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Protein

Olfactory receptor 5AC2

Gene

OR5AC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AC2
Alternative name(s):
HSA1
Gene namesi
Name:OR5AC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196578.4
HGNCiHGNC:15431 OR5AC2
neXtProtiNX_Q9NZP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 135CytoplasmicSequence analysisAdd BLAST13
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 198ExtracellularSequence analysisAdd BLAST42
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 309CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196578
PharmGKBiPA32457

Polymorphism and mutation databases

BioMutaiOR5AC2
DMDMi85541038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505741 – 309Olfactory receptor 5AC2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NZP5
PRIDEiQ9NZP5
ProteomicsDBi83472

PTM databases

iPTMnetiQ9NZP5
PhosphoSitePlusiQ9NZP5

Expressioni

Gene expression databases

BgeeiENSG00000196578 Expressed in 3 organ(s), highest expression level in temporal lobe
CleanExiHS_OR5AC2

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351466

Structurei

3D structure databases

ProteinModelPortaliQ9NZP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AR Eukaryota
ENOG41113B9 LUCA
GeneTreeiENSGT00550000074564
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ9NZP5
KOiK04257
OMAiYFFASSA
OrthoDBiEOG091G0AZH
PhylomeDBiQ9NZP5
TreeFamiTF352737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NZP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDISEGNKTL VTEFVLTGLT DRPWLHVLFF VVFLVVYLIT MVGNLGLIVL
60 70 80 90 100
IWNDPHLHMP MYLFLGGLAF SDACTSTSIT PRMLVNFLDK TAMISLAECI
110 120 130 140 150
TQFYFFASSA TTECFLLVMM AYDRYVAICN PLLYPVMMSN KLSAQLLSIS
160 170 180 190 200
YVIGFLHPLV HVSLLLRLTF CRFNIIHYFY CEILQLFKIS CNGPSINALM
210 220 230 240 250
IFIFGAFIQI PTLMTIIISY TRVLFDILKK KSEKGRSKAF STCGAHLLSV
260 270 280 290 300
SLYYGTLIFM YVRPASGLAE DQDKVYSLFY TIIIPLLNPF IYSLRNKKVM

HALRRVIRK
Length:309
Mass (Da):35,304
Last modified:January 10, 2006 - v2
Checksum:iBB9FD5CD01F0C5A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034214200M → I1 PublicationCorresponds to variant dbSNP:rs4518168Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133439 Genomic DNA No translation available.
AF179759 Genomic DNA Translation: AAF40348.1
CCDSiCCDS33796.1
RefSeqiNP_473447.1, NM_054106.1
UniGeneiHs.554715

Genome annotation databases

EnsembliENST00000358642; ENSP00000351466; ENSG00000196578
GeneIDi81050
KEGGihsa:81050
UCSCiuc011bgs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133439 Genomic DNA No translation available.
AF179759 Genomic DNA Translation: AAF40348.1
CCDSiCCDS33796.1
RefSeqiNP_473447.1, NM_054106.1
UniGeneiHs.554715

3D structure databases

ProteinModelPortaliQ9NZP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351466

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NZP5
PhosphoSitePlusiQ9NZP5

Polymorphism and mutation databases

BioMutaiOR5AC2
DMDMi85541038

Proteomic databases

PaxDbiQ9NZP5
PRIDEiQ9NZP5
ProteomicsDBi83472

Protocols and materials databases

DNASUi81050
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358642; ENSP00000351466; ENSG00000196578
GeneIDi81050
KEGGihsa:81050
UCSCiuc011bgs.2 human

Organism-specific databases

CTDi81050
EuPathDBiHostDB:ENSG00000196578.4
GeneCardsiOR5AC2
HGNCiHGNC:15431 OR5AC2
neXtProtiNX_Q9NZP5
OpenTargetsiENSG00000196578
PharmGKBiPA32457
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9AR Eukaryota
ENOG41113B9 LUCA
GeneTreeiENSGT00550000074564
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ9NZP5
KOiK04257
OMAiYFFASSA
OrthoDBiEOG091G0AZH
PhylomeDBiQ9NZP5
TreeFamiTF352737

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR5AC2
GenomeRNAii81050
PROiPR:Q9NZP5

Gene expression databases

BgeeiENSG00000196578 Expressed in 3 organ(s), highest expression level in temporal lobe
CleanExiHS_OR5AC2

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO5AC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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