Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 125 (18 Sep 2019)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

BRD4-interacting chromatin-remodeling complex-associated protein

Gene

BICRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BRD4-interacting chromatin-remodeling complex-associated proteinCurated
Alternative name(s):
Glioma tumor suppressor candidate region gene 1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BICRAImported
Synonyms:GLTSCR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4332 BICRA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605690 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZM4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29998

Open Targets

More...
OpenTargetsi
ENSG00000063169

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28735

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BICRA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000838641 – 1560BRD4-interacting chromatin-remodeling complex-associated proteinAdd BLAST1560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei919PhosphoserineCombined sources1
Modified residuei921PhosphothreonineCombined sources1
Modified residuei1057N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1413PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NZM4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZM4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NZM4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZM4

PeptideAtlas

More...
PeptideAtlasi
Q9NZM4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZM4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83449 [Q9NZM4-1]
83450 [Q9NZM4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000063169 Expressed in 221 organ(s), highest expression level in cerebral cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZM4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZM4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056211

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific.

Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).

Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:21555454).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1754943,EBI-389883

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119022, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant
CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant
CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant
CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant

Protein interaction database and analysis system

More...
IntActi
Q9NZM4, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379946

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi88 – 96Poly-Gly9
Compositional biasi935 – 940Poly-Pro6
Compositional biasi1265 – 1276Poly-SerAdd BLAST12
Compositional biasi1333 – 1337Poly-Pro5
Compositional biasi1345 – 1355Poly-ProAdd BLAST11

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIYC Eukaryota
ENOG41126SK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112824

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNIMLQA

Database of Orthologous Groups

More...
OrthoDBi
352636at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZM4

TreeFam database of animal gene trees

More...
TreeFami
TF335495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038842 BICRA
IPR015671 GSCR1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15572 PTHR15572, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15249 GLTSCR1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDEDGRCLL DVICDPQALN DFLHGSEKLD SDDLLDNPGE AQSAFYEGPG
60 70 80 90 100
LHVQEASGNH LNPEPNQPAP SVDLDFLEDD ILGSPATGGG GGGSGGADQP
110 120 130 140 150
CDILQQSLQE ANITEQTLEA EAELDLGPFQ LPTLQPADGG AGPTGAGGAA
160 170 180 190 200
AVAAGPQALF PGSTDLLGLQ GPPTVLTHQA LVPPQDVVNK ALSVQPFLQP
210 220 230 240 250
VGLGNVTLQP IPGLQGLPNG SPGGATAATL GLAPIQVVGQ PVMALNTPTS
260 270 280 290 300
QLLAKQVPVS GYLASAAGPS EPVTLASAGV SPQGAGLVIQ KNLSAAVATT
310 320 330 340 350
LNGNSVFGGA GAASAPTGTP SGQPLAVAPG LGSSPLVPAP NVILHRTPTP
360 370 380 390 400
IQPKPAGVLP PKLYQLTPKP FAPAGATLTI QGEPGALPQQ PKAPQNLTFM
410 420 430 440 450
AAGKAGQNVV LSGFPAPALQ ANVFKQPPAT TTGAAPPQPP GALSKPMSVH
460 470 480 490 500
LLNQGSSIVI PAQHMLPGQN QFLLPGAPAV QLPQQLSALP ANVGGQILAA
510 520 530 540 550
AAPHTGGQLI ANPILTNQNL AGPLSLGPVL APHSGAHSAH ILSAAPIQVG
560 570 580 590 600
QPALFQMPVS LAAGSLPTQS QPAPAGPAAT TVLQGVTLPP SAVAMLNTPD
610 620 630 640 650
GLVQPATPAA ATGEAAPVLT VQPAPQAPPA VSTPLPLGLQ QPQAQQPPQA
660 670 680 690 700
PTPQAAAPPQ ATTPQPSPGL ASSPEKIVLG QPPSATPTAI LTQDSLQMFL
710 720 730 740 750
PQERSQQPLS AEGPHLSVPA SVIVSAPPPA QDPAPATPVA KGAGLGPQAP
760 770 780 790 800
DSQASPAPAP QIPAAAPLKG PGPSSSPSLP HQAPLGDSPH LPSPHPTRPP
810 820 830 840 850
SRPPSRPQSV SRPPSEPPLH PCPPPQAPPT LPGIFVIQNQ LGVPPPASNP
860 870 880 890 900
APTAPGPPQP PLRPQSQPPE GPLPPAPHLP PSSTSSAVAS SSETSSRLPA
910 920 930 940 950
PTPSDFQLQF PPSQGPHKSP TPPPTLHLVP EPAAPPPPPP RTFQMVTTPF
960 970 980 990 1000
PALPQPKALL ERFHQVPSGI ILQNKAGGAP AAPQTSTSLG PLTSPAASVL
1010 1020 1030 1040 1050
VSGQAPSGTP TAPSHAPAPA PMAATGLPPL LPAENKAFAS NLPTLNVAKA
1060 1070 1080 1090 1100
ASSGPGKPSG LQYESKLSGL KKPPTLQPSK EACFLEHLHK HQGSVLHPDY
1110 1120 1130 1140 1150
KTAFPSFEDA LHRLLPYHVY QGALPSPSDY HKVDEEFETV STQLLKRTQA
1160 1170 1180 1190 1200
MLNKYRLLLL EESRRVSPSA EMVMIDRMFI QEEKTTLALD KQLAKEKPDE
1210 1220 1230 1240 1250
YVSSSRSLGL PIAASSEGHR LPGHGPLSSS APGASTQPPP HLPTKLVIRH
1260 1270 1280 1290 1300
GGAGGSPSVT WARASSSLSS SSSSSSAASS LDADEDGPMP SRNRPPIKTY
1310 1320 1330 1340 1350
EARSRIGLKL KIKQEAGLSK VVHNTALDPV HQPPPPPATL KVAEPPPRPP
1360 1370 1380 1390 1400
PPPPPTGQMN GTVDHPPPAA PERKPLGTAP HCPRLPLRKT YRENVGGPGA
1410 1420 1430 1440 1450
PEGTPAGRAR GGSPAPLPAK VDEATSGLIR ELAAVEDELY QRMLKGPPPE
1460 1470 1480 1490 1500
PAASAAQGTG DPDWEAPGLP PAKRRKSESP DVDQASFSSD SPQDDTLTEH
1510 1520 1530 1540 1550
LQSAIDSILN LQQAPGRTPA PSYPHAASAG TPASPPPLHR PEAYPPSSHN
1560
GGLGARTLTR
Note: No experimental confirmation available.
Length:1,560
Mass (Da):158,490
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32453B35C9219462
GO
Isoform 2 (identifier: Q9NZM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Note: No experimental confirmation available.
Show »
Length:1,318
Mass (Da):134,207
Checksum:i18A75F49F76AAE0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWH3A0A087WWH3_HUMAN
BRD4-interacting chromatin-remodeli...
BICRA
1,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYC3M0QYC3_HUMAN
BRD4-interacting chromatin-remodeli...
BICRA
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF62874 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061663683P → S. Corresponds to variant dbSNP:rs3745762Ensembl.1
Natural variantiVAR_0596651044T → A. Corresponds to variant dbSNP:rs13346368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357761 – 242Missing in isoform 2. 1 PublicationAdd BLAST242

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF182077 mRNA Translation: AAF62874.1 Different initiation.
AC008985 Genomic DNA No translation available.
AC010519 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57504.1
BC032065 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46134.1 [Q9NZM4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_056526.3, NM_015711.3 [Q9NZM4-1]
XP_005258890.1, XM_005258833.4 [Q9NZM4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396720; ENSP00000379946; ENSG00000063169 [Q9NZM4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29998

UCSC genome browser

More...
UCSCi
uc002phh.4 human [Q9NZM4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182077 mRNA Translation: AAF62874.1 Different initiation.
AC008985 Genomic DNA No translation available.
AC010519 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57504.1
BC032065 mRNA No translation available.
CCDSiCCDS46134.1 [Q9NZM4-1]
RefSeqiNP_056526.3, NM_015711.3 [Q9NZM4-1]
XP_005258890.1, XM_005258833.4 [Q9NZM4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119022, 11 interactors
ComplexPortaliCPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant
CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant
CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant
CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant
IntActiQ9NZM4, 16 interactors
STRINGi9606.ENSP00000379946

PTM databases

iPTMnetiQ9NZM4
PhosphoSitePlusiQ9NZM4

Polymorphism and mutation databases

BioMutaiBICRA
DMDMi215273990

Proteomic databases

EPDiQ9NZM4
jPOSTiQ9NZM4
MassIVEiQ9NZM4
MaxQBiQ9NZM4
PaxDbiQ9NZM4
PeptideAtlasiQ9NZM4
PRIDEiQ9NZM4
ProteomicsDBi83449 [Q9NZM4-1]
83450 [Q9NZM4-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396720; ENSP00000379946; ENSG00000063169 [Q9NZM4-1]
GeneIDi29998
KEGGihsa:29998
UCSCiuc002phh.4 human [Q9NZM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29998
DisGeNETi29998

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BICRA
HGNCiHGNC:4332 BICRA
HPAiHPA056211
MIMi605690 gene
neXtProtiNX_Q9NZM4
OpenTargetsiENSG00000063169
PharmGKBiPA28735

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIYC Eukaryota
ENOG41126SK LUCA
GeneTreeiENSGT00940000159112
HOGENOMiHOG000112824
InParanoidiQ9NZM4
OMAiQNIMLQA
OrthoDBi352636at2759
PhylomeDBiQ9NZM4
TreeFamiTF335495

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GLTSCR1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29998

Pharos

More...
Pharosi
Q9NZM4

Protein Ontology

More...
PROi
PR:Q9NZM4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000063169 Expressed in 221 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9NZM4 baseline and differential
GenevisibleiQ9NZM4 HS

Family and domain databases

InterProiView protein in InterPro
IPR038842 BICRA
IPR015671 GSCR1_dom
PANTHERiPTHR15572 PTHR15572, 1 hit
PfamiView protein in Pfam
PF15249 GLTSCR1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBICRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZM4
Secondary accession number(s): A8MW01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 25, 2008
Last modified: September 18, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again