Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Upstream-binding protein 1

Gene

UBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.By similarity3 Publications

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity Source: GO_Central
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • sequence-specific DNA binding Source: GO_Central
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Upstream-binding protein 1
Alternative name(s):
Transcription factor LBP-1
Gene namesi
Name:UBP1
Synonyms:LBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000153560.11
HGNCiHGNC:12507 UBP1
MIMi609784 gene
neXtProtiNX_Q9NZI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153560
PharmGKBiPA37154

Polymorphism and mutation databases

BioMutaiUBP1
DMDMi74719655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002290261 – 540Upstream-binding protein 1Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei390PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZI7
MaxQBiQ9NZI7
PaxDbiQ9NZI7
PeptideAtlasiQ9NZI7
PRIDEiQ9NZI7
ProteomicsDBi83408
83409 [Q9NZI7-4]

PTM databases

iPTMnetiQ9NZI7
PhosphoSitePlusiQ9NZI7

Expressioni

Tissue specificityi

Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.1 Publication

Inductioni

By HIV-1 infection of lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000153560 Expressed in 228 organ(s), highest expression level in forebrain
CleanExiHS_UBP1
ExpressionAtlasiQ9NZI7 baseline and differential
GenevisibleiQ9NZI7 HS

Organism-specific databases

HPAiHPA003967

Interactioni

Subunit structurei

Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi113189, 34 interactors
IntActiQ9NZI7, 17 interactors
MINTiQ9NZI7
STRINGi9606.ENSP00000283628

Structurei

3D structure databases

ProteinModelPortaliQ9NZI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00760000119235
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ9NZI7
KOiK09275
OMAiHPSATIQ
OrthoDBiEOG091G0YV2
PhylomeDBiQ9NZI7
TreeFamiTF314132

Family and domain databases

CDDicd09588 SAM_LBP1, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037600 Ubp1_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZI7-1) [UniParc]FASTAAdd to basket
Also known as: LBP-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED
60 70 80 90 100
SSLPLDGETE HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR
110 120 130 140 150
KMGDMPEING KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD
160 170 180 190 200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG
210 220 230 240 250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKTDREK
260 270 280 290 300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
310 320 330 340 350
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN
360 370 380 390 400
HQGDGASQTS GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL
410 420 430 440 450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCREQPS STVLQGQQQA
460 470 480 490 500
ASSASENGSG APYVYHAIYL EEMIASEVAR KLALVFNIPL HQINQVYRQG
510 520 530 540
PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
Length:540
Mass (Da):60,491
Last modified:October 1, 2000 - v1
Checksum:iCD95819AA86A7F39
GO
Isoform 2 (identifier: Q9NZI7-4) [UniParc]FASTAAdd to basket
Also known as: LBP-1a

The sequence of this isoform differs from the canonical sequence as follows:
     274-309: Missing.

Show »
Length:504
Mass (Da):56,453
Checksum:iBF9A5F42A77A33A9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWL3C9JWL3_HUMAN
Upstream-binding protein 1
UBP1
148Annotation score:
F8WEP8F8WEP8_HUMAN
Upstream-binding protein 1
UBP1
164Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 94EI → D in BAB14501 (PubMed:14702039).Curated2
Sequence conflicti273E → EE (PubMed:8114710).Curated1
Sequence conflicti291 – 297SSKRTLP → VQQADFA (PubMed:8114710).Curated7
Sequence conflicti418Y → V (PubMed:8114710).Curated1
Sequence conflicti424R → RR in CAH18658 (PubMed:17974005).Curated1
Sequence conflicti503G → GH (PubMed:8114710).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049294109N → S1 PublicationCorresponds to variant dbSNP:rs3736563Ensembl.1
Natural variantiVAR_025730212T → A1 PublicationCorresponds to variant dbSNP:rs17854430Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017730274 – 309Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198487 mRNA Translation: AAF32274.1
AK023274 mRNA Translation: BAB14501.1
BC047235 mRNA Translation: AAH47235.1
CR749798 mRNA Translation: CAH18658.1
CCDSiCCDS2659.1 [Q9NZI7-1]
CCDS46788.1 [Q9NZI7-4]
PIRiA56205
B56205
RefSeqiNP_001121632.1, NM_001128160.1 [Q9NZI7-4]
NP_001121633.1, NM_001128161.1 [Q9NZI7-1]
NP_055332.3, NM_014517.4 [Q9NZI7-1]
UniGeneiHs.729120

Genome annotation databases

EnsembliENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4]
GeneIDi7342
KEGGihsa:7342
UCSCiuc003cfq.5 human [Q9NZI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198487 mRNA Translation: AAF32274.1
AK023274 mRNA Translation: BAB14501.1
BC047235 mRNA Translation: AAH47235.1
CR749798 mRNA Translation: CAH18658.1
CCDSiCCDS2659.1 [Q9NZI7-1]
CCDS46788.1 [Q9NZI7-4]
PIRiA56205
B56205
RefSeqiNP_001121632.1, NM_001128160.1 [Q9NZI7-4]
NP_001121633.1, NM_001128161.1 [Q9NZI7-1]
NP_055332.3, NM_014517.4 [Q9NZI7-1]
UniGeneiHs.729120

3D structure databases

ProteinModelPortaliQ9NZI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113189, 34 interactors
IntActiQ9NZI7, 17 interactors
MINTiQ9NZI7
STRINGi9606.ENSP00000283628

PTM databases

iPTMnetiQ9NZI7
PhosphoSitePlusiQ9NZI7

Polymorphism and mutation databases

BioMutaiUBP1
DMDMi74719655

Proteomic databases

EPDiQ9NZI7
MaxQBiQ9NZI7
PaxDbiQ9NZI7
PeptideAtlasiQ9NZI7
PRIDEiQ9NZI7
ProteomicsDBi83408
83409 [Q9NZI7-4]

Protocols and materials databases

DNASUi7342
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4]
GeneIDi7342
KEGGihsa:7342
UCSCiuc003cfq.5 human [Q9NZI7-1]

Organism-specific databases

CTDi7342
EuPathDBiHostDB:ENSG00000153560.11
GeneCardsiUBP1
HGNCiHGNC:12507 UBP1
HPAiHPA003967
MIMi609784 gene
neXtProtiNX_Q9NZI7
OpenTargetsiENSG00000153560
PharmGKBiPA37154
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00760000119235
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ9NZI7
KOiK09275
OMAiHPSATIQ
OrthoDBiEOG091G0YV2
PhylomeDBiQ9NZI7
TreeFamiTF314132

Miscellaneous databases

ChiTaRSiUBP1 human
GenomeRNAii7342
PROiPR:Q9NZI7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153560 Expressed in 228 organ(s), highest expression level in forebrain
CleanExiHS_UBP1
ExpressionAtlasiQ9NZI7 baseline and differential
GenevisibleiQ9NZI7 HS

Family and domain databases

CDDicd09588 SAM_LBP1, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037600 Ubp1_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZI7
Secondary accession number(s): Q68CT0
, Q86Y57, Q9H8V0, Q9UD76, Q9UD78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again