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UniProtKB - Q9NZQ7 (PD1L1_HUMAN)

Entry version 182 (10 Feb 2021)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
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Protein

Programmed cell death 1 ligand 1

Gene

CD274

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).4 Publications
The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813417, PubMed:28813410). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZQ7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389948, PD-1 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NZQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Programmed cell death 1 ligand 11 Publication
Short name:
PD-L12 Publications
Short name:
PDCD1 ligand 1
Short name:
Programmed death ligand 1
Short name:
hPD-L11 Publication
Alternative name(s):
B7 homolog 11 Publication
Short name:
B7-H11 Publication
CD_antigen: CD274
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD274Imported
Synonyms:B7H1, PDCD1L1, PDCD1LG1, PDL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17635, CD274

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605402, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZQ7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120217.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 238ExtracellularSequence analysisAdd BLAST220
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 290CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Truncation of the 3'-untranslated (3'-UTR) region of CD274 transcripts leads to elevated expression of CD274 in multiple cancers including T-cell leukemia, diffuse large B-cell lymphoma and stomach adenocarcinoma (PubMed:27281199). Disruption of 3'-UTR region is caused by structural variants that stabilize CD274 transcripts, leading to overexpression (PubMed:27281199). Increased expression in tumors promotes immune evasion and tumor cell growth by allowing malignant cells to escape destruction by the immune system (PubMed:27281199).1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		29126

Open Targets

More...OpenTargetsi		ENSG00000120217

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134915280

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZQ7, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3580522

Drug and drug target database

More...DrugBanki		DB11595, Atezolizumab
DB11945, Avelumab
DB11714, Durvalumab

DrugCentral

More...DrugCentrali		Q9NZQ7

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD274

Domain mapping of disease mutations (DMDM)

More...DMDMi		83287884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001455319 – 290Programmed cell death 1 ligand 1Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 114PROSITE-ProRule annotation2 Publications
Disulfide bondi155 ↔ 209PROSITE-ProRule annotation1 Publication
Glycosylationi192N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZQ7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZQ7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZQ7

PeptideAtlas

More...PeptideAtlasi		Q9NZQ7

PRoteomics IDEntifications database

More...PRIDEi		Q9NZQ7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83483 [Q9NZQ7-1]
83484 [Q9NZQ7-2]
83485 [Q9NZQ7-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZQ7, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZQ7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9NZQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120217, Expressed in chorionic villus and 167 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZQ7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120217, Tissue enhanced (lung, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDCD1 (PubMed:11015443, PubMed:18287011, PubMed:26602187).

Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118891, 55 interactors

Database of interacting proteins

More...DIPi		DIP-29731N

Protein interaction database and analysis system

More...IntActi		Q9NZQ7, 34 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370989

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9NZQ7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZQ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZQ7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NZQ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 127Ig-like V-typeAdd BLAST109
Domaini133 – 225Ig-like C2-typeAdd BLAST93

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S1Y9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1744717_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZQ7

Identification of Orthologs from Complete Genome Data

More...OMAi		CTFRRLG

Database of Orthologous Groups

More...OrthoDBi		892262at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZQ7

TreeFam database of animal gene trees

More...TreeFami		TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205, C2-set_2, 1 hit
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NZQ7-1) [UniParc]FASTAAdd to basket
Also known as: PD-L1I

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL 
        60         70         80         90        100
AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ 
       110        120        130        140        150
ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE 
       160        170        180        190        200
HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN 
       210        220        230        240        250
TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC 
       260        270        280        290
LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET
Length:290
Mass (Da):33,275
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE957086E62A31A8
GO
Isoform 2 (identifier: Q9NZQ7-2) [UniParc]FASTAAdd to basket
Also known as: PD-L1II

The sequence of this isoform differs from the canonical sequence as follows:
     19-132: Missing.

Show »
Length:176
Mass (Da):20,246
Checksum:iB8BD0CFF9DEA722F
GO
Isoform 3 (identifier: Q9NZQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: K → D
     179-290: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:178
Mass (Da):20,454
Checksum:iA306BF2018885F0B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91966 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01373519 – 132Missing in isoform 2. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_013736178K → D in isoform 3. 2 Publications1
Alternative sequenceiVSP_013737179 – 290Missing in isoform 3. 2 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF177937 mRNA Translation: AAF25807.1
AF233516 mRNA Translation: AAG18508.1
AY254342 mRNA Translation: AAP13470.1
AY291313 mRNA Translation: AAP42144.1
AY714881 mRNA Translation: AAU09634.1
DQ286582 mRNA Translation: ABB90152.1
AK001894 mRNA Translation: BAA91966.1 Different initiation.
AK300470 mRNA Translation: BAG62189.1
AK314567 mRNA Translation: BAG37149.1
AL162253 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58763.1
BC069381 mRNA Translation: AAH69381.1
BC074984 mRNA Translation: AAH74984.1
BC113734 mRNA Translation: AAI13735.1
BC113736 mRNA Translation: AAI13737.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59118.1 [Q9NZQ7-2]
CCDS6464.1 [Q9NZQ7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001254635.1, NM_001267706.1 [Q9NZQ7-2]
NP_054862.1, NM_014143.3 [Q9NZQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381573; ENSP00000370985; ENSG00000120217 [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217 [Q9NZQ7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29126

UCSC genome browser

More...UCSCi		uc003zje.4, human [Q9NZQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177937 mRNA Translation: AAF25807.1
AF233516 mRNA Translation: AAG18508.1
AY254342 mRNA Translation: AAP13470.1
AY291313 mRNA Translation: AAP42144.1
AY714881 mRNA Translation: AAU09634.1
DQ286582 mRNA Translation: ABB90152.1
AK001894 mRNA Translation: BAA91966.1 Different initiation.
AK300470 mRNA Translation: BAG62189.1
AK314567 mRNA Translation: BAG37149.1
AL162253 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58763.1
BC069381 mRNA Translation: AAH69381.1
BC074984 mRNA Translation: AAH74984.1
BC113734 mRNA Translation: AAI13735.1
BC113736 mRNA Translation: AAI13737.1
CCDSiCCDS59118.1 [Q9NZQ7-2]
CCDS6464.1 [Q9NZQ7-1]
RefSeqiNP_001254635.1, NM_001267706.1 [Q9NZQ7-2]
NP_054862.1, NM_014143.3 [Q9NZQ7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BIKX-ray2.65A18-239[»]
3BISX-ray2.64A/B18-239[»]
3FN3X-ray2.70A/B19-238[»]
3SBWX-ray2.28C19-239[»]
4Z18X-ray1.95A/B19-239[»]
4ZQKX-ray2.45A18-132[»]
5C3TX-ray1.80A18-134[»]
5GGTX-ray2.80A18-134[»]
5GRJX-ray3.21A18-238[»]
5IUSX-ray2.89C/D18-239[»]
5J89X-ray2.20A/B/C/D2-134[»]
5J8OX-ray2.30A/B18-134[»]
5JDRX-ray2.70A/B18-239[»]
5JDSX-ray1.70A18-132[»]
5N2DX-ray2.35A/B/C/D2-134[»]
5N2FX-ray1.70A/B18-134[»]
5NIUX-ray2.01A/B/C/D18-134[»]
5O45X-ray0.99A17-134[»]
5O4YX-ray2.30B/C/E18-132[»]
5X8LX-ray3.10A/B/C/D/E18-134[»]
5X8MX-ray2.66A18-134[»]
5XJ4X-ray2.30A19-238[»]
5XXYX-ray2.90A18-133[»]
6NM7X-ray2.43A/B19-134[»]
6NM8X-ray2.79A/B19-134[»]
6NNVX-ray1.92A/B/C/D18-134[»]
6NOJX-ray2.33A/B18-134[»]
6NOSX-ray2.70A/B18-134[»]
6NP9X-ray1.27A18-134[»]
6PV9X-ray2.00A19-239[»]
6R3KX-ray2.20A/B/C/D18-134[»]
6RPGX-ray2.70A/B18-134[»]
SMRiQ9NZQ7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118891, 55 interactors
DIPiDIP-29731N
IntActiQ9NZQ7, 34 interactors
STRINGi9606.ENSP00000370989

Chemistry databases

BindingDBiQ9NZQ7
ChEMBLiCHEMBL3580522
DrugBankiDB11595, Atezolizumab
DB11945, Avelumab
DB11714, Durvalumab
DrugCentraliQ9NZQ7

PTM databases

GlyGeniQ9NZQ7, 5 sites
iPTMnetiQ9NZQ7
PhosphoSitePlusiQ9NZQ7
SwissPalmiQ9NZQ7

Genetic variation databases

BioMutaiCD274
DMDMi83287884

Proteomic databases

EPDiQ9NZQ7
jPOSTiQ9NZQ7
MassIVEiQ9NZQ7
MaxQBiQ9NZQ7
PaxDbiQ9NZQ7
PeptideAtlasiQ9NZQ7
PRIDEiQ9NZQ7
ProteomicsDBi83483 [Q9NZQ7-1]
83484 [Q9NZQ7-2]
83485 [Q9NZQ7-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NZQ7, 137 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24139, 1766 antibodies

The CPTC Antibody Portal

More...CPTCi		Q9NZQ7, 1 antibody

Genome annotation databases

EnsembliENST00000381573; ENSP00000370985; ENSG00000120217 [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217 [Q9NZQ7-1]
GeneIDi29126
KEGGihsa:29126
UCSCiuc003zje.4, human [Q9NZQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29126
DisGeNETi29126

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD274
HGNCiHGNC:17635, CD274
HPAiENSG00000120217, Tissue enhanced (lung, placenta)
MIMi605402, gene
neXtProtiNX_Q9NZQ7
OpenTargetsiENSG00000120217
PharmGKBiPA134915280
VEuPathDBiHostDB:ENSG00000120217.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S1Y9, Eukaryota
GeneTreeiENSGT00940000161430
HOGENOMiCLU_1744717_0_0_1
InParanoidiQ9NZQ7
OMAiCTFRRLG
OrthoDBi892262at2759
PhylomeDBiQ9NZQ7
TreeFamiTF331083

Enzyme and pathway databases

PathwayCommonsiQ9NZQ7
ReactomeiR-HSA-389948, PD-1 signaling
SIGNORiQ9NZQ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29126, 8 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD274, human
EvolutionaryTraceiQ9NZQ7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PD-L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29126
PharosiQ9NZQ7, Tclin

Protein Ontology

More...PROi		PR:Q9NZQ7
RNActiQ9NZQ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120217, Expressed in chorionic villus and 167 other tissues
GenevisibleiQ9NZQ7, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPD1L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZQ7
Secondary accession number(s): B2RBA2
, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: February 10, 2021
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
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