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Protein

Leucine-rich repeat transmembrane protein FLRT3

Gene

FLRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).By similarity2 Publications

GO - Molecular functioni

  • chemorepellent activity Source: Ensembl
  • fibroblast growth factor receptor binding Source: Ensembl
  • protein binding, bridging Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-376176 Signaling by ROBO receptors
R-HSA-5654687 Downstream signaling of activated FGFR1

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT3
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 3
Gene namesi
Name:FLRT3
Synonyms:KIAA1469
ORF Names:UNQ856/PRO1865
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125848.9
HGNCiHGNC:3762 FLRT3
MIMi604808 gene
neXtProtiNX_Q9NZU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 528ExtracellularSequence analysisAdd BLAST500
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 649CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
See also OMIM:615271
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06995069Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398124653EnsemblClinVar.1
Natural variantiVAR_06995197E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124651EnsemblClinVar.1
Natural variantiVAR_069952144S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124652EnsemblClinVar.1
Natural variantiVAR_069953339K → R in HH21. 1 PublicationCorresponds to variant dbSNP:rs398124654EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38D → A: Abolishes ADGRL3 binding; when associated with A-43; A-45 and A-47. 1 Publication1
Mutagenesisi43Y → A: Abolishes ADGRL3 binding; when associated with A-64. Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication1
Mutagenesisi45N → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication1
Mutagenesisi47R → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-45. 1 Publication1
Mutagenesisi64Y → A: Abolishes ADGRL3 binding; when associated with A-43. 1 Publication1
Mutagenesisi89Y → A: Abolishes ADGRL3 binding; when associated with A-91. 1 Publication1
Mutagenesisi91Y → A: Abolishes ADGRL3 binding; when associated with A-89. 1 Publication1
Mutagenesisi181R → A: No effect on homodimerization; when associated with A-183. 1 Publication1
Mutagenesisi181R → N: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication1
Mutagenesisi183D → A: No effect on homodimerization; when associated with A-181. 1 Publication1
Mutagenesisi183D → T: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNETi23767
MalaCardsiFLRT3
MIMi615271 phenotype
OpenTargetsiENSG00000125848
Orphaneti478 Kallmann syndrome
PharmGKBiPA28179

Polymorphism and mutation databases

BioMutaiFLRT3
DMDMi20138400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002128029 – 649Leucine-rich repeat transmembrane protein FLRT3Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 371 Publication
Disulfide bondi35 ↔ 441 Publication
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1 Publication1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 3341 Publication

Post-translational modificationi

N-glycosylated.By similarity
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NZU0
MaxQBiQ9NZU0
PaxDbiQ9NZU0
PeptideAtlasiQ9NZU0
PRIDEiQ9NZU0
ProteomicsDBi83509

PTM databases

GlyConnecti1454
iPTMnetiQ9NZU0
PhosphoSitePlusiQ9NZU0

Expressioni

Tissue specificityi

Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.1 Publication

Gene expression databases

BgeeiENSG00000125848 Expressed in 203 organ(s), highest expression level in metanephros
CleanExiHS_FLRT3
GenevisibleiQ9NZU0 HS

Organism-specific databases

HPAiCAB026166
HPA056033

Interactioni

Subunit structurei

Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADGRL3Q9HAR24EBI-1057092,EBI-2689295

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117267, 2 interactors
CORUMiQ9NZU0
DIPiDIP-50407N
IntActiQ9NZU0, 1 interactor
STRINGi9606.ENSP00000339912

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZU0
SMRiQ9NZU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 58LRRNTSequence analysisAdd BLAST30
Repeati59 – 80LRR 1Sequence analysisAdd BLAST22
Repeati84 – 104LRR 2Sequence analysisAdd BLAST21
Repeati105 – 126LRR 3Sequence analysisAdd BLAST22
Repeati129 – 150LRR 4Sequence analysisAdd BLAST22
Repeati155 – 175LRR 5Sequence analysisAdd BLAST21
Repeati176 – 197LRR 6Sequence analysisAdd BLAST22
Repeati200 – 220LRR 7Sequence analysisAdd BLAST21
Repeati226 – 247LRR 8Sequence analysisAdd BLAST22
Repeati248 – 269LRR 9Sequence analysisAdd BLAST22
Repeati272 – 293LRR 10Sequence analysisAdd BLAST22
Domaini305 – 357LRRCTSequence analysisAdd BLAST53
Domaini409 – 504Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 67Interaction with ADGRL31 PublicationAdd BLAST30

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEA Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148996
HOVERGENiHBG051629
InParanoidiQ9NZU0
KOiK16362
OMAiSPYRVCM
OrthoDBiEOG091G05YU
PhylomeDBiQ9NZU0
TreeFamiTF331598

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT
60 70 80 90 100
SIPTGIPEDA TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT
110 120 130 140 150
NLPKYVKELH LQENNIRTIT YDSLSKIPYL EELHLDDNSV SAVSIEEGAF
160 170 180 190 200
RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL RLDDNRISTI SSPSLQGLTS
210 220 230 240 250
LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA PVNLPGTNLR
260 270 280 290 300
KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL
310 320 330 340 350
ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA
360 370 380 390 400
ELFDCKDSGI VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH
410 420 430 440 450
QTTGSPSRKT ITITVKSVTS DTIHISWKLA LPMTALRLSW LKLGHSPAFG
460 470 480 490 500
SITETIVTGE RSEYLVTALE PDSPYKVCMV PMETSNLYLF DETPVCIETE
510 520 530 540 550
TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV TIALLALVCW
560 570 580 590 600
YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS
610 620 630 640
NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS
Length:649
Mass (Da):73,004
Last modified:October 1, 2000 - v1
Checksum:i9EFF666C46181F08
GO

Sequence cautioni

The sequence BAA95993 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55282 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55303 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → P in BAB55282 (PubMed:14702039).Curated1
Sequence conflicti307W → R in BAB55282 (PubMed:14702039).Curated1
Sequence conflicti519K → Q in BAB55023 (PubMed:14702039).Curated1
Sequence conflicti638D → G in BAB55282 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06995069Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398124653EnsemblClinVar.1
Natural variantiVAR_06995197E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124651EnsemblClinVar.1
Natural variantiVAR_069952144S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant dbSNP:rs398124652EnsemblClinVar.1
Natural variantiVAR_069953339K → R in HH21. 1 PublicationCorresponds to variant dbSNP:rs398124654EnsemblClinVar.1
Natural variantiVAR_050997377A → T. Corresponds to variant dbSNP:rs8120693EnsemblClinVar.1
Natural variantiVAR_017152400H → Q3 PublicationsCorresponds to variant dbSNP:rs6079391Ensembl.1
Natural variantiVAR_064714452I → V Found in a renal cell carcinoma case; somatic mutation. 1 Publication1
Natural variantiVAR_050998460E → D. Corresponds to variant dbSNP:rs35253731Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA Translation: AAF28461.1
AB040902 mRNA Translation: BAA95993.1 Different initiation.
AK027297 mRNA Translation: BAB55023.1
AK027670 mRNA Translation: BAB55282.1 Different initiation.
AK027694 mRNA Translation: BAB55303.1 Different initiation.
AY358319 mRNA Translation: AAQ88685.1
AK074909 mRNA Translation: BAC11284.1
AL132826 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10300.1
CH471133 Genomic DNA Translation: EAX10301.1
BC020870 mRNA Translation: AAH20870.1
CCDSiCCDS13121.1
RefSeqiNP_037413.1, NM_013281.3
NP_938205.1, NM_198391.2
XP_005260739.1, XM_005260682.4
XP_011527506.1, XM_011529204.2
XP_011527507.1, XM_011529205.2
UniGeneiHs.41296

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848
ENST00000378053; ENSP00000367292; ENSG00000125848
GeneIDi23767
KEGGihsa:23767
UCSCiuc002wov.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA Translation: AAF28461.1
AB040902 mRNA Translation: BAA95993.1 Different initiation.
AK027297 mRNA Translation: BAB55023.1
AK027670 mRNA Translation: BAB55282.1 Different initiation.
AK027694 mRNA Translation: BAB55303.1 Different initiation.
AY358319 mRNA Translation: AAQ88685.1
AK074909 mRNA Translation: BAC11284.1
AL132826 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10300.1
CH471133 Genomic DNA Translation: EAX10301.1
BC020870 mRNA Translation: AAH20870.1
CCDSiCCDS13121.1
RefSeqiNP_037413.1, NM_013281.3
NP_938205.1, NM_198391.2
XP_005260739.1, XM_005260682.4
XP_011527506.1, XM_011529204.2
XP_011527507.1, XM_011529205.2
UniGeneiHs.41296

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CMNX-ray3.61A/B/C/D29-357[»]
5CMPX-ray2.60A/B/C/D29-357[»]
ProteinModelPortaliQ9NZU0
SMRiQ9NZU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117267, 2 interactors
CORUMiQ9NZU0
DIPiDIP-50407N
IntActiQ9NZU0, 1 interactor
STRINGi9606.ENSP00000339912

PTM databases

GlyConnecti1454
iPTMnetiQ9NZU0
PhosphoSitePlusiQ9NZU0

Polymorphism and mutation databases

BioMutaiFLRT3
DMDMi20138400

Proteomic databases

EPDiQ9NZU0
MaxQBiQ9NZU0
PaxDbiQ9NZU0
PeptideAtlasiQ9NZU0
PRIDEiQ9NZU0
ProteomicsDBi83509

Protocols and materials databases

DNASUi23767
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848
ENST00000378053; ENSP00000367292; ENSG00000125848
GeneIDi23767
KEGGihsa:23767
UCSCiuc002wov.3 human

Organism-specific databases

CTDi23767
DisGeNETi23767
EuPathDBiHostDB:ENSG00000125848.9
GeneCardsiFLRT3
HGNCiHGNC:3762 FLRT3
HPAiCAB026166
HPA056033
MalaCardsiFLRT3
MIMi604808 gene
615271 phenotype
neXtProtiNX_Q9NZU0
OpenTargetsiENSG00000125848
Orphaneti478 Kallmann syndrome
PharmGKBiPA28179
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEA Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148996
HOVERGENiHBG051629
InParanoidiQ9NZU0
KOiK16362
OMAiSPYRVCM
OrthoDBiEOG091G05YU
PhylomeDBiQ9NZU0
TreeFamiTF331598

Enzyme and pathway databases

ReactomeiR-HSA-376176 Signaling by ROBO receptors
R-HSA-5654687 Downstream signaling of activated FGFR1

Miscellaneous databases

GeneWikiiFLRT3
GenomeRNAii23767
PROiPR:Q9NZU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125848 Expressed in 203 organ(s), highest expression level in metanephros
CleanExiHS_FLRT3
GenevisibleiQ9NZU0 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFLRT3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU0
Secondary accession number(s): D3DW20
, Q542Z9, Q96K39, Q96K42, Q96KB1, Q9P259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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