Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9NZR2 (LRP1B_HUMAN)

Entry version 173 (02 Jun 2021)
Sequence version 2 (04 Jan 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Low-density lipoprotein receptor-related protein 1B

Gene

LRP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Miscellaneous

The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZR2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NZR2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 1B
Short name:
LRP-1B
Alternative name(s):
Low-density lipoprotein receptor-related protein-deleted in tumor
Short name:
LRP-DIT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRP1B
Synonyms:LRPDIT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6693, LRP1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608766, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZR2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168702.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 4444ExtracellularSequence analysisAdd BLAST4420
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4445 – 4467HelicalSequence analysisAdd BLAST23
Topological domaini4468 – 4599CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		53353

Open Targets

More...OpenTargetsi		ENSG00000168702

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30451

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZR2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRP1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		57015418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001731921 – 4599Low-density lipoprotein receptor-related protein 1BAdd BLAST4579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 45By similarity
Disulfide bondi39 ↔ 58By similarity
Disulfide bondi52 ↔ 69By similarity
Disulfide bondi77 ↔ 90By similarity
Disulfide bondi84 ↔ 103By similarity
Disulfide bondi97 ↔ 113By similarity
Disulfide bondi120 ↔ 129By similarity
Disulfide bondi125 ↔ 138By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 153By similarity
Disulfide bondi159 ↔ 169By similarity
Disulfide bondi165 ↔ 178By similarity
Disulfide bondi180 ↔ 193By similarity
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi725N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi758N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi798 ↔ 809By similarity
Disulfide bondi805 ↔ 818By similarity
Disulfide bondi820 ↔ 833By similarity
Glycosylationi829N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi845 ↔ 857By similarity
Disulfide bondi852 ↔ 870By similarity
Disulfide bondi864 ↔ 881By similarity
Glycosylationi883N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi886 ↔ 898By similarity
Disulfide bondi893 ↔ 911By similarity
Disulfide bondi905 ↔ 922By similarity
Glycosylationi919N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi927 ↔ 939By similarity
Disulfide bondi934 ↔ 952By similarity
Disulfide bondi946 ↔ 962By similarity
Disulfide bondi967 ↔ 980By similarity
Disulfide bondi975 ↔ 993By similarity
Disulfide bondi987 ↔ 1002By similarity
Disulfide bondi1006 ↔ 1018By similarity
Disulfide bondi1013 ↔ 1031By similarity
Disulfide bondi1025 ↔ 1042By similarity
Glycosylationi1041N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1053 ↔ 1066By similarity
Disulfide bondi1060 ↔ 1079By similarity
Disulfide bondi1073 ↔ 1088By similarity
Glycosylationi1089N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1095 ↔ 1109By similarity
Disulfide bondi1103 ↔ 1122By similarity
Disulfide bondi1116 ↔ 1131By similarity
Disulfide bondi1136 ↔ 1150By similarity
Disulfide bondi1143 ↔ 1163By similarity
Glycosylationi1145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1157 ↔ 1173By similarity
Glycosylationi1209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1816N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1838 ↔ 1849By similarity
Disulfide bondi1845 ↔ 1859By similarity
Disulfide bondi1861 ↔ 1874By similarity
Glycosylationi1921N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1983N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2147 ↔ 2158By similarity
Disulfide bondi2154 ↔ 2168By similarity
Disulfide bondi2170 ↔ 2182By similarity
Glycosylationi2458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2507N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2510 ↔ 2523By similarity
Disulfide bondi2518 ↔ 2536By similarity
Disulfide bondi2530 ↔ 2547By similarity
Glycosylationi2549N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2552 ↔ 2564By similarity
Disulfide bondi2559 ↔ 2577By similarity
Disulfide bondi2571 ↔ 2586By similarity
Disulfide bondi2591 ↔ 2603By similarity
Disulfide bondi2598 ↔ 2616By similarity
Disulfide bondi2610 ↔ 2625By similarity
Glycosylationi2626N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2630 ↔ 2652By similarity
Disulfide bondi2646 ↔ 2665By similarity
Glycosylationi2647N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2659 ↔ 2674By similarity
Disulfide bondi2682 ↔ 2694By similarity
Disulfide bondi2689 ↔ 2707By similarity
Disulfide bondi2701 ↔ 2716By similarity
Disulfide bondi2720 ↔ 2732By similarity
Disulfide bondi2727 ↔ 2745By similarity
Disulfide bondi2739 ↔ 2756By similarity
Disulfide bondi2761 ↔ 2774By similarity
Disulfide bondi2768 ↔ 2787By similarity
Disulfide bondi2781 ↔ 2799By similarity
Glycosylationi2802N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2805 ↔ 2817By similarity
Disulfide bondi2812 ↔ 2830By similarity
Disulfide bondi2824 ↔ 2840By similarity
Disulfide bondi2845 ↔ 2857By similarity
Disulfide bondi2852 ↔ 2871By similarity
Disulfide bondi2865 ↔ 2884By similarity
Disulfide bondi2891 ↔ 2903By similarity
Glycosylationi2892N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2898 ↔ 2916By similarity
Disulfide bondi2910 ↔ 2925By similarity
Disulfide bondi2930 ↔ 2942By similarity
Disulfide bondi2938 ↔ 2951By similarity
Disulfide bondi2953 ↔ 2966By similarity
Disulfide bondi2972 ↔ 2982By similarity
Disulfide bondi2978 ↔ 2991By similarity
Disulfide bondi2993 ↔ 3007By similarity
Glycosylationi3034N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3066N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3076N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3317 ↔ 3329By similarity
Disulfide bondi3324 ↔ 3342By similarity
Disulfide bondi3336 ↔ 3352By similarity
Disulfide bondi3357 ↔ 3369By similarity
Disulfide bondi3364 ↔ 3382By similarity
Disulfide bondi3376 ↔ 3391By similarity
Disulfide bondi3396 ↔ 3409By similarity
Disulfide bondi3403 ↔ 3422By similarity
Disulfide bondi3416 ↔ 3431By similarity
Disulfide bondi3436 ↔ 3449By similarity
Disulfide bondi3443 ↔ 3462By similarity
Disulfide bondi3456 ↔ 3471By similarity
Disulfide bondi3476 ↔ 3488By similarity
Disulfide bondi3483 ↔ 3501By similarity
Disulfide bondi3495 ↔ 3510By similarity
Disulfide bondi3515 ↔ 3527By similarity
Disulfide bondi3522 ↔ 3540By similarity
Disulfide bondi3534 ↔ 3549By similarity
Disulfide bondi3553 ↔ 3565By similarity
Disulfide bondi3560 ↔ 3578By similarity
Disulfide bondi3572 ↔ 3587By similarity
Disulfide bondi3594 ↔ 3606By similarity
Disulfide bondi3601 ↔ 3619By similarity
Disulfide bondi3613 ↔ 3628By similarity
Disulfide bondi3632 ↔ 3645By similarity
Disulfide bondi3639 ↔ 3658By similarity
Disulfide bondi3652 ↔ 3667By similarity
Disulfide bondi3674 ↔ 3686By similarity
Disulfide bondi3681 ↔ 3699By similarity
Glycosylationi3682N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3693 ↔ 3710By similarity
Disulfide bondi3715 ↔ 3729By similarity
Disulfide bondi3723 ↔ 3742By similarity
Disulfide bondi3736 ↔ 3751By similarity
Disulfide bondi3762 ↔ 3774By similarity
Disulfide bondi3769 ↔ 3787By similarity
Disulfide bondi3781 ↔ 3796By similarity
Disulfide bondi3805 ↔ 3818By similarity
Disulfide bondi3812 ↔ 3827By similarity
Disulfide bondi3829 ↔ 3842By similarity
Disulfide bondi3848 ↔ 3858By similarity
Disulfide bondi3854 ↔ 3867By similarity
Disulfide bondi3869 ↔ 3880By similarity
Glycosylationi3877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3894N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3906N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4217 ↔ 4227By similarity
Disulfide bondi4221 ↔ 4237By similarity
Disulfide bondi4253 ↔ 4263By similarity
Disulfide bondi4257 ↔ 4273By similarity
Disulfide bondi4275 ↔ 4284By similarity
Disulfide bondi4289 ↔ 4299By similarity
Disulfide bondi4293 ↔ 4309By similarity
Disulfide bondi4311 ↔ 4320By similarity
Disulfide bondi4325 ↔ 4335By similarity
Disulfide bondi4329 ↔ 4345By similarity
Disulfide bondi4347 ↔ 4356By similarity
Glycosylationi4381N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4394 ↔ 4404By similarity
Disulfide bondi4398 ↔ 4415By similarity
Disulfide bondi4417 ↔ 4426By similarity
Glycosylationi4420N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZR2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZR2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZR2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZR2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZR2

PeptideAtlas

More...PeptideAtlasi		Q9NZR2

PRoteomics IDEntifications database

More...PRIDEi		Q9NZR2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83492

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1466, 4 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZR2, 46 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168702, Expressed in corpus callosum and 150 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZR2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZR2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168702, Tissue enhanced (brain, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119750, 43 interactors

Protein interaction database and analysis system

More...IntActi		Q9NZR2, 28 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000374135

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZR2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 70LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST40
Domaini76 – 114LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST39
Domaini116 – 154EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini155 – 194EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati295 – 337LDL-receptor class B 1Add BLAST43
Repeati338 – 381LDL-receptor class B 2Add BLAST44
Repeati382 – 425LDL-receptor class B 3Add BLAST44
Domaini471 – 517EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Repeati568 – 610LDL-receptor class B 4Add BLAST43
Repeati611 – 656LDL-receptor class B 5Add BLAST46
Repeati657 – 706LDL-receptor class B 6Add BLAST50
Repeati707 – 750LDL-receptor class B 7Add BLAST44
Domaini794 – 834EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini844 – 882LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini885 – 923LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST39
Domaini926 – 963LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST38
Domaini966 – 1003LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST38
Domaini1005 – 1043LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1052 – 1089LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST38
Domaini1094 – 1132LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST39
Domaini1135 – 1174LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST40
Domaini1174 – 1213EGF-like 5PROSITE-ProRule annotationAdd BLAST40
Domaini1214 – 1253EGF-like 6PROSITE-ProRule annotationAdd BLAST40
Repeati1300 – 1346LDL-receptor class B 8Add BLAST47
Repeati1347 – 1389LDL-receptor class B 9Add BLAST43
Repeati1390 – 1436LDL-receptor class B 10Add BLAST47
Repeati1437 – 1480LDL-receptor class B 11Add BLAST44
Repeati1481 – 1522LDL-receptor class B 12Add BLAST42
Domaini1527 – 1570EGF-like 7PROSITE-ProRule annotationAdd BLAST44
Repeati1618 – 1660LDL-receptor class B 13Add BLAST43
Repeati1661 – 1704LDL-receptor class B 14Add BLAST44
Repeati1705 – 1744LDL-receptor class B 15Add BLAST40
Repeati1745 – 1787LDL-receptor class B 16Add BLAST43
Domaini1834 – 1875EGF-like 8PROSITE-ProRule annotationAdd BLAST42
Repeati1922 – 1964LDL-receptor class B 17Add BLAST43
Repeati1965 – 2007LDL-receptor class B 28Add BLAST43
Repeati2008 – 2051LDL-receptor class B 19Add BLAST44
Repeati2052 – 2095LDL-receptor class B 20Add BLAST44
Domaini2143 – 2183EGF-like 9PROSITE-ProRule annotationAdd BLAST41
Repeati2239 – 2280LDL-receptor class B 21Add BLAST42
Repeati2281 – 2329LDL-receptor class B 22Add BLAST49
Repeati2330 – 2374LDL-receptor class B 23Add BLAST45
Repeati2375 – 2416LDL-receptor class B 24Add BLAST42
Repeati2417 – 2459LDL-receptor class B 25Add BLAST43
Domaini2464 – 2504EGF-like 10PROSITE-ProRule annotationAdd BLAST41
Domaini2509 – 2548LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST40
Domaini2551 – 2587LDL-receptor class A 12PROSITE-ProRule annotationAdd BLAST37
Domaini2590 – 2626LDL-receptor class A 13PROSITE-ProRule annotationAdd BLAST37
Domaini2629 – 2675LDL-receptor class A 14PROSITE-ProRule annotationAdd BLAST47
Domaini2681 – 2717LDL-receptor class A 15PROSITE-ProRule annotationAdd BLAST37
Domaini2719 – 2757LDL-receptor class A 16PROSITE-ProRule annotationAdd BLAST39
Domaini2760 – 2800LDL-receptor class A 17PROSITE-ProRule annotationAdd BLAST41
Domaini2804 – 2841LDL-receptor class A 18PROSITE-ProRule annotationAdd BLAST38
Domaini2844 – 2885LDL-receptor class A 19PROSITE-ProRule annotationAdd BLAST42
Domaini2890 – 2926LDL-receptor class A 20PROSITE-ProRule annotationAdd BLAST37
Domaini2927 – 2967EGF-like 11PROSITE-ProRule annotationAdd BLAST41
Domaini2968 – 3008EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Repeati3055 – 3098LDL-receptor class B 26Add BLAST44
Repeati3099 – 3141LDL-receptor class B 27Add BLAST43
Repeati3142 – 3185LDL-receptor class B 28Add BLAST44
Repeati3186 – 3224LDL-receptor class B 29Add BLAST39
Repeati3225 – 3268LDL-receptor class B 30Add BLAST44
Domaini3273 – 3314EGF-like 13PROSITE-ProRule annotationAdd BLAST42
Domaini3316 – 3353LDL-receptor class A 21PROSITE-ProRule annotationAdd BLAST38
Domaini3356 – 3392LDL-receptor class A 22PROSITE-ProRule annotationAdd BLAST37
Domaini3395 – 3432LDL-receptor class A 23PROSITE-ProRule annotationAdd BLAST38
Domaini3435 – 3472LDL-receptor class A 24PROSITE-ProRule annotationAdd BLAST38
Domaini3475 – 3511LDL-receptor class A 25PROSITE-ProRule annotationAdd BLAST37
Domaini3514 – 3550LDL-receptor class A 26PROSITE-ProRule annotationAdd BLAST37
Domaini3552 – 3588LDL-receptor class A 27PROSITE-ProRule annotationAdd BLAST37
Domaini3593 – 3629LDL-receptor class A 28PROSITE-ProRule annotationAdd BLAST37
Domaini3631 – 3668LDL-receptor class A 29PROSITE-ProRule annotationAdd BLAST38
Domaini3673 – 3711LDL-receptor class A 30PROSITE-ProRule annotationAdd BLAST39
Domaini3714 – 3752LDL-receptor class A 31PROSITE-ProRule annotationAdd BLAST39
Domaini3761 – 3797LDL-receptor class A 32PROSITE-ProRule annotationAdd BLAST37
Domaini3801 – 3843EGF-like 14PROSITE-ProRule annotationAdd BLAST43
Domaini3844 – 3881EGF-like 15PROSITE-ProRule annotationAdd BLAST38
Repeati3933 – 3980LDL-receptor class B 31Add BLAST48
Repeati3981 – 4038LDL-receptor class B 32Add BLAST58
Repeati4039 – 4082LDL-receptor class B 33Add BLAST44
Repeati4083 – 4127LDL-receptor class B 34Add BLAST45
Domaini4171 – 4208EGF-like 16PROSITE-ProRule annotationAdd BLAST38
Domaini4213 – 4249EGF-like 17PROSITE-ProRule annotationAdd BLAST37
Domaini4249 – 4285EGF-like 18PROSITE-ProRule annotationAdd BLAST37
Domaini4285 – 4321EGF-like 19PROSITE-ProRule annotationAdd BLAST37
Domaini4321 – 4357EGF-like 20PROSITE-ProRule annotationAdd BLAST37
Domaini4357 – 4392EGF-like 21PROSITE-ProRule annotationAdd BLAST36
Domaini4390 – 4427EGF-like 22PROSITE-ProRule annotationAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi4492 – 4495Endocytosis signalSequence analysis4
Motifi4559 – 4562Endocytosis signalSequence analysis4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1215, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000085_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZR2

Identification of Orthologs from Complete Genome Data

More...OMAi		QCIPAKW

Database of Orthologous Groups

More...OrthoDBi		1606at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZR2

TreeFam database of animal gene trees

More...TreeFami		TF315253

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112, LDLa, 28 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 8 hits
4.10.400.10, 31 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF00008, EGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 30 hits
PF00058, Ldl_recept_b, 11 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 25 hits
SM00179, EGF_CA, 6 hits
SM00192, LDLa, 32 hits
SM00135, LY, 37 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 32 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 9 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 27 hits
PS50068, LDLRA_2, 32 hits
PS51120, LDLRB, 37 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NZR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW 
        60         70         80         90        100
LCDGDPDCPD DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV 
       110        120        130        140        150
LDCPDGYDEG VHCQELLSNC QQLNCQYKCT MVRNSTRCYC EDGFEITEDG 
       160        170        180        190        200
RSCKDQDECA VYGTCSQTCR NTHGSYTCSC VEGYLMQPDN RSCKAKIEPT 
       210        220        230        240        250
DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF IYNEDMICWI 
       260        270        280        290        300
ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV 
       310        320        330        340        350
DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK 
       360        370        380        390        400
VERCDMDGMN RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ 
       410        420        430        440        450
GKNRHTVIQG RQVRHLYGIT VFEDYLYATN SDNYNIVRIN RFNGTDIHSL 
       460        470        480        490        500
IKIENAWGIR IYQKRTQPTV RSHACEVDPY GMPGGCSHIC LLSSSYKTRT 
       510        520        530        540        550
CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL NTKIADEYMI 
       560        570        580        590        600
PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 
       610        620        630        640        650
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI 
       660        670        680        690        700
VVDPVNGWMY WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL 
       710        720        730        740        750
TLDFHTNTLY WCDAYYDHIE KVFLNGTHRK IVYSGRELNH PFGLSHHGNY 
       760        770        780        790        800
VFWTDYMNGS IFQLDLITSE VTLLRHERPP LFGLQIYDPR KQQGDNMCRV 
       810        820        830        840        850
NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA LPHICKAGEF 
       860        870        880        890        900
RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP 
       910        920        930        940        950
KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED 
       960        970        980        990       1000
DCGDQTDEMA SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV 
      1010       1020       1030       1040       1050
GCVHSCFDNQ FRCSSGRCIP GHWACDGDND CGDFSDEAQI NCTKEEIHSP 
      1060       1070       1080       1090       1100
AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE DGSDEKGCNG TIRLCDHKTK 
      1110       1120       1130       1140       1150
FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK HPCANDTSVC 
      1160       1170       1180       1190       1200
LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP 
      1210       1220       1230       1240       1250
EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE 
      1260       1270       1280       1290       1300
SCTSVDPFEA FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS 
      1310       1320       1330       1340       1350
LLYWTDVVED RIYRGKLSES GGVSAIEVVV EHGLATPEGL TVDWIAGNIY 
      1360       1370       1380       1390       1400
WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP RAIALDPRYG ILFWTDWDAN 
      1410       1420       1430       1440       1450
FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV WTDARSDAIY 
      1460       1470       1480       1490       1500
SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG 
      1510       1520       1530       1540       1550
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR 
      1560       1570       1580       1590       1600
SAACACPHLM KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF 
      1610       1620       1630       1640       1650
TVPDIDDVTV IDFDASEERL YWTDIKTQTI KRAFINGTGL ETVISRDIQS 
      1660       1670       1680       1690       1700
IRGLAVDWVS RNLYWISSEF DETQINVARL DGSLKTSIIH GIDKPQCLAA 
      1710       1720       1730       1740       1750
HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI DYVENKLYWI 
      1760       1770       1780       1790       1800
SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 
      1810       1820       1830       1840       1850
GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL 
      1860       1870       1880       1890       1900
PTSETTRTCM CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM 
      1910       1920       1930       1940       1950
DALMPISGTS FAVGIDFHAE NDTIYWTDMG FNKISRAKRD QTWKEDIITN 
      1960       1970       1980       1990       2000
GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA RLNGSFRYVI ISQGLDQPRS 
      2010       2020       2030       2040       2050
IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA WPNGISIDYE 
      2060       2070       2080       2090       2100
ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD 
      2110       2120       2130       2140       2150
RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD 
      2160       2170       2180       2190       2200
NGGCKQLCLY RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI 
      2210       2220       2230       2240       2250
HLSDETNLNS PIRPYENPRY FKNVIALAFD YNQRRKGTNR IFYSDAHFGN 
      2260       2270       2280       2290       2300
IQLIKDNWED RQVIVENVGS VEGLAYHRAW DTLYWTSSTT SSITRHTVDQ 
      2310       2320       2330       2340       2350
TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ HPSIMRSTLT 
      2360       2370       2380       2390       2400
GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI 
      2410       2420       2430       2440       2450
VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP 
      2460       2470       2480       2490       2500
MGIIAVANDT NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED 
      2510       2520       2530       2540       2550
NRCVTKNSSC NAYSEFECGN GECIDYQLTC DGIPHCKDKS DEKLLYCENR 
      2560       2570       2580       2590       2600
SCRRGFKPCY NRRCIPHGKL CDGENDCGDN SDELDCKVST CATVEFRCAD 
      2610       2620       2630       2640       2650
GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT TGFIRCNSTS 
      2660       2670       2680       2690       2700
LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI 
      2710       2720       2730       2740       2750
CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD 
      2760       2770       2780       2790       2800
ESDSICGAIT CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA 
      2810       2820       2830       2840       2850
PNNTCDENAF MCHNKVCIPK QFVCDHDDDC GDGSDESPQC GYRQCGTEEF 
      2860       2870       2880       2890       2900
SCADGRCLLN TQWQCDGDFD CPDHSDEAPL NPKCKSAEQS CNSSFFMCKN 
      2910       2920       2930       2940       2950
GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ DCQDLPVSYK 
      2960       2970       2980       2990       3000
CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ 
      3010       3020       3030       3040       3050
PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF 
      3060       3070       3080       3090       3100
DYREEFIYWI DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN 
      3110       3120       3130       3140       3150
LYWSDTEKRI IEVSKLNGLY PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC 
      3160       3170       3180       3190       3200
EYPHIGRVGM DGTNQSVVIE TKISRPMALT IDYVNRRLYW ADENHIEFSN 
      3210       3220       3230       3240       3250
MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA HKTSGADRLS 
      3260       3270       3280       3290       3300
LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC 
      3310       3320       3330       3340       3350
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD 
      3360       3370       3380       3390       3400
DCPEFRCQPG RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ 
      3410       3420       3430       3440       3450
FKCTKNQKCI PVNLRCNGQD DCGDEEDERD CPENSCSPDY FQCKTTKHCI 
      3460       3470       3480       3490       3500
SKLWVCDEDP DCADASDEAN CDKKTCGPHE FQCKNNNCIP DHWRCDSQND 
      3510       3520       3530       3540       3550
CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC ADGSDERNCE 
      3560       3570       3580       3590       3600
TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI 
      3610       3620       3630       3640       3650
CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW 
      3660       3670       3680       3690       3700
LCDGIHDCVD GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG 
      3710       3720       3730       3740       3750
DNSDEAPDMC VKFLCPSTRP HRCRNNRICL QSEQMCNGID ECGDNSDEDH 
      3760       3770       3780       3790       3800
CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ CDRLDDCGDG SDEQGCRIAP 
      3810       3820       3830       3840       3850
TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR QCEDLNECLV 
      3860       3870       3880       3890       3900
FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG 
      3910       3920       3930       3940       3950
FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR 
      3960       3970       3980       3990       4000
IHGREKRQAN SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH 
      4010       4020       4030       4040       4050
WTSLRYSINV GQLNGPNCTR LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS 
      4060       4070       4080       4090       4100
HIEEAAMDGT LRRILVQKNL QRPTGLAVDY FSERIYWADF ELSIIGSVLY 
      4110       4120       4130       4140       4150
DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV QKFGHGSVEY 
      4160       4170       4180       4190       4200
LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK 
      4210       4220       4230       4240       4250
YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV 
      4260       4270       4280       4290       4300
NHCSNYCQNG GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI 
      4310       4320       4330       4340       4350
VTAGNQPYCH CQPEYTGDRC QYYVCHHYCV NSESCTIGDD GSVECVCPTR 
      4360       4370       4380       4390       4400
YEGPKCEVDK CVRCHGGHCI INKDSEDIFC NCTNGKIASS CQLCDGYCYN 
      4410       4420       4430       4440       4450
GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS TRSIAIIVPL 
      4460       4470       4480       4490       4500
VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 
      4510       4520       4530       4540       4550
DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL 
      4560       4570       4580       4590 
TAGPTNYSNP VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA
Length:4,599
Mass (Da):515,498
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98B70555F46CAE66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7T7H0Y7T7_HUMAN
Low-density lipoprotein receptor-re...
LRP1B
798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERG8E7ERG8_HUMAN
Low-density lipoprotein receptor-re...
LRP1B
781Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0A8H7C0A8_HUMAN
Low-density lipoprotein receptor-re...
LRP1B
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti516C → Y in AAL38107 (PubMed:11031110).Curated1
Sequence conflicti1257P → S in AAL38108 (PubMed:11031110).Curated1
Sequence conflicti1571E → G in AAL38108 (PubMed:11031110).Curated1
Sequence conflicti2654 – 2655LP → CQ in AAL38108 (PubMed:11031110).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04975948Q → R. Corresponds to variant dbSNP:rs12990449Ensembl.1
Natural variantiVAR_0497603140Q → R. Corresponds to variant dbSNP:rs34488772Ensembl.1
Natural variantiVAR_0183283157R → C in NSCLC cells. 1 PublicationCorresponds to variant dbSNP:rs371536401Ensembl.1
Natural variantiVAR_0497613458E → K. Corresponds to variant dbSNP:rs1878740Ensembl.1
Natural variantiVAR_0497623734Q → K. Corresponds to variant dbSNP:rs35546150Ensembl.1
Natural variantiVAR_0497634264V → L. Corresponds to variant dbSNP:rs17386226Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF176832 mRNA Translation: AAF70379.1
AF283343 Genomic DNA No translation available.
AF283342 AF283341 Genomic DNA Translation: AAL38107.1
AF283374 AF283373 Genomic DNA Translation: AAL38108.1
AF283408 AF283407 Genomic DNA Translation: AAL38109.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2182.1

NCBI Reference Sequences

More...RefSeqi		NP_061027.2, NM_018557.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389484; ENSP00000374135; ENSG00000168702

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53353

UCSC genome browser

More...UCSCi		uc002tvj.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176832 mRNA Translation: AAF70379.1
AF283343 Genomic DNA No translation available.
AF283342 AF283341 Genomic DNA Translation: AAL38107.1
AF283374 AF283373 Genomic DNA Translation: AAL38108.1
AF283408 AF283407 Genomic DNA Translation: AAL38109.1
CCDSiCCDS2182.1
RefSeqiNP_061027.2, NM_018557.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119750, 43 interactors
IntActiQ9NZR2, 28 interactors
STRINGi9606.ENSP00000374135

PTM databases

GlyConnecti1466, 4 N-Linked glycans (1 site)
GlyGeniQ9NZR2, 46 sites
iPTMnetiQ9NZR2
PhosphoSitePlusiQ9NZR2

Genetic variation databases

BioMutaiLRP1B
DMDMi57015418

Proteomic databases

EPDiQ9NZR2
jPOSTiQ9NZR2
MassIVEiQ9NZR2
MaxQBiQ9NZR2
PaxDbiQ9NZR2
PeptideAtlasiQ9NZR2
PRIDEiQ9NZR2
ProteomicsDBi83492

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33599, 54 antibodies

The DNASU plasmid repository

More...DNASUi		53353

Genome annotation databases

EnsembliENST00000389484; ENSP00000374135; ENSG00000168702
GeneIDi53353
KEGGihsa:53353
UCSCiuc002tvj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53353
DisGeNETi53353

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRP1B
HGNCiHGNC:6693, LRP1B
HPAiENSG00000168702, Tissue enhanced (brain, thyroid gland)
MIMi608766, gene
neXtProtiNX_Q9NZR2
OpenTargetsiENSG00000168702
PharmGKBiPA30451
VEuPathDBiHostDB:ENSG00000168702.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
GeneTreeiENSGT00940000157521
HOGENOMiCLU_000085_2_1_1
InParanoidiQ9NZR2
OMAiQCIPAKW
OrthoDBi1606at2759
PhylomeDBiQ9NZR2
TreeFamiTF315253

Enzyme and pathway databases

PathwayCommonsiQ9NZR2
SIGNORiQ9NZR2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53353, 12 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRP1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LRP1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53353
PharosiQ9NZR2, Tbio

Protein Ontology

More...PROi		PR:Q9NZR2
RNActiQ9NZR2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168702, Expressed in corpus callosum and 150 other tissues
ExpressionAtlasiQ9NZR2, baseline and differential
GenevisibleiQ9NZR2, HS

Family and domain databases

CDDicd00112, LDLa, 28 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 31 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF00008, EGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 30 hits
PF00058, Ldl_recept_b, 11 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 25 hits
SM00179, EGF_CA, 6 hits
SM00192, LDLa, 32 hits
SM00135, LY, 37 hits
SUPFAMiSSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 32 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS00022, EGF_1, 5 hits
PS01186, EGF_2, 9 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 27 hits
PS50068, LDLRA_2, 32 hits
PS51120, LDLRB, 37 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRP1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZR2
Secondary accession number(s): Q8WY29, Q8WY30, Q8WY31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 4, 2005
Last modified: June 2, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again