UniProtKB - Q9NZI7 (UBIP1_HUMAN)
Protein
Upstream-binding protein 1
Gene
UBP1
Organism
Homo sapiens (Human)
Status
Functioni
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.By similarity3 Publications
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- angiogenesis Source: Ensembl
- negative regulation of viral transcription Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9NZI7 |
Names & Taxonomyi
Protein namesi | Recommended name: Upstream-binding protein 1Alternative name(s): Transcription factor LBP-1 |
Gene namesi | Name:UBP1 Synonyms:LBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000153560.11 |
HGNCi | HGNC:12507, UBP1 |
MIMi | 609784, gene |
neXtProti | NX_Q9NZI7 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7342 |
OpenTargetsi | ENSG00000153560 |
PharmGKBi | PA37154 |
Miscellaneous databases
Pharosi | Q9NZI7, Tbio |
Polymorphism and mutation databases
BioMutai | UBP1 |
DMDMi | 74719655 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000229026 | 1 – 540 | Upstream-binding protein 1Add BLAST | 540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | PhosphoserineCombined sources | 1 | |
Modified residuei | 390 | PhosphoserineBy similarity | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NZI7 |
jPOSTi | Q9NZI7 |
MassIVEi | Q9NZI7 |
MaxQBi | Q9NZI7 |
PaxDbi | Q9NZI7 |
PeptideAtlasi | Q9NZI7 |
PRIDEi | Q9NZI7 |
ProteomicsDBi | 83408 [Q9NZI7-1] 83409 [Q9NZI7-4] |
PTM databases
iPTMneti | Q9NZI7 |
PhosphoSitePlusi | Q9NZI7 |
Expressioni
Tissue specificityi
Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.1 Publication
Inductioni
By HIV-1 infection of lymphocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000153560, Expressed in forebrain and 236 other tissues |
ExpressionAtlasi | Q9NZI7, baseline and differential |
Genevisiblei | Q9NZI7, HS |
Organism-specific databases
HPAi | ENSG00000153560, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TFCP2.
Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ9NZI7
With | #Exp. | IntAct |
---|---|---|
LNX1 [Q8TBB1] | 3 | EBI-2795133,EBI-739832 |
MORF4L1 - isoform 2 [Q9UBU8-2] | 3 | EBI-2795133,EBI-10288852 |
Protein-protein interaction databases
BioGRIDi | 113189, 39 interactors |
IntActi | Q9NZI7, 27 interactors |
MINTi | Q9NZI7 |
STRINGi | 9606.ENSP00000283629 |
Miscellaneous databases
RNActi | Q9NZI7, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4091, Eukaryota |
GeneTreei | ENSGT00940000156148 |
HOGENOMi | CLU_015127_2_0_1 |
InParanoidi | Q9NZI7 |
OMAi | CFLVTTI |
PhylomeDBi | Q9NZI7 |
TreeFami | TF314132 |
Family and domain databases
CDDi | cd09588, SAM_LBP1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR007604, CP2 IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR040167, TF_CP2-like IPR037600, Ubp1_SAM |
PANTHERi | PTHR11037, PTHR11037, 1 hit |
Pfami | View protein in Pfam PF04516, CP2, 1 hit PF18016, SAM_3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NZI7-1) [UniParc]FASTAAdd to basket
Also known as: LBP-1b
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED
60 70 80 90 100
SSLPLDGETE HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR
110 120 130 140 150
KMGDMPEING KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD
160 170 180 190 200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG
210 220 230 240 250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKTDREK
260 270 280 290 300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY
310 320 330 340 350
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN
360 370 380 390 400
HQGDGASQTS GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL
410 420 430 440 450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCREQPS STVLQGQQQA
460 470 480 490 500
ASSASENGSG APYVYHAIYL EEMIASEVAR KLALVFNIPL HQINQVYRQG
510 520 530 540
PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WEP8 | F8WEP8_HUMAN | Upstream-binding protein 1 | UBP1 | 164 | Annotation score: | ||
C9JWL3 | C9JWL3_HUMAN | Upstream-binding protein 1 | UBP1 | 148 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 – 94 | EI → D in BAB14501 (PubMed:14702039).Curated | 2 | |
Sequence conflicti | 273 | E → EE (PubMed:8114710).Curated | 1 | |
Sequence conflicti | 291 – 297 | SSKRTLP → VQQADFA (PubMed:8114710).Curated | 7 | |
Sequence conflicti | 418 | Y → V (PubMed:8114710).Curated | 1 | |
Sequence conflicti | 424 | R → RR in CAH18658 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 503 | G → GH (PubMed:8114710).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049294 | 109 | N → S1 PublicationCorresponds to variant dbSNP:rs3736563Ensembl. | 1 | |
Natural variantiVAR_025730 | 212 | T → A1 PublicationCorresponds to variant dbSNP:rs17854430Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017730 | 274 – 309 | Missing in isoform 2. 2 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF198487 mRNA Translation: AAF32274.1 AK023274 mRNA Translation: BAB14501.1 BC047235 mRNA Translation: AAH47235.1 CR749798 mRNA Translation: CAH18658.1 |
CCDSi | CCDS2659.1 [Q9NZI7-1] CCDS46788.1 [Q9NZI7-4] |
PIRi | A56205 B56205 |
RefSeqi | NP_001121632.1, NM_001128160.1 [Q9NZI7-4] NP_001121633.1, NM_001128161.1 [Q9NZI7-1] NP_055332.3, NM_014517.4 [Q9NZI7-1] |
Genome annotation databases
Ensembli | ENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1] ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1] ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4] |
GeneIDi | 7342 |
KEGGi | hsa:7342 |
UCSCi | uc003cfq.5, human [Q9NZI7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF198487 mRNA Translation: AAF32274.1 AK023274 mRNA Translation: BAB14501.1 BC047235 mRNA Translation: AAH47235.1 CR749798 mRNA Translation: CAH18658.1 |
CCDSi | CCDS2659.1 [Q9NZI7-1] CCDS46788.1 [Q9NZI7-4] |
PIRi | A56205 B56205 |
RefSeqi | NP_001121632.1, NM_001128160.1 [Q9NZI7-4] NP_001121633.1, NM_001128161.1 [Q9NZI7-1] NP_055332.3, NM_014517.4 [Q9NZI7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113189, 39 interactors |
IntActi | Q9NZI7, 27 interactors |
MINTi | Q9NZI7 |
STRINGi | 9606.ENSP00000283629 |
PTM databases
iPTMneti | Q9NZI7 |
PhosphoSitePlusi | Q9NZI7 |
Polymorphism and mutation databases
BioMutai | UBP1 |
DMDMi | 74719655 |
Proteomic databases
EPDi | Q9NZI7 |
jPOSTi | Q9NZI7 |
MassIVEi | Q9NZI7 |
MaxQBi | Q9NZI7 |
PaxDbi | Q9NZI7 |
PeptideAtlasi | Q9NZI7 |
PRIDEi | Q9NZI7 |
ProteomicsDBi | 83408 [Q9NZI7-1] 83409 [Q9NZI7-4] |
Protocols and materials databases
Antibodypediai | 11705, 311 antibodies |
DNASUi | 7342 |
Genome annotation databases
Ensembli | ENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1] ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1] ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4] |
GeneIDi | 7342 |
KEGGi | hsa:7342 |
UCSCi | uc003cfq.5, human [Q9NZI7-1] |
Organism-specific databases
CTDi | 7342 |
DisGeNETi | 7342 |
EuPathDBi | HostDB:ENSG00000153560.11 |
GeneCardsi | UBP1 |
HGNCi | HGNC:12507, UBP1 |
HPAi | ENSG00000153560, Low tissue specificity |
MIMi | 609784, gene |
neXtProti | NX_Q9NZI7 |
OpenTargetsi | ENSG00000153560 |
PharmGKBi | PA37154 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4091, Eukaryota |
GeneTreei | ENSGT00940000156148 |
HOGENOMi | CLU_015127_2_0_1 |
InParanoidi | Q9NZI7 |
OMAi | CFLVTTI |
PhylomeDBi | Q9NZI7 |
TreeFami | TF314132 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZI7 |
Miscellaneous databases
BioGRID-ORCSi | 7342, 6 hits in 865 CRISPR screens |
ChiTaRSi | UBP1, human |
GenomeRNAii | 7342 |
Pharosi | Q9NZI7, Tbio |
PROi | PR:Q9NZI7 |
RNActi | Q9NZI7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153560, Expressed in forebrain and 236 other tissues |
ExpressionAtlasi | Q9NZI7, baseline and differential |
Genevisiblei | Q9NZI7, HS |
Family and domain databases
CDDi | cd09588, SAM_LBP1, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR007604, CP2 IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR040167, TF_CP2-like IPR037600, Ubp1_SAM |
PANTHERi | PTHR11037, PTHR11037, 1 hit |
Pfami | View protein in Pfam PF04516, CP2, 1 hit PF18016, SAM_3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIP1_HUMAN | |
Accessioni | Q9NZI7Primary (citable) accession number: Q9NZI7 Secondary accession number(s): Q68CT0 Q9UD78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations