Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9NZN8 (CNOT2_HUMAN)

Entry version 182 (25 May 2022)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Add a publicationFeedback
Protein

CCR4-NOT transcription complex subunit 2

Gene

CNOT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZN8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-429947, Deadenylation of mRNA
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NZN8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 2
Alternative name(s):
CCR4-associated factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNOT2
Synonyms:CDC36, NOT2
ORF Names:HSPC131, MSTP046
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7878, CNOT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604909, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZN8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111596

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies (IDNADFS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by delayed development, speech delay with nasal speech, and characteristic facial features including upslanted palpebral fissures, anteverted nares, a thin upper lip, and micrognathia. Some patients may have skeletal anomalies, such as brachydactyly, toe syndactyly and flat feet.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083417316 – 540Missing in IDNADFS. 1 PublicationAdd BLAST225

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		4848

MalaCards human disease database

More...MalaCardsi		CNOT2
MIMi618608, phenotype

Open Targets

More...OpenTargetsi		ENSG00000111596

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		289513, 12q15q21.1 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26673

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZN8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105920

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CNOT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		46396017

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001983311 – 540CCR4-NOT transcription complex subunit 2Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei93PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei169PhosphoserineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZN8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZN8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZN8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZN8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZN8

PeptideAtlas

More...PeptideAtlasi		Q9NZN8

PRoteomics IDEntifications database

More...PRIDEi		Q9NZN8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83462 [Q9NZN8-1]
83463 [Q9NZN8-2]
83464 [Q9NZN8-3]
83465 [Q9NZN8-4]
83466 [Q9NZN8-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZN8, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZN8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NZN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111596, Expressed in intestine and 253 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZN8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZN8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111596, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3.

Interacts with NCOR1, NCOR2. HDAC3 and GPS2.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110910, 164 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2522, CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT7 variant
CPX-2535, CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT8 variant
CPX-2849, CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT8 variant
CPX-707, CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT7 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NZN8

Database of interacting proteins

More...DIPi		DIP-42656N

Protein interaction database and analysis system

More...IntActi		Q9NZN8, 88 interactors

Molecular INTeraction database

More...MINTi		Q9NZN8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229195

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZN8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NZN8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZN8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 126DisorderedSequence analysisAdd BLAST31
Regioni276 – 342DisorderedSequence analysisAdd BLAST67
Regioni437 – 540Repressor domainAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 125Polar residuesSequence analysisAdd BLAST30
Compositional biasi287 – 335Polar residuesSequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT2/3/5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2151, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033275_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZN8

Identification of Orthologs from Complete Genome Data

More...OMAi		GMNRNQV

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZN8

TreeFam database of animal gene trees

More...TreeFami		TF313102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.1020, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00503

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C

The PANTHER Classification System

More...PANTHERi		PTHR23326, PTHR23326, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04153, NOT2_3_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF 
        60         70         80         90        100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL 
       110        120        130        140        150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG 
       160        170        180        190        200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ 
       210        220        230        240        250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN 
       260        270        280        290        300
PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS 
       310        320        330        340        350
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM 
       360        370        380        390        400
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA 
       410        420        430        440        450
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM 
       460        470        480        490        500
NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY 
       510        520        530        540
FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF
Length:540
Mass (Da):59,738
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7183890F033E3B83
GO
Isoform 2 (identifier: Q9NZN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:365
Mass (Da):40,818
Checksum:i27FC908ADA1A6201
GO
Isoform 3 (identifier: Q9NZN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:191
Mass (Da):22,254
Checksum:i803037A4A6F670CC
GO
Isoform 4 (identifier: Q9NZN8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-475: FNRDWRYHKEE → YVQSILITFVL
     476-540: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:475
Mass (Da):51,537
Checksum:i5D5C630BB3E89F06
GO
Isoform 5 (identifier: Q9NZN8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-278: Missing.

Show »
Length:490
Mass (Da):54,306
Checksum:i7C6A4CC0F0992C9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV52F8VV52_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUB4F8VUB4_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
520Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRS8F8VRS8_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W145F8W145_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQF4F8VQF4_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH84H0YH84_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI11H0YI11_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQD8F8VQD8_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX63F8VX63_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVY1F8VVY1_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29095 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13426 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083417316 – 540Missing in IDNADFS. 1 PublicationAdd BLAST225
Natural variantiVAR_048750460A → T. Corresponds to variant dbSNP:rs11178192Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0099131 – 349Missing in isoform 3. 1 PublicationAdd BLAST349
Alternative sequenceiVSP_0099121 – 175Missing in isoform 2. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_009914229 – 278Missing in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_009915465 – 475FNRDWRYHKEE → YVQSILITFVL in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009916476 – 540Missing in isoform 4. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF180473 mRNA Translation: AAF29827.1
AF113226 mRNA Translation: AAG39297.1
AF161480 mRNA Translation: AAF29095.1 Frameshift.
AK000662 mRNA Translation: BAA91313.1
AL137674 mRNA Translation: CAB70869.1
BX641116 mRNA Translation: CAE46054.1
BC002597 mRNA Translation: AAH02597.1
BC011826 mRNA Translation: AAH11826.1
AF044215 mRNA Translation: AAQ13426.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31857.1 [Q9NZN8-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46494

NCBI Reference Sequences

More...RefSeqi		NP_001186231.1, NM_001199302.1 [Q9NZN8-1]
NP_001186232.1, NM_001199303.1 [Q9NZN8-1]
NP_055330.1, NM_014515.5 [Q9NZN8-1]
XP_011536701.1, XM_011538399.1 [Q9NZN8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229195.8; ENSP00000229195.3; ENSG00000111596.14
ENST00000418359.7; ENSP00000412091.3; ENSG00000111596.14
ENST00000551043.5; ENSP00000449260.1; ENSG00000111596.14
ENST00000551483.5; ENSP00000448883.1; ENSG00000111596.14 [Q9NZN8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4848

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000229195.8; ENSP00000229195.3; NM_014515.7; NP_055330.1

UCSC genome browser

More...UCSCi		uc001svv.4, human [Q9NZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180473 mRNA Translation: AAF29827.1
AF113226 mRNA Translation: AAG39297.1
AF161480 mRNA Translation: AAF29095.1 Frameshift.
AK000662 mRNA Translation: BAA91313.1
AL137674 mRNA Translation: CAB70869.1
BX641116 mRNA Translation: CAE46054.1
BC002597 mRNA Translation: AAH02597.1
BC011826 mRNA Translation: AAH11826.1
AF044215 mRNA Translation: AAQ13426.1 Frameshift.
CCDSiCCDS31857.1 [Q9NZN8-1]
PIRiT46494
RefSeqiNP_001186231.1, NM_001199302.1 [Q9NZN8-1]
NP_001186232.1, NM_001199303.1 [Q9NZN8-1]
NP_055330.1, NM_014515.5 [Q9NZN8-1]
XP_011536701.1, XM_011538399.1 [Q9NZN8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20B344-540[»]
4C0FX-ray2.40A/B/C/D429-540[»]
5FU6X-ray2.90B/E350-540[»]
5FU7X-ray3.10B/F350-540[»]
AlphaFoldDBiQ9NZN8
SMRiQ9NZN8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110910, 164 interactors
ComplexPortaliCPX-2522, CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT7 variant
CPX-2535, CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT8 variant
CPX-2849, CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT8 variant
CPX-707, CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT7 variant
CORUMiQ9NZN8
DIPiDIP-42656N
IntActiQ9NZN8, 88 interactors
MINTiQ9NZN8
STRINGi9606.ENSP00000229195

Chemistry databases

ChEMBLiCHEMBL4105920

PTM databases

GlyGeniQ9NZN8, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ9NZN8
MetOSiteiQ9NZN8
PhosphoSitePlusiQ9NZN8

Genetic variation databases

BioMutaiCNOT2
DMDMi46396017

Proteomic databases

EPDiQ9NZN8
jPOSTiQ9NZN8
MassIVEiQ9NZN8
MaxQBiQ9NZN8
PaxDbiQ9NZN8
PeptideAtlasiQ9NZN8
PRIDEiQ9NZN8
ProteomicsDBi83462 [Q9NZN8-1]
83463 [Q9NZN8-2]
83464 [Q9NZN8-3]
83465 [Q9NZN8-4]
83466 [Q9NZN8-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17029, 440 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		4848

Genome annotation databases

EnsembliENST00000229195.8; ENSP00000229195.3; ENSG00000111596.14
ENST00000418359.7; ENSP00000412091.3; ENSG00000111596.14
ENST00000551043.5; ENSP00000449260.1; ENSG00000111596.14
ENST00000551483.5; ENSP00000448883.1; ENSG00000111596.14 [Q9NZN8-3]
GeneIDi4848
KEGGihsa:4848
MANE-SelectiENST00000229195.8; ENSP00000229195.3; NM_014515.7; NP_055330.1
UCSCiuc001svv.4, human [Q9NZN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4848
DisGeNETi4848

GeneCards: human genes, protein and diseases

More...GeneCardsi		CNOT2
HGNCiHGNC:7878, CNOT2
HPAiENSG00000111596, Low tissue specificity
MalaCardsiCNOT2
MIMi604909, gene
618608, phenotype
neXtProtiNX_Q9NZN8
OpenTargetsiENSG00000111596
Orphaneti289513, 12q15q21.1 microdeletion syndrome
PharmGKBiPA26673
VEuPathDBiHostDB:ENSG00000111596

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2151, Eukaryota
GeneTreeiENSGT00390000001285
HOGENOMiCLU_033275_1_0_1
InParanoidiQ9NZN8
OMAiGMNRNQV
PhylomeDBiQ9NZN8
TreeFamiTF313102

Enzyme and pathway databases

PathwayCommonsiQ9NZN8
ReactomeiR-HSA-429947, Deadenylation of mRNA
R-HSA-6804115, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
SignaLinkiQ9NZN8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4848, 295 hits in 1086 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CNOT2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CNOT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4848
PharosiQ9NZN8, Tbio

Protein Ontology

More...PROi		PR:Q9NZN8
RNActiQ9NZN8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111596, Expressed in intestine and 253 other tissues
ExpressionAtlasiQ9NZN8, baseline and differential
GenevisibleiQ9NZN8, HS

Family and domain databases

Gene3Di2.30.30.1020, 1 hit
IDEALiIID00503
InterProiView protein in InterPro
IPR038635, CCR4-NOT_su2/3/5_N_sf
IPR040168, Not2/3/5
IPR007282, NOT2/3/5_C
PANTHERiPTHR23326, PTHR23326, 1 hit
PfamiView protein in Pfam
PF04153, NOT2_3_5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNOT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZN8
Secondary accession number(s): Q9H3E0
, Q9NSX5, Q9NWR6, Q9P028
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: May 25, 2022
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again