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Entry version 165 (13 Nov 2019)
Sequence version 2 (18 Apr 2006)
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Protein

Ribosome biogenesis protein NOP53

Gene

NOP53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081).12 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome biogenesis protein NOP53Curated
Alternative name(s):
Glioma tumor suppressor candidate region gene 2 proteinImported
Protein interacting with carboxyl terminus 11 Publication
Short name:
PICT-11 Publication
p601 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOP53Imported
Synonyms:GLT1 Publication, GLTSCR21 Publication, PICT11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:4333 NOP53

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605691 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZM5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi233S → A: Decreased phosphorylation, degradation and increased interaction with RPL11 in response to DNA damage; when associated with A-289. 1 Publication1
Mutagenesisi233S → D: Loss of localization to the nucleolus and in response to DNA damage increased degradation and decreased interaction with RPL11; when associated with D-289. 1 Publication1
Mutagenesisi289T → A: Decreased degradation in response to DNA damage. Decreased phosphorylation, degradation and increased interaction with RPL11 in response to DNA damage; when associated with A-233. 1 Publication1
Mutagenesisi289T → D: Loss of localization to the nucleolus and in response to DNA damage increased degradation and decreased interaction with RPL11; when associated with D-233. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
29997

Open Targets

More...
OpenTargetsi
ENSG00000105373

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28736

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NZM5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOP53

Domain mapping of disease mutations (DMDM)

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DMDMi
93141272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189602 – 478Ribosome biogenesis protein NOP53Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei305PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitin-mediated proteasomal degradation is regulated by c-JUN. It is associated with relocalization to the nucleoplasm and decreased homooligomerization.1 Publication
Phosphorylated upon DNA damage probably by ATM and DNA-PK; may regulate NOP53 degradation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NZM5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NZM5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NZM5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NZM5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NZM5

PeptideAtlas

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PeptideAtlasi
Q9NZM5

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZM5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
83451

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q9NZM5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NZM5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by nucleolar stress through ubiquitin-independent proteasomal degradation (at protein level) (PubMed:24923447). Up-regulated upon mitochondrial stress (at protein level) (PubMed:24556985). Expression of the protein might be regulated by DNA damage but results are not consistent (PubMed:21741933, PubMed:27829214).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105373 Expressed in 230 organ(s), highest expression level in mammary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NZM5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NZM5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018999
HPA049600

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:24735870, PubMed:26903295).

Interacts with PTEN; regulates PTEN phosphorylation and increases its stability (PubMed:15355975).

Interacts with RPL11; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).

Interacts with CDKN2A/isoform tumor suppressor ARF; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (PubMed:27323397).

Interacts with NPM1; the interaction is direct and competitive with MYC (PubMed:25956029).

Interacts with NF2 (via FERM domain); the interaction is direct (PubMed:21167305).

Interacts with p53/TP53 (via the oligomerization region); the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of p53/TP53 (PubMed:22522597).

Interacts with DDX58; may regulate DDX58 through USP15-mediated 'Lys-63'-linked deubiquitination (PubMed:27824081).

Interacts with UBTF (PubMed:27729611).

11 Publications

(Microbial infection) Interacts with herpes simplex virus 1 early proteins ICP22 and ICP0.

1 Publication

(Microbial infection) Interacts with Human herpesvirus 8 protein ORF16; may sequester ORF16 in host nucleolus and reduce its antiapoptotic activity.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119021, 166 interactors

Protein interaction database and analysis system

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IntActi
Q9NZM5, 112 interactors

Molecular INTeraction database

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MINTi
Q9NZM5

STRING: functional protein association networks

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STRINGi
9606.ENSP00000246802

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 431Mediates interaction with CDKN2A/isoform tumor suppressor ARF1 PublicationAdd BLAST284
Regioni181 – 478Mediates interaction with NF21 PublicationAdd BLAST298
Regioni342 – 386Mediates interaction with human herpesvirus 8 protein ORF161 PublicationAdd BLAST45
Regioni347 – 395Nucleolar localization signal1 PublicationAdd BLAST49
Regioni396 – 478Nucleolar localization signal1 PublicationAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOP53 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2823 Eukaryota
ENOG4111GSN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000017267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070127

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NZM5

KEGG Orthology (KO)

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KOi
K14840

Identification of Orthologs from Complete Genome Data

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OMAi
KSAWRKT

Database of Orthologous Groups

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OrthoDBi
1025498at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NZM5

TreeFam database of animal gene trees

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TreeFami
TF313004

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011687 Nop53/GLTSCR2

The PANTHER Classification System

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PANTHERi
PTHR14211 PTHR14211, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07767 Nop53, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF017302 Gltscr2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9NZM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGSGVGG KRSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR
60 70 80 90 100
LAQEPLGLEV DQFLEDVRLQ ERTSGGLLSE APNEKLFFVD TGSKEKGLTK
110 120 130 140 150
KRTKVQKKSL LLKKPLRVDL ILENTSKVPA PKDVLAHQVP NAKKLRRKEQ
160 170 180 190 200
LWEKLAKQGE LPREVRRAQA RLLNPSATRA KPGPQDTVER PFYDLWASDN
210 220 230 240 250
PLDRPLVGQD EFFLEQTKKK GVKRPARLHT KPSQAPAVEV APAGASYNPS
260 270 280 290 300
FEDHQTLLSA AHEVELQRQK EAEKLERQLA LPATEQAATQ ESTFQELCEG
310 320 330 340 350
LLEESDGEGE PGQGEGPEAG DAEVCPTPAR LATTEKKTEQ QRRREKAVHR
360 370 380 390 400
LRVQQAALRA ARLRHQELFR LRGIKAQVAL RLAELARRQR RRQARREAEA
410 420 430 440 450
DKPRRLGRLK YQAPDIDVQL SSELTDSLRT LKPEGNILRD RFKSFQRRNM
460 470
IEPRERAKFK RKYKVKLVEK RAFREIQL
Length:478
Mass (Da):54,389
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F1BA13D04BFB618
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ34M0QZ34_HUMAN
Ribosome biogenesis protein NOP53
NOP53
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYZ9M0QYZ9_HUMAN
Ribosome biogenesis protein NOP53
NOP53
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX73M0QX73_HUMAN
Ribosome biogenesis protein NOP53
NOP53
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZU5M0QZU5_HUMAN
Ribosome biogenesis protein NOP53
NOP53
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9G → R in AAG30413 (PubMed:10196275).Curated1
Sequence conflicti146 – 191RRKEQ…TVERP → SGRSSYGRSWPSRASSPGGA QGPSPVAQPFCNKGPNPAPG HRIAA in AAG30413 (PubMed:10196275).CuratedAdd BLAST46
Sequence conflicti198 – 215SDNPL…EFFLE → LNNPDKPVVWPGCLFPG in AAG30413 (PubMed:10196275).CuratedAdd BLAST18
Sequence conflicti235A → S in AAH04229 (PubMed:15489334).Curated1
Sequence conflicti417D → H in AAG30413 (PubMed:10196275).Curated1
Sequence conflicti433 – 477PEGNI…FREIQ → VLTVSCRGAPCPVMTPSLLP VPPRGYGRHHGCPWAGPVGP MPRG in CAB59242 (PubMed:17974005).CuratedAdd BLAST45
Sequence conflicti434 – 478EGNIL…REIQL → RGQHSFETGSRAFRGGI in AAG30413 (PubMed:10196275).CuratedAdd BLAST45

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02445616S → R. Corresponds to variant dbSNP:rs1042401Ensembl.1
Natural variantiVAR_011486389Q → R4 PublicationsCorresponds to variant dbSNP:rs1804994Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF182076 mRNA Translation: AAF62873.1
BC004229 mRNA Translation: AAH04229.2
BC006311 mRNA Translation: AAH06311.1
BC010095 mRNA Translation: AAH10095.1
AF296124 mRNA Translation: AAG30413.1
AL359335 mRNA Translation: CAB94786.1
AL359336 mRNA Translation: CAB94787.1
AL122063 mRNA Translation: CAB59242.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12705.1

NCBI Reference Sequences

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RefSeqi
NP_056525.2, NM_015710.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000246802; ENSP00000246802; ENSG00000105373

Database of genes from NCBI RefSeq genomes

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GeneIDi
29997

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29997

UCSC genome browser

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UCSCi
uc002phm.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182076 mRNA Translation: AAF62873.1
BC004229 mRNA Translation: AAH04229.2
BC006311 mRNA Translation: AAH06311.1
BC010095 mRNA Translation: AAH10095.1
AF296124 mRNA Translation: AAG30413.1
AL359335 mRNA Translation: CAB94786.1
AL359336 mRNA Translation: CAB94787.1
AL122063 mRNA Translation: CAB59242.1
CCDSiCCDS12705.1
RefSeqiNP_056525.2, NM_015710.4

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119021, 166 interactors
IntActiQ9NZM5, 112 interactors
MINTiQ9NZM5
STRINGi9606.ENSP00000246802

PTM databases

iPTMnetiQ9NZM5
PhosphoSitePlusiQ9NZM5

Polymorphism and mutation databases

BioMutaiNOP53
DMDMi93141272

2D gel databases

SWISS-2DPAGEiQ9NZM5

Proteomic databases

EPDiQ9NZM5
jPOSTiQ9NZM5
MassIVEiQ9NZM5
MaxQBiQ9NZM5
PaxDbiQ9NZM5
PeptideAtlasiQ9NZM5
PRIDEiQ9NZM5
ProteomicsDBi83451

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
29997

Genome annotation databases

EnsembliENST00000246802; ENSP00000246802; ENSG00000105373
GeneIDi29997
KEGGihsa:29997
UCSCiuc002phm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29997
DisGeNETi29997

GeneCards: human genes, protein and diseases

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GeneCardsi
NOP53
HGNCiHGNC:4333 NOP53
HPAiHPA018999
HPA049600
MIMi605691 gene
neXtProtiNX_Q9NZM5
OpenTargetsiENSG00000105373
PharmGKBiPA28736

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2823 Eukaryota
ENOG4111GSN LUCA
GeneTreeiENSGT00390000017267
HOGENOMiHOG000070127
InParanoidiQ9NZM5
KOiK14840
OMAiKSAWRKT
OrthoDBi1025498at2759
PhylomeDBiQ9NZM5
TreeFamiTF313004

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GLTSCR2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GLTSCR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29997
PharosiQ9NZM5

Protein Ontology

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PROi
PR:Q9NZM5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105373 Expressed in 230 organ(s), highest expression level in mammary gland
ExpressionAtlasiQ9NZM5 baseline and differential
GenevisibleiQ9NZM5 HS

Family and domain databases

InterProiView protein in InterPro
IPR011687 Nop53/GLTSCR2
PANTHERiPTHR14211 PTHR14211, 1 hit
PfamiView protein in Pfam
PF07767 Nop53, 1 hit
PIRSFiPIRSF017302 Gltscr2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOP53_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZM5
Secondary accession number(s): Q9BTC6
, Q9HAX6, Q9NPP1, Q9NPR4, Q9UFI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 18, 2006
Last modified: November 13, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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