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Entry version 189 (12 Aug 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Zinc finger protein 224

Gene

ZNF224

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NZL3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NZL3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 224
Alternative name(s):
Bone marrow zinc finger 2
Short name:
BMZF-2
Zinc finger protein 233
Zinc finger protein 255
Zinc finger protein 27
Zinc finger protein KOX22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF224
Synonyms:BMZF2, KOX22, ZNF233, ZNF255, ZNF27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000267680.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13017, ZNF224

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194555, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZL3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7767

Open Targets

More...
OpenTargetsi
ENSG00000267680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37596

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NZL3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF224

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474651 – 707Zinc finger protein 224Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki473Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki625Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZL3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NZL3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZL3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZL3

PeptideAtlas

More...
PeptideAtlasi
Q9NZL3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZL3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83427

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Mainly expressed in fetal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000267680, Expressed in oviduct epithelium and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZL3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZL3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000267680, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WT1.

Interacts with DEPDC1A.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113550, 14 interactors

Protein interaction database and analysis system

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IntActi
Q9NZL3, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337368

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NZL3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1707
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZL3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NZL3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160225

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZL3

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQHEMET

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZL3

TreeFam database of animal gene trees

More...
TreeFami
TF341885

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NZL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTFKEAMTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
AFHRDTFHFL REEKIWMMKT AIQREGNSGD KIQTEMETVS EAGTHQEWSF
110 120 130 140 150
QQIWEKIASD LTRSQDLMIN SSQFSKEGDF PCQTEAGLSV IHTRQKSSQG
160 170 180 190 200
NGYKPSFSDV SHFDFHQQLH SGEKSHTCDE CGKNFCYISA LRIHQRVHMG
210 220 230 240 250
EKCYKCDVCG KEFSQSSHLQ THQRVHTGEK PFKCVECGKG FSRRSALNVH
260 270 280 290 300
HKLHTGEKPY NCEECGKAFI HDSQLQEHQR IHTGEKPFKC DICGKSFCGR
310 320 330 340 350
SRLNRHSMVH TAEKPFRCDT CDKSFRQRSA LNSHRMIHTG EKPYKCEECG
360 370 380 390 400
KGFICRRDLY THHMVHTGEK PYNCKECGKS FRWASCLLKH QRVHSGEKPF
410 420 430 440 450
KCEECGKGFY TNSQCYSHQR SHSGEKPYKC VECGKGYKRR LDLDFHQRVH
460 470 480 490 500
TGEKLYNCKE CGKSFSRAPC LLKHERLHSG EKPFQCEECG KRFTQNSHLH
510 520 530 540 550
SHQRVHTGEK PYKCEKCGKG YNSKFNLDMH QKVHTGERPY NCKECGKSFG
560 570 580 590 600
WASCLLKHQR LHSGEKPFKC EECGKRFTQN SQLHSHQRVH TGEKPYKCDE
610 620 630 640 650
CGKGFSWSST RLTHQRRHSR ETPLKCEQHG KNIVQNSFSK VQEKVHSVEK
660 670 680 690 700
PYKCEDCGKG YNRRLNLDMH QRVHMGEKTW KCRECDMCFS QASSLRLHQN

VHVGEKP
Length:707
Mass (Da):82,280
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9C1346D52BBF38F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJ30K7EJ30_HUMAN
Zinc finger protein 224
ZNF224
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL24K7EL24_HUMAN
Zinc finger protein 224
ZNF224
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENI7K7ENI7_HUMAN
Zinc finger protein 224
ZNF224
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137 – 151GLSVI…SSQGN → RTICNSHKTEIFPRAI in AAD32448 (PubMed:15489334).CuratedAdd BLAST15
Sequence conflicti286K → T in CAA36579 (PubMed:12239212).Curated1
Sequence conflicti400 – 401FK → IQ in AAD32448 (PubMed:15489334).Curated2
Sequence conflicti412N → I in AAD32448 (PubMed:15489334).Curated1
Sequence conflicti521Y → H in AAD32448 (PubMed:15489334).Curated1
Sequence conflicti562H → R in AAF04106 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047061118M → V4 PublicationsCorresponds to variant dbSNP:rs2068061Ensembl.1
Natural variantiVAR_024204162H → L3 PublicationsCorresponds to variant dbSNP:rs4239529Ensembl.1
Natural variantiVAR_047062438K → N. Corresponds to variant dbSNP:rs3208201Ensembl.1
Natural variantiVAR_061941447Q → H. Corresponds to variant dbSNP:rs58935748Ensembl.1
Natural variantiVAR_047063506H → D. Corresponds to variant dbSNP:rs3746323Ensembl.1
Natural variantiVAR_021891640K → E2 PublicationsCorresponds to variant dbSNP:rs3746319Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF187990 mRNA Translation: AAF04106.2
AC084219 Genomic DNA No translation available.
AC114266 Genomic DNA No translation available.
BC051902 mRNA Translation: AAH51902.1
AF067164 mRNA Translation: AAD32448.1
AY148489 mRNA Translation: AAN61121.1
X52353 mRNA Translation: CAA36579.1
AC021092 Genomic DNA Translation: AAF24968.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33046.1

Protein sequence database of the Protein Information Resource

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PIRi
I37962

NCBI Reference Sequences

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RefSeqi
NP_001308574.1, NM_001321645.1
NP_037530.2, NM_013398.3
XP_016882750.1, XM_017027261.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336976; ENSP00000337368; ENSG00000267680

Database of genes from NCBI RefSeq genomes

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GeneIDi
7767

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7767

UCSC genome browser

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UCSCi
uc002oyh.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187990 mRNA Translation: AAF04106.2
AC084219 Genomic DNA No translation available.
AC114266 Genomic DNA No translation available.
BC051902 mRNA Translation: AAH51902.1
AF067164 mRNA Translation: AAD32448.1
AY148489 mRNA Translation: AAN61121.1
X52353 mRNA Translation: CAA36579.1
AC021092 Genomic DNA Translation: AAF24968.1
CCDSiCCDS33046.1
PIRiI37962
RefSeqiNP_001308574.1, NM_001321645.1
NP_037530.2, NM_013398.3
XP_016882750.1, XM_017027261.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ELYNMR-A227-259[»]
2ELZNMR-A647-679[»]
2EM0NMR-A675-707[»]
2EM6NMR-A199-231[»]
2EM7NMR-A339-371[»]
2EM8NMR-A423-455[»]
2EM9NMR-A367-399[»]
2EN1NMR-A563-595[»]
2EN8NMR-A171-203[»]
2ENANMR-A311-343[»]
2ENCNMR-A395-427[»]
2EOQNMR-A283-315[»]
2EORNMR-A255-287[»]
2EQ4NMR-A451-483[»]
2YSPNMR-A507-539[»]
2YTHNMR-A479-511[»]
SMRiQ9NZL3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113550, 14 interactors
IntActiQ9NZL3, 12 interactors
STRINGi9606.ENSP00000337368

PTM databases

iPTMnetiQ9NZL3
PhosphoSitePlusiQ9NZL3

Polymorphism and mutation databases

BioMutaiZNF224
DMDMi313104253

Proteomic databases

jPOSTiQ9NZL3
MassIVEiQ9NZL3
MaxQBiQ9NZL3
PaxDbiQ9NZL3
PeptideAtlasiQ9NZL3
PRIDEiQ9NZL3
ProteomicsDBi83427

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
65029, 121 antibodies

The DNASU plasmid repository

More...
DNASUi
7767

Genome annotation databases

EnsembliENST00000336976; ENSP00000337368; ENSG00000267680
GeneIDi7767
KEGGihsa:7767
UCSCiuc002oyh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7767
DisGeNETi7767
EuPathDBiHostDB:ENSG00000267680.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF224
HGNCiHGNC:13017, ZNF224
HPAiENSG00000267680, Low tissue specificity
MIMi194555, gene
neXtProtiNX_Q9NZL3
OpenTargetsiENSG00000267680
PharmGKBiPA37596

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000160225
HOGENOMiCLU_002678_17_1_1
InParanoidiQ9NZL3
KOiK09228
OMAiVQHEMET
OrthoDBi1318335at2759
PhylomeDBiQ9NZL3
TreeFamiTF341885

Enzyme and pathway databases

PathwayCommonsiQ9NZL3
ReactomeiR-HSA-212436, Generic Transcription Pathway
SIGNORiQ9NZL3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7767, 1 hit in 892 CRISPR screens
EvolutionaryTraceiQ9NZL3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF224

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7767
PharosiQ9NZL3, Tbio

Protein Ontology

More...
PROi
PR:Q9NZL3
RNActiQ9NZL3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000267680, Expressed in oviduct epithelium and 221 other tissues
ExpressionAtlasiQ9NZL3, baseline and differential
GenevisibleiQ9NZL3, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 18 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 18 hits
PS50157, ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN224_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZL3
Secondary accession number(s): A6NFW9
, P17033, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 30, 2010
Last modified: August 12, 2020
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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