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Protein

Intersectin-2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).3 Publications

Miscellaneous

Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated
Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2 suggesting a partially overlapping role of the EH domain-containing proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi67 – 79PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processDifferentiation, Endocytosis, Host-virus interaction
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Intersectin-2
Alternative name(s):
SH3 domain-containing protein 1B
SH3P18
SH3P18-like WASP-associated protein
Gene namesi
Name:ITSN2
Synonyms:KIAA1256, SH3D1B, SWAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000198399.14
HGNCiHGNC:6184 ITSN2
MIMi604464 gene
neXtProtiNX_Q9NZM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi50618
OpenTargetsiENSG00000198399
PharmGKBiPA29982

Polymorphism and mutation databases

BioMutaiITSN2
DMDMi294862505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809611 – 1697Intersectin-2Add BLAST1697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei553PhosphotyrosineBy similarity1
Modified residuei573PhosphothreonineCombined sources1
Modified residuei882PhosphothreonineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei968PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZM3
MaxQBiQ9NZM3
PaxDbiQ9NZM3
PeptideAtlasiQ9NZM3
PRIDEiQ9NZM3
ProteomicsDBi83445
83446 [Q9NZM3-2]
83447 [Q9NZM3-3]
83448 [Q9NZM3-4]

PTM databases

CarbonylDBiQ9NZM3
iPTMnetiQ9NZM3
PhosphoSitePlusiQ9NZM3

Expressioni

Tissue specificityi

Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.1 Publication

Gene expression databases

BgeeiENSG00000198399 Expressed in 236 organ(s), highest expression level in visceral pleura
CleanExiHS_ITSN2
ExpressionAtlasiQ9NZM3 baseline and differential
GenevisibleiQ9NZM3 HS

Organism-specific databases

HPAiHPA036475

Interactioni

Subunit structurei

Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process. Interacts with ADAM15. Interacts with FASLG. Interacts with ANKRD54 (By similarity). Interacts with FCHO2.By similarity3 Publications
(Microbial infection) Interacts with herpes virus 8 protein K15.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
K15-MQ9WNA92EBI-308689,EBI-7555439From Human herpesvirus 8.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119098, 93 interactors
IntActiQ9NZM3, 37 interactors
MINTiQ9NZM3
STRINGi9606.ENSP00000347244

Structurei

Secondary structure

11697
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZM3
SMRiQ9NZM3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZM3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 110EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini54 – 89EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini244 – 333EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini757 – 818SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini898 – 956SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini981 – 1039SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1053 – 1117SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1127 – 1186SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1209 – 1395DHPROSITE-ProRule annotationAdd BLAST187
Domaini1434 – 1544PHPROSITE-ProRule annotationAdd BLAST111
Domaini1556 – 1652C2PROSITE-ProRule annotationAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili361 – 756Sequence analysisAdd BLAST396

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1029 Eukaryota
KOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000118985
HOVERGENiHBG052159
InParanoidiQ9NZM3
KOiK20045
OMAiTTPAFHP
OrthoDBiEOG091G0TXR
PhylomeDBiQ9NZM3
TreeFamiTF324293

Family and domain databases

CDDicd00052 EH, 2 hits
cd00160 RhoGEF, 1 hit
cd11988 SH3_Intersectin2_1, 1 hit
cd11990 SH3_Intersectin2_2, 1 hit
cd11992 SH3_Intersectin2_3, 1 hit
cd11994 SH3_Intersectin2_4, 1 hit
cd11996 SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR027029 Intersectin-2
IPR035737 Intersectin-2_SH3_1
IPR035738 Intersectin-2_SH3_2
IPR035739 Intersectin-2_SH3_3
IPR035740 Intersectin-2_SH3_4
IPR035741 Intersectin-2_SH3_5
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR11216:SF29 PTHR11216:SF29, 3 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12763 EF-hand_4, 2 hits
PF16652 PH_13, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 2 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00027 EH, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50010 DH_2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS50031 EH, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 5 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZM3-1) [UniParc]FASTAAdd to basket
Also known as: ITSN2-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIPQP LPPAAPITSL SSATSGTNLP
160 170 180 190 200
PLMMPTPLVP SVSTSSLPNG TASLIQPLPI PYSSSTLPHG SSYSLMMGGF
210 220 230 240 250
GGASIQKAQS LIDLGSSSST SSTASLSGNS PKTGTSEWAV PQPTRLKYRQ
260 270 280 290 300
KFNTLDKSMS GYLSGFQARN ALLQSNLSQT QLATIWTLAD VDGDGQLKAE
310 320 330 340 350
EFILAMHLTD MAKAGQPLPL TLPPELVPPS FRGGKQIDSI NGTLPSYQKM
360 370 380 390 400
QEEEPQKKLP VTFEDKRKAN YERGNMELEK RRQALMEQQQ REAERKAQKE
410 420 430 440 450
KEEWERKQRE LQEQEWKKQL ELEKRLEKQR ELERQREEER RKDIERREAA
460 470 480 490 500
KQELERQRRL EWERIRRQEL LNQKNREQEE IVRLNSKKKN LHLELEALNG
510 520 530 540 550
KHQQISGRLQ DVRLKKQTQK TELEVLDKQC DLEIMEIKQL QQELQEYQNK
560 570 580 590 600
LIYLVPEKQL LNERIKNMQF SNTPDSGVSL LHKKSLEKEE LCQRLKEQLD
610 620 630 640 650
ALEKETASKL SEMDSFNNQL KCGNMDDSVL QCLLSLLSCL NNLFLLLKEL
660 670 680 690 700
RETYNTQQLA LEQLYKIKRD KLKEIERKRL ELMQKKKLED EAARKAKQGK
710 720 730 740 750
ENLWKENLRK EEEEKQKRLQ EEKTQEKIQE EERKAEEKQR KDKDTLKAEE
760 770 780 790 800
KKRETASVLV NYRALYPFEA RNHDEMSFNS GDIIQVDEKT VGEPGWLYGS
810 820 830 840 850
FQGNFGWFPC NYVEKMPSSE NEKAVSPKKA LLPPTVSLSA TSTSSEPLSS
860 870 880 890 900
NQPASVTDYQ NVSFSNLTVN TSWQKKSAFT RTVSPGSVSP IHGQGQVVEN
910 920 930 940 950
LKAQALCSWT AKKDNHLNFS KHDIITVLEQ QENWWFGEVH GGRGWFPKSY
960 970 980 990 1000
VKIIPGSEVK REEPEALYAA VNKKPTSAAY SVGEEYIALY PYSSVEPGDL
1010 1020 1030 1040 1050
TFTEGEEILV TQKDGEWWTG SIGDRSGIFP SNYVKPKDQE SFGSASKSGA
1060 1070 1080 1090 1100
SNKKPEIAQV TSAYVASGSE QLSLAPGQLI LILKKNTSGW WQGELQARGK
1110 1120 1130 1140 1150
KRQKGWFPAS HVKLLGPSSE RATPAFHPVC QVIAMYDYAA NNEDELSFSK
1160 1170 1180 1190 1200
GQLINVMNKD DPDWWQGEIN GVTGLFPSNY VKMTTDSDPS QQWCADLQTL
1210 1220 1230 1240 1250
DTMQPIERKR QGYIHELIQT EERYMADLQL VVEVFQKRMA ESGFLTEGEM
1260 1270 1280 1290 1300
ALIFVNWKEL IMSNTKLLKA LRVRKKTGGE KMPVQMIGDI LAAELSHMQA
1310 1320 1330 1340 1350
YIRFCSCQLN GAALLQQKTD EDTDFKEFLK KLASDPRCKG MPLSSFLLKP
1360 1370 1380 1390 1400
MQRITRYPLL IRSILENTPE SHADHSSLKL ALERAEELCS QVNEGVREKE
1410 1420 1430 1440 1450
NSDRLEWIQA HVQCEGLAEQ LIFNSLTNCL GPRKLLHSGK LYKTKSNKEL
1460 1470 1480 1490 1500
HGFLFNDFLL LTYMVKQFAV SSGSEKLFSS KSNAQFKMYK TPIFLNEVLV
1510 1520 1530 1540 1550
KLPTDPSSDE PVFHISHIDR VYTLRTDNIN ERTAWVQKIK AASEQYIDTE
1560 1570 1580 1590 1600
KKKREKAYQA RSQKTSGIGR LMVHVIEATE LKACKPNGKS NPYCEISMGS
1610 1620 1630 1640 1650
QSYTTRTIQD TLNPKWNFNC QFFIKDLYQD VLCLTLFDRD QFSPDDFLGR
1660 1670 1680 1690
TEIPVAKIRT EQESKGPMTR RLLLHEVPTG EVWVRFDLQL FEQKTLL
Length:1,697
Mass (Da):193,461
Last modified:April 20, 2010 - v3
Checksum:i49C41AE1E32E1BD0
GO
Isoform 2 (identifier: Q9NZM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-648: Missing.

Show »
Length:1,670
Mass (Da):190,496
Checksum:i91E65C08E5AB26F1
GO
Isoform 3 (identifier: Q9NZM3-3) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S1

The sequence of this isoform differs from the canonical sequence as follows:
     1235-1249: FQKRMAESGFLTEGE → RRLLLASSRGICCLS
     1250-1697: Missing.

Show »
Length:1,249
Mass (Da):141,820
Checksum:i271797AF71A0EB28
GO
Isoform 4 (identifier: Q9NZM3-4) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S2, SH3P18

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1697: Missing.

Show »
Length:1,192
Mass (Da):135,144
Checksum:i2DA2049587CF4082
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVF7A0A087WVF7_HUMAN
Intersectin-2
ITSN2
1,680Annotation score:
E7EPJ2E7EPJ2_HUMAN
Intersectin-2
ITSN2
609Annotation score:
F8W719F8W719_HUMAN
Intersectin-2
ITSN2
183Annotation score:
H7BZD4H7BZD4_HUMAN
Intersectin-2
ITSN2
120Annotation score:
H7C0L8H7C0L8_HUMAN
Intersectin-2
ITSN2
55Annotation score:
H7C3E2H7C3E2_HUMAN
Intersectin-2
ITSN2
36Annotation score:

Sequence cautioni

The sequence AAF59903 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF59904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF63600 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA86570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti679R → G in BAB13841 (PubMed:14702039).Curated1
Sequence conflicti823 – 828KAVSPK → FAAAST in AAD00899 (Ref. 6) Curated6
Sequence conflicti945 – 951WFPKSYV → EFAAAST in AAC50593 (PubMed:9630982).Curated7
Sequence conflicti1279 – 1285GEKMPVQ → VDAAANS in AAD00899 (Ref. 6) Curated7
Sequence conflicti1553K → Q in AAF63600 (Ref. 2) Curated1
Sequence conflicti1553K → Q in BAA86570 (PubMed:10574462).Curated1
Isoform 3 (identifier: Q9NZM3-3)
Sequence conflicti1235R → W in AAF59904 (PubMed:10922467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024287254T → A. Corresponds to variant dbSNP:rs6744320Ensembl.1
Natural variantiVAR_024288291V → I1 PublicationCorresponds to variant dbSNP:rs7603997Ensembl.1
Natural variantiVAR_0201931287I → T. Corresponds to variant dbSNP:rs3731625Ensembl.1
Natural variantiVAR_0219371534A → T. Corresponds to variant dbSNP:rs2303291Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003892622 – 648Missing in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_0038951193 – 1697Missing in isoform 4. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0038931235 – 1249FQKRM…LTEGE → RRLLLASSRGICCLS in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0038941250 – 1697Missing in isoform 3. 1 PublicationAdd BLAST448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182198 mRNA Translation: AAF59903.1 Different initiation.
AF182199 mRNA Translation: AAF59904.1 Different initiation.
AF248540 mRNA Translation: AAF63600.1 Different initiation.
AB033082 mRNA Translation: BAA86570.1 Different initiation.
AC008073 Genomic DNA No translation available.
AC009228 Genomic DNA No translation available.
AK021545 mRNA Translation: BAB13841.1
AK000302 mRNA Translation: BAA91068.1
AF001630 mRNA Translation: AAD00899.1
U61167 mRNA Translation: AAC50593.1
CCDSiCCDS1710.2 [Q9NZM3-1]
CCDS1711.2 [Q9NZM3-2]
CCDS46230.1 [Q9NZM3-3]
RefSeqiNP_006268.2, NM_006277.2 [Q9NZM3-1]
NP_062541.3, NM_019595.3 [Q9NZM3-2]
NP_671494.2, NM_147152.2 [Q9NZM3-3]
UniGeneiHs.432562

Genome annotation databases

EnsembliENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3]
GeneIDi50618
KEGGihsa:50618
UCSCiuc002rfe.3 human [Q9NZM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182198 mRNA Translation: AAF59903.1 Different initiation.
AF182199 mRNA Translation: AAF59904.1 Different initiation.
AF248540 mRNA Translation: AAF63600.1 Different initiation.
AB033082 mRNA Translation: BAA86570.1 Different initiation.
AC008073 Genomic DNA No translation available.
AC009228 Genomic DNA No translation available.
AK021545 mRNA Translation: BAB13841.1
AK000302 mRNA Translation: BAA91068.1
AF001630 mRNA Translation: AAD00899.1
U61167 mRNA Translation: AAC50593.1
CCDSiCCDS1710.2 [Q9NZM3-1]
CCDS1711.2 [Q9NZM3-2]
CCDS46230.1 [Q9NZM3-3]
RefSeqiNP_006268.2, NM_006277.2 [Q9NZM3-1]
NP_062541.3, NM_019595.3 [Q9NZM3-2]
NP_671494.2, NM_147152.2 [Q9NZM3-3]
UniGeneiHs.432562

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J3TNMR-A898-958[»]
1UDLNMR-A1103-1187[»]
1UE9NMR-A1056-1122[»]
1UFFNMR-A762-842[»]
1UHFNMR-A983-1038[»]
3GF9X-ray2.50A1130-1406[»]
3JZYX-ray1.56A1201-1692[»]
4IIOX-ray1.70A/B901-955[»]
ProteinModelPortaliQ9NZM3
SMRiQ9NZM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119098, 93 interactors
IntActiQ9NZM3, 37 interactors
MINTiQ9NZM3
STRINGi9606.ENSP00000347244

PTM databases

CarbonylDBiQ9NZM3
iPTMnetiQ9NZM3
PhosphoSitePlusiQ9NZM3

Polymorphism and mutation databases

BioMutaiITSN2
DMDMi294862505

Proteomic databases

EPDiQ9NZM3
MaxQBiQ9NZM3
PaxDbiQ9NZM3
PeptideAtlasiQ9NZM3
PRIDEiQ9NZM3
ProteomicsDBi83445
83446 [Q9NZM3-2]
83447 [Q9NZM3-3]
83448 [Q9NZM3-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3]
GeneIDi50618
KEGGihsa:50618
UCSCiuc002rfe.3 human [Q9NZM3-1]

Organism-specific databases

CTDi50618
DisGeNETi50618
EuPathDBiHostDB:ENSG00000198399.14
GeneCardsiITSN2
H-InvDBiHIX0001876
HGNCiHGNC:6184 ITSN2
HPAiHPA036475
MIMi604464 gene
neXtProtiNX_Q9NZM3
OpenTargetsiENSG00000198399
PharmGKBiPA29982
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1029 Eukaryota
KOG4305 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00760000118985
HOVERGENiHBG052159
InParanoidiQ9NZM3
KOiK20045
OMAiTTPAFHP
OrthoDBiEOG091G0TXR
PhylomeDBiQ9NZM3
TreeFamiTF324293

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiITSN2 human
EvolutionaryTraceiQ9NZM3
GeneWikiiITSN2
GenomeRNAii50618
PROiPR:Q9NZM3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198399 Expressed in 236 organ(s), highest expression level in visceral pleura
CleanExiHS_ITSN2
ExpressionAtlasiQ9NZM3 baseline and differential
GenevisibleiQ9NZM3 HS

Family and domain databases

CDDicd00052 EH, 2 hits
cd00160 RhoGEF, 1 hit
cd11988 SH3_Intersectin2_1, 1 hit
cd11990 SH3_Intersectin2_2, 1 hit
cd11992 SH3_Intersectin2_3, 1 hit
cd11994 SH3_Intersectin2_4, 1 hit
cd11996 SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR027029 Intersectin-2
IPR035737 Intersectin-2_SH3_1
IPR035738 Intersectin-2_SH3_2
IPR035739 Intersectin-2_SH3_3
IPR035740 Intersectin-2_SH3_4
IPR035741 Intersectin-2_SH3_5
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR11216:SF29 PTHR11216:SF29, 3 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12763 EF-hand_4, 2 hits
PF16652 PH_13, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 2 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00027 EH, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50010 DH_2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS50031 EH, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiITSN2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZM3
Secondary accession number(s): O95062
, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 198 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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