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Protein

Calmodulin-like protein 5

Gene

CALML5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1023PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi127 – 1384PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 5
Alternative name(s):
Calmodulin-like skin protein
Gene namesi
Name:CALML5
Synonyms:CLSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000178372.7
HGNCiHGNC:18180 CALML5
MIMi605183 gene
neXtProtiNX_Q9NZT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi51806
OpenTargetsiENSG00000178372
PharmGKBiPA134862009

Polymorphism and mutation databases

BioMutaiCALML5
DMDMi215273944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000738542 – 146Calmodulin-like protein 5Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NZT1
MaxQBiQ9NZT1
PaxDbiQ9NZT1
PeptideAtlasiQ9NZT1
PRIDEiQ9NZT1
ProteomicsDBi83506
TopDownProteomicsiQ9NZT1

PTM databases

iPTMnetiQ9NZT1
PhosphoSitePlusiQ9NZT1

Expressioni

Tissue specificityi

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Gene expression databases

BgeeiENSG00000178372 Expressed in 94 organ(s), highest expression level in skin of leg
CleanExiHS_CALML5
GenevisibleiQ9NZT1 HS

Organism-specific databases

HPAiHPA040725

Interactioni

Subunit structurei

Associates with transglutaminase 3.

Protein-protein interaction databases

BioGridi119732, 46 interactors
IntActiQ9NZT1, 10 interactors
STRINGi9606.ENSP00000369689

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZT1
SMRiQ9NZT1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZT1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 77EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 146EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9NZT1
KOiK02183
OMAiYKSAFSA
OrthoDBiEOG091G0RVC
PhylomeDBiQ9NZT1
TreeFamiTF300912

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR
60 70 80 90 100
KLISEVDSDG DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV
110 120 130 140
DELRRAMAGL GQPLPQEELD AMIREADVDQ DGRVNYEEFA RMLAQE
Length:146
Mass (Da):15,893
Last modified:November 25, 2008 - v2
Checksum:i70746291268494CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04754558S → G Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs11546426Ensembl.1
Natural variantiVAR_04754674K → R Polymorphism; confirmed at protein level. 3 PublicationsCorresponds to variant dbSNP:rs10904516Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA Translation: AAF66821.1
AL732437 Genomic DNA No translation available.
BC039172 mRNA Translation: AAH39172.1
CCDSiCCDS7068.1
RefSeqiNP_059118.2, NM_017422.4
UniGeneiHs.180142

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372
GeneIDi51806
KEGGihsa:51806
UCSCiuc001iic.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA Translation: AAF66821.1
AL732437 Genomic DNA No translation available.
BC039172 mRNA Translation: AAH39172.1
CCDSiCCDS7068.1
RefSeqiNP_059118.2, NM_017422.4
UniGeneiHs.180142

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortaliQ9NZT1
SMRiQ9NZT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119732, 46 interactors
IntActiQ9NZT1, 10 interactors
STRINGi9606.ENSP00000369689

PTM databases

iPTMnetiQ9NZT1
PhosphoSitePlusiQ9NZT1

Polymorphism and mutation databases

BioMutaiCALML5
DMDMi215273944

Proteomic databases

EPDiQ9NZT1
MaxQBiQ9NZT1
PaxDbiQ9NZT1
PeptideAtlasiQ9NZT1
PRIDEiQ9NZT1
ProteomicsDBi83506
TopDownProteomicsiQ9NZT1

Protocols and materials databases

DNASUi51806
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372
GeneIDi51806
KEGGihsa:51806
UCSCiuc001iic.3 human

Organism-specific databases

CTDi51806
DisGeNETi51806
EuPathDBiHostDB:ENSG00000178372.7
GeneCardsiCALML5
H-InvDBiHIX0025916
HGNCiHGNC:18180 CALML5
HPAiHPA040725
MIMi605183 gene
neXtProtiNX_Q9NZT1
OpenTargetsiENSG00000178372
PharmGKBiPA134862009
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ9NZT1
KOiK02183
OMAiYKSAFSA
OrthoDBiEOG091G0RVC
PhylomeDBiQ9NZT1
TreeFamiTF300912

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiQ9NZT1
GeneWikiiCALML5
GenomeRNAii51806
PROiPR:Q9NZT1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178372 Expressed in 94 organ(s), highest expression level in skin of leg
CleanExiHS_CALML5
GenevisibleiQ9NZT1 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALL5_HUMAN
AccessioniPrimary (citable) accession number: Q9NZT1
Secondary accession number(s): Q5SQI3, Q8IXU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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