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Entry version 164 (16 Oct 2019)
Sequence version 3 (06 Mar 2007)
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Protein

Opioid growth factor receptor

Gene

OGFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • opioid receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processGrowth regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Opioid growth factor receptor
Short name:
OGFr
Alternative name(s):
Protein 7-60
Zeta-type opioid receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGFR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15768 OGFR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606459 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11054

Open Targets

More...
OpenTargetsi
ENSG00000060491

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31911

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NZT2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105797

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OGFR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146331047

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000580301 – 677Opioid growth factor receptorAdd BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei637PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NZT2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZT2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NZT2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZT2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZT2

PeptideAtlas

More...
PeptideAtlasi
Q9NZT2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZT2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83507 [Q9NZT2-1]
83508 [Q9NZT2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZT2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NZT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000060491 Expressed in 222 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NZT2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZT2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017899

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1044212,EBI-750109

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116239, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NZT2, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9NZT2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290291

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati517 – 5361Add BLAST20
Repeati537 – 5562Add BLAST20
Repeati557 – 5763Add BLAST20
Repeati577 – 5964Add BLAST20
Repeati597 – 6165Add BLAST20
Repeati617 – 6366Add BLAST20
Repeati637 – 6567Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni517 – 6567 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]-[GR]-D-E-P-A-[EK]Add BLAST140

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi267 – 283Bipartite nuclear localization signalSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH5X Eukaryota
ENOG4111XCW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018730

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZT2

Identification of Orthologs from Complete Genome Data

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OMAi
TGTRNWR

Database of Orthologous Groups

More...
OrthoDBi
1450738at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZT2

TreeFam database of animal gene trees

More...
TreeFami
TF331377

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006757 OGF_rcpt
IPR006770 OGF_rcpt_rpt
IPR039574 OGFr

The PANTHER Classification System

More...
PANTHERi
PTHR14015 PTHR14015, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04680 OGFr_III, 7 hits
PF04664 OGFr_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA
60 70 80 90 100
ARPSSFQSRM TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE
110 120 130 140 150
IRFLPNGCFI EDILQNWTDN YDLLEDNHSY IQWLFPLREP GVNWHAKPLT
160 170 180 190 200
LREVEVFKSS QEIQERLVRA YELMLGFYGI RLEDRGTGTV GRAQNYQKRF
210 220 230 240 250
QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET LVRRELPGVR
260 270 280 290 300
QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL
310 320 330 340 350
PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV
360 370 380 390 400
EPQDAGPLER SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG
410 420 430 440 450
PQSASEVEKI ALNLEGCALS QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR
460 470 480 490 500
VADKVRKRRK VDEGAGDSAA VASGGAQTLA LAGSPAPSGH PKAGHSENGV
510 520 530 540 550
EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE TPGPRPAGPA
560 570 580 590 600
GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE
610 620 630 640 650
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT
660 670
RDEPAKAGEA AELQDAEVES SAKSGKP
Length:677
Mass (Da):73,325
Last modified:March 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4DD6AF86291B663
GO
Isoform 2 (identifier: Q9NZT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-577: Missing.

Show »
Length:657
Mass (Da):71,424
Checksum:iB7A3F384ECCE5FB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRN5A0A0A0MRN5_HUMAN
Opioid growth factor receptor
OGFR hCG_21023
625Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X028A0A087X028_HUMAN
Opioid growth factor receptor
OGFR
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4VXW3Q4VXW3_HUMAN
Opioid growth factor receptor
OGFR
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD03737 differs from that shown. Reason: Frameshift.Curated
The sequence AAD03745 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27 – 28DG → EA (Ref. 2) Curated2
Sequence conflicti37 – 80DAGDE…RHNYP → GARRALGVLGQPGGLQMRLP ERHGGPQGSLCLMDPCCPLS LALQ (PubMed:11214971).CuratedAdd BLAST44
Sequence conflicti50 – 52AAR → GPE (Ref. 2) Curated3
Sequence conflicti172E → A (Ref. 2) Curated1
Sequence conflicti220 – 221LG → PC in AAF64404 (PubMed:10677613).Curated2
Sequence conflicti220 – 221LG → PC in AAF64405 (PubMed:10677613).Curated2
Sequence conflicti224G → S in AAF64404 (PubMed:10677613).Curated1
Sequence conflicti224G → S in AAF64405 (PubMed:10677613).Curated1
Sequence conflicti224G → S in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti240T → S in AAD03745 (Ref. 2) Curated1
Sequence conflicti240T → S in AAD03737 (Ref. 2) Curated1
Sequence conflicti262R → G in AAD03745 (Ref. 2) Curated1
Sequence conflicti262R → G in AAD03737 (Ref. 2) Curated1
Sequence conflicti331G → E in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti398E → G in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti465A → T in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti535A → AKTPSETPGPSPAGPTRDEP A in AAF64405 (PubMed:10677613).Curated1
Sequence conflicti564P → L in AAF64404 (PubMed:10677613).Curated1
Sequence conflicti576E → K in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti576E → K (Ref. 2) Curated1
Sequence conflicti576E → K in BAB15775 (PubMed:11214971).Curated1
Sequence conflicti577S → I in AAF64406 (PubMed:10677613).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059706545R → S. Corresponds to variant dbSNP:rs6122313Ensembl.1
Natural variantiVAR_030011577S → T3 PublicationsCorresponds to variant dbSNP:rs6122315Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004060558 – 577Missing in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF172451 mRNA Translation: AAF64404.1
AF172452 mRNA Translation: AAF64405.1
AF172453 mRNA Translation: AAF64406.1
AF112980 Genomic DNA Translation: AAD03745.1 Frameshift.
AF109134 mRNA Translation: AAD03737.1 Frameshift.
AL035669 Genomic DNA No translation available.
BC014137 mRNA Translation: AAH14137.1
AK024485 mRNA Translation: BAB15775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13504.1 [Q9NZT2-1]

NCBI Reference Sequences

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RefSeqi
NP_031372.2, NM_007346.3 [Q9NZT2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290291; ENSP00000290291; ENSG00000060491 [Q9NZT2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11054

UCSC genome browser

More...
UCSCi
uc002ydj.4 human [Q9NZT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

OGFr entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172451 mRNA Translation: AAF64404.1
AF172452 mRNA Translation: AAF64405.1
AF172453 mRNA Translation: AAF64406.1
AF112980 Genomic DNA Translation: AAD03745.1 Frameshift.
AF109134 mRNA Translation: AAD03737.1 Frameshift.
AL035669 Genomic DNA No translation available.
BC014137 mRNA Translation: AAH14137.1
AK024485 mRNA Translation: BAB15775.1
CCDSiCCDS13504.1 [Q9NZT2-1]
RefSeqiNP_031372.2, NM_007346.3 [Q9NZT2-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116239, 21 interactors
IntActiQ9NZT2, 6 interactors
MINTiQ9NZT2
STRINGi9606.ENSP00000290291

Chemistry databases

ChEMBLiCHEMBL4105797

PTM databases

iPTMnetiQ9NZT2
PhosphoSitePlusiQ9NZT2
SwissPalmiQ9NZT2

Polymorphism and mutation databases

BioMutaiOGFR
DMDMi146331047

Proteomic databases

EPDiQ9NZT2
jPOSTiQ9NZT2
MassIVEiQ9NZT2
MaxQBiQ9NZT2
PaxDbiQ9NZT2
PeptideAtlasiQ9NZT2
PRIDEiQ9NZT2
ProteomicsDBi83507 [Q9NZT2-1]
83508 [Q9NZT2-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
11054

Genome annotation databases

EnsembliENST00000290291; ENSP00000290291; ENSG00000060491 [Q9NZT2-1]
GeneIDi11054
KEGGihsa:11054
UCSCiuc002ydj.4 human [Q9NZT2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11054
DisGeNETi11054

GeneCards: human genes, protein and diseases

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GeneCardsi
OGFR
HGNCiHGNC:15768 OGFR
HPAiHPA017899
MIMi606459 gene
neXtProtiNX_Q9NZT2
OpenTargetsiENSG00000060491
PharmGKBiPA31911

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IH5X Eukaryota
ENOG4111XCW LUCA
GeneTreeiENSGT00390000018730
InParanoidiQ9NZT2
OMAiTGTRNWR
OrthoDBi1450738at2759
PhylomeDBiQ9NZT2
TreeFamiTF331377

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OGFR human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OGFr

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11054
PharosiQ9NZT2

Protein Ontology

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PROi
PR:Q9NZT2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000060491 Expressed in 222 organ(s), highest expression level in blood
ExpressionAtlasiQ9NZT2 baseline and differential
GenevisibleiQ9NZT2 HS

Family and domain databases

InterProiView protein in InterPro
IPR006757 OGF_rcpt
IPR006770 OGF_rcpt_rpt
IPR039574 OGFr
PANTHERiPTHR14015 PTHR14015, 1 hit
PfamiView protein in Pfam
PF04680 OGFr_III, 7 hits
PF04664 OGFr_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGFR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZT2
Secondary accession number(s): O96029
, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 6, 2007
Last modified: October 16, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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