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Entry version 172 (12 Aug 2020)
Sequence version 2 (05 Jul 2005)
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Protein

Diphosphoinositol polyphosphate phosphohydrolase 2

Gene

NUDT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 3 Mg2+ or Mn2+ ions per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.2 nM for PP-InsP51 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei10SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi50Magnesium 1; via carbonyl oxygenBy similarity1
    Metal bindingi66Magnesium 2By similarity1
    Metal bindingi66Magnesium 3By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei69Proton acceptorBy similarity1
    Metal bindingi70Magnesium 1By similarity1
    Binding sitei115SubstrateBy similarity1
    Binding sitei133SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, RNA-binding
    LigandMagnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS10696-MONOMER

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q9NZJ9

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1855167, Synthesis of pyrophosphates in the cytosol

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9NZJ9

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 2Curated (EC:3.6.1.522 Publications)
    Short name:
    DIPP-2
    Alternative name(s):
    Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
    Nucleoside diphosphate-linked moiety X motif 4
    Short name:
    Nudix motif 4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NUDT4Imported
    Synonyms:DIPP2, KIAA0487
    ORF Names:HDCMB47P
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000173598.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8051, NUDT4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609229, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NZJ9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000173598

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA31835

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9NZJ9, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4295967

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NUDT4

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    68565946

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000570581 – 180Diphosphoinositol polyphosphate phosphohydrolase 2Add BLAST180

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NZJ9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NZJ9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9NZJ9

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NZJ9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NZJ9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NZJ9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NZJ9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    83421 [Q9NZJ9-1]
    83422 [Q9NZJ9-2]
    83423 [Q9NZJ9-3]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q9NZJ9-2 [Q9NZJ9-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NZJ9

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    Q9NZJ9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NZJ9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000173598, Expressed in heart right ventricle and 246 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NZJ9, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NZJ9, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000173598, Tissue enhanced (heart)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    116334, 7 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NZJ9, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000338352

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9NZJ9, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1180
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NZJ9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 144Nudix hydrolasePROSITE-ProRule annotationAdd BLAST127

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 20Substrate bindingBy similarity3
    Regioni39 – 41Substrate bindingBy similarity3
    Regioni89 – 91Substrate bindingBy similarity3

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi51 – 72Nudix boxAdd BLAST22

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Nudix hydrolase family. DIPP subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2839, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155210

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_037162_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NZJ9

    KEGG Orthology (KO)

    More...
    KOi
    K07766

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YGTNANT

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NZJ9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106349

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015797, NUDIX_hydrolase-like_dom_sf
    IPR020084, NUDIX_hydrolase_CS
    IPR000086, NUDIX_hydrolase_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00293, NUDIX, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55811, SSF55811, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51462, NUDIX, 1 hit
    PS00893, NUDIX_BOX, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NZJ9-1) [UniParc]FASTAAdd to basket
    Also known as: Alpha, DIPP2alpha

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG
    60 70 80 90 100
    GGMEPEEEPG GAAVREVYEE AGVKGKLGRL LGIFENQDRK HRTYVYVLTV
    110 120 130 140 150
    TEILEDWEDS VNIGRKREWF KVEDAIKVLQ CHKPVHAEYL EKLKLGCSPA
    160 170 180
    NGNSTVPSLP DNNALFVTAA QTSGLPSSVR
    Length:180
    Mass (Da):20,306
    Last modified:July 5, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86D766F8F5B22D13
    GO
    Isoform 2 (identifier: Q9NZJ9-2) [UniParc]FASTAAdd to basket
    Also known as: Beta, DIPP2beta

    The sequence of this isoform differs from the canonical sequence as follows:
         85-85: E → EQ

    Show »
    Length:181
    Mass (Da):20,434
    Checksum:iCB3C131FAD21A4AA
    GO
    Isoform 3 (identifier: Q9NZJ9-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: Missing.
         85-85: E → EQ

    Show »
    Length:129
    Mass (Da):14,395
    Checksum:i2A8C483085B2D4D3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8VRL4F8VRL4_HUMAN
    Diphosphoinositol polyphosphate pho...
    NUDT4
    95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DGJ4A0A0C4DGJ4_HUMAN
    Diphosphoinositol polyphosphate pho...
    NUDT4
    128Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VRR0F8VRR0_HUMAN
    Diphosphoinositol polyphosphate pho...
    NUDT4
    112Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAF75563 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated
    The sequence BAE16985 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16G → D in AAF68857 (PubMed:10777568).Curated1
    Sequence conflicti41R → Q in BAD97217 (Ref. 7) Curated1
    Sequence conflicti73V → D in AAF75563 (Ref. 3) Curated1
    Sequence conflicti164A → V in AAF68857 (PubMed:10777568).Curated1
    Sequence conflicti177S → P in AAF68858 (PubMed:10777568).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0142691 – 52Missing in isoform 3. 3 PublicationsAdd BLAST52
    Alternative sequenceiVSP_01427085E → EQ in isoform 2 and isoform 3. 6 Publications1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF191649 mRNA Translation: AAF68855.1
    AF191650 mRNA Translation: AAF68856.1
    AF191651 mRNA Translation: AAF68857.1
    AF191652 mRNA Translation: AAF68858.2
    AF191653 mRNA Translation: AAF68859.1
    AB007956 mRNA Translation: BAE16985.1 Different initiation.
    AF067803 mRNA Translation: AAF75563.1 Sequence problems.
    CR749445 mRNA Translation: CAH18283.1
    BT020109 mRNA Translation: AAV38912.1
    BT020110 mRNA Translation: AAV38913.1
    AK304296 mRNA Translation: BAH14152.1
    AK223497 mRNA Translation: BAD97217.1
    BC012069 mRNA Translation: AAH12069.1
    BC051310 mRNA Translation: AAH51310.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS44952.1 [Q9NZJ9-1]
    CCDS73504.1 [Q9NZJ9-3]
    CCDS9044.1 [Q9NZJ9-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001287951.1, NM_001301022.1 [Q9NZJ9-3]
    NP_001287952.1, NM_001301023.1
    NP_001287953.1, NM_001301024.1
    NP_061967.3, NM_019094.5 [Q9NZJ9-1]
    NP_950241.1, NM_199040.3 [Q9NZJ9-2]
    XP_011536096.1, XM_011537794.2 [Q9NZJ9-3]
    XP_011536097.1, XM_011537795.2
    XP_011536098.1, XM_011537796.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000337179; ENSP00000338352; ENSG00000173598 [Q9NZJ9-2]
    ENST00000415493; ENSP00000406612; ENSG00000173598 [Q9NZJ9-1]
    ENST00000547014; ENSP00000448032; ENSG00000173598 [Q9NZJ9-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    11163

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:11163

    UCSC genome browser

    More...
    UCSCi
    uc001tcm.4, human [Q9NZJ9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF191649 mRNA Translation: AAF68855.1
    AF191650 mRNA Translation: AAF68856.1
    AF191651 mRNA Translation: AAF68857.1
    AF191652 mRNA Translation: AAF68858.2
    AF191653 mRNA Translation: AAF68859.1
    AB007956 mRNA Translation: BAE16985.1 Different initiation.
    AF067803 mRNA Translation: AAF75563.1 Sequence problems.
    CR749445 mRNA Translation: CAH18283.1
    BT020109 mRNA Translation: AAV38912.1
    BT020110 mRNA Translation: AAV38913.1
    AK304296 mRNA Translation: BAH14152.1
    AK223497 mRNA Translation: BAD97217.1
    BC012069 mRNA Translation: AAH12069.1
    BC051310 mRNA Translation: AAH51310.1
    CCDSiCCDS44952.1 [Q9NZJ9-1]
    CCDS73504.1 [Q9NZJ9-3]
    CCDS9044.1 [Q9NZJ9-2]
    RefSeqiNP_001287951.1, NM_001301022.1 [Q9NZJ9-3]
    NP_001287952.1, NM_001301023.1
    NP_001287953.1, NM_001301024.1
    NP_061967.3, NM_019094.5 [Q9NZJ9-1]
    NP_950241.1, NM_199040.3 [Q9NZJ9-2]
    XP_011536096.1, XM_011537794.2 [Q9NZJ9-3]
    XP_011536097.1, XM_011537795.2
    XP_011536098.1, XM_011537796.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5LTUX-ray2.23A/B1-180[»]
    SMRiQ9NZJ9
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116334, 7 interactors
    IntActiQ9NZJ9, 2 interactors
    STRINGi9606.ENSP00000338352

    Chemistry databases

    ChEMBLiCHEMBL4295967

    PTM databases

    iPTMnetiQ9NZJ9
    MetOSiteiQ9NZJ9
    PhosphoSitePlusiQ9NZJ9

    Polymorphism and mutation databases

    BioMutaiNUDT4
    DMDMi68565946

    Proteomic databases

    EPDiQ9NZJ9
    jPOSTiQ9NZJ9
    MassIVEiQ9NZJ9
    MaxQBiQ9NZJ9
    PaxDbiQ9NZJ9
    PeptideAtlasiQ9NZJ9
    PRIDEiQ9NZJ9
    ProteomicsDBi83421 [Q9NZJ9-1]
    83422 [Q9NZJ9-2]
    83423 [Q9NZJ9-3]
    TopDownProteomicsiQ9NZJ9-2 [Q9NZJ9-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    17488, 88 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    11163

    Genome annotation databases

    EnsembliENST00000337179; ENSP00000338352; ENSG00000173598 [Q9NZJ9-2]
    ENST00000415493; ENSP00000406612; ENSG00000173598 [Q9NZJ9-1]
    ENST00000547014; ENSP00000448032; ENSG00000173598 [Q9NZJ9-3]
    GeneIDi11163
    KEGGihsa:11163
    UCSCiuc001tcm.4, human [Q9NZJ9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    11163
    EuPathDBiHostDB:ENSG00000173598.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NUDT4
    HGNCiHGNC:8051, NUDT4
    HPAiENSG00000173598, Tissue enhanced (heart)
    MIMi609229, gene
    neXtProtiNX_Q9NZJ9
    OpenTargetsiENSG00000173598
    PharmGKBiPA31835

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2839, Eukaryota
    GeneTreeiENSGT00940000155210
    HOGENOMiCLU_037162_1_0_1
    InParanoidiQ9NZJ9
    KOiK07766
    OMAiYGTNANT
    PhylomeDBiQ9NZJ9
    TreeFamiTF106349

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10696-MONOMER
    PathwayCommonsiQ9NZJ9
    ReactomeiR-HSA-1855167, Synthesis of pyrophosphates in the cytosol
    SABIO-RKiQ9NZJ9

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    11163, 534 hits in 870 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NUDT4, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    NUDT4

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    11163
    PharosiQ9NZJ9, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q9NZJ9
    RNActiQ9NZJ9, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000173598, Expressed in heart right ventricle and 246 other tissues
    ExpressionAtlasiQ9NZJ9, baseline and differential
    GenevisibleiQ9NZJ9, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR015797, NUDIX_hydrolase-like_dom_sf
    IPR020084, NUDIX_hydrolase_CS
    IPR000086, NUDIX_hydrolase_dom
    PfamiView protein in Pfam
    PF00293, NUDIX, 1 hit
    SUPFAMiSSF55811, SSF55811, 1 hit
    PROSITEiView protein in PROSITE
    PS51462, NUDIX, 1 hit
    PS00893, NUDIX_BOX, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUDT4_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZJ9
    Secondary accession number(s): B7Z916
    , Q4AEJ6, Q53EZ2, Q68DD7, Q9NPC5, Q9NS30, Q9NZK0, Q9NZK1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: August 12, 2020
    This is version 172 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
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