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Protein

Programmed cell death 1 ligand 1

Gene

CD274

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-389948 PD-1 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NZQ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Programmed cell death 1 ligand 11 Publication
Short name:
PD-L12 Publications
Short name:
PDCD1 ligand 1
Short name:
Programmed death ligand 1
Alternative name(s):
B7 homolog 11 Publication
Short name:
B7-H11 Publication
CD_antigen: CD274
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD274Imported
Synonyms:B7H1, PDCD1L1, PDCD1LG1, PDL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000120217.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17635 CD274

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605402 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 238ExtracellularSequence analysisAdd BLAST220
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 290CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29126

Open Targets

More...
OpenTargetsi
ENSG00000120217

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134915280

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580522

Drug and drug target database

More...
DrugBanki
DB11595 Atezolizumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD274

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83287884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001455319 – 290Programmed cell death 1 ligand 1Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 114PROSITE-ProRule annotation1 Publication
Disulfide bondi155 ↔ 209PROSITE-ProRule annotation1 Publication
Glycosylationi192N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NZQ7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NZQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZQ7

PeptideAtlas

More...
PeptideAtlasi
Q9NZQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZQ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83483
83484 [Q9NZQ7-2]
83485 [Q9NZQ7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120217 Expressed in 152 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

More...
CleanExi
HS_CD274

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB030018
CAB076385

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDCD1 (PubMed:11015443, PubMed:18287011). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118891, 48 interactors

Database of interacting proteins

More...
DIPi
DIP-29731N

Protein interaction database and analysis system

More...
IntActi
Q9NZQ7, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370989

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NZQ7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NZQ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZQ7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NZQ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 127Ig-like V-typeAdd BLAST109
Domaini133 – 225Ig-like C2-typeAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIBU Eukaryota
ENOG4111V14 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059625

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082112

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZQ7

KEGG Orthology (KO)

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KOi
K06745

Identification of Orthologs from Complete Genome Data

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OMAi
ANEIFYC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F5W

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZQ7

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NZQ7-1) [UniParc]FASTAAdd to basket
Also known as: PD-L1I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL
60 70 80 90 100
AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ
110 120 130 140 150
ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE
160 170 180 190 200
HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN
210 220 230 240 250
TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC
260 270 280 290
LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET
Length:290
Mass (Da):33,275
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE957086E62A31A8
GO
Isoform 2 (identifier: Q9NZQ7-2) [UniParc]FASTAAdd to basket
Also known as: PD-L1II

The sequence of this isoform differs from the canonical sequence as follows:
     19-132: Missing.

Show »
Length:176
Mass (Da):20,246
Checksum:iB8BD0CFF9DEA722F
GO
Isoform 3 (identifier: Q9NZQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: K → D
     179-290: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:178
Mass (Da):20,454
Checksum:iA306BF2018885F0B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91966 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01373519 – 132Missing in isoform 2. 2 PublicationsAdd BLAST114
Alternative sequenceiVSP_013736178K → D in isoform 3. 2 Publications1
Alternative sequenceiVSP_013737179 – 290Missing in isoform 3. 2 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177937 mRNA Translation: AAF25807.1
AF233516 mRNA Translation: AAG18508.1
AY254342 mRNA Translation: AAP13470.1
AY291313 mRNA Translation: AAP42144.1
AY714881 mRNA Translation: AAU09634.1
DQ286582 mRNA Translation: ABB90152.1
AK001894 mRNA Translation: BAA91966.1 Different initiation.
AK300470 mRNA Translation: BAG62189.1
AK314567 mRNA Translation: BAG37149.1
AL162253 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58763.1
BC069381 mRNA Translation: AAH69381.1
BC074984 mRNA Translation: AAH74984.1
BC113734 mRNA Translation: AAI13735.1
BC113736 mRNA Translation: AAI13737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59118.1 [Q9NZQ7-2]
CCDS6464.1 [Q9NZQ7-1]

NCBI Reference Sequences

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RefSeqi
NP_001254635.1, NM_001267706.1 [Q9NZQ7-2]
NP_054862.1, NM_014143.3 [Q9NZQ7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.521989

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381573; ENSP00000370985; ENSG00000120217 [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217 [Q9NZQ7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29126

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29126

UCSC genome browser

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UCSCi
uc003zje.4 human [Q9NZQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177937 mRNA Translation: AAF25807.1
AF233516 mRNA Translation: AAG18508.1
AY254342 mRNA Translation: AAP13470.1
AY291313 mRNA Translation: AAP42144.1
AY714881 mRNA Translation: AAU09634.1
DQ286582 mRNA Translation: ABB90152.1
AK001894 mRNA Translation: BAA91966.1 Different initiation.
AK300470 mRNA Translation: BAG62189.1
AK314567 mRNA Translation: BAG37149.1
AL162253 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58763.1
BC069381 mRNA Translation: AAH69381.1
BC074984 mRNA Translation: AAH74984.1
BC113734 mRNA Translation: AAI13735.1
BC113736 mRNA Translation: AAI13737.1
CCDSiCCDS59118.1 [Q9NZQ7-2]
CCDS6464.1 [Q9NZQ7-1]
RefSeqiNP_001254635.1, NM_001267706.1 [Q9NZQ7-2]
NP_054862.1, NM_014143.3 [Q9NZQ7-1]
UniGeneiHs.521989

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BIKX-ray2.65A18-239[»]
3BISX-ray2.64A/B18-239[»]
3FN3X-ray2.70A/B19-238[»]
3SBWX-ray2.28C19-239[»]
4Z18X-ray1.95A/B19-239[»]
4ZQKX-ray2.45A18-132[»]
5C3TX-ray1.80A18-134[»]
5GGTX-ray2.80A18-134[»]
5GRJX-ray3.21A18-238[»]
5IUSX-ray2.89C/D18-239[»]
5J89X-ray2.20A/B/C/D2-134[»]
5J8OX-ray2.30A/B18-134[»]
5JDRX-ray2.70A/B18-239[»]
5JDSX-ray1.70A18-132[»]
5N2DX-ray2.35A/B/C/D2-134[»]
5N2FX-ray1.70A/B18-134[»]
5NIUX-ray2.01A/B/C/D18-134[»]
5NIXX-ray2.20A/B/C/D18-134[»]
5O45X-ray0.99A17-134[»]
5O4YX-ray2.30B/C/E18-132[»]
5X8LX-ray3.10A/B/C/D/E18-134[»]
5X8MX-ray2.66A18-134[»]
5XJ4X-ray2.30A19-238[»]
5XXYX-ray2.90A18-133[»]
ProteinModelPortaliQ9NZQ7
SMRiQ9NZQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118891, 48 interactors
DIPiDIP-29731N
IntActiQ9NZQ7, 7 interactors
STRINGi9606.ENSP00000370989

Chemistry databases

BindingDBiQ9NZQ7
ChEMBLiCHEMBL3580522
DrugBankiDB11595 Atezolizumab

PTM databases

iPTMnetiQ9NZQ7
PhosphoSitePlusiQ9NZQ7

Polymorphism and mutation databases

BioMutaiCD274
DMDMi83287884

Proteomic databases

EPDiQ9NZQ7
MaxQBiQ9NZQ7
PaxDbiQ9NZQ7
PeptideAtlasiQ9NZQ7
PRIDEiQ9NZQ7
ProteomicsDBi83483
83484 [Q9NZQ7-2]
83485 [Q9NZQ7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381573; ENSP00000370985; ENSG00000120217 [Q9NZQ7-2]
ENST00000381577; ENSP00000370989; ENSG00000120217 [Q9NZQ7-1]
GeneIDi29126
KEGGihsa:29126
UCSCiuc003zje.4 human [Q9NZQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29126
DisGeNETi29126
EuPathDBiHostDB:ENSG00000120217.13

GeneCards: human genes, protein and diseases

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GeneCardsi
CD274
HGNCiHGNC:17635 CD274
HPAiCAB030018
CAB076385
MIMi605402 gene
neXtProtiNX_Q9NZQ7
OpenTargetsiENSG00000120217
PharmGKBiPA134915280

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIBU Eukaryota
ENOG4111V14 LUCA
GeneTreeiENSGT00940000161430
HOGENOMiHOG000059625
HOVERGENiHBG082112
InParanoidiQ9NZQ7
KOiK06745
OMAiANEIFYC
OrthoDBiEOG091G0F5W
PhylomeDBiQ9NZQ7
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-389948 PD-1 signaling
SIGNORiQ9NZQ7

Miscellaneous databases

EvolutionaryTraceiQ9NZQ7

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PD-L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29126

Protein Ontology

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PROi
PR:Q9NZQ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120217 Expressed in 152 organ(s), highest expression level in chorionic villus
CleanExiHS_CD274
GenevisibleiQ9NZQ7 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPD1L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZQ7
Secondary accession number(s): B2RBA2
, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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