UniProtKB - Q9NZL6 (RGL1_HUMAN)
Protein
Ral guanine nucleotide dissociation stimulator-like 1
Gene
RGL1
Organism
Homo sapiens (Human)
Status
Functioni
Probable guanine nucleotide exchange factor.
GO - Molecular functioni
- Ral guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- regulation of lipid metabolic process Source: Reactome
- small GTPase mediated signal transduction Source: UniProtKB
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
Reactomei | R-HSA-1989781 PPARA activates gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Ral guanine nucleotide dissociation stimulator-like 1Short name: RalGDS-like 1 |
Gene namesi | Name:RGL1 Synonyms:KIAA0959, RGL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30281 RGL1 |
MIMi | 605667 gene |
neXtProti | NX_Q9NZL6 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23179 |
OpenTargetsi | ENSG00000143344 |
PharmGKBi | PA134934636 |
Miscellaneous databases
Pharosi | Q9NZL6 |
Polymorphism and mutation databases
BioMutai | RGL1 |
DMDMi | 14548230 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068885 | 1 – 768 | Ral guanine nucleotide dissociation stimulator-like 1Add BLAST | 768 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 520 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NZL6 |
jPOSTi | Q9NZL6 |
MassIVEi | Q9NZL6 |
PaxDbi | Q9NZL6 |
PeptideAtlasi | Q9NZL6 |
PRIDEi | Q9NZL6 |
ProteomicsDBi | 83430 [Q9NZL6-1] 83431 [Q9NZL6-2] |
PTM databases
iPTMneti | Q9NZL6 |
PhosphoSitePlusi | Q9NZL6 |
Expressioni
Tissue specificityi
Expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis.
Gene expression databases
Bgeei | ENSG00000143344 Expressed in 235 organ(s), highest expression level in endothelial cell |
Genevisiblei | Q9NZL6 HS |
Organism-specific databases
HPAi | HPA019788 |
Interactioni
Subunit structurei
Interacts with Ras.
By similarityBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P01112 | 3 | EBI-365926,EBI-350145 |
GO - Molecular functioni
- Ral guanyl-nucleotide exchange factor activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 116791, 12 interactors |
DIPi | DIP-31372N |
IntActi | Q9NZL6, 2 interactors |
STRINGi | 9606.ENSP00000303192 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 196 | N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 232 – 501 | Ras-GEFPROSITE-ProRule annotationAdd BLAST | 270 | |
Domaini | 648 – 735 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 541 – 613 | Ser-richAdd BLAST | 73 |
Phylogenomic databases
eggNOGi | KOG3629 Eukaryota ENOG410ZUT5 LUCA |
GeneTreei | ENSGT00940000156012 |
HOGENOMi | HOG000231592 |
InParanoidi | Q9NZL6 |
KOi | K17635 |
OMAi | TDFSSAW |
OrthoDBi | 940219at2759 |
PhylomeDBi | Q9NZL6 |
TreeFami | TF315204 |
Family and domain databases
CDDi | cd00155 RasGEF, 1 hit cd06224 REM, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR000159 RA_dom IPR008937 Ras-like_GEF IPR000651 Ras-like_Gua-exchang_fac_N IPR019804 Ras_G-nucl-exch_fac_CS IPR023578 Ras_GEF_dom_sf IPR001895 RASGEF_cat_dom IPR036964 RASGEF_cat_dom_sf IPR030748 RGL1 IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR23113 PTHR23113, 1 hit PTHR23113:SF199 PTHR23113:SF199, 1 hit |
Pfami | View protein in Pfam PF00788 RA, 1 hit PF00617 RasGEF, 1 hit PF00618 RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00314 RA, 1 hit SM00147 RasGEF, 1 hit SM00229 RasGEFN, 1 hit |
SUPFAMi | SSF48366 SSF48366, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200 RA, 1 hit PS00720 RASGEF, 1 hit PS50009 RASGEF_CAT, 1 hit PS50212 RASGEF_NTER, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform A (identifier: Q9NZL6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD
60 70 80 90 100
QLPPGHTVSQ YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY
110 120 130 140 150
RGFASTKEVL ELLLDRYGNL TSPNCEEDGS QSSSESKMVI RNAIASILRA
160 170 180 190 200
WLDQCAEDFR EPPHFPCLQK LLDYLTRMMP GSDPERRAQN LLEQFQKQEV
210 220 230 240 250
ETDNGLPNTI SFSLEEEEEL EGGESAEFTC FSEDLVAEQL TYMDAQLFKK
260 270 280 290 300
VVPHHCLGCI WSRRDKKENK HLAPTIRATI SQFNTLTKCV VSTILGGKEL
310 320 330 340 350
KTQQRAKIIE KWINIAHECR LLKNFSSLRA IVSALQSNSI YRLKKTWAAV
360 370 380 390 400
PRDRMLMFEE LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT
410 420 430 440 450
QRRLQLQKDM GVMQGTVPYL GTFLTDLTML DTALQDYIEG GLINFEKRRR
460 470 480 490 500
EFEVIAQIKL LQSACNSYCM TPDQKFIQWF QRQQLLTEEE SYALSCEIEA
510 520 530 540 550
AADASTTSPK PRKSMVKRLS LLFLGSDMIT SPTPTKEQPK STASGSSGES
560 570 580 590 600
MDSVSVSSCE SNHSEAEEGS ITPMDTPDEP QKKLSESSSS CSSIHSMDTN
610 620 630 640 650
SSGMSSLINP LSSPPSCNNN PKIHKRSVSV TSITSTVLPP VYNQQNEDTC
660 670 680 690 700
IIRISVEDNN GNMYKSIMLT SQDKTPAVIQ RAMLKHNLDS DPAEEYELVQ
710 720 730 740 750
VISEDKELVI PDSANVFYAM NSQVNFDFIL RKKNSMEEQV KLRSRTSLTL
760
PRTAKRGCWS NRHSKITL
Sequence cautioni
The sequence BAA76803 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | W → G (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 687 | N → Y (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 761 | N → Y in AAF67281 (PubMed:10760592).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035823 | 174 | Y → S in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035824 | 699 | V → M in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001824 | 1 – 9 | MKLLWQAKM → MEVKPVGEPTQEVSKFKLST KVESTGHWLVEDHVRIWEVL KTEE in isoform B. 2 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186779 mRNA Translation: AAF67280.1 AF186780 mRNA Translation: AAF67281.1 AF186798 AF186797 Genomic DNA Translation: AAG14400.1 AF186798 AF186797 Genomic DNA Translation: AAG14401.1 AB023176 mRNA Translation: BAA76803.1 Different initiation. AL590422 Genomic DNA No translation available. AL592299 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91166.1 CH471067 Genomic DNA Translation: EAW91167.1 BC136591 mRNA Translation: AAI36592.1 AL080117 mRNA Translation: CAB45716.1 |
CCDSi | CCDS1359.1 [Q9NZL6-2] CCDS72992.1 [Q9NZL6-1] |
PIRi | T12453 |
RefSeqi | NP_001284598.1, NM_001297669.1 NP_001284599.1, NM_001297670.1 NP_001284600.1, NM_001297671.1 [Q9NZL6-1] NP_001284601.1, NM_001297672.1 NP_055964.3, NM_015149.4 [Q9NZL6-2] XP_011507641.1, XM_011509339.2 [Q9NZL6-2] |
Genome annotation databases
Ensembli | ENST00000304685; ENSP00000303192; ENSG00000143344 [Q9NZL6-2] ENST00000360851; ENSP00000354097; ENSG00000143344 [Q9NZL6-1] |
GeneIDi | 23179 |
KEGGi | hsa:23179 |
UCSCi | uc001gqm.4 human [Q9NZL6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF186779 mRNA Translation: AAF67280.1 AF186780 mRNA Translation: AAF67281.1 AF186798 AF186797 Genomic DNA Translation: AAG14400.1 AF186798 AF186797 Genomic DNA Translation: AAG14401.1 AB023176 mRNA Translation: BAA76803.1 Different initiation. AL590422 Genomic DNA No translation available. AL592299 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91166.1 CH471067 Genomic DNA Translation: EAW91167.1 BC136591 mRNA Translation: AAI36592.1 AL080117 mRNA Translation: CAB45716.1 |
CCDSi | CCDS1359.1 [Q9NZL6-2] CCDS72992.1 [Q9NZL6-1] |
PIRi | T12453 |
RefSeqi | NP_001284598.1, NM_001297669.1 NP_001284599.1, NM_001297670.1 NP_001284600.1, NM_001297671.1 [Q9NZL6-1] NP_001284601.1, NM_001297672.1 NP_055964.3, NM_015149.4 [Q9NZL6-2] XP_011507641.1, XM_011509339.2 [Q9NZL6-2] |
3D structure databases
SMRi | Q9NZL6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 116791, 12 interactors |
DIPi | DIP-31372N |
IntActi | Q9NZL6, 2 interactors |
STRINGi | 9606.ENSP00000303192 |
PTM databases
iPTMneti | Q9NZL6 |
PhosphoSitePlusi | Q9NZL6 |
Polymorphism and mutation databases
BioMutai | RGL1 |
DMDMi | 14548230 |
Proteomic databases
EPDi | Q9NZL6 |
jPOSTi | Q9NZL6 |
MassIVEi | Q9NZL6 |
PaxDbi | Q9NZL6 |
PeptideAtlasi | Q9NZL6 |
PRIDEi | Q9NZL6 |
ProteomicsDBi | 83430 [Q9NZL6-1] 83431 [Q9NZL6-2] |
Genome annotation databases
Ensembli | ENST00000304685; ENSP00000303192; ENSG00000143344 [Q9NZL6-2] ENST00000360851; ENSP00000354097; ENSG00000143344 [Q9NZL6-1] |
GeneIDi | 23179 |
KEGGi | hsa:23179 |
UCSCi | uc001gqm.4 human [Q9NZL6-1] |
Organism-specific databases
CTDi | 23179 |
DisGeNETi | 23179 |
GeneCardsi | RGL1 |
HGNCi | HGNC:30281 RGL1 |
HPAi | HPA019788 |
MIMi | 605667 gene |
neXtProti | NX_Q9NZL6 |
OpenTargetsi | ENSG00000143344 |
PharmGKBi | PA134934636 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3629 Eukaryota ENOG410ZUT5 LUCA |
GeneTreei | ENSGT00940000156012 |
HOGENOMi | HOG000231592 |
InParanoidi | Q9NZL6 |
KOi | K17635 |
OMAi | TDFSSAW |
OrthoDBi | 940219at2759 |
PhylomeDBi | Q9NZL6 |
TreeFami | TF315204 |
Enzyme and pathway databases
Reactomei | R-HSA-1989781 PPARA activates gene expression |
Miscellaneous databases
ChiTaRSi | RGL1 human |
GenomeRNAii | 23179 |
Pharosi | Q9NZL6 |
PROi | PR:Q9NZL6 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143344 Expressed in 235 organ(s), highest expression level in endothelial cell |
Genevisiblei | Q9NZL6 HS |
Family and domain databases
CDDi | cd00155 RasGEF, 1 hit cd06224 REM, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR000159 RA_dom IPR008937 Ras-like_GEF IPR000651 Ras-like_Gua-exchang_fac_N IPR019804 Ras_G-nucl-exch_fac_CS IPR023578 Ras_GEF_dom_sf IPR001895 RASGEF_cat_dom IPR036964 RASGEF_cat_dom_sf IPR030748 RGL1 IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR23113 PTHR23113, 1 hit PTHR23113:SF199 PTHR23113:SF199, 1 hit |
Pfami | View protein in Pfam PF00788 RA, 1 hit PF00617 RasGEF, 1 hit PF00618 RasGEF_N, 1 hit |
SMARTi | View protein in SMART SM00314 RA, 1 hit SM00147 RasGEF, 1 hit SM00229 RasGEFN, 1 hit |
SUPFAMi | SSF48366 SSF48366, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200 RA, 1 hit PS00720 RASGEF, 1 hit PS50009 RASGEF_CAT, 1 hit PS50212 RASGEF_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RGL1_HUMAN | |
Accessioni | Q9NZL6Primary (citable) accession number: Q9NZL6 Secondary accession number(s): Q5SXQ2 Q9Y2G6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | October 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot