HSPBP1

Functionⁱ

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.4 Publications

GO - Molecular functionⁱ

enzyme inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 9830037
ubiquitin protein ligase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16831871
positive regulation of protein ubiquitination
Source: BHF-UCL
Inferred from direct assayⁱ
- 16831871
protein folding
Source: ProtInc
Traceable author statementⁱ
- 9830037

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hsp70-binding protein 1Curated Short name: HspBP1 Alternative name(s): Heat shock protein-binding protein 1 Hsp70-binding protein 2 Short name: HspBP2 Hsp70-interacting protein 1 Hsp70-interacting protein 2
Gene namesⁱ	Name:HSPBP1Imported Synonyms:HSPBP ORF Names:PP1845
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133265.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24989 HSPBP1
MIMⁱ	612939 gene
neXtProtⁱ	NX_Q9NZL4

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23640
Open Targets More...OpenTargetsⁱ	ENSG00000133265
PharmGKBⁱ	PA164720725

Polymorphism and mutation databases

BioMutaⁱ	HSPBP1
DMDMⁱ	74734730

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084035	1 – 359	Hsp70-binding protein 1Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	351	PhosphoserineCombined sources		1
Modified residueⁱ	356	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NZL4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZL4
PaxDbⁱ	Q9NZL4
PeptideAtlas More...PeptideAtlasⁱ	Q9NZL4
PRIDEⁱ	Q9NZL4
ProteomicsDBⁱ	83428 83429 [Q9NZL4-2]

PTM databases

iPTMnetⁱ	Q9NZL4
PhosphoSitePlusⁱ	Q9NZL4

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000133265 Expressed in 205 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasⁱ	Q9NZL4 baseline and differential
Genevisibleⁱ	Q9NZL4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005865 HPA071444

HPAⁱ

CAB005865
HPA071444

Interactionⁱ

Subunit structureⁱ

Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HSPA2	P54652	6	EBI-356763,EBI-356991
HSPA8	P11142	11	EBI-356763,EBI-351896
HSPA8	Q96IS6	5	EBI-356763,EBI-10289199
NOTCH2NL	Q7Z3S9	3	EBI-356763,EBI-945833

GO - Molecular functionⁱ

ubiquitin protein ligase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117168, 93 interactors
IntActⁱ	Q9NZL4, 26 interactors
Molecular INTeraction database More...MINTⁱ	Q9NZL4
STRINGⁱ	9606.ENSP00000255631

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	87 – 101	Combined sources	15
Helixⁱ	110 – 131	Combined sources	22
Helixⁱ	134 – 142	Combined sources	9
Helixⁱ	145 – 151	Combined sources	7
Turnⁱ	152 – 155	Combined sources	4
Helixⁱ	159 – 173	Combined sources	15
Helixⁱ	177 – 185	Combined sources	9
Helixⁱ	188 – 198	Combined sources	11
Helixⁱ	202 – 216	Combined sources	15
Helixⁱ	220 – 228	Combined sources	9
Helixⁱ	231 – 240	Combined sources	10
Helixⁱ	244 – 260	Combined sources	17
Helixⁱ	262 – 264	Combined sources	3
Helixⁱ	265 – 270	Combined sources	6
Helixⁱ	273 – 281	Combined sources	9
Helixⁱ	288 – 300	Combined sources	13
Helixⁱ	304 – 311	Combined sources	8
Helixⁱ	313 – 315	Combined sources	3
Helixⁱ	317 – 328	Combined sources	12
Helixⁱ	332 – 334	Combined sources	3
Helixⁱ	335 – 348	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZL4
SMRⁱ	Q9NZL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NZL4

EvolutionaryTraceⁱ

Q9NZL4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	132 – 174	ARM 1Add BLAST	43
Repeatⁱ	177 – 217	ARM 2Add BLAST	41
Repeatⁱ	220 – 259	ARM 3Add BLAST	40
Repeatⁱ	262 – 301	ARM 4Add BLAST	40

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	21 – 37	Gly-richAdd BLAST		17

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2160 Eukaryota ENOG410Y90B LUCA
HOGENOMⁱ	HOG000007740
HOVERGENⁱ	HBG053282
InParanoidⁱ	Q9NZL4
KEGG Orthology (KO) More...KOⁱ	K09562
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HDF
PhylomeDBⁱ	Q9NZL4
TreeFamⁱ	TF324307

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013918 Nucleotide_exch_fac_Fes1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08609 Fes1, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NZL4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEGSRGSR LPLALPPASQ GCSSGGGGGG SSAGGSGNSR PPRNLQGLLQ 
        60         70         80         90        100
MAITAGSEEP DPPPEPMSEE RRQWLQEAMS AAFRGQREEV EQMKSCLRVL 
       110        120        130        140        150
SQPMPPTAGE AEQAADQQER EGALELLADL CENMDNAADF CQLSGMHLLV 
       160        170        180        190        200
GRYLEAGAAG LRWRAAQLIG TCSQNVAAIQ EQVLGLGALR KLLRLLDRDA 
       210        220        230        240        250
CDTVRVKALF AISCLVREQE AGLLQFLRLD GFSVLMRAMQ QQVQKLKVKS 
       260        270        280        290        300
AFLLQNLLVG HPEHKGTLCS MGMVQQLVAL VRTEHSPFHE HVLGALCSLV 
       310        320        330        340        350
TDFPQGVREC REPELGLEEL LRHRCQLLQQ HEEYQEELEF CEKLLQTCFS 

SPADDSMDR

Length:359

Mass (Da):39,303

Last modified:September 12, 2018 - v2

Checksum:ⁱ99C3B7ECD4DFAF33

GO

Isoform 2 (identifier: Q9NZL4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
204-306: Missing.

« Hide

        10         20         30         40         50
MSDEGSRGSR LPLALPPASQ GCSSGGGGGG SSAGGSGNSR PPRNLQGLLQ 
        60         70         80         90        100
MAITAGSEEP DPPPEPMSEE RRQWLQEAMS AAFRGQREEV EQMKSCLRVL 
       110        120        130        140        150
SQPMPPTAGE AEQAADQQER EGALELLADL CENMDNAADF CQLSGMHLLV 
       160        170        180        190        200
GRYLEAGAAG LRWRAAQLIG TCSQNVAAIQ EQVLGLGALR KLLRLLDRDA 
       210        220        230        240        250
CDTVRECREP ELGLEELLRH RCQLLQQHEE YQEELEFCEK LLQTCFSSPA 

DDSMDR

Note: No experimental confirmation available.

Show »

Length:256

Mass (Da):27,853

Checksum:ⁱ655FC577C83E494F

GO

Isoform 3 (identifier: Q9NZL4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGGRRAPLKRRLLSRPSRIDPSGRQSCFSGDHLLPLTHSSLLHKRPM
25-27: Missing.

« Hide

        10         20         30         40         50
MGGRRAPLKR RLLSRPSRID PSGRQSCFSG DHLLPLTHSS LLHKRPMSDE 
        60         70         80         90        100
GSRGSRLPLA LPPASQGCSS GGGSSAGGSG NSRPPRNLQG LLQMAITAGS 
       110        120        130        140        150
EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT 
       160        170        180        190        200
AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG 
       210        220        230        240        250
AAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKLLRLLD RDACDTVRVK 
       260        270        280        290        300
ALFAISCLVR EQEAGLLQFL RLDGFSVLMR AMQQQVQKLK VKSAFLLQNL 
       310        320        330        340        350
LVGHPEHKGT LCSMGMVQQL VALVRTEHSP FHEHVLGALC SLVTDFPQGV 
       360        370        380        390        400
RECREPELGL EELLRHRCQL LQQHEEYQEE LEFCEKLLQT CFSSPADDSM 

DR

Note: No experimental confirmation available.

Show »

Length:402

Mass (Da):44,303

Checksum:ⁱ4BE524054C4F5F33

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EL16	K7EL16_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	214	Annotation score:
K7EKM6	K7EKM6_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	137	Annotation score:
K7EMM7	K7EMM7_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	190	Annotation score:
K7ERT9	K7ERT9_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	136	Annotation score:
K7EN20	K7EN20_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	97	Annotation score:
K7EQQ0	K7EQQ0_HUMAN	Hsp70-binding protein 1 Hsp70-binding protein 1	HSPBP1	31	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	273	M → V in BAG57622 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_080621	25	G → V1 PublicationCorresponds to variant dbSNP:rs140649061Ensembl.		1
Natural variantⁱVAR_023645	30	G → GGGG5 Publications		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053681	1	M → MGGRRAPLKRRLLSRPSRID PSGRQSCFSGDHLLPLTHSS LLHKRPM in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_053682	25 – 27	Missing in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_015945	204 – 306	Missing in isoform 2. 1 PublicationAdd BLAST	103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF093420 mRNA Translation: AAC79703.1 AF187859 mRNA Translation: AAF35833.1 AB020592 mRNA Translation: BAB18742.1 AF217996 mRNA Translation: AAG17238.1 AK130636 mRNA Translation: BAC85399.1 AK294358 mRNA Translation: BAG57622.1 CR457118 mRNA Translation: CAG33399.1 AK075293 mRNA Translation: BAG52102.1 BC001236 mRNA Translation: AAH01236.1 BC002373 mRNA Translation: AAH02373.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001123578.1, NM_001130106.1 NP_001284529.1, NM_001297600.1 [Q9NZL4-3] NP_036399.3, NM_012267.4 XP_016882033.1, XM_017026544.1
UniGeneⁱ	Hs.53066

Genome annotation databases

Ensemblⁱ	ENST00000255631; ENSP00000255631; ENSG00000133265 [Q9NZL4-1] ENST00000433386; ENSP00000398244; ENSG00000133265 [Q9NZL4-1] ENST00000587922; ENSP00000467574; ENSG00000133265 [Q9NZL4-1]
GeneIDⁱ	23640
KEGGⁱ	hsa:23640
UCSC genome browser More...UCSCⁱ	uc002qkc.4 human [Q9NZL4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9NZL4	Hsp70-binding protein 1		MACFA		364	UniRef90_Q9NZL4
Hsp70-binding protein 1		RAT		357
Hsp70-binding protein 1		MOUSE		357
hsp70-binding protein 1 isoform X1		LEPWE		421
hsp70-binding protein 1		NEOSC		357
+99
Q9NZL4-2	Uncharacterized protein		PONAB		240	UniRef90_Q9NZL4-2
UPI00062A994C		NOMLE		272

Protein	Similar proteins		Species	Score	Length	Source
Q9NZL4	Hsp70-binding protein 1		MACFA		364	UniRef50_Q9NZL4
Hsp70-binding protein 1		RAT		357
Hsp70-binding protein 1		MOUSE		357
hsp70-binding protein 1 isoform X1		LEPWE		421
hsp70-binding protein 1		NEOSC		357
+163
Q9NZL4-2	Uncharacterized protein		PONAB		240	UniRef50_Q9NZL4-2
Hsp70-interacting protein, isoform CRA_a		HUMAN		216
Hsp70-binding protein 1 (Fragment)		MOUSE		256
UPI00062A994C		NOMLE		272
UPI00073274C9		MACMU		262
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF093420 mRNA Translation: AAC79703.1 AF187859 mRNA Translation: AAF35833.1 AB020592 mRNA Translation: BAB18742.1 AF217996 mRNA Translation: AAG17238.1 AK130636 mRNA Translation: BAC85399.1 AK294358 mRNA Translation: BAG57622.1 CR457118 mRNA Translation: CAG33399.1 AK075293 mRNA Translation: BAG52102.1 BC001236 mRNA Translation: AAH01236.1 BC002373 mRNA Translation: AAH02373.1
RefSeqⁱ	NP_001123578.1, NM_001130106.1 NP_001284529.1, NM_001297600.1 [Q9NZL4-3] NP_036399.3, NM_012267.4 XP_016882033.1, XM_017026544.1
UniGeneⁱ	Hs.53066

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XQR	X-ray	2.10	A/B	84-359	[»]
	1XQS	X-ray	2.90	A/B	84-359	[»]
ProteinModelPortalⁱ	Q9NZL4
SMRⁱ	Q9NZL4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117168, 93 interactors
IntActⁱ	Q9NZL4, 26 interactors
MINTⁱ	Q9NZL4
STRINGⁱ	9606.ENSP00000255631

PTM databases

iPTMnetⁱ	Q9NZL4
PhosphoSitePlusⁱ	Q9NZL4

Polymorphism and mutation databases

BioMutaⁱ	HSPBP1
DMDMⁱ	74734730

Proteomic databases

EPDⁱ	Q9NZL4
MaxQBⁱ	Q9NZL4
PaxDbⁱ	Q9NZL4
PeptideAtlasⁱ	Q9NZL4
PRIDEⁱ	Q9NZL4
ProteomicsDBⁱ	83428 83429 [Q9NZL4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23640
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000255631; ENSP00000255631; ENSG00000133265 [Q9NZL4-1] ENST00000433386; ENSP00000398244; ENSG00000133265 [Q9NZL4-1] ENST00000587922; ENSP00000467574; ENSG00000133265 [Q9NZL4-1]
GeneIDⁱ	23640
KEGGⁱ	hsa:23640
UCSCⁱ	uc002qkc.4 human [Q9NZL4-1]

Organism-specific databases

CTDⁱ	23640
DisGeNETⁱ	23640
EuPathDBⁱ	HostDB:ENSG00000133265.10
GeneCardsⁱ	HSPBP1
H-InvDBⁱ	HIX0015460
HGNCⁱ	HGNC:24989 HSPBP1
HPAⁱ	CAB005865 HPA071444
MIMⁱ	612939 gene
neXtProtⁱ	NX_Q9NZL4
OpenTargetsⁱ	ENSG00000133265
PharmGKBⁱ	PA164720725
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2160 Eukaryota ENOG410Y90B LUCA
HOGENOMⁱ	HOG000007740
HOVERGENⁱ	HBG053282
InParanoidⁱ	Q9NZL4
KOⁱ	K09562
OrthoDBⁱ	EOG091G0HDF
PhylomeDBⁱ	Q9NZL4
TreeFamⁱ	TF324307

Miscellaneous databases

ChiTaRSⁱ	HSPBP1 human
EvolutionaryTraceⁱ	Q9NZL4
GeneWikiⁱ	HSPBP1
GenomeRNAiⁱ	23640
Protein Ontology More...PROⁱ	PR:Q9NZL4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133265 Expressed in 205 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasⁱ	Q9NZL4 baseline and differential
Genevisibleⁱ	Q9NZL4 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR013918 Nucleotide_exch_fac_Fes1
Pfamⁱ	View protein in Pfam PF08609 Fes1, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HPBP1_HUMAN
Accessionⁱ	Q9NZL4Primary (citable) accession number: Q9NZL4 Secondary accession number(s): B3KQP0 , B4DG11, O95351, Q6ZNU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	September 12, 2018
	Last modified:	October 10, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9NZL4 (HPBP1_HUMAN)

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Hsp70-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ