UniProtKB - Q9NZM4 (BICRA_HUMAN)
BRD4-interacting chromatin-remodeling complex-associated protein
BICRA
Functioni
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
May play a role in BRD4-mediated gene transcription (PubMed:21555454).
2 PublicationsGO - Molecular functioni
- transcription regulator activator activity Source: UniProtKB
GO - Biological processi
- chromatin remodeling Source: ComplexPortal
- negative regulation of cell differentiation Source: ComplexPortal
- positive regulation of cell population proliferation Source: ComplexPortal
- positive regulation of stem cell population maintenance Source: ComplexPortal
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: ComplexPortal
Enzyme and pathway databases
PathwayCommonsi | Q9NZM4 |
SignaLinki | Q9NZM4 |
Names & Taxonomyi
Protein namesi | Recommended name: BRD4-interacting chromatin-remodeling complex-associated proteinCuratedAlternative name(s): Glioma tumor suppressor candidate region gene 1 proteinImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4332, BICRA |
MIMi | 605690, gene |
neXtProti | NX_Q9NZM4 |
VEuPathDBi | HostDB:ENSG00000063169 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- GBAF complex Source: ComplexPortal
- nucleus Source: UniProtKB
- SWI/SNF complex Source: UniProtKB
Other locations
- chromatin Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Coffin-Siris syndrome 12 (CSS12)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085989 | 64 | E → D in CSS12; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_085990 | 665 – 1560 | Missing in CSS12. 1 PublicationAdd BLAST | 896 | |
Natural variantiVAR_085991 | 1423 | E → K in CSS12; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_085992 | 1457 – 1560 | Missing in CSS12. 1 PublicationAdd BLAST | 104 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 29998 |
MalaCardsi | BICRA |
MIMi | 619325, phenotype |
OpenTargetsi | ENSG00000063169 |
PharmGKBi | PA28735 |
Miscellaneous databases
Pharosi | Q9NZM4, Tbio |
Genetic variation databases
BioMutai | BICRA |
DMDMi | 215273990 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083864 | 1 – 1560 | BRD4-interacting chromatin-remodeling complex-associated proteinAdd BLAST | 1560 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 919 | PhosphoserineCombined sources | 1 | |
Modified residuei | 921 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1057 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 1313 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1413 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NZM4 |
jPOSTi | Q9NZM4 |
MassIVEi | Q9NZM4 |
MaxQBi | Q9NZM4 |
PaxDbi | Q9NZM4 |
PeptideAtlasi | Q9NZM4 |
PRIDEi | Q9NZM4 |
ProteomicsDBi | 83449 [Q9NZM4-1] 83450 [Q9NZM4-2] |
PTM databases
GlyGeni | Q9NZM4, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9NZM4 |
PhosphoSitePlusi | Q9NZM4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000063169, Expressed in cerebral cortex and 234 other tissues |
ExpressionAtlasi | Q9NZM4, baseline and differential |
Genevisiblei | Q9NZM4, HS |
Organism-specific databases
HPAi | ENSG00000063169, Low tissue specificity |
Interactioni
Subunit structurei
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific.
Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).
Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:21555454).
2 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 119022, 50 interactors |
ComplexPortali | CPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant |
IntActi | Q9NZM4, 27 interactors |
MINTi | Q9NZM4 |
STRINGi | 9606.ENSP00000379946 |
Miscellaneous databases
RNActi | Q9NZM4, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9NZM4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 99 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 624 – 688 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 723 – 949 | DisorderedSequence analysisAdd BLAST | 227 | |
Regioni | 974 – 1028 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 1049 – 1075 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1215 – 1300 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 1324 – 1424 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 1440 – 1560 | DisorderedSequence analysisAdd BLAST | 121 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 646 – 665 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 753 – 767 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 787 – 831 | Pro residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 845 – 881 | Pro residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 882 – 914 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 915 – 945 | Pro residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 979 – 1011 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1012 – 1026 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1259 – 1281 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1329 – 1361 | Pro residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1482 – 1517 | Polar residuesSequence analysisAdd BLAST | 36 |
Phylogenomic databases
eggNOGi | ENOG502QU2K, Eukaryota |
GeneTreei | ENSGT00940000159112 |
HOGENOMi | CLU_002283_0_0_1 |
InParanoidi | Q9NZM4 |
OMAi | WVGQSHS |
OrthoDBi | 352636at2759 |
PhylomeDBi | Q9NZM4 |
TreeFami | TF335495 |
Family and domain databases
InterProi | View protein in InterPro IPR038842, BICRA IPR015671, GSCR1_dom |
PANTHERi | PTHR15572:SF1, PTHR15572:SF1, 1 hit |
Pfami | View protein in Pfam PF15249, GLTSCR1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG
60 70 80 90 100
LHVQEASGNH LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP
110 120 130 140 150
CDILQQSLQE ANITEQTLEA EAELDLGPFQ LPTLQPADGG AGPTGAGGAA
160 170 180 190 200
AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA LVPPQDVVNK ALSVQPFLQP
210 220 230 240 250
VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ PVMALNTPTS
260 270 280 290 300
QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT
310 320 330 340 350
LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP
360 370 380 390 400
IQPKPAGVLP PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM
410 420 430 440 450
AAGKAGQNVV LSGFPAPALQ ANVFKQPPAT TTGAAPPQPP GALSKPMSVH
460 470 480 490 500
LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV QLPQQLSALP ANVGGQILAA
510 520 530 540 550
AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH ILSAAPIQVG
560 570 580 590 600
QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD
610 620 630 640 650
GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA
660 670 680 690 700
PTPQAAAPPQ ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL
710 720 730 740 750
PQERSQQPLS AEGPHLSVPA SVIVSAPPPA QDPAPATPVA KGAGLGPQAP
760 770 780 790 800
DSQASPAPAP QIPAAAPLKG PGPSSSPSLP HQAPLGDSPH LPSPHPTRPP
810 820 830 840 850
SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ LGVPPPASNP
860 870 880 890 900
APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA
910 920 930 940 950
PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF
960 970 980 990 1000
PALPQPKALL ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL
1010 1020 1030 1040 1050
VSGQAPSGTP TAPSHAPAPA PMAATGLPPL LPAENKAFAS NLPTLNVAKA
1060 1070 1080 1090 1100
ASSGPGKPSG LQYESKLSGL KKPPTLQPSK EACFLEHLHK HQGSVLHPDY
1110 1120 1130 1140 1150
KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV STQLLKRTQA
1160 1170 1180 1190 1200
MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE
1210 1220 1230 1240 1250
YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH
1260 1270 1280 1290 1300
GGAGGSPSVT WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY
1310 1320 1330 1340 1350
EARSRIGLKL KIKQEAGLSK VVHNTALDPV HQPPPPPATL KVAEPPPRPP
1360 1370 1380 1390 1400
PPPPPTGQMN GTVDHPPPAA PERKPLGTAP HCPRLPLRKT YRENVGGPGA
1410 1420 1430 1440 1450
PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY QRMLKGPPPE
1460 1470 1480 1490 1500
PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH
1510 1520 1530 1540 1550
LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN
1560
GGLGARTLTR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QYC3 | M0QYC3_HUMAN | BRD4-interacting chromatin-remodeli... | BICRA | 126 | Annotation score: | ||
A0A087WWH3 | A0A087WWH3_HUMAN | BRD4-interacting chromatin-remodeli... | BICRA | 1,508 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085989 | 64 | E → D in CSS12; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_085990 | 665 – 1560 | Missing in CSS12. 1 PublicationAdd BLAST | 896 | |
Natural variantiVAR_061663 | 683 | P → S. Corresponds to variant dbSNP:rs3745762Ensembl. | 1 | |
Natural variantiVAR_059665 | 1044 | T → A. Corresponds to variant dbSNP:rs13346368Ensembl. | 1 | |
Natural variantiVAR_085991 | 1423 | E → K in CSS12; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_085992 | 1457 – 1560 | Missing in CSS12. 1 PublicationAdd BLAST | 104 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035776 | 1 – 242 | Missing in isoform 2. 1 PublicationAdd BLAST | 242 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182077 mRNA Translation: AAF62874.1 Different initiation. AC008985 Genomic DNA No translation available. AC010519 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57504.1 BC032065 mRNA No translation available. |
CCDSi | CCDS46134.1 [Q9NZM4-1] |
RefSeqi | NP_056526.3, NM_015711.3 [Q9NZM4-1] XP_005258890.1, XM_005258833.4 [Q9NZM4-1] |
Genome annotation databases
Ensembli | ENST00000396720.7; ENSP00000379946.2; ENSG00000063169.12 ENST00000594866.3; ENSP00000469738.2; ENSG00000063169.12 ENST00000614245.2; ENSP00000480219.2; ENSG00000063169.12 [Q9NZM4-2] |
GeneIDi | 29998 |
KEGGi | hsa:29998 |
MANE-Selecti | ENST00000594866.3; ENSP00000469738.2; NM_001394372.1; NP_001381301.1 |
UCSCi | uc002phh.4, human [Q9NZM4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182077 mRNA Translation: AAF62874.1 Different initiation. AC008985 Genomic DNA No translation available. AC010519 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57504.1 BC032065 mRNA No translation available. |
CCDSi | CCDS46134.1 [Q9NZM4-1] |
RefSeqi | NP_056526.3, NM_015711.3 [Q9NZM4-1] XP_005258890.1, XM_005258833.4 [Q9NZM4-1] |
3D structure databases
AlphaFoldDBi | Q9NZM4 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119022, 50 interactors |
ComplexPortali | CPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant |
IntActi | Q9NZM4, 27 interactors |
MINTi | Q9NZM4 |
STRINGi | 9606.ENSP00000379946 |
PTM databases
GlyGeni | Q9NZM4, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9NZM4 |
PhosphoSitePlusi | Q9NZM4 |
Genetic variation databases
BioMutai | BICRA |
DMDMi | 215273990 |
Proteomic databases
EPDi | Q9NZM4 |
jPOSTi | Q9NZM4 |
MassIVEi | Q9NZM4 |
MaxQBi | Q9NZM4 |
PaxDbi | Q9NZM4 |
PeptideAtlasi | Q9NZM4 |
PRIDEi | Q9NZM4 |
ProteomicsDBi | 83449 [Q9NZM4-1] 83450 [Q9NZM4-2] |
Protocols and materials databases
Antibodypediai | 65070, 78 antibodies from 18 providers |
DNASUi | 29998 |
Genome annotation databases
Ensembli | ENST00000396720.7; ENSP00000379946.2; ENSG00000063169.12 ENST00000594866.3; ENSP00000469738.2; ENSG00000063169.12 ENST00000614245.2; ENSP00000480219.2; ENSG00000063169.12 [Q9NZM4-2] |
GeneIDi | 29998 |
KEGGi | hsa:29998 |
MANE-Selecti | ENST00000594866.3; ENSP00000469738.2; NM_001394372.1; NP_001381301.1 |
UCSCi | uc002phh.4, human [Q9NZM4-1] |
Organism-specific databases
CTDi | 29998 |
DisGeNETi | 29998 |
GeneCardsi | BICRA |
HGNCi | HGNC:4332, BICRA |
HPAi | ENSG00000063169, Low tissue specificity |
MalaCardsi | BICRA |
MIMi | 605690, gene 619325, phenotype |
neXtProti | NX_Q9NZM4 |
OpenTargetsi | ENSG00000063169 |
PharmGKBi | PA28735 |
VEuPathDBi | HostDB:ENSG00000063169 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU2K, Eukaryota |
GeneTreei | ENSGT00940000159112 |
HOGENOMi | CLU_002283_0_0_1 |
InParanoidi | Q9NZM4 |
OMAi | WVGQSHS |
OrthoDBi | 352636at2759 |
PhylomeDBi | Q9NZM4 |
TreeFami | TF335495 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZM4 |
SignaLinki | Q9NZM4 |
Miscellaneous databases
BioGRID-ORCSi | 29998, 28 hits in 1086 CRISPR screens |
ChiTaRSi | BICRA, human |
GenomeRNAii | 29998 |
Pharosi | Q9NZM4, Tbio |
PROi | PR:Q9NZM4 |
RNActi | Q9NZM4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000063169, Expressed in cerebral cortex and 234 other tissues |
ExpressionAtlasi | Q9NZM4, baseline and differential |
Genevisiblei | Q9NZM4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038842, BICRA IPR015671, GSCR1_dom |
PANTHERi | PTHR15572:SF1, PTHR15572:SF1, 1 hit |
Pfami | View protein in Pfam PF15249, GLTSCR1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BICRA_HUMAN | |
Accessioni | Q9NZM4Primary (citable) accession number: Q9NZM4 Secondary accession number(s): A8MW01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot