UniProtKB - Q9NZM3 (ITSN2_HUMAN)
Intersectin-2
ITSN2
Functioni
Miscellaneous
Caution
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1640 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 1643 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 1646 | CalciumPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 67 – 79 | PROSITE-ProRule annotationAdd BLAST | 13 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- guanyl-nucleotide exchange factor activity Source: InterPro
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- clathrin-dependent synaptic vesicle endocytosis Source: GO_Central
- endocytosis Source: GO_Central
- endosomal transport Source: GO_Central
- positive regulation of dendrite extension Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Differentiation, Endocytosis, Host-virus interaction |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NZM3 |
Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Intersectin-2Alternative name(s): SH3 domain-containing protein 1B SH3P18 SH3P18-like WASP-associated protein |
Gene namesi | Name:ITSN2 Synonyms:KIAA1256, SH3D1B, SWAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6184, ITSN2 |
MIMi | 604464, gene |
neXtProti | NX_Q9NZM3 |
VEuPathDBi | HostDB:ENSG00000198399.14 |
Subcellular locationi
Other locations
Cytoskeleton
- centrosome Source: CACAO
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- clathrin-coated pit Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
- presynapse Source: GOC
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 50618 |
OpenTargetsi | ENSG00000198399 |
PharmGKBi | PA29982 |
Miscellaneous databases
Pharosi | Q9NZM3, Tbio |
Genetic variation databases
BioMutai | ITSN2 |
DMDMi | 294862505 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080961 | 1 – 1697 | Intersectin-2Add BLAST | 1697 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 230 | PhosphoserineCombined sources | 1 | |
Modified residuei | 553 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 573 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 882 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 884 | PhosphoserineCombined sources | 1 | |
Modified residuei | 889 | PhosphoserineCombined sources | 1 | |
Modified residuei | 968 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NZM3 |
jPOSTi | Q9NZM3 |
MassIVEi | Q9NZM3 |
MaxQBi | Q9NZM3 |
PaxDbi | Q9NZM3 |
PeptideAtlasi | Q9NZM3 |
PRIDEi | Q9NZM3 |
ProteomicsDBi | 83445 [Q9NZM3-1] 83446 [Q9NZM3-2] 83447 [Q9NZM3-3] 83448 [Q9NZM3-4] |
PTM databases
CarbonylDBi | Q9NZM3 |
GlyGeni | Q9NZM3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NZM3 |
MetOSitei | Q9NZM3 |
PhosphoSitePlusi | Q9NZM3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198399, Expressed in visceral pleura and 247 other tissues |
ExpressionAtlasi | Q9NZM3, baseline and differential |
Genevisiblei | Q9NZM3, HS |
Organism-specific databases
HPAi | ENSG00000198399, Low tissue specificity |
Interactioni
Subunit structurei
Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.
Interacts with ADAM15.
Interacts with FASLG.
Interacts with ANKRD54 (By similarity).
Interacts with FCHO2.
By similarity3 Publications(Microbial infection) Interacts with herpes virus 8 protein K15.
1 PublicationBinary interactionsi
Q9NZM3
With | #Exp. | IntAct |
---|---|---|
K15-M [Q9WNA9] from Human herpesvirus 8. | 2 | EBI-308689,EBI-7555439 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 119098, 106 interactors |
IntActi | Q9NZM3, 45 interactors |
MINTi | Q9NZM3 |
STRINGi | 9606.ENSP00000347244 |
Miscellaneous databases
RNActi | Q9NZM3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZM3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZM3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 110 | EH 1PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 54 – 89 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 244 – 333 | EH 2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 757 – 818 | SH3 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 898 – 956 | SH3 2PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 981 – 1039 | SH3 3PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1053 – 1117 | SH3 4PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 1127 – 1186 | SH3 5PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 1209 – 1395 | DHPROSITE-ProRule annotationAdd BLAST | 187 | |
Domaini | 1434 – 1544 | PHPROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 1552 – 1668 | C2PROSITE-ProRule annotationAdd BLAST | 117 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 361 – 756 | Sequence analysisAdd BLAST | 396 |
Keywords - Domaini
Coiled coil, Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG1029, Eukaryota KOG4305, Eukaryota |
GeneTreei | ENSGT00940000155936 |
HOGENOMi | CLU_002819_2_0_1 |
InParanoidi | Q9NZM3 |
OMAi | QWCADLN |
OrthoDBi | 807060at2759 |
PhylomeDBi | Q9NZM3 |
TreeFami | TF324293 |
Family and domain databases
CDDi | cd00052, EH, 2 hits cd00160, RhoGEF, 1 hit cd11988, SH3_Intersectin2_1, 1 hit cd11990, SH3_Intersectin2_2, 1 hit cd11992, SH3_Intersectin2_3, 1 hit cd11994, SH3_Intersectin2_4, 1 hit cd11996, SH3_Intersectin2_5, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR027029, Intersectin-2 IPR035737, Intersectin-2_SH3_1 IPR035738, Intersectin-2_SH3_2 IPR035739, Intersectin-2_SH3_3 IPR035740, Intersectin-2_SH3_4 IPR035741, Intersectin-2_SH3_5 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR11216:SF29, PTHR11216:SF29, 3 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF12763, EF-hand_4, 2 hits PF16652, PH_13, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits PF07653, SH3_2, 1 hit PF14604, SH3_9, 2 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00027, EH, 2 hits SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 5 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50010, DH_2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50031, EH, 2 hits PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 5 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL
60 70 80 90 100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP
110 120 130 140 150
PIMKQPPMFS PLISARFGMG SMPNLSIPQP LPPAAPITSL SSATSGTNLP
160 170 180 190 200
PLMMPTPLVP SVSTSSLPNG TASLIQPLPI PYSSSTLPHG SSYSLMMGGF
210 220 230 240 250
GGASIQKAQS LIDLGSSSST SSTASLSGNS PKTGTSEWAV PQPTRLKYRQ
260 270 280 290 300
KFNTLDKSMS GYLSGFQARN ALLQSNLSQT QLATIWTLAD VDGDGQLKAE
310 320 330 340 350
EFILAMHLTD MAKAGQPLPL TLPPELVPPS FRGGKQIDSI NGTLPSYQKM
360 370 380 390 400
QEEEPQKKLP VTFEDKRKAN YERGNMELEK RRQALMEQQQ REAERKAQKE
410 420 430 440 450
KEEWERKQRE LQEQEWKKQL ELEKRLEKQR ELERQREEER RKDIERREAA
460 470 480 490 500
KQELERQRRL EWERIRRQEL LNQKNREQEE IVRLNSKKKN LHLELEALNG
510 520 530 540 550
KHQQISGRLQ DVRLKKQTQK TELEVLDKQC DLEIMEIKQL QQELQEYQNK
560 570 580 590 600
LIYLVPEKQL LNERIKNMQF SNTPDSGVSL LHKKSLEKEE LCQRLKEQLD
610 620 630 640 650
ALEKETASKL SEMDSFNNQL KCGNMDDSVL QCLLSLLSCL NNLFLLLKEL
660 670 680 690 700
RETYNTQQLA LEQLYKIKRD KLKEIERKRL ELMQKKKLED EAARKAKQGK
710 720 730 740 750
ENLWKENLRK EEEEKQKRLQ EEKTQEKIQE EERKAEEKQR KDKDTLKAEE
760 770 780 790 800
KKRETASVLV NYRALYPFEA RNHDEMSFNS GDIIQVDEKT VGEPGWLYGS
810 820 830 840 850
FQGNFGWFPC NYVEKMPSSE NEKAVSPKKA LLPPTVSLSA TSTSSEPLSS
860 870 880 890 900
NQPASVTDYQ NVSFSNLTVN TSWQKKSAFT RTVSPGSVSP IHGQGQVVEN
910 920 930 940 950
LKAQALCSWT AKKDNHLNFS KHDIITVLEQ QENWWFGEVH GGRGWFPKSY
960 970 980 990 1000
VKIIPGSEVK REEPEALYAA VNKKPTSAAY SVGEEYIALY PYSSVEPGDL
1010 1020 1030 1040 1050
TFTEGEEILV TQKDGEWWTG SIGDRSGIFP SNYVKPKDQE SFGSASKSGA
1060 1070 1080 1090 1100
SNKKPEIAQV TSAYVASGSE QLSLAPGQLI LILKKNTSGW WQGELQARGK
1110 1120 1130 1140 1150
KRQKGWFPAS HVKLLGPSSE RATPAFHPVC QVIAMYDYAA NNEDELSFSK
1160 1170 1180 1190 1200
GQLINVMNKD DPDWWQGEIN GVTGLFPSNY VKMTTDSDPS QQWCADLQTL
1210 1220 1230 1240 1250
DTMQPIERKR QGYIHELIQT EERYMADLQL VVEVFQKRMA ESGFLTEGEM
1260 1270 1280 1290 1300
ALIFVNWKEL IMSNTKLLKA LRVRKKTGGE KMPVQMIGDI LAAELSHMQA
1310 1320 1330 1340 1350
YIRFCSCQLN GAALLQQKTD EDTDFKEFLK KLASDPRCKG MPLSSFLLKP
1360 1370 1380 1390 1400
MQRITRYPLL IRSILENTPE SHADHSSLKL ALERAEELCS QVNEGVREKE
1410 1420 1430 1440 1450
NSDRLEWIQA HVQCEGLAEQ LIFNSLTNCL GPRKLLHSGK LYKTKSNKEL
1460 1470 1480 1490 1500
HGFLFNDFLL LTYMVKQFAV SSGSEKLFSS KSNAQFKMYK TPIFLNEVLV
1510 1520 1530 1540 1550
KLPTDPSSDE PVFHISHIDR VYTLRTDNIN ERTAWVQKIK AASEQYIDTE
1560 1570 1580 1590 1600
KKKREKAYQA RSQKTSGIGR LMVHVIEATE LKACKPNGKS NPYCEISMGS
1610 1620 1630 1640 1650
QSYTTRTIQD TLNPKWNFNC QFFIKDLYQD VLCLTLFDRD QFSPDDFLGR
1660 1670 1680 1690
TEIPVAKIRT EQESKGPMTR RLLLHEVPTG EVWVRFDLQL FEQKTLL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVF7 | A0A087WVF7_HUMAN | Intersectin-2 | ITSN2 | 1,680 | Annotation score: | ||
E7EPJ2 | E7EPJ2_HUMAN | Intersectin-2 | ITSN2 | 609 | Annotation score: | ||
F8W719 | F8W719_HUMAN | Intersectin-2 | ITSN2 | 183 | Annotation score: | ||
H7BZD4 | H7BZD4_HUMAN | Intersectin-2 | ITSN2 | 120 | Annotation score: | ||
H7C0L8 | H7C0L8_HUMAN | Intersectin-2 | ITSN2 | 55 | Annotation score: | ||
H7C3E2 | H7C3E2_HUMAN | Intersectin-2 | ITSN2 | 36 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 679 | R → G in BAB13841 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 823 – 828 | KAVSPK → FAAAST in AAD00899 (Ref. 6) Curated | 6 | ||
Sequence conflicti | 945 – 951 | WFPKSYV → EFAAAST in AAC50593 (PubMed:9630982).Curated | 7 | ||
Sequence conflicti | 1279 – 1285 | GEKMPVQ → VDAAANS in AAD00899 (Ref. 6) Curated | 7 | ||
Sequence conflicti | 1553 | K → Q in AAF63600 (Ref. 2) Curated | 1 | ||
Sequence conflicti | 1553 | K → Q in BAA86570 (PubMed:10574462).Curated | 1 | ||
Isoform 3 (identifier: Q9NZM3-3) | |||||
Sequence conflicti | 1235 | R → W in AAF59904 (PubMed:10922467).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024287 | 254 | T → A. Corresponds to variant dbSNP:rs6744320Ensembl. | 1 | |
Natural variantiVAR_024288 | 291 | V → I1 PublicationCorresponds to variant dbSNP:rs7603997Ensembl. | 1 | |
Natural variantiVAR_020193 | 1287 | I → T. Corresponds to variant dbSNP:rs3731625Ensembl. | 1 | |
Natural variantiVAR_021937 | 1534 | A → T. Corresponds to variant dbSNP:rs2303291Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003892 | 622 – 648 | Missing in isoform 2. 3 PublicationsAdd BLAST | 27 | |
Alternative sequenceiVSP_003895 | 1193 – 1697 | Missing in isoform 4. 1 PublicationAdd BLAST | 505 | |
Alternative sequenceiVSP_003893 | 1235 – 1249 | FQKRM…LTEGE → RRLLLASSRGICCLS in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_003894 | 1250 – 1697 | Missing in isoform 3. 1 PublicationAdd BLAST | 448 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182198 mRNA Translation: AAF59903.1 Different initiation. AF182199 mRNA Translation: AAF59904.1 Different initiation. AF248540 mRNA Translation: AAF63600.1 Different initiation. AB033082 mRNA Translation: BAA86570.1 Different initiation. AC008073 Genomic DNA No translation available. AC009228 Genomic DNA No translation available. AK021545 mRNA Translation: BAB13841.1 AK000302 mRNA Translation: BAA91068.1 AF001630 mRNA Translation: AAD00899.1 U61167 mRNA Translation: AAC50593.1 |
CCDSi | CCDS1710.2 [Q9NZM3-1] CCDS1711.2 [Q9NZM3-2] CCDS46230.1 [Q9NZM3-3] |
RefSeqi | NP_006268.2, NM_006277.2 [Q9NZM3-1] NP_062541.3, NM_019595.3 [Q9NZM3-2] NP_671494.2, NM_147152.2 [Q9NZM3-3] |
Genome annotation databases
Ensembli | ENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1] ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2] ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3] |
GeneIDi | 50618 |
KEGGi | hsa:50618 |
UCSCi | uc002rfe.3, human [Q9NZM3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF182198 mRNA Translation: AAF59903.1 Different initiation. AF182199 mRNA Translation: AAF59904.1 Different initiation. AF248540 mRNA Translation: AAF63600.1 Different initiation. AB033082 mRNA Translation: BAA86570.1 Different initiation. AC008073 Genomic DNA No translation available. AC009228 Genomic DNA No translation available. AK021545 mRNA Translation: BAB13841.1 AK000302 mRNA Translation: BAA91068.1 AF001630 mRNA Translation: AAD00899.1 U61167 mRNA Translation: AAC50593.1 |
CCDSi | CCDS1710.2 [Q9NZM3-1] CCDS1711.2 [Q9NZM3-2] CCDS46230.1 [Q9NZM3-3] |
RefSeqi | NP_006268.2, NM_006277.2 [Q9NZM3-1] NP_062541.3, NM_019595.3 [Q9NZM3-2] NP_671494.2, NM_147152.2 [Q9NZM3-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J3T | NMR | - | A | 898-958 | [»] | |
1UDL | NMR | - | A | 1103-1187 | [»] | |
1UE9 | NMR | - | A | 1056-1122 | [»] | |
1UFF | NMR | - | A | 762-842 | [»] | |
1UHF | NMR | - | A | 983-1038 | [»] | |
3GF9 | X-ray | 2.50 | A | 1130-1406 | [»] | |
3JZY | X-ray | 1.56 | A | 1201-1692 | [»] | |
4IIO | X-ray | 1.70 | A/B | 901-955 | [»] | |
SMRi | Q9NZM3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119098, 106 interactors |
IntActi | Q9NZM3, 45 interactors |
MINTi | Q9NZM3 |
STRINGi | 9606.ENSP00000347244 |
PTM databases
CarbonylDBi | Q9NZM3 |
GlyGeni | Q9NZM3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NZM3 |
MetOSitei | Q9NZM3 |
PhosphoSitePlusi | Q9NZM3 |
Genetic variation databases
BioMutai | ITSN2 |
DMDMi | 294862505 |
Proteomic databases
EPDi | Q9NZM3 |
jPOSTi | Q9NZM3 |
MassIVEi | Q9NZM3 |
MaxQBi | Q9NZM3 |
PaxDbi | Q9NZM3 |
PeptideAtlasi | Q9NZM3 |
PRIDEi | Q9NZM3 |
ProteomicsDBi | 83445 [Q9NZM3-1] 83446 [Q9NZM3-2] 83447 [Q9NZM3-3] 83448 [Q9NZM3-4] |
Protocols and materials databases
ABCDi | Q9NZM3, 9 sequenced antibodies |
Antibodypediai | 27453, 74 antibodies |
Genome annotation databases
Ensembli | ENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1] ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2] ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3] |
GeneIDi | 50618 |
KEGGi | hsa:50618 |
UCSCi | uc002rfe.3, human [Q9NZM3-1] |
Organism-specific databases
CTDi | 50618 |
DisGeNETi | 50618 |
GeneCardsi | ITSN2 |
HGNCi | HGNC:6184, ITSN2 |
HPAi | ENSG00000198399, Low tissue specificity |
MIMi | 604464, gene |
neXtProti | NX_Q9NZM3 |
OpenTargetsi | ENSG00000198399 |
PharmGKBi | PA29982 |
VEuPathDBi | HostDB:ENSG00000198399.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1029, Eukaryota KOG4305, Eukaryota |
GeneTreei | ENSGT00940000155936 |
HOGENOMi | CLU_002819_2_0_1 |
InParanoidi | Q9NZM3 |
OMAi | QWCADLN |
OrthoDBi | 807060at2759 |
PhylomeDBi | Q9NZM3 |
TreeFami | TF324293 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZM3 |
Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 50618, 17 hits in 876 CRISPR screens |
ChiTaRSi | ITSN2, human |
EvolutionaryTracei | Q9NZM3 |
GeneWikii | ITSN2 |
GenomeRNAii | 50618 |
Pharosi | Q9NZM3, Tbio |
PROi | PR:Q9NZM3 |
RNActi | Q9NZM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198399, Expressed in visceral pleura and 247 other tissues |
ExpressionAtlasi | Q9NZM3, baseline and differential |
Genevisiblei | Q9NZM3, HS |
Family and domain databases
CDDi | cd00052, EH, 2 hits cd00160, RhoGEF, 1 hit cd11988, SH3_Intersectin2_1, 1 hit cd11990, SH3_Intersectin2_2, 1 hit cd11992, SH3_Intersectin2_3, 1 hit cd11994, SH3_Intersectin2_4, 1 hit cd11996, SH3_Intersectin2_5, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000261, EH_dom IPR027029, Intersectin-2 IPR035737, Intersectin-2_SH3_1 IPR035738, Intersectin-2_SH3_2 IPR035739, Intersectin-2_SH3_3 IPR035740, Intersectin-2_SH3_4 IPR035741, Intersectin-2_SH3_5 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR11216:SF29, PTHR11216:SF29, 3 hits |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF12763, EF-hand_4, 2 hits PF16652, PH_13, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 2 hits PF07653, SH3_2, 1 hit PF14604, SH3_9, 2 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00027, EH, 2 hits SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 5 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 5 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50010, DH_2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50031, EH, 2 hits PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ITSN2_HUMAN | |
Accessioni | Q9NZM3Primary (citable) accession number: Q9NZM3 Secondary accession number(s): O95062 Q9ULG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2002 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants