CNOT2

Functionⁱ

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.4 Publications

GO - Molecular functionⁱ

RNA polymerase II transcription corepressor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16712523
transcription coregulator activity
Source: UniProtKB
Traceable author statementⁱ
- 10637334

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
gene silencing by RNA Source: UniProtKB-KW
negative regulation of intracellular estrogen receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16778766
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 14707134
- 16712523
negative regulation of translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
positive regulation of cytoplasmic mRNA processing body assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21299754
regulation of stem cell population maintenance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22367759
regulation of transcription by RNA polymerase II
Source: UniProtKB
Non-traceable author statementⁱ
- 10637334
RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
trophectodermal cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Repressor
Biological process	RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-429947 Deadenylation of mRNA R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Reactomeⁱ

R-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CCR4-NOT transcription complex subunit 2 Alternative name(s): CCR4-associated factor 2
Gene namesⁱ	Name:CNOT2 Synonyms:CDC36, NOT2 ORF Names:HSPC131, MSTP046
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111596.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7878 CNOT2
MIMⁱ	604909 gene
neXtProtⁱ	NX_Q9NZN8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4848
Open Targets More...OpenTargetsⁱ	ENSG00000111596
PharmGKBⁱ	PA26673

Polymorphism and mutation databases

BioMutaⁱ	CNOT2
DMDMⁱ	46396017

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000198331	1 – 540	CCR4-NOT transcription complex subunit 2Add BLAST		540

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	93	PhosphothreonineCombined sources	1
Modified residueⁱ	126	PhosphoserineCombined sources	1
Modified residueⁱ	157	PhosphoserineBy similarity	1
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	169	PhosphoserineBy similarity	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	274	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NZN8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZN8
PaxDbⁱ	Q9NZN8
PeptideAtlas More...PeptideAtlasⁱ	Q9NZN8
PRIDEⁱ	Q9NZN8
ProteomicsDBⁱ	83462 83463 [Q9NZN8-2] 83464 [Q9NZN8-3] 83465 [Q9NZN8-4] 83466 [Q9NZN8-5]

PTM databases

iPTMnetⁱ	Q9NZN8
PhosphoSitePlusⁱ	Q9NZN8

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.1 Publication

Developmental stageⁱ

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111596 Expressed in 241 organ(s), highest expression level in intestine
CleanExⁱ	HS_CNOT2
ExpressionAtlasⁱ	Q9NZN8 baseline and differential
Genevisibleⁱ	Q9NZN8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067711

HPAⁱ

HPA067711

Interactionⁱ

Subunit structureⁱ

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q9UFF9	3	EBI-743033,EBI-742299
CNOT1	A5YKK6	5	EBI-743033,EBI-1222758
CNOT3	O75175	6	EBI-743033,EBI-743073
CNOT6L	Q96LI5	2	EBI-743033,EBI-1046635
TNRC6C	Q9HCJ0	4	EBI-743033,EBI-6507625

GO - Molecular functionⁱ

RNA polymerase II transcription corepressor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16712523

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110910, 64 interactors
CORUMⁱ	Q9NZN8
Database of interacting proteins More...DIPⁱ	DIP-42656N
IntActⁱ	Q9NZN8, 62 interactors
Molecular INTeraction database More...MINTⁱ	Q9NZN8
STRINGⁱ	9606.ENSP00000229195

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	357 – 366	Combined sources	10
Helixⁱ	371 – 373	Combined sources	3
Turnⁱ	376 – 378	Combined sources	3
Helixⁱ	382 – 385	Combined sources	4
Helixⁱ	396 – 398	Combined sources	3
Turnⁱ	410 – 412	Combined sources	3
Helixⁱ	419 – 421	Combined sources	3
Helixⁱ	424 – 427	Combined sources	4
Helixⁱ	429 – 432	Combined sources	4
Helixⁱ	436 – 438	Combined sources	3
Helixⁱ	441 – 449	Combined sources	9
Helixⁱ	453 – 466	Combined sources	14
Beta strandⁱ	470 – 472	Combined sources	3
Turnⁱ	473 – 476	Combined sources	4
Beta strandⁱ	477 – 481	Combined sources	5
Beta strandⁱ	488 – 490	Combined sources	3
Beta strandⁱ	492 – 503	Combined sources	12
Turnⁱ	504 – 507	Combined sources	4
Beta strandⁱ	508 – 517	Combined sources	10
Helixⁱ	518 – 520	Combined sources	3
Helixⁱ	537 – 539	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZN8
SMRⁱ	Q9NZN8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	437 – 540	Repressor domainAdd BLAST		104

Sequence similaritiesⁱ

Belongs to the CNOT2/3/5 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2151 Eukaryota COG5601 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001285
HOGENOMⁱ	HOG000246523
HOVERGENⁱ	HBG051041
InParanoidⁱ	Q9NZN8
KEGG Orthology (KO) More...KOⁱ	K12605
OMAⁱ	LKTNTYE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C7Y
PhylomeDBⁱ	Q9NZN8
TreeFamⁱ	TF313102

Family and domain databases

Gene3Dⁱ	2.30.30.1020, 1 hit
InterProⁱ	View protein in InterPro IPR038635 CCR4-NOT_su2/3/5_N_sf IPR007282 NOT2/3/5_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04153 NOT2_3_5, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NZN8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF 
        60         70         80         90        100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL 
       110        120        130        140        150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG 
       160        170        180        190        200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ 
       210        220        230        240        250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN 
       260        270        280        290        300
PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS 
       310        320        330        340        350
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM 
       360        370        380        390        400
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA 
       410        420        430        440        450
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM 
       460        470        480        490        500
NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY 
       510        520        530        540
FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

Length:540

Mass (Da):59,738

Last modified:October 1, 2000 - v1

Checksum:ⁱ7183890F033E3B83

GO

Isoform 2 (identifier: Q9NZN8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-175: Missing.

« Hide

        10         20         30         40         50
MPKQQPSRQP FTVNSMSGFG MNRNQAFGMN NSLSSNIFNG TDGSENVTGL 
        60         70         80         90        100
DLSDFPALAD RNRREGSGNP TPLINPLAGR APYVGMVTKP ANEQSQDFSI 
       110        120        130        140        150
HNEDFPALPG SSYKDPTSSN DDSKSNLNTS GKTTSSTDGP KFPGDKSSTT 
       160        170        180        190        200
QNNNQQKKGI QVLPDGRVTN IPQGMVTDQF GMIGLLTFIR AAETDPGMVH 
       210        220        230        240        250
LALGSDLTTL GLNLNSPENL YPKFASPWAS SPCRPQDIDF HVPSEYLTNI 
       260        270        280        290        300
HIRDKLAAIK LGRYGEDLLF YLYYMNGGDV LQLLAAVELF NRDWRYHKEE 
       310        320        330        340        350
RVWITRAPGM EPTMKTNTYE RGTYYFFDCL NWRKVAKEFH LEYDKLEERP 
       360 
HLPSTFNYNP AQQAF

Note: No experimental confirmation available.

Show »

Length:365

Mass (Da):40,818

Checksum:ⁱ27FC908ADA1A6201

GO

Isoform 3 (identifier: Q9NZN8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-349: Missing.

« Hide

        10         20         30         40         50
MVTDQFGMIG LLTFIRAAET DPGMVHLALG SDLTTLGLNL NSPENLYPKF 
        60         70         80         90        100
ASPWASSPCR PQDIDFHVPS EYLTNIHIRD KLAAIKLGRY GEDLLFYLYY 
       110        120        130        140        150
MNGGDVLQLL AAVELFNRDW RYHKEERVWI TRAPGMEPTM KTNTYERGTY 
       160        170        180        190 
YFFDCLNWRK VAKEFHLEYD KLEERPHLPS TFNYNPAQQA F

Note: May be due to an intron retention. No experimental confirmation available.

Show »

Length:191

Mass (Da):22,254

Checksum:ⁱ803037A4A6F670CC

GO

Isoform 4 (identifier: Q9NZN8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
465-475: FNRDWRYHKEE → YVQSILITFVL
476-540: Missing.

« Hide

        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF 
        60         70         80         90        100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL 
       110        120        130        140        150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG 
       160        170        180        190        200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ 
       210        220        230        240        250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN 
       260        270        280        290        300
PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS 
       310        320        330        340        350
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM 
       360        370        380        390        400
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA 
       410        420        430        440        450
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM 
       460        470 
NGGDVLQLLA AVELYVQSIL ITFVL

Note: May be due to an intron retention. No experimental confirmation available.

Show »

Length:475

Mass (Da):51,537

Checksum:ⁱ5D5C630BB3E89F06

GO

Isoform 5 (identifier: Q9NZN8-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-278: Missing.

« Hide

        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF 
        60         70         80         90        100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL 
       110        120        130        140        150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG 
       160        170        180        190        200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ 
       210        220        230        240        250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALPGSSYKD PTSSNDDSKS 
       260        270        280        290        300
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM 
       310        320        330        340        350
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA 
       360        370        380        390        400
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM 
       410        420        430        440        450
NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY 
       460        470        480        490
FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF

Note: No experimental confirmation available.

Show »

Length:490

Mass (Da):54,306

Checksum:ⁱ7C6A4CC0F0992C9C

GO

Computationally mapped potential isoform sequencesⁱ

There are 22 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	F8VV52	F8VV52_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	531	Annotation score:
	F8VRS8	F8VRS8_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	276	Annotation score:
	F8VP97	F8VP97_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	321	Annotation score:
	F8VQF4	F8VQF4_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	144	Annotation score:
	F8W145	F8W145_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	309	Annotation score:
	F8VUB4	F8VUB4_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	520	Annotation score:
	H0YH84	H0YH84_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	186	Annotation score:
	H0YHT6	H0YHT6_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	104	Annotation score:
	H0YI11	H0YI11_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	182	Annotation score:
	H0YI80	H0YI80_HUMAN	CCR4-NOT transcription complex subu... CCR4-NOT transcription complex subunit 2	CNOT2	99	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAF29095 differs from that shown. Reason: Frameshift at position 474.Curated

The sequence AAQ13426 differs from that shown. Reason: Frameshift at positions 71, 76, 84, 98, 123, 370, 384 and 393.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048750	460	A → T. Corresponds to variant dbSNP:rs11178192Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_009913	1 – 349	Missing in isoform 3. 1 PublicationAdd BLAST	349
Alternative sequenceⁱVSP_009912	1 – 175	Missing in isoform 2. 1 PublicationAdd BLAST	175
Alternative sequenceⁱVSP_009914	229 – 278	Missing in isoform 5. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_009915	465 – 475	FNRDWRYHKEE → YVQSILITFVL in isoform 4. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_009916	476 – 540	Missing in isoform 4. 1 PublicationAdd BLAST	65

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF180473 mRNA Translation: AAF29827.1 AF113226 mRNA Translation: AAG39297.1 AF161480 mRNA Translation: AAF29095.1 Frameshift. AK000662 mRNA Translation: BAA91313.1 AL137674 mRNA Translation: CAB70869.1 BX641116 mRNA Translation: CAE46054.1 BC002597 mRNA Translation: AAH02597.1 BC011826 mRNA Translation: AAH11826.1 AF044215 mRNA Translation: AAQ13426.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31857.1 [Q9NZN8-1]
PIRⁱ	T46494
NCBI Reference Sequences More...RefSeqⁱ	NP_001186231.1, NM_001199302.1 [Q9NZN8-1] NP_001186232.1, NM_001199303.1 [Q9NZN8-1] NP_055330.1, NM_014515.5 [Q9NZN8-1] XP_011536701.1, XM_011538399.1 [Q9NZN8-1]
UniGeneⁱ	Hs.133350 Hs.730666

Genome annotation databases

Ensemblⁱ	ENST00000229195; ENSP00000229195; ENSG00000111596 [Q9NZN8-1] ENST00000418359; ENSP00000412091; ENSG00000111596 [Q9NZN8-1] ENST00000551043; ENSP00000449260; ENSG00000111596 [Q9NZN8-1] ENST00000551483; ENSP00000448883; ENSG00000111596 [Q9NZN8-3]
GeneIDⁱ	4848
KEGGⁱ	hsa:4848
UCSC genome browser More...UCSCⁱ	uc001svv.4 human [Q9NZN8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NZN8	CCR4-NOT transcription complex subunit 2		GORGO		455	UniRef100_Q9NZN8
CCR4-NOT transcription complex subunit 2 isoform X4		DELLE		455
CCR4-NOT transcription complex subunit 2 isoform X4		URSMA		455
Uncharacterized protein (Fragment)		AILME		524
CCR4-NOT transcription complex subunit 2 isoform X1		Enhydra lutris kenyoni		550
+58
Q9NZN8-3	CNOT2 isoform 32		PONAB		191	UniRef100_A0A2J8W1D1
CNOT2 isoform 5		PANTR		191
Uncharacterized protein		CERAT		191
Uncharacterized protein		FELCA		191
Uncharacterized protein		RHIBE		191
+5
Q9NZN8-4	CNOT2 isoform 34 (Fragment)		PONAB		185	UniRef100_Q9NZN8-4
CNOT2 isoform 14 (Fragment)		PANTR		185

Protein	Similar proteins		Species	Score	Length	Source
Q9NZN8	CCR4-NOT transcription complex subunit 2		GORGO		455	UniRef90_Q9NZN8
CCR4-NOT transcription complex subunit 2 isoform X4		DELLE		455
CCR4-NOT transcription complex subunit 2 isoform X4		URSMA		455
Uncharacterized protein (Fragment)		AILME		524
CCR4-NOT transcription complex subunit 2 isoform X1		Enhydra lutris kenyoni		550
+130
Q9NZN8-3	CCR4-NOT transcription complex subunit 2		MOUSE		540	UniRef90_Q8C5L3
CCR4-NOT transcription complex, subunit 2		RAT		540
Uncharacterized protein		ANOCA		614
Uncharacterized protein		PIG		578
CCR4-NOT transcription complex subunit 2 isoform X2		TURTR		574
+293
Q9NZN8-4	CNOT2 isoform 34 (Fragment)		PONAB		185	UniRef90_Q9NZN8-4
CNOT2 isoform 14 (Fragment)		PANTR		185
CCR4-NOT transcription complex subunit 2		TAEGU		524
CCR4-NOT transcription complex subunit 2 (Fragment)		MERNU		496
CCR4-NOT transcription complex subunit 2 (Fragment)		brown roatelo		496
+37
Q9NZN8-5	CCR4-NOT transcription complex subunit 2		MOUSE		490	UniRef90_Q9NZN8-5
Uncharacterized protein		PAPAN		488
Uncharacterized protein		CERAT		488
Uncharacterized protein		MANLE		488
Uncharacterized protein		MACFA		488
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9NZN8	CCR4-NOT transcription complex subunit 2		MOUSE		540	UniRef50_Q9NZN8
CCR4-NOT transcription complex subunit 2		GORGO		455
CCR4-NOT transcription complex subunit 2 isoform X4		DELLE		455
CCR4-NOT transcription complex subunit 2 isoform X4		URSMA		455
Uncharacterized protein (Fragment)		AILME		524
+732
Q9NZN8-5	CCR4-NOT transcription complex subunit 2		MOUSE		490	UniRef50_Q9NZN8-5
Uncharacterized protein		PAPAN		488
Uncharacterized protein		CERAT		488
Uncharacterized protein		MANLE		488
Uncharacterized protein		MACFA		488
+59

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF180473 mRNA Translation: AAF29827.1 AF113226 mRNA Translation: AAG39297.1 AF161480 mRNA Translation: AAF29095.1 Frameshift. AK000662 mRNA Translation: BAA91313.1 AL137674 mRNA Translation: CAB70869.1 BX641116 mRNA Translation: CAE46054.1 BC002597 mRNA Translation: AAH02597.1 BC011826 mRNA Translation: AAH11826.1 AF044215 mRNA Translation: AAQ13426.1 Frameshift.
CCDSⁱ	CCDS31857.1 [Q9NZN8-1]
PIRⁱ	T46494
RefSeqⁱ	NP_001186231.1, NM_001199302.1 [Q9NZN8-1] NP_001186232.1, NM_001199303.1 [Q9NZN8-1] NP_055330.1, NM_014515.5 [Q9NZN8-1] XP_011536701.1, XM_011538399.1 [Q9NZN8-1]
UniGeneⁱ	Hs.133350 Hs.730666

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4C0D	X-ray	3.20	B	344-540	[»]
	4C0F	X-ray	2.40	A/B/C/D	429-540	[»]
	5FU6	X-ray	2.90	B/E	350-540	[»]
	5FU7	X-ray	3.10	B/F	350-540	[»]
ProteinModelPortalⁱ	Q9NZN8
SMRⁱ	Q9NZN8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110910, 64 interactors
CORUMⁱ	Q9NZN8
DIPⁱ	DIP-42656N
IntActⁱ	Q9NZN8, 62 interactors
MINTⁱ	Q9NZN8
STRINGⁱ	9606.ENSP00000229195

PTM databases

iPTMnetⁱ	Q9NZN8
PhosphoSitePlusⁱ	Q9NZN8

Polymorphism and mutation databases

BioMutaⁱ	CNOT2
DMDMⁱ	46396017

Proteomic databases

EPDⁱ	Q9NZN8
MaxQBⁱ	Q9NZN8
PaxDbⁱ	Q9NZN8
PeptideAtlasⁱ	Q9NZN8
PRIDEⁱ	Q9NZN8
ProteomicsDBⁱ	83462 83463 [Q9NZN8-2] 83464 [Q9NZN8-3] 83465 [Q9NZN8-4] 83466 [Q9NZN8-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4848
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229195; ENSP00000229195; ENSG00000111596 [Q9NZN8-1] ENST00000418359; ENSP00000412091; ENSG00000111596 [Q9NZN8-1] ENST00000551043; ENSP00000449260; ENSG00000111596 [Q9NZN8-1] ENST00000551483; ENSP00000448883; ENSG00000111596 [Q9NZN8-3]
GeneIDⁱ	4848
KEGGⁱ	hsa:4848
UCSCⁱ	uc001svv.4 human [Q9NZN8-1]

Organism-specific databases

CTDⁱ	4848
DisGeNETⁱ	4848
EuPathDBⁱ	HostDB:ENSG00000111596.11
GeneCardsⁱ	CNOT2
HGNCⁱ	HGNC:7878 CNOT2
HPAⁱ	HPA067711
MIMⁱ	604909 gene
neXtProtⁱ	NX_Q9NZN8
OpenTargetsⁱ	ENSG00000111596
PharmGKBⁱ	PA26673
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2151 Eukaryota COG5601 LUCA
GeneTreeⁱ	ENSGT00390000001285
HOGENOMⁱ	HOG000246523
HOVERGENⁱ	HBG051041
InParanoidⁱ	Q9NZN8
KOⁱ	K12605
OMAⁱ	LKTNTYE
OrthoDBⁱ	EOG091G0C7Y
PhylomeDBⁱ	Q9NZN8
TreeFamⁱ	TF313102

Enzyme and pathway databases

Reactomeⁱ	R-HSA-429947 Deadenylation of mRNA R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Reactomeⁱ

R-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRSⁱ	CNOT2 human
GeneWikiⁱ	CNOT2
GenomeRNAiⁱ	4848
Protein Ontology More...PROⁱ	PR:Q9NZN8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111596 Expressed in 241 organ(s), highest expression level in intestine
CleanExⁱ	HS_CNOT2
ExpressionAtlasⁱ	Q9NZN8 baseline and differential
Genevisibleⁱ	Q9NZN8 HS

Family and domain databases

Gene3Dⁱ	2.30.30.1020, 1 hit
InterProⁱ	View protein in InterPro IPR038635 CCR4-NOT_su2/3/5_N_sf IPR007282 NOT2/3/5_C
Pfamⁱ	View protein in Pfam PF04153 NOT2_3_5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CNOT2_HUMAN
Accessionⁱ	Q9NZN8Primary (citable) accession number: Q9NZN8 Secondary accession number(s): Q9H3E0 , Q9NSX5, Q9NWR6, Q9P028
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q9NZN8 (CNOT2_HUMAN)

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CCR4-NOT transcription complex subunit 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ