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Entry version 144 (02 Dec 2020)
Sequence version 3 (13 Feb 2019)
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Protein

Killer cell lectin-like receptor subfamily F member 1

Gene

KLRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NZS2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily F member 1
Short name:
Lectin-like receptor F1
Alternative name(s):
Activating coreceptor NKp80
C-type lectin domain family 5 member C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLRF1
Synonyms:CLEC5C, ML
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000150045.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13342, KLRF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605029, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 231ExtracellularSequence analysisAdd BLAST172

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51348

Open Targets

More...
OpenTargetsi
ENSG00000150045

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30169

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NZS2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLRF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373373

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000465911 – 231Killer cell lectin-like receptor subfamily F member 1Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi142 ↔ 229PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 221PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZS2

PeptideAtlas

More...
PeptideAtlasi
Q9NZS2

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZS2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83501 [Q9NZS2-1]
83502 [Q9NZS2-2]
83503 [Q9NZS2-3]
83504 [Q9NZS2-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NZS2, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NZS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150045, Expressed in granulocyte and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZS2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZS2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150045, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119491, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-58613N

Protein interaction database and analysis system

More...
IntActi
Q9NZS2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NZS2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZS2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini121 – 230C-type lectinPROSITE-ProRule annotationAdd BLAST110

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163227

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_197693_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZS2

Identification of Orthologs from Complete Genome Data

More...
OMAi
SDSYRYC

Database of Orthologous Groups

More...
OrthoDBi
1341815at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZS2

TreeFam database of animal gene trees

More...
TreeFami
TF337735

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03593, CLECT_NK_receptors_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI
60 70 80 90 100
LTLTLISLIL LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK
110 120 130 140 150
DLCASRSADQ TVLCQSEWLK YQGKCYWFSN EMKSWSDSYV YCLERKSHLL
160 170 180 190 200
IIHDQLEMAF IQKNLRQLNY VWIGLNFTSL KMTWTWVDGS PIDSKIFFIK
210 220 230
GPAKENSCAA IKESKIFSET CSSVFKWICQ Y
Length:231
Mass (Da):26,563
Last modified:February 13, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2F7BE6D4341AFDE
GO
Isoform 2 (identifier: Q9NZS2-2) [UniParc]FASTAAdd to basket
Also known as: KLRF1-s1

The sequence of this isoform differs from the canonical sequence as follows:
     63-112: Missing.

Show »
Length:181
Mass (Da):21,205
Checksum:i64642240CAE1E551
GO
Isoform 3 (identifier: Q9NZS2-3) [UniParc]FASTAAdd to basket
Also known as: KLRF1-s3

The sequence of this isoform differs from the canonical sequence as follows:
     62-64: VSQ → DSS
     65-231: Missing.

Show »
Length:64
Mass (Da):7,251
Checksum:iC451F5F560FD75D7
GO
Isoform 4 (identifier: Q9NZS2-4) [UniParc]FASTAAdd to basket
Also known as: KLRF1-s2

The sequence of this isoform differs from the canonical sequence as follows:
     62-78: VSQGVLLKCQKGSCSNA → GFYTEKPKTIKLRMDWA
     79-231: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:78
Mass (Da):9,029
Checksum:i3DE810CF5656D634
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4KN05Q4KN05_HUMAN
KLRF1 protein
KLRF1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4KN30Q4KN30_HUMAN
KLRF1 protein
KLRF1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4KMZ4Q4KMZ4_HUMAN
KLRF1 protein
KLRF1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04754467L → F. Corresponds to variant dbSNP:rs2232548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01039362 – 78VSQGV…SCSNA → GFYTEKPKTIKLRMDWA in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_01039062 – 64VSQ → DSS in isoform 3. 1 Publication3
Alternative sequenceiVSP_01039163 – 112Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_01039265 – 231Missing in isoform 3. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_01039479 – 231Missing in isoform 4. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF175206 mRNA Translation: AAF37804.1
AF175207 mRNA Translation: AAF37805.1
AF267244 mRNA Translation: AAL14873.1
AF267245 mRNA Translation: AAL14874.1
AJ305370 mRNA Translation: CAC29425.1
AC007068 Genomic DNA No translation available.
KF573680 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96124.1
BC098354 mRNA Translation: AAH98354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41750.1 [Q9NZS2-1]
CCDS76526.1 [Q9NZS2-2]
CCDS76527.1 [Q9NZS2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001278751.1, NM_001291822.1 [Q9NZS2-2]
NP_001278752.1, NM_001291823.1 [Q9NZS2-3]
NP_057607.1, NM_016523.2 [Q9NZS2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000279545; ENSP00000279545; ENSG00000150045 [Q9NZS2-2]
ENST00000354855; ENSP00000346919; ENSG00000150045 [Q9NZS2-3]
ENST00000612321; ENSP00000483880; ENSG00000150045 [Q9NZS2-4]
ENST00000617889; ENSP00000483713; ENSG00000150045 [Q9NZS2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51348

UCSC genome browser

More...
UCSCi
uc009zgy.4, human [Q9NZS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

KLRF1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175206 mRNA Translation: AAF37804.1
AF175207 mRNA Translation: AAF37805.1
AF267244 mRNA Translation: AAL14873.1
AF267245 mRNA Translation: AAL14874.1
AJ305370 mRNA Translation: CAC29425.1
AC007068 Genomic DNA No translation available.
KF573680 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96124.1
BC098354 mRNA Translation: AAH98354.1
CCDSiCCDS41750.1 [Q9NZS2-1]
CCDS76526.1 [Q9NZS2-2]
CCDS76527.1 [Q9NZS2-3]
RefSeqiNP_001278751.1, NM_001291822.1 [Q9NZS2-2]
NP_001278752.1, NM_001291823.1 [Q9NZS2-3]
NP_057607.1, NM_016523.2 [Q9NZS2-1]

3D structure databases

SMRiQ9NZS2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119491, 8 interactors
DIPiDIP-58613N
IntActiQ9NZS2, 1 interactor
STRINGi9606.ENSP00000483713

PTM databases

GlyGeniQ9NZS2, 4 sites
iPTMnetiQ9NZS2
PhosphoSitePlusiQ9NZS2

Polymorphism and mutation databases

BioMutaiKLRF1
DMDMi317373373

Proteomic databases

PaxDbiQ9NZS2
PeptideAtlasiQ9NZS2
PRIDEiQ9NZS2
ProteomicsDBi83501 [Q9NZS2-1]
83502 [Q9NZS2-2]
83503 [Q9NZS2-3]
83504 [Q9NZS2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23183, 221 antibodies

The DNASU plasmid repository

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DNASUi
51348

Genome annotation databases

EnsembliENST00000279545; ENSP00000279545; ENSG00000150045 [Q9NZS2-2]
ENST00000354855; ENSP00000346919; ENSG00000150045 [Q9NZS2-3]
ENST00000612321; ENSP00000483880; ENSG00000150045 [Q9NZS2-4]
ENST00000617889; ENSP00000483713; ENSG00000150045 [Q9NZS2-1]
GeneIDi51348
KEGGihsa:51348
UCSCiuc009zgy.4, human [Q9NZS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51348
DisGeNETi51348
EuPathDBiHostDB:ENSG00000150045.11

GeneCards: human genes, protein and diseases

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GeneCardsi
KLRF1
HGNCiHGNC:13342, KLRF1
HPAiENSG00000150045, Group enriched (blood, lymphoid tissue)
MIMi605029, gene
neXtProtiNX_Q9NZS2
OpenTargetsiENSG00000150045
PharmGKBiPA30169

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000163227
HOGENOMiCLU_197693_0_0_1
InParanoidiQ9NZS2
OMAiSDSYRYC
OrthoDBi1341815at2759
PhylomeDBiQ9NZS2
TreeFamiTF337735

Enzyme and pathway databases

PathwayCommonsiQ9NZS2
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51348, 3 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KLRF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51348
PharosiQ9NZS2, Tbio

Protein Ontology

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PROi
PR:Q9NZS2
RNActiQ9NZS2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150045, Expressed in granulocyte and 131 other tissues
ExpressionAtlasiQ9NZS2, baseline and differential
GenevisibleiQ9NZS2, HS

Family and domain databases

CDDicd03593, CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLRF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZS2
Secondary accession number(s): A0A0C4DGY9
, Q4KMT5, Q96PR2, Q96PR3, Q9NZS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: February 13, 2019
Last modified: December 2, 2020
This is version 144 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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