repeati | 129 – 150 | LRR 4Sequence analysisAdd BLAST | 22 | |
Repeati | 155 – 175 | LRR 5Sequence analysisAdd BLAST | 21 | |
Repeati | 176 – 197 | LRR 6Sequence analysisAdd BLAST | 22 | |
Repeati | 200 – 220 | LRR 7Sequence analysisAdd BLAST | 21 | |
Repeati | 226 – 247 | LRR 8Sequence analysisAdd BLAST | 22 | |
Repeati | 248 – 269 | LRR 9Sequence analysisAdd BLAST | 22 | |
Repeati | 272 – 293 | LRR 10Sequence analysisAdd BLAST | 22 | |
Domaini | 305 – 357 | LRRCTSequence analysisAdd BLAST | 53 | |
Domaini | 409 – 504 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 38 – 67 | Interaction with ADGRL31 PublicationAdd BLAST | 30 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQBZ, Eukaryota |
GeneTreei | ENSGT00940000159704 |
HOGENOMi | CLU_027624_0_0_1 |
InParanoidi | Q9NZU0 |
OMAi | SPYRVCM |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q9NZU0 |
TreeFami | TF331598 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS51450, LRR, 8 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT
60 70 80 90 100
SIPTGIPEDA TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT
110 120 130 140 150
NLPKYVKELH LQENNIRTIT YDSLSKIPYL EELHLDDNSV SAVSIEEGAF
160 170 180 190 200
RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL RLDDNRISTI SSPSLQGLTS
210 220 230 240 250
LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA PVNLPGTNLR
260 270 280 290 300
KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL
310 320 330 340 350
ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA
360 370 380 390 400
ELFDCKDSGI VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH
410 420 430 440 450
QTTGSPSRKT ITITVKSVTS DTIHISWKLA LPMTALRLSW LKLGHSPAFG
460 470 480 490 500
SITETIVTGE RSEYLVTALE PDSPYKVCMV PMETSNLYLF DETPVCIETE
510 520 530 540 550
TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV TIALLALVCW
560 570 580 590 600
YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS
610 620 630 640
NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 198 | L → P in BAB55282 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 307 | W → R in BAB55282 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 519 | K → Q in BAB55023 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 638 | D → G in BAB55282 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069950 | 69 | Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398124653EnsemblClinVar. | 1 | |
Natural variantiVAR_069951 | 97 | E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124651EnsemblClinVar. | 1 | |
Natural variantiVAR_069952 | 144 | S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124652EnsemblClinVar. | 1 | |
Natural variantiVAR_069953 | 339 | K → R in HH21. 1 PublicationCorresponds to variant dbSNP:rs398124654EnsemblClinVar. | 1 | |
Natural variantiVAR_050997 | 377 | A → T. Corresponds to variant dbSNP:rs8120693EnsemblClinVar. | 1 | |
Natural variantiVAR_017152 | 400 | H → Q3 PublicationsCorresponds to variant dbSNP:rs6079391Ensembl. | 1 | |
Natural variantiVAR_064714 | 452 | I → V Found in a renal cell carcinoma case; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1393315241Ensembl. | 1 | |
Natural variantiVAR_050998 | 460 | E → D. Corresponds to variant dbSNP:rs35253731Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF169677 mRNA Translation: AAF28461.1 AB040902 mRNA Translation: BAA95993.1 Different initiation. AK027297 mRNA Translation: BAB55023.1 AK027670 mRNA Translation: BAB55282.1 Different initiation. AK027694 mRNA Translation: BAB55303.1 Different initiation. AY358319 mRNA Translation: AAQ88685.1 AK074909 mRNA Translation: BAC11284.1 AL132826 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10300.1 CH471133 Genomic DNA Translation: EAX10301.1 BC020870 mRNA Translation: AAH20870.1 |
CCDSi | CCDS13121.1 |
RefSeqi | NP_037413.1, NM_013281.3 NP_938205.1, NM_198391.2 XP_005260739.1, XM_005260682.4 XP_011527506.1, XM_011529204.2 XP_011527507.1, XM_011529205.2 |
Genome annotation databases
Ensembli | ENST00000341420; ENSP00000339912; ENSG00000125848 ENST00000378053; ENSP00000367292; ENSG00000125848 |
GeneIDi | 23767 |
KEGGi | hsa:23767 |
UCSCi | uc002wov.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF169677 mRNA Translation: AAF28461.1 AB040902 mRNA Translation: BAA95993.1 Different initiation. AK027297 mRNA Translation: BAB55023.1 AK027670 mRNA Translation: BAB55282.1 Different initiation. AK027694 mRNA Translation: BAB55303.1 Different initiation. AY358319 mRNA Translation: AAQ88685.1 AK074909 mRNA Translation: BAC11284.1 AL132826 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10300.1 CH471133 Genomic DNA Translation: EAX10301.1 BC020870 mRNA Translation: AAH20870.1 |
CCDSi | CCDS13121.1 |
RefSeqi | NP_037413.1, NM_013281.3 NP_938205.1, NM_198391.2 XP_005260739.1, XM_005260682.4 XP_011527506.1, XM_011529204.2 XP_011527507.1, XM_011529205.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5CMN | X-ray | 3.61 | A/B/C/D | 29-357 | [»] | |
5CMP | X-ray | 2.60 | A/B/C/D | 29-357 | [»] | |
6JBU | X-ray | 1.85 | B | 29-358 | [»] | |
SMRi | Q9NZU0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117267, 11 interactors |
CORUMi | Q9NZU0 |
DIPi | DIP-50407N |
IntActi | Q9NZU0, 9 interactors |
STRINGi | 9606.ENSP00000367292 |
PTM databases
GlyConnecti | 1454, 2 N-Linked glycans (1 site) |
GlyGeni | Q9NZU0, 3 sites |
iPTMneti | Q9NZU0 |
PhosphoSitePlusi | Q9NZU0 |
Genetic variation databases
BioMutai | FLRT3 |
DMDMi | 20138400 |
Proteomic databases
EPDi | Q9NZU0 |
jPOSTi | Q9NZU0 |
MassIVEi | Q9NZU0 |
MaxQBi | Q9NZU0 |
PaxDbi | Q9NZU0 |
PeptideAtlasi | Q9NZU0 |
PRIDEi | Q9NZU0 |
ProteomicsDBi | 83509 |
Protocols and materials databases
Antibodypediai | 24361, 100 antibodies |
DNASUi | 23767 |
Genome annotation databases
Ensembli | ENST00000341420; ENSP00000339912; ENSG00000125848 ENST00000378053; ENSP00000367292; ENSG00000125848 |
GeneIDi | 23767 |
KEGGi | hsa:23767 |
UCSCi | uc002wov.3, human |
Organism-specific databases
CTDi | 23767 |
DisGeNETi | 23767 |
GeneCardsi | FLRT3 |
GeneReviewsi | FLRT3 |
HGNCi | HGNC:3762, FLRT3 |
HPAi | ENSG00000125848, Tissue enhanced (kidney) |
MalaCardsi | FLRT3 |
MIMi | 604808, gene 615271, phenotype |
neXtProti | NX_Q9NZU0 |
OpenTargetsi | ENSG00000125848 |
Orphaneti | 478, Kallmann syndrome |
PharmGKBi | PA28179 |
VEuPathDBi | HostDB:ENSG00000125848.9 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQBZ, Eukaryota |
GeneTreei | ENSGT00940000159704 |
HOGENOMi | CLU_027624_0_0_1 |
InParanoidi | Q9NZU0 |
OMAi | SPYRVCM |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q9NZU0 |
TreeFami | TF331598 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZU0 |
Reactomei | R-HSA-376176, Signaling by ROBO receptors R-HSA-5654687, Downstream signaling of activated FGFR1 |
Miscellaneous databases
BioGRID-ORCSi | 23767, 3 hits in 979 CRISPR screens |
GeneWikii | FLRT3 |
GenomeRNAii | 23767 |
Pharosi | Q9NZU0, Tbio |
PROi | PR:Q9NZU0 |
RNActi | Q9NZU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125848, Expressed in metanephros and 213 other tissues |
Genevisiblei | Q9NZU0, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS51450, LRR, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLRT3_HUMAN | |
Accessioni | Q9NZU0Primary (citable) accession number: Q9NZU0 Secondary accession number(s): D3DW20 Q9P259 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references