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Protein

Olfactory receptor 6C3

Gene

OR6C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C3
Alternative name(s):
HSA8
Gene namesi
Name:OR6C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000205329.1
HGNCiHGNC:15437 OR6C3
neXtProtiNX_Q9NZP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 51CytoplasmicSequence analysis8
Transmembranei52 – 72Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini73 – 96ExtracellularSequence analysisAdd BLAST24
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 214Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini215 – 234CytoplasmicSequence analysisAdd BLAST20
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 268ExtracellularSequence analysisAdd BLAST13
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 311CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32581

Polymorphism and mutation databases

BioMutaiOR6C3
DMDMi85541048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506251 – 311Olfactory receptor 6C3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NZP0
PRIDEiQ9NZP0
ProteomicsDBi83470

PTM databases

iPTMnetiQ9NZP0
PhosphoSitePlusiQ9NZP0

Expressioni

Gene expression databases

CleanExiHS_OR6C3
ExpressionAtlasiQ9NZP0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368989

Structurei

3D structure databases

ProteinModelPortaliQ9NZP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ9NZP0
KOiK04257
OMAiDYCASNI
OrthoDBiEOG091G0F9F
PhylomeDBiQ9NZP0
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NZP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS
60 70 80 90 100
HLQTPMYFFL RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF
110 120 130 140 150
FIFMGVTEFY ILTAMSYDRY VAICKPLHYT SIMNRKLCTL LVLCAWLSGF
160 170 180 190 200
LTIFPPLMLL LQLDYCASNV IDHFACDYFP LLQLSCSDTW LLEVIGFYFA
210 220 230 240 250
LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS HMIVISISYG
260 270 280 290 300
SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN
310
VVHKVVFYAN Q
Length:311
Mass (Da):35,531
Last modified:January 10, 2006 - v2
Checksum:i1C5D41AA2738DA91
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05321869S → L. Corresponds to variant dbSNP:rs4318060Ensembl.1
Natural variantiVAR_053219133M → T. Corresponds to variant dbSNP:rs11835321Ensembl.1
Natural variantiVAR_034245234A → S. Corresponds to variant dbSNP:rs11832940Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA No translation available.
AF179770 Genomic DNA Translation: AAF40353.1
CCDSiCCDS31819.1
RefSeqiNP_473445.1, NM_054104.1
UniGeneiHs.553653

Genome annotation databases

EnsembliENST00000379667; ENSP00000368989; ENSG00000205329
ENST00000641364; ENSP00000493034; ENSG00000205329
ENST00000641740; ENSP00000493380; ENSG00000205329
GeneIDi254786
KEGGihsa:254786
UCSCiuc010spj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122684 Genomic DNA No translation available.
AF179770 Genomic DNA Translation: AAF40353.1
CCDSiCCDS31819.1
RefSeqiNP_473445.1, NM_054104.1
UniGeneiHs.553653

3D structure databases

ProteinModelPortaliQ9NZP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368989

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9NZP0
PhosphoSitePlusiQ9NZP0

Polymorphism and mutation databases

BioMutaiOR6C3
DMDMi85541048

Proteomic databases

PaxDbiQ9NZP0
PRIDEiQ9NZP0
ProteomicsDBi83470

Protocols and materials databases

DNASUi254786
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379667; ENSP00000368989; ENSG00000205329
ENST00000641364; ENSP00000493034; ENSG00000205329
ENST00000641740; ENSP00000493380; ENSG00000205329
GeneIDi254786
KEGGihsa:254786
UCSCiuc010spj.2 human

Organism-specific databases

CTDi254786
EuPathDBiHostDB:ENSG00000205329.1
GeneCardsiOR6C3
H-InvDBiHIX0037270
HGNCiHGNC:15437 OR6C3
neXtProtiNX_Q9NZP0
PharmGKBiPA32581
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJ6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ9NZP0
KOiK04257
OMAiDYCASNI
OrthoDBiEOG091G0F9F
PhylomeDBiQ9NZP0
TreeFamiTF336833

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR6C3
GenomeRNAii254786
PROiPR:Q9NZP0

Gene expression databases

CleanExiHS_OR6C3
ExpressionAtlasiQ9NZP0 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR6C3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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