UniProtKB - Q9NZL4 (HPBP1_HUMAN)
Protein
Hsp70-binding protein 1
Gene
HSPBP1
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.5 Publications
GO - Molecular functioni
- adenyl-nucleotide exchange factor activity Source: GO_Central
- enzyme inhibitor activity Source: ProtInc
- ubiquitin protein ligase binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
- positive regulation of protein ubiquitination Source: BHF-UCL
- protein folding Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | Q9NZL4 |
Names & Taxonomyi
Protein namesi | Recommended name: Hsp70-binding protein 1CuratedShort name: HspBP1 Alternative name(s): Heat shock protein-binding protein 1 Hsp70-binding protein 2 Short name: HspBP2 Hsp70-interacting protein 1 Hsp70-interacting protein 2 |
Gene namesi | ORF Names:PP1845 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24989, HSPBP1 |
MIMi | 612939, gene |
neXtProti | NX_Q9NZL4 |
VEuPathDBi | HostDB:ENSG00000133265.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23640 |
OpenTargetsi | ENSG00000133265 |
PharmGKBi | PA164720725 |
Miscellaneous databases
Pharosi | Q9NZL4, Tbio |
Genetic variation databases
BioMutai | HSPBP1 |
DMDMi | 74734730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084035 | 1 – 359 | Hsp70-binding protein 1Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 351 | PhosphoserineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NZL4 |
jPOSTi | Q9NZL4 |
MassIVEi | Q9NZL4 |
PaxDbi | Q9NZL4 |
PeptideAtlasi | Q9NZL4 |
PRIDEi | Q9NZL4 |
ProteomicsDBi | 83428 [Q9NZL4-1] 83429 [Q9NZL4-2] |
PTM databases
iPTMneti | Q9NZL4 |
MetOSitei | Q9NZL4 |
PhosphoSitePlusi | Q9NZL4 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000133265, Expressed in nucleus accumbens and 217 other tissues |
ExpressionAtlasi | Q9NZL4, baseline and differential |
Genevisiblei | Q9NZL4, HS |
Organism-specific databases
HPAi | ENSG00000133265, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.
Interacts with PGLYRP1; this interaction blocks the cytotoxic activity of the PGLYRP1-HSPA1A complex (PubMed:21247889).
5 PublicationsBinary interactionsi
Hide detailsQ9NZL4
With | #Exp. | IntAct |
---|---|---|
HSPA2 [P54652] | 7 | EBI-356763,EBI-356991 |
HSPA8 [P11142] | 12 | EBI-356763,EBI-351896 |
HSPA8 [Q96IS6] | 5 | EBI-356763,EBI-10289199 |
NOTCH2NLA [Q7Z3S9] | 4 | EBI-356763,EBI-945833 |
GO - Molecular functioni
- ubiquitin protein ligase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 117168, 116 interactors |
IntActi | Q9NZL4, 66 interactors |
MINTi | Q9NZL4 |
STRINGi | 9606.ENSP00000255631 |
Miscellaneous databases
RNActi | Q9NZL4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NZL4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZL4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 132 – 174 | ARM 1Add BLAST | 43 | |
Repeati | 177 – 217 | ARM 2Add BLAST | 41 | |
Repeati | 220 – 259 | ARM 3Add BLAST | 40 | |
Repeati | 262 – 301 | ARM 4Add BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 37 | Gly-richAdd BLAST | 17 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2160, Eukaryota |
GeneTreei | ENSGT00940000153909 |
HOGENOMi | CLU_049387_0_1_1 |
InParanoidi | Q9NZL4 |
OMAi | LCCLVED |
OrthoDBi | 1310125at2759 |
PhylomeDBi | Q9NZL4 |
TreeFami | TF324307 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013918, Nucleotide_exch_fac_Fes1 |
Pfami | View protein in Pfam PF08609, Fes1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NZL4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDEGSRGSR LPLALPPASQ GCSSGGGGGG SSAGGSGNSR PPRNLQGLLQ
60 70 80 90 100
MAITAGSEEP DPPPEPMSEE RRQWLQEAMS AAFRGQREEV EQMKSCLRVL
110 120 130 140 150
SQPMPPTAGE AEQAADQQER EGALELLADL CENMDNAADF CQLSGMHLLV
160 170 180 190 200
GRYLEAGAAG LRWRAAQLIG TCSQNVAAIQ EQVLGLGALR KLLRLLDRDA
210 220 230 240 250
CDTVRVKALF AISCLVREQE AGLLQFLRLD GFSVLMRAMQ QQVQKLKVKS
260 270 280 290 300
AFLLQNLLVG HPEHKGTLCS MGMVQQLVAL VRTEHSPFHE HVLGALCSLV
310 320 330 340 350
TDFPQGVREC REPELGLEEL LRHRCQLLQQ HEEYQEELEF CEKLLQTCFS
SPADDSMDR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EL16 | K7EL16_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 214 | Annotation score: | ||
K7EKM6 | K7EKM6_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 137 | Annotation score: | ||
K7EMM7 | K7EMM7_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 190 | Annotation score: | ||
K7ERT9 | K7ERT9_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 136 | Annotation score: | ||
K7EQQ0 | K7EQQ0_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 31 | Annotation score: | ||
K7EN20 | K7EN20_HUMAN | Hsp70-binding protein 1 | HSPBP1 | 97 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 273 | M → V in BAG57622 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080621 | 25 | G → V1 PublicationCorresponds to variant dbSNP:rs140649061Ensembl. | 1 | |
Natural variantiVAR_023645 | 30 | G → GGGG5 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053681 | 1 | M → MGGRRAPLKRRLLSRPSRID PSGRQSCFSGDHLLPLTHSS LLHKRPM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_053682 | 25 – 27 | Missing in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_015945 | 204 – 306 | Missing in isoform 2. 1 PublicationAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF093420 mRNA Translation: AAC79703.1 AF187859 mRNA Translation: AAF35833.1 AB020592 mRNA Translation: BAB18742.1 AF217996 mRNA Translation: AAG17238.1 AK130636 mRNA Translation: BAC85399.1 AK294358 mRNA Translation: BAG57622.1 CR457118 mRNA Translation: CAG33399.1 AK075293 mRNA Translation: BAG52102.1 BC001236 mRNA Translation: AAH01236.1 BC002373 mRNA Translation: AAH02373.1 |
CCDSi | CCDS33111.1 [Q9NZL4-1] |
RefSeqi | NP_001123578.1, NM_001130106.1 [Q9NZL4-1] NP_001284529.1, NM_001297600.1 NP_036399.3, NM_012267.4 [Q9NZL4-1] XP_016882033.1, XM_017026544.1 [Q9NZL4-1] |
Genome annotation databases
Ensembli | ENST00000255631; ENSP00000255631; ENSG00000133265 [Q9NZL4-1] ENST00000433386; ENSP00000398244; ENSG00000133265 [Q9NZL4-1] ENST00000587922; ENSP00000467574; ENSG00000133265 [Q9NZL4-1] |
GeneIDi | 23640 |
KEGGi | hsa:23640 |
UCSCi | uc002qkc.4, human [Q9NZL4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF093420 mRNA Translation: AAC79703.1 AF187859 mRNA Translation: AAF35833.1 AB020592 mRNA Translation: BAB18742.1 AF217996 mRNA Translation: AAG17238.1 AK130636 mRNA Translation: BAC85399.1 AK294358 mRNA Translation: BAG57622.1 CR457118 mRNA Translation: CAG33399.1 AK075293 mRNA Translation: BAG52102.1 BC001236 mRNA Translation: AAH01236.1 BC002373 mRNA Translation: AAH02373.1 |
CCDSi | CCDS33111.1 [Q9NZL4-1] |
RefSeqi | NP_001123578.1, NM_001130106.1 [Q9NZL4-1] NP_001284529.1, NM_001297600.1 NP_036399.3, NM_012267.4 [Q9NZL4-1] XP_016882033.1, XM_017026544.1 [Q9NZL4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XQR | X-ray | 2.10 | A/B | 84-359 | [»] | |
1XQS | X-ray | 2.90 | A/B | 84-359 | [»] | |
SMRi | Q9NZL4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117168, 116 interactors |
IntActi | Q9NZL4, 66 interactors |
MINTi | Q9NZL4 |
STRINGi | 9606.ENSP00000255631 |
PTM databases
iPTMneti | Q9NZL4 |
MetOSitei | Q9NZL4 |
PhosphoSitePlusi | Q9NZL4 |
Genetic variation databases
BioMutai | HSPBP1 |
DMDMi | 74734730 |
Proteomic databases
EPDi | Q9NZL4 |
jPOSTi | Q9NZL4 |
MassIVEi | Q9NZL4 |
PaxDbi | Q9NZL4 |
PeptideAtlasi | Q9NZL4 |
PRIDEi | Q9NZL4 |
ProteomicsDBi | 83428 [Q9NZL4-1] 83429 [Q9NZL4-2] |
Protocols and materials databases
Antibodypediai | 33053, 296 antibodies |
DNASUi | 23640 |
Genome annotation databases
Ensembli | ENST00000255631; ENSP00000255631; ENSG00000133265 [Q9NZL4-1] ENST00000433386; ENSP00000398244; ENSG00000133265 [Q9NZL4-1] ENST00000587922; ENSP00000467574; ENSG00000133265 [Q9NZL4-1] |
GeneIDi | 23640 |
KEGGi | hsa:23640 |
UCSCi | uc002qkc.4, human [Q9NZL4-1] |
Organism-specific databases
CTDi | 23640 |
DisGeNETi | 23640 |
GeneCardsi | HSPBP1 |
HGNCi | HGNC:24989, HSPBP1 |
HPAi | ENSG00000133265, Low tissue specificity |
MIMi | 612939, gene |
neXtProti | NX_Q9NZL4 |
OpenTargetsi | ENSG00000133265 |
PharmGKBi | PA164720725 |
VEuPathDBi | HostDB:ENSG00000133265.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2160, Eukaryota |
GeneTreei | ENSGT00940000153909 |
HOGENOMi | CLU_049387_0_1_1 |
InParanoidi | Q9NZL4 |
OMAi | LCCLVED |
OrthoDBi | 1310125at2759 |
PhylomeDBi | Q9NZL4 |
TreeFami | TF324307 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZL4 |
Miscellaneous databases
BioGRID-ORCSi | 23640, 7 hits in 994 CRISPR screens |
ChiTaRSi | HSPBP1, human |
EvolutionaryTracei | Q9NZL4 |
GeneWikii | HSPBP1 |
GenomeRNAii | 23640 |
Pharosi | Q9NZL4, Tbio |
PROi | PR:Q9NZL4 |
RNActi | Q9NZL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133265, Expressed in nucleus accumbens and 217 other tissues |
ExpressionAtlasi | Q9NZL4, baseline and differential |
Genevisiblei | Q9NZL4, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013918, Nucleotide_exch_fac_Fes1 |
Pfami | View protein in Pfam PF08609, Fes1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HPBP1_HUMAN | |
Accessioni | Q9NZL4Primary (citable) accession number: Q9NZL4 Secondary accession number(s): B3KQP0 Q6ZNU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | September 12, 2018 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references