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Protein

Methionine adenosyltransferase 2 subunit beta

Gene

MAT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).4 Publications

Miscellaneous

Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.3 Publications
Proteins known to be involved in this subpathway in this organism are:
  1. Methionine adenosyltransferase 2 subunit beta, S-adenosylmethionine synthase (metK), S-adenosylmethionine synthase, Methionine adenosyltransferase 2 subunit beta, S-adenosylmethionine synthase (MAT2A), Methionine adenosyltransferase 2 subunit beta (MAT2B), Methionine adenosyltransferase 2 subunit beta (MAT2B), S-adenosylmethionine synthase, S-adenosylmethionine synthase (metK), Methionine adenosyltransferase 2 subunit beta, S-adenosylmethionine synthase isoform type-1 (MAT1A), S-adenosylmethionine synthase isoform type-2 (MAT2A), Methionine adenosyltransferase 2 subunit beta (MAT2B)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei93NADP; via carbonyl oxygenCombined sources1
Binding sitei97NADPCombined sources1
Binding sitei159NADPCombined sources1
Binding sitei185NADP; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi37 – 40NADPCombined sources4
Nucleotide bindingi60 – 62NADPCombined sources3
Nucleotide bindingi71 – 72NADPCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • methionine adenosyltransferase regulator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00531-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.6 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156581 Methylation
R-HSA-5689880 Ub-specific processing proteases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00315;UER00080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine adenosyltransferase 2 subunit beta
Alternative name(s):
Methionine adenosyltransferase II beta
Short name:
MAT II beta
Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAT2B
Synonyms:TGR
ORF Names:MSTP045, Nbla02999, UNQ2435/PRO4995
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000038274.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6905 MAT2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605527 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZL9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27430

Open Targets

More...
OpenTargetsi
ENSG00000038274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30648

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00134 L-Methionine

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74719662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002875202 – 334Methionine adenosyltransferase 2 subunit betaAdd BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei309PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NZL9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZL9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZL9

PeptideAtlas

More...
PeptideAtlasi
Q9NZL9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZL9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83432
83433 [Q9NZL9-2]
83434 [Q9NZL9-3]
83435 [Q9NZL9-4]
83436 [Q9NZL9-5]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00002324

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZL9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NZL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000038274 Expressed in 233 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZL9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZL9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037721
HPA037722

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345). NADP binding increases the affinity for MAT2A (PubMed:23189196).1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118166, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NZL9

Protein interaction database and analysis system

More...
IntActi
Q9NZL9, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325425

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NZL9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZL9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NZL9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 334Required for interaction with MAT2A1 PublicationAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ9F Eukaryota
COG1091 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006721

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105851

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZL9

KEGG Orthology (KO)

More...
KOi
K00789

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHYSNEG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AS1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZL9

TreeFam database of animal gene trees

More...
TreeFami
TF332849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005913 dTDP_dehydrorham_reduct
IPR036291 NAD(P)-bd_dom_sf
IPR029903 RmlD-like-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10491 PTHR10491, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04321 RmlD_sub_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGREKELSI HFVPGSCRLV EEEVNIPNRR VLVTGATGLL GRAVHKEFQQ
60 70 80 90 100
NNWHAVGCGF RRARPKFEQV NLLDSNAVHH IIHDFQPHVI VHCAAERRPD
110 120 130 140 150
VVENQPDAAS QLNVDASGNL AKEAAAVGAF LIYISSDYVF DGTNPPYREE
160 170 180 190 200
DIPAPLNLYG KTKLDGEKAV LENNLGAAVL RIPILYGEVE KLEESAVTVM
210 220 230 240 250
FDKVQFSNKS ANMDHWQQRF PTHVKDVATV CRQLAEKRML DPSIKGTFHW
260 270 280 290 300
SGNEQMTKYE MACAIADAFN LPSSHLRPIT DSPVLGAQRP RNAQLDCSKL
310 320 330
ETLGIGQRTP FRIGIKESLW PFLIDKRWRQ TVFH
Length:334
Mass (Da):37,552
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AAA5381BAF3F65F
GO
Isoform 2 (identifier: Q9NZL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVGREKELSIHFVPGSCRLVE → MPEMPEDMEQ

Show »
Length:323
Mass (Da):36,401
Checksum:i4B2197246063E711
GO
Isoform 3 (identifier: Q9NZL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: DPSIKGTFHWSGNEQMTKY → VRRIPESCLSEGPLCLFHA
     260-334: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,954
Checksum:i7F4682A780B15E47
GO
Isoform 4 (identifier: Q9NZL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVGREKELSIHFVPGSCRLVE → MPEMPEDMEQ
     279-295: Missing.

Show »
Length:306
Mass (Da):34,583
Checksum:iECF509E5B6BE02EF
GO
Isoform 5 (identifier: Q9NZL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MVGREKELSIHFVPGSCRLV → MPEMPEDMEQ
     87-93: PHVIVHC → VLLTALS
     94-334: Missing.

Show »
Length:83
Mass (Da):9,488
Checksum:iF471368C041DE99A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0X7H7C0X7_HUMAN
Methionine adenosyltransferase 2 su...
MAT2B
198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJR3E5RJR3_HUMAN
Methionine adenosyltransferase 2 su...
MAT2B
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG39296 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150E → G in AAH93030 (PubMed:15489334).Curated1
Sequence conflicti302T → I in AAH66645 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032318293A → T1 PublicationCorresponds to variant dbSNP:rs17849948Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255341 – 21MVGRE…CRLVE → MPEMPEDMEQ in isoform 2 and isoform 4. 4 PublicationsAdd BLAST21
Alternative sequenceiVSP_0255351 – 20MVGRE…SCRLV → MPEMPEDMEQ in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02553687 – 93PHVIVHC → VLLTALS in isoform 5. 1 Publication7
Alternative sequenceiVSP_02553794 – 334Missing in isoform 5. 1 PublicationAdd BLAST241
Alternative sequenceiVSP_025538241 – 259DPSIK…QMTKY → VRRIPESCLSEGPLCLFHA in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_025539260 – 334Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_025540279 – 295Missing in isoform 4. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF182814 mRNA Translation: AAF28477.1
AJ243721 mRNA Translation: CAB56837.1
DQ395260 mRNA Translation: ABD59011.1
DQ413183 mRNA Translation: ABD85290.1
AL136664 mRNA Translation: CAB66599.1
AB073390 mRNA Translation: BAE45720.1
AY358695 mRNA Translation: AAQ89058.1
AK312365 mRNA Translation: BAG35283.1
CH471062 Genomic DNA Translation: EAW61517.1
BC005218 mRNA Translation: AAH05218.1
BC066645 mRNA Translation: AAH66645.1
BC093030 mRNA Translation: AAH93030.1
AF113225 mRNA Translation: AAG39296.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4364.1 [Q9NZL9-2]
CCDS4365.1 [Q9NZL9-1]

NCBI Reference Sequences

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RefSeqi
NP_037415.1, NM_013283.4 [Q9NZL9-1]
NP_877725.1, NM_182796.2 [Q9NZL9-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.54642

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000280969; ENSP00000280969; ENSG00000038274 [Q9NZL9-2]
ENST00000321757; ENSP00000325425; ENSG00000038274 [Q9NZL9-1]
ENST00000518095; ENSP00000428046; ENSG00000038274 [Q9NZL9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27430

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27430

UCSC genome browser

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UCSCi
uc003lzj.5 human [Q9NZL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182814 mRNA Translation: AAF28477.1
AJ243721 mRNA Translation: CAB56837.1
DQ395260 mRNA Translation: ABD59011.1
DQ413183 mRNA Translation: ABD85290.1
AL136664 mRNA Translation: CAB66599.1
AB073390 mRNA Translation: BAE45720.1
AY358695 mRNA Translation: AAQ89058.1
AK312365 mRNA Translation: BAG35283.1
CH471062 Genomic DNA Translation: EAW61517.1
BC005218 mRNA Translation: AAH05218.1
BC066645 mRNA Translation: AAH66645.1
BC093030 mRNA Translation: AAH93030.1
AF113225 mRNA Translation: AAG39296.1 Different initiation.
CCDSiCCDS4364.1 [Q9NZL9-2]
CCDS4365.1 [Q9NZL9-1]
RefSeqiNP_037415.1, NM_013283.4 [Q9NZL9-1]
NP_877725.1, NM_182796.2 [Q9NZL9-2]
UniGeneiHs.54642

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YDXX-ray2.80A/B/C/D/E28-334[»]
2YDYX-ray2.25A28-334[»]
4KTTX-ray2.59E/F22-334[»]
4KTVX-ray3.30E/F22-334[»]
4NDNX-ray2.34E/F22-334[»]
ProteinModelPortaliQ9NZL9
SMRiQ9NZL9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118166, 40 interactors
CORUMiQ9NZL9
IntActiQ9NZL9, 9 interactors
STRINGi9606.ENSP00000325425

Chemistry databases

DrugBankiDB00134 L-Methionine

PTM databases

iPTMnetiQ9NZL9
PhosphoSitePlusiQ9NZL9
SwissPalmiQ9NZL9

Polymorphism and mutation databases

DMDMi74719662

2D gel databases

REPRODUCTION-2DPAGEiIPI00002324

Proteomic databases

EPDiQ9NZL9
MaxQBiQ9NZL9
PaxDbiQ9NZL9
PeptideAtlasiQ9NZL9
PRIDEiQ9NZL9
ProteomicsDBi83432
83433 [Q9NZL9-2]
83434 [Q9NZL9-3]
83435 [Q9NZL9-4]
83436 [Q9NZL9-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
27430
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280969; ENSP00000280969; ENSG00000038274 [Q9NZL9-2]
ENST00000321757; ENSP00000325425; ENSG00000038274 [Q9NZL9-1]
ENST00000518095; ENSP00000428046; ENSG00000038274 [Q9NZL9-3]
GeneIDi27430
KEGGihsa:27430
UCSCiuc003lzj.5 human [Q9NZL9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27430
DisGeNETi27430
EuPathDBiHostDB:ENSG00000038274.16

GeneCards: human genes, protein and diseases

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GeneCardsi
MAT2B
HGNCiHGNC:6905 MAT2B
HPAiHPA037721
HPA037722
MIMi605527 gene
neXtProtiNX_Q9NZL9
OpenTargetsiENSG00000038274
PharmGKBiPA30648

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ9F Eukaryota
COG1091 LUCA
GeneTreeiENSGT00390000006721
HOVERGENiHBG105851
InParanoidiQ9NZL9
KOiK00789
OMAiYHYSNEG
OrthoDBiEOG091G0AS1
PhylomeDBiQ9NZL9
TreeFamiTF332849

Enzyme and pathway databases

UniPathwayi
UPA00315;UER00080

BioCyciMetaCyc:HS00531-MONOMER
BRENDAi2.5.1.6 2681
ReactomeiR-HSA-156581 Methylation
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAT2B human
EvolutionaryTraceiQ9NZL9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27430

Protein Ontology

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PROi
PR:Q9NZL9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000038274 Expressed in 233 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9NZL9 baseline and differential
GenevisibleiQ9NZL9 HS

Family and domain databases

InterProiView protein in InterPro
IPR005913 dTDP_dehydrorham_reduct
IPR036291 NAD(P)-bd_dom_sf
IPR029903 RmlD-like-bd
PANTHERiPTHR10491 PTHR10491, 1 hit
PfamiView protein in Pfam
PF04321 RmlD_sub_bind, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAT2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZL9
Secondary accession number(s): B2R5Y6
, Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89, Q9H3E1, Q9UJ54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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