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UniProtKB - Q9NZM3 (ITSN2_HUMAN)

Entry version 213 (10 Feb 2021)
Sequence version 3 (20 Apr 2010)
Previous versions | rss
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Protein

Intersectin-2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003).3 Publications

Miscellaneous

Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated
Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2 suggesting a partially overlapping role of the EH domain-containing proteins.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1640CalciumPROSITE-ProRule annotation1
Metal bindingi1643CalciumPROSITE-ProRule annotation1
Metal bindingi1646CalciumPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi67 – 79PROSITE-ProRule annotationAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Endocytosis, Host-virus interaction
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZM3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intersectin-2
Alternative name(s):
SH3 domain-containing protein 1B
SH3P18
SH3P18-like WASP-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITSN2
Synonyms:KIAA1256, SH3D1B, SWAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6184, ITSN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604464, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZM3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198399.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		50618

Open Targets

More...OpenTargetsi		ENSG00000198399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29982

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZM3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ITSN2

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809611 – 1697Intersectin-2Add BLAST1697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei553PhosphotyrosineBy similarity1
Modified residuei573PhosphothreonineCombined sources1
Modified residuei882PhosphothreonineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei968PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZM3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZM3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZM3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZM3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZM3

PeptideAtlas

More...PeptideAtlasi		Q9NZM3

PRoteomics IDEntifications database

More...PRIDEi		Q9NZM3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83445 [Q9NZM3-1]
83446 [Q9NZM3-2]
83447 [Q9NZM3-3]
83448 [Q9NZM3-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9NZM3

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NZM3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZM3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NZM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198399, Expressed in visceral pleura and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZM3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZM3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198399, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.

Interacts with ADAM15.

Interacts with FASLG.

Interacts with ANKRD54 (By similarity).

Interacts with FCHO2.

By similarity3 Publications

(Microbial infection) Interacts with herpes virus 8 protein K15.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119098, 106 interactors

Protein interaction database and analysis system

More...IntActi		Q9NZM3, 45 interactors

Molecular INTeraction database

More...MINTi		Q9NZM3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347244

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZM3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11697
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZM3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NZM3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 110EH 1PROSITE-ProRule annotationAdd BLAST89
Domaini54 – 89EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini244 – 333EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini757 – 818SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini898 – 956SH3 2PROSITE-ProRule annotationAdd BLAST59
Domaini981 – 1039SH3 3PROSITE-ProRule annotationAdd BLAST59
Domaini1053 – 1117SH3 4PROSITE-ProRule annotationAdd BLAST65
Domaini1127 – 1186SH3 5PROSITE-ProRule annotationAdd BLAST60
Domaini1209 – 1395DHPROSITE-ProRule annotationAdd BLAST187
Domaini1434 – 1544PHPROSITE-ProRule annotationAdd BLAST111
Domaini1552 – 1668C2PROSITE-ProRule annotationAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili361 – 756Sequence analysisAdd BLAST396

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1029, Eukaryota
KOG4305, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002819_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZM3

Identification of Orthologs from Complete Genome Data

More...OMAi		QWCADLN

Database of Orthologous Groups

More...OrthoDBi		807060at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZM3

TreeFam database of animal gene trees

More...TreeFami		TF324293

Family and domain databases

Conserved Domains Database

More...CDDi		cd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit
cd11988, SH3_Intersectin2_1, 1 hit
cd11990, SH3_Intersectin2_2, 1 hit
cd11992, SH3_Intersectin2_3, 1 hit
cd11994, SH3_Intersectin2_4, 1 hit
cd11996, SH3_Intersectin2_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR027029, Intersectin-2
IPR035737, Intersectin-2_SH3_1
IPR035738, Intersectin-2_SH3_2
IPR035739, Intersectin-2_SH3_3
IPR035740, Intersectin-2_SH3_4
IPR035741, Intersectin-2_SH3_5
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...PANTHERi		PTHR11216:SF29, PTHR11216:SF29, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZM3-1) [UniParc]FASTAAdd to basket
Also known as: ITSN2-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL 
        60         70         80         90        100
QSGLPAPVLA EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP 
       110        120        130        140        150
PIMKQPPMFS PLISARFGMG SMPNLSIPQP LPPAAPITSL SSATSGTNLP 
       160        170        180        190        200
PLMMPTPLVP SVSTSSLPNG TASLIQPLPI PYSSSTLPHG SSYSLMMGGF 
       210        220        230        240        250
GGASIQKAQS LIDLGSSSST SSTASLSGNS PKTGTSEWAV PQPTRLKYRQ 
       260        270        280        290        300
KFNTLDKSMS GYLSGFQARN ALLQSNLSQT QLATIWTLAD VDGDGQLKAE 
       310        320        330        340        350
EFILAMHLTD MAKAGQPLPL TLPPELVPPS FRGGKQIDSI NGTLPSYQKM 
       360        370        380        390        400
QEEEPQKKLP VTFEDKRKAN YERGNMELEK RRQALMEQQQ REAERKAQKE 
       410        420        430        440        450
KEEWERKQRE LQEQEWKKQL ELEKRLEKQR ELERQREEER RKDIERREAA 
       460        470        480        490        500
KQELERQRRL EWERIRRQEL LNQKNREQEE IVRLNSKKKN LHLELEALNG 
       510        520        530        540        550
KHQQISGRLQ DVRLKKQTQK TELEVLDKQC DLEIMEIKQL QQELQEYQNK 
       560        570        580        590        600
LIYLVPEKQL LNERIKNMQF SNTPDSGVSL LHKKSLEKEE LCQRLKEQLD 
       610        620        630        640        650
ALEKETASKL SEMDSFNNQL KCGNMDDSVL QCLLSLLSCL NNLFLLLKEL 
       660        670        680        690        700
RETYNTQQLA LEQLYKIKRD KLKEIERKRL ELMQKKKLED EAARKAKQGK 
       710        720        730        740        750
ENLWKENLRK EEEEKQKRLQ EEKTQEKIQE EERKAEEKQR KDKDTLKAEE 
       760        770        780        790        800
KKRETASVLV NYRALYPFEA RNHDEMSFNS GDIIQVDEKT VGEPGWLYGS 
       810        820        830        840        850
FQGNFGWFPC NYVEKMPSSE NEKAVSPKKA LLPPTVSLSA TSTSSEPLSS 
       860        870        880        890        900
NQPASVTDYQ NVSFSNLTVN TSWQKKSAFT RTVSPGSVSP IHGQGQVVEN 
       910        920        930        940        950
LKAQALCSWT AKKDNHLNFS KHDIITVLEQ QENWWFGEVH GGRGWFPKSY 
       960        970        980        990       1000
VKIIPGSEVK REEPEALYAA VNKKPTSAAY SVGEEYIALY PYSSVEPGDL 
      1010       1020       1030       1040       1050
TFTEGEEILV TQKDGEWWTG SIGDRSGIFP SNYVKPKDQE SFGSASKSGA 
      1060       1070       1080       1090       1100
SNKKPEIAQV TSAYVASGSE QLSLAPGQLI LILKKNTSGW WQGELQARGK 
      1110       1120       1130       1140       1150
KRQKGWFPAS HVKLLGPSSE RATPAFHPVC QVIAMYDYAA NNEDELSFSK 
      1160       1170       1180       1190       1200
GQLINVMNKD DPDWWQGEIN GVTGLFPSNY VKMTTDSDPS QQWCADLQTL 
      1210       1220       1230       1240       1250
DTMQPIERKR QGYIHELIQT EERYMADLQL VVEVFQKRMA ESGFLTEGEM 
      1260       1270       1280       1290       1300
ALIFVNWKEL IMSNTKLLKA LRVRKKTGGE KMPVQMIGDI LAAELSHMQA 
      1310       1320       1330       1340       1350
YIRFCSCQLN GAALLQQKTD EDTDFKEFLK KLASDPRCKG MPLSSFLLKP 
      1360       1370       1380       1390       1400
MQRITRYPLL IRSILENTPE SHADHSSLKL ALERAEELCS QVNEGVREKE 
      1410       1420       1430       1440       1450
NSDRLEWIQA HVQCEGLAEQ LIFNSLTNCL GPRKLLHSGK LYKTKSNKEL 
      1460       1470       1480       1490       1500
HGFLFNDFLL LTYMVKQFAV SSGSEKLFSS KSNAQFKMYK TPIFLNEVLV 
      1510       1520       1530       1540       1550
KLPTDPSSDE PVFHISHIDR VYTLRTDNIN ERTAWVQKIK AASEQYIDTE 
      1560       1570       1580       1590       1600
KKKREKAYQA RSQKTSGIGR LMVHVIEATE LKACKPNGKS NPYCEISMGS 
      1610       1620       1630       1640       1650
QSYTTRTIQD TLNPKWNFNC QFFIKDLYQD VLCLTLFDRD QFSPDDFLGR 
      1660       1670       1680       1690 
TEIPVAKIRT EQESKGPMTR RLLLHEVPTG EVWVRFDLQL FEQKTLL
Length:1,697
Mass (Da):193,461
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49C41AE1E32E1BD0
GO
Isoform 2 (identifier: Q9NZM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     622-648: Missing.

Show »
Length:1,670
Mass (Da):190,496
Checksum:i91E65C08E5AB26F1
GO
Isoform 3 (identifier: Q9NZM3-3) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S1

The sequence of this isoform differs from the canonical sequence as follows:
     1235-1249: FQKRMAESGFLTEGE → RRLLLASSRGICCLS
     1250-1697: Missing.

Show »
Length:1,249
Mass (Da):141,820
Checksum:i271797AF71A0EB28
GO
Isoform 4 (identifier: Q9NZM3-4) [UniParc]FASTAAdd to basket
Also known as: ITSN2-S2, SH3P18

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1697: Missing.

Show »
Length:1,192
Mass (Da):135,144
Checksum:i2DA2049587CF4082
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVF7A0A087WVF7_HUMAN
Intersectin-2
ITSN2
1,680Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPJ2E7EPJ2_HUMAN
Intersectin-2
ITSN2
609Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W719F8W719_HUMAN
Intersectin-2
ITSN2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZD4H7BZD4_HUMAN
Intersectin-2
ITSN2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0L8H7C0L8_HUMAN
Intersectin-2
ITSN2
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3E2H7C3E2_HUMAN
Intersectin-2
ITSN2
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF59903 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAF59904 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAF63600 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA86570 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti679R → G in BAB13841 (PubMed:14702039).Curated1
Sequence conflicti823 – 828KAVSPK → FAAAST in AAD00899 (Ref. 6) Curated6
Sequence conflicti945 – 951WFPKSYV → EFAAAST in AAC50593 (PubMed:9630982).Curated7
Sequence conflicti1279 – 1285GEKMPVQ → VDAAANS in AAD00899 (Ref. 6) Curated7
Sequence conflicti1553K → Q in AAF63600 (Ref. 2) Curated1
Sequence conflicti1553K → Q in BAA86570 (PubMed:10574462).Curated1
Isoform 3 (identifier: Q9NZM3-3)
Sequence conflicti1235R → W in AAF59904 (PubMed:10922467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024287254T → A. Corresponds to variant dbSNP:rs6744320Ensembl.1
Natural variantiVAR_024288291V → I1 PublicationCorresponds to variant dbSNP:rs7603997Ensembl.1
Natural variantiVAR_0201931287I → T. Corresponds to variant dbSNP:rs3731625Ensembl.1
Natural variantiVAR_0219371534A → T. Corresponds to variant dbSNP:rs2303291Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003892622 – 648Missing in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_0038951193 – 1697Missing in isoform 4. 1 PublicationAdd BLAST505
Alternative sequenceiVSP_0038931235 – 1249FQKRM…LTEGE → RRLLLASSRGICCLS in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0038941250 – 1697Missing in isoform 3. 1 PublicationAdd BLAST448

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF182198 mRNA Translation: AAF59903.1 Different initiation.
AF182199 mRNA Translation: AAF59904.1 Different initiation.
AF248540 mRNA Translation: AAF63600.1 Different initiation.
AB033082 mRNA Translation: BAA86570.1 Different initiation.
AC008073 Genomic DNA No translation available.
AC009228 Genomic DNA No translation available.
AK021545 mRNA Translation: BAB13841.1
AK000302 mRNA Translation: BAA91068.1
AF001630 mRNA Translation: AAD00899.1
U61167 mRNA Translation: AAC50593.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1710.2 [Q9NZM3-1]
CCDS1711.2 [Q9NZM3-2]
CCDS46230.1 [Q9NZM3-3]

NCBI Reference Sequences

More...RefSeqi		NP_006268.2, NM_006277.2 [Q9NZM3-1]
NP_062541.3, NM_019595.3 [Q9NZM3-2]
NP_671494.2, NM_147152.2 [Q9NZM3-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50618

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:50618

UCSC genome browser

More...UCSCi		uc002rfe.3, human [Q9NZM3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182198 mRNA Translation: AAF59903.1 Different initiation.
AF182199 mRNA Translation: AAF59904.1 Different initiation.
AF248540 mRNA Translation: AAF63600.1 Different initiation.
AB033082 mRNA Translation: BAA86570.1 Different initiation.
AC008073 Genomic DNA No translation available.
AC009228 Genomic DNA No translation available.
AK021545 mRNA Translation: BAB13841.1
AK000302 mRNA Translation: BAA91068.1
AF001630 mRNA Translation: AAD00899.1
U61167 mRNA Translation: AAC50593.1
CCDSiCCDS1710.2 [Q9NZM3-1]
CCDS1711.2 [Q9NZM3-2]
CCDS46230.1 [Q9NZM3-3]
RefSeqiNP_006268.2, NM_006277.2 [Q9NZM3-1]
NP_062541.3, NM_019595.3 [Q9NZM3-2]
NP_671494.2, NM_147152.2 [Q9NZM3-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J3TNMR-A898-958[»]
1UDLNMR-A1103-1187[»]
1UE9NMR-A1056-1122[»]
1UFFNMR-A762-842[»]
1UHFNMR-A983-1038[»]
3GF9X-ray2.50A1130-1406[»]
3JZYX-ray1.56A1201-1692[»]
4IIOX-ray1.70A/B901-955[»]
SMRiQ9NZM3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119098, 106 interactors
IntActiQ9NZM3, 45 interactors
MINTiQ9NZM3
STRINGi9606.ENSP00000347244

PTM databases

CarbonylDBiQ9NZM3
GlyGeniQ9NZM3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9NZM3
MetOSiteiQ9NZM3
PhosphoSitePlusiQ9NZM3

Genetic variation databases

BioMutaiITSN2
DMDMi294862505

Proteomic databases

EPDiQ9NZM3
jPOSTiQ9NZM3
MassIVEiQ9NZM3
MaxQBiQ9NZM3
PaxDbiQ9NZM3
PeptideAtlasiQ9NZM3
PRIDEiQ9NZM3
ProteomicsDBi83445 [Q9NZM3-1]
83446 [Q9NZM3-2]
83447 [Q9NZM3-3]
83448 [Q9NZM3-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9NZM3, 9 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27453, 74 antibodies

Genome annotation databases

EnsembliENST00000355123; ENSP00000347244; ENSG00000198399 [Q9NZM3-1]
ENST00000361999; ENSP00000354561; ENSG00000198399 [Q9NZM3-2]
ENST00000406921; ENSP00000384499; ENSG00000198399 [Q9NZM3-3]
GeneIDi50618
KEGGihsa:50618
UCSCiuc002rfe.3, human [Q9NZM3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		50618
DisGeNETi50618

GeneCards: human genes, protein and diseases

More...GeneCardsi		ITSN2
HGNCiHGNC:6184, ITSN2
HPAiENSG00000198399, Low tissue specificity
MIMi604464, gene
neXtProtiNX_Q9NZM3
OpenTargetsiENSG00000198399
PharmGKBiPA29982
VEuPathDBiHostDB:ENSG00000198399.14

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1029, Eukaryota
KOG4305, Eukaryota
GeneTreeiENSGT00940000155936
HOGENOMiCLU_002819_2_0_1
InParanoidiQ9NZM3
OMAiQWCADLN
OrthoDBi807060at2759
PhylomeDBiQ9NZM3
TreeFamiTF324293

Enzyme and pathway databases

PathwayCommonsiQ9NZM3
ReactomeiR-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		50618, 17 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ITSN2, human
EvolutionaryTraceiQ9NZM3

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ITSN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		50618
PharosiQ9NZM3, Tbio

Protein Ontology

More...PROi		PR:Q9NZM3
RNActiQ9NZM3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198399, Expressed in visceral pleura and 247 other tissues
ExpressionAtlasiQ9NZM3, baseline and differential
GenevisibleiQ9NZM3, HS

Family and domain databases

CDDicd00052, EH, 2 hits
cd00160, RhoGEF, 1 hit
cd11988, SH3_Intersectin2_1, 1 hit
cd11990, SH3_Intersectin2_2, 1 hit
cd11992, SH3_Intersectin2_3, 1 hit
cd11994, SH3_Intersectin2_4, 1 hit
cd11996, SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR027029, Intersectin-2
IPR035737, Intersectin-2_SH3_1
IPR035738, Intersectin-2_SH3_2
IPR035739, Intersectin-2_SH3_3
IPR035740, Intersectin-2_SH3_4
IPR035741, Intersectin-2_SH3_5
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR11216:SF29, PTHR11216:SF29, 3 hits
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12763, EF-hand_4, 2 hits
PF16652, PH_13, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 2 hits
PF07653, SH3_2, 1 hit
PF14604, SH3_9, 2 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 5 hits
SUPFAMiSSF47473, SSF47473, 2 hits
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50010, DH_2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITSN2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZM3
Secondary accession number(s): O95062
, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 213 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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