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UniProtKB - Q9NZM4 (BICRA_HUMAN)

Entry version 139 (25 May 2022)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
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Protein

BRD4-interacting chromatin-remodeling complex-associated protein

Gene

BICRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).

May play a role in BRD4-mediated gene transcription (PubMed:21555454).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription regulator activator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZM4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NZM4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BRD4-interacting chromatin-remodeling complex-associated proteinCurated
Alternative name(s):
Glioma tumor suppressor candidate region gene 1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BICRAImported
Synonyms:GLTSCR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4332, BICRA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605690, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZM4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000063169

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coffin-Siris syndrome 12 (CSS12)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. CSS12 is an autosomal dominant form characterized by global developmental delay with variably impaired intellectual development, speech and language delay, and behavioral abnormalities, such as autism or hyperactivity. Most CSS12 patients do not have the classic hypoplastic fifth digit/nail abnormalities that are often observed in other forms the disease.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08598964E → D in CSS12; unknown pathological significance. 1 Publication1
Natural variantiVAR_085990665 – 1560Missing in CSS12. 1 PublicationAdd BLAST896
Natural variantiVAR_0859911423E → K in CSS12; unknown pathological significance. 1 Publication1
Natural variantiVAR_0859921457 – 1560Missing in CSS12. 1 PublicationAdd BLAST104

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		29998

MalaCards human disease database

More...MalaCardsi		BICRA
MIMi619325, phenotype

Open Targets

More...OpenTargetsi		ENSG00000063169

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28735

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZM4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BICRA

Domain mapping of disease mutations (DMDM)

More...DMDMi		215273990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000838641 – 1560BRD4-interacting chromatin-remodeling complex-associated proteinAdd BLAST1560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei919PhosphoserineCombined sources1
Modified residuei921PhosphothreonineCombined sources1
Modified residuei1057N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZM4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZM4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZM4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZM4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZM4

PeptideAtlas

More...PeptideAtlasi		Q9NZM4

PRoteomics IDEntifications database

More...PRIDEi		Q9NZM4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83449 [Q9NZM4-1]
83450 [Q9NZM4-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZM4, 3 sites, 2 O-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000063169, Expressed in cerebral cortex and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZM4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZM4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000063169, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific.

Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).

Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:21555454).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119022, 50 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant
CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant
CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant
CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant

Protein interaction database and analysis system

More...IntActi		Q9NZM4, 27 interactors

Molecular INTeraction database

More...MINTi		Q9NZM4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379946

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZM4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NZM4

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 99DisorderedSequence analysisAdd BLAST47
Regioni624 – 688DisorderedSequence analysisAdd BLAST65
Regioni723 – 949DisorderedSequence analysisAdd BLAST227
Regioni974 – 1028DisorderedSequence analysisAdd BLAST55
Regioni1049 – 1075DisorderedSequence analysisAdd BLAST27
Regioni1215 – 1300DisorderedSequence analysisAdd BLAST86
Regioni1324 – 1424DisorderedSequence analysisAdd BLAST101
Regioni1440 – 1560DisorderedSequence analysisAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi646 – 665Pro residuesSequence analysisAdd BLAST20
Compositional biasi753 – 767Pro residuesSequence analysisAdd BLAST15
Compositional biasi787 – 831Pro residuesSequence analysisAdd BLAST45
Compositional biasi845 – 881Pro residuesSequence analysisAdd BLAST37
Compositional biasi882 – 914Polar residuesSequence analysisAdd BLAST33
Compositional biasi915 – 945Pro residuesSequence analysisAdd BLAST31
Compositional biasi979 – 1011Polar residuesSequence analysisAdd BLAST33
Compositional biasi1012 – 1026Pro residuesSequence analysisAdd BLAST15
Compositional biasi1259 – 1281Polar residuesSequence analysisAdd BLAST23
Compositional biasi1329 – 1361Pro residuesSequence analysisAdd BLAST33
Compositional biasi1482 – 1517Polar residuesSequence analysisAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QU2K, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002283_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZM4

Identification of Orthologs from Complete Genome Data

More...OMAi		WVGQSHS

Database of Orthologous Groups

More...OrthoDBi		352636at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZM4

TreeFam database of animal gene trees

More...TreeFami		TF335495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038842, BICRA
IPR015671, GSCR1_dom

The PANTHER Classification System

More...PANTHERi		PTHR15572:SF1, PTHR15572:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15249, GLTSCR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG 
        60         70         80         90        100
LHVQEASGNH LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP 
       110        120        130        140        150
CDILQQSLQE ANITEQTLEA EAELDLGPFQ LPTLQPADGG AGPTGAGGAA 
       160        170        180        190        200
AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA LVPPQDVVNK ALSVQPFLQP 
       210        220        230        240        250
VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ PVMALNTPTS 
       260        270        280        290        300
QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT 
       310        320        330        340        350
LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP 
       360        370        380        390        400
IQPKPAGVLP PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM 
       410        420        430        440        450
AAGKAGQNVV LSGFPAPALQ ANVFKQPPAT TTGAAPPQPP GALSKPMSVH 
       460        470        480        490        500
LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV QLPQQLSALP ANVGGQILAA 
       510        520        530        540        550
AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH ILSAAPIQVG 
       560        570        580        590        600
QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD 
       610        620        630        640        650
GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA 
       660        670        680        690        700
PTPQAAAPPQ ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL 
       710        720        730        740        750
PQERSQQPLS AEGPHLSVPA SVIVSAPPPA QDPAPATPVA KGAGLGPQAP 
       760        770        780        790        800
DSQASPAPAP QIPAAAPLKG PGPSSSPSLP HQAPLGDSPH LPSPHPTRPP 
       810        820        830        840        850
SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ LGVPPPASNP 
       860        870        880        890        900
APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA 
       910        920        930        940        950
PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF 
       960        970        980        990       1000
PALPQPKALL ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL 
      1010       1020       1030       1040       1050
VSGQAPSGTP TAPSHAPAPA PMAATGLPPL LPAENKAFAS NLPTLNVAKA 
      1060       1070       1080       1090       1100
ASSGPGKPSG LQYESKLSGL KKPPTLQPSK EACFLEHLHK HQGSVLHPDY 
      1110       1120       1130       1140       1150
KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV STQLLKRTQA 
      1160       1170       1180       1190       1200
MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE 
      1210       1220       1230       1240       1250
YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH 
      1260       1270       1280       1290       1300
GGAGGSPSVT WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY 
      1310       1320       1330       1340       1350
EARSRIGLKL KIKQEAGLSK VVHNTALDPV HQPPPPPATL KVAEPPPRPP 
      1360       1370       1380       1390       1400
PPPPPTGQMN GTVDHPPPAA PERKPLGTAP HCPRLPLRKT YRENVGGPGA 
      1410       1420       1430       1440       1450
PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY QRMLKGPPPE 
      1460       1470       1480       1490       1500
PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH 
      1510       1520       1530       1540       1550
LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN 
      1560
GGLGARTLTR
Length:1,560
Mass (Da):158,490
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32453B35C9219462
GO
Isoform 2 (identifier: Q9NZM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Show »
Length:1,318
Mass (Da):134,207
Checksum:i18A75F49F76AAE0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYC3M0QYC3_HUMAN
BRD4-interacting chromatin-remodeli...
BICRA
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWH3A0A087WWH3_HUMAN
BRD4-interacting chromatin-remodeli...
BICRA
1,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF62874 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08598964E → D in CSS12; unknown pathological significance. 1 Publication1
Natural variantiVAR_085990665 – 1560Missing in CSS12. 1 PublicationAdd BLAST896
Natural variantiVAR_061663683P → S. Corresponds to variant dbSNP:rs3745762Ensembl.1
Natural variantiVAR_0596651044T → A. Corresponds to variant dbSNP:rs13346368Ensembl.1
Natural variantiVAR_0859911423E → K in CSS12; unknown pathological significance. 1 Publication1
Natural variantiVAR_0859921457 – 1560Missing in CSS12. 1 PublicationAdd BLAST104

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357761 – 242Missing in isoform 2. 1 PublicationAdd BLAST242

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF182077 mRNA Translation: AAF62874.1 Different initiation.
AC008985 Genomic DNA No translation available.
AC010519 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57504.1
BC032065 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46134.1 [Q9NZM4-1]

NCBI Reference Sequences

More...RefSeqi		NP_056526.3, NM_015711.3 [Q9NZM4-1]
XP_005258890.1, XM_005258833.4 [Q9NZM4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396720.7; ENSP00000379946.2; ENSG00000063169.12
ENST00000594866.3; ENSP00000469738.2; ENSG00000063169.12
ENST00000614245.2; ENSP00000480219.2; ENSG00000063169.12 [Q9NZM4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29998

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000594866.3; ENSP00000469738.2; NM_001394372.1; NP_001381301.1

UCSC genome browser

More...UCSCi		uc002phh.4, human [Q9NZM4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182077 mRNA Translation: AAF62874.1 Different initiation.
AC008985 Genomic DNA No translation available.
AC010519 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57504.1
BC032065 mRNA No translation available.
CCDSiCCDS46134.1 [Q9NZM4-1]
RefSeqiNP_056526.3, NM_015711.3 [Q9NZM4-1]
XP_005258890.1, XM_005258833.4 [Q9NZM4-1]

3D structure databases

AlphaFoldDBiQ9NZM4
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi119022, 50 interactors
ComplexPortaliCPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant
CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant
CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant
CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant
IntActiQ9NZM4, 27 interactors
MINTiQ9NZM4
STRINGi9606.ENSP00000379946

PTM databases

GlyGeniQ9NZM4, 3 sites, 2 O-linked glycans (3 sites)
iPTMnetiQ9NZM4
PhosphoSitePlusiQ9NZM4

Genetic variation databases

BioMutaiBICRA
DMDMi215273990

Proteomic databases

EPDiQ9NZM4
jPOSTiQ9NZM4
MassIVEiQ9NZM4
MaxQBiQ9NZM4
PaxDbiQ9NZM4
PeptideAtlasiQ9NZM4
PRIDEiQ9NZM4
ProteomicsDBi83449 [Q9NZM4-1]
83450 [Q9NZM4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65070, 78 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		29998

Genome annotation databases

EnsembliENST00000396720.7; ENSP00000379946.2; ENSG00000063169.12
ENST00000594866.3; ENSP00000469738.2; ENSG00000063169.12
ENST00000614245.2; ENSP00000480219.2; ENSG00000063169.12 [Q9NZM4-2]
GeneIDi29998
KEGGihsa:29998
MANE-SelectiENST00000594866.3; ENSP00000469738.2; NM_001394372.1; NP_001381301.1
UCSCiuc002phh.4, human [Q9NZM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29998
DisGeNETi29998

GeneCards: human genes, protein and diseases

More...GeneCardsi		BICRA
HGNCiHGNC:4332, BICRA
HPAiENSG00000063169, Low tissue specificity
MalaCardsiBICRA
MIMi605690, gene
619325, phenotype
neXtProtiNX_Q9NZM4
OpenTargetsiENSG00000063169
PharmGKBiPA28735
VEuPathDBiHostDB:ENSG00000063169

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QU2K, Eukaryota
GeneTreeiENSGT00940000159112
HOGENOMiCLU_002283_0_0_1
InParanoidiQ9NZM4
OMAiWVGQSHS
OrthoDBi352636at2759
PhylomeDBiQ9NZM4
TreeFamiTF335495

Enzyme and pathway databases

PathwayCommonsiQ9NZM4
SignaLinkiQ9NZM4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29998, 28 hits in 1086 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BICRA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29998
PharosiQ9NZM4, Tbio

Protein Ontology

More...PROi		PR:Q9NZM4
RNActiQ9NZM4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000063169, Expressed in cerebral cortex and 234 other tissues
ExpressionAtlasiQ9NZM4, baseline and differential
GenevisibleiQ9NZM4, HS

Family and domain databases

InterProiView protein in InterPro
IPR038842, BICRA
IPR015671, GSCR1_dom
PANTHERiPTHR15572:SF1, PTHR15572:SF1, 1 hit
PfamiView protein in Pfam
PF15249, GLTSCR1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBICRA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZM4
Secondary accession number(s): A8MW01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 25, 2008
Last modified: May 25, 2022
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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