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UniProtKB - Q9NZI7 (UBIP1_HUMAN)

Entry version 158 (02 Jun 2021)
Sequence version 1 (01 Oct 2000)
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Protein

Upstream-binding protein 1

Gene

UBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity).

Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZI7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Upstream-binding protein 1
Alternative name(s):
Transcription factor LBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBP1
Synonyms:LBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12507, UBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609784, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZI7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000153560.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7342

Open Targets

More...OpenTargetsi		ENSG00000153560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZI7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74719655

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002290261 – 540Upstream-binding protein 1Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei390PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZI7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZI7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZI7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZI7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZI7

PeptideAtlas

More...PeptideAtlasi		Q9NZI7

PRoteomics IDEntifications database

More...PRIDEi		Q9NZI7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83408 [Q9NZI7-1]
83409 [Q9NZI7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By HIV-1 infection of lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153560, Expressed in forebrain and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZI7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZI7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153560, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TFCP2.

Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113189, 46 interactors

Protein interaction database and analysis system

More...IntActi		Q9NZI7, 28 interactors

Molecular INTeraction database

More...MINTi		Q9NZI7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000283629

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZI7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZI7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 296Grh/CP2 DBPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 270DisorderedSequence analysisAdd BLAST35
Regioni285 – 368DisorderedSequence analysisAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi236 – 264Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi316 – 368Polar residuesSequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4091, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156148

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015127_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZI7

Identification of Orthologs from Complete Genome Data

More...OMAi		CFLVTTI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZI7

TreeFam database of animal gene trees

More...TreeFami		TF314132

Family and domain databases

Conserved Domains Database

More...CDDi		cd09588, SAM_LBP1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007604, CP2
IPR013761, SAM/pointed_sf
IPR041418, SAM_3
IPR037600, Ubp1_SAM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04516, CP2, 1 hit
PF18016, SAM_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51968, GRH_CP2_DB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZI7-1) [UniParc]FASTAAdd to basket
Also known as: LBP-1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWVLKMDEV IESGLVHDFD ASLSGIGQEL GAGAYSMSDV LALPIFKQED 
        60         70         80         90        100
SSLPLDGETE HPPFQYVMCA ATSPAVKLHD ETLTYLNQGQ SYEIRMLDNR 
       110        120        130        140        150
KMGDMPEING KLVKSIIRVV FHDRRLQYTE HQQLEGWKWN RPGDRLLDLD 
       160        170        180        190        200
IPMSVGIIDT RTNPSQLNAV EFLWDPAKRT SAFIQVHCIS TEFTPRKHGG 
       210        220        230        240        250
EKGVPFRIQV DTFKQNENGE YTDHLHSASC QIKVFKPKGA DRKQKTDREK 
       260        270        280        290        300
MEKRTAHEKE KYQPSYDTTI LTEMRLEPII EDAVEHEQKK SSKRTLPADY 
       310        320        330        340        350
GDSLAKRGSC SPWPDAPTAY VNNSPSPAPT FTSPQQSTCS VPDSNSSSPN 
       360        370        380        390        400
HQGDGASQTS GEQIQPSATI QETQQWLLKN RFSSYTRLFS NFSGADLLKL 
       410        420        430        440        450
TKEDLVQICG AADGIRLYNS LKSRSVRPRL TIYVCREQPS STVLQGQQQA 
       460        470        480        490        500
ASSASENGSG APYVYHAIYL EEMIASEVAR KLALVFNIPL HQINQVYRQG 
       510        520        530        540
PTGIHILVSD QMVQNFQDES CFLFSTVKAE SSDGIHIILK
Length:540
Mass (Da):60,491
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD95819AA86A7F39
GO
Isoform 2 (identifier: Q9NZI7-4) [UniParc]FASTAAdd to basket
Also known as: LBP-1a

The sequence of this isoform differs from the canonical sequence as follows:
     274-309: Missing.

Show »
Length:504
Mass (Da):56,453
Checksum:iBF9A5F42A77A33A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEP8F8WEP8_HUMAN
Upstream-binding protein 1
UBP1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWL3C9JWL3_HUMAN
Upstream-binding protein 1
UBP1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93 – 94EI → D in BAB14501 (PubMed:14702039).Curated2
Sequence conflicti273E → EE (PubMed:8114710).Curated1
Sequence conflicti291 – 297SSKRTLP → VQQADFA (PubMed:8114710).Curated7
Sequence conflicti418Y → V (PubMed:8114710).Curated1
Sequence conflicti424R → RR in CAH18658 (PubMed:17974005).Curated1
Sequence conflicti503G → GH (PubMed:8114710).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049294109N → S1 PublicationCorresponds to variant dbSNP:rs3736563Ensembl.1
Natural variantiVAR_025730212T → A1 PublicationCorresponds to variant dbSNP:rs17854430Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017730274 – 309Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF198487 mRNA Translation: AAF32274.1
AK023274 mRNA Translation: BAB14501.1
BC047235 mRNA Translation: AAH47235.1
CR749798 mRNA Translation: CAH18658.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2659.1 [Q9NZI7-1]
CCDS46788.1 [Q9NZI7-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A56205
B56205

NCBI Reference Sequences

More...RefSeqi		NP_001121632.1, NM_001128160.1 [Q9NZI7-4]
NP_001121633.1, NM_001128161.1 [Q9NZI7-1]
NP_055332.3, NM_014517.4 [Q9NZI7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7342

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7342

UCSC genome browser

More...UCSCi		uc003cfq.5, human [Q9NZI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198487 mRNA Translation: AAF32274.1
AK023274 mRNA Translation: BAB14501.1
BC047235 mRNA Translation: AAH47235.1
CR749798 mRNA Translation: CAH18658.1
CCDSiCCDS2659.1 [Q9NZI7-1]
CCDS46788.1 [Q9NZI7-4]
PIRiA56205
B56205
RefSeqiNP_001121632.1, NM_001128160.1 [Q9NZI7-4]
NP_001121633.1, NM_001128161.1 [Q9NZI7-1]
NP_055332.3, NM_014517.4 [Q9NZI7-1]

3D structure databases

SMRiQ9NZI7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113189, 46 interactors
IntActiQ9NZI7, 28 interactors
MINTiQ9NZI7
STRINGi9606.ENSP00000283629

PTM databases

iPTMnetiQ9NZI7
PhosphoSitePlusiQ9NZI7

Genetic variation databases

BioMutaiUBP1
DMDMi74719655

Proteomic databases

EPDiQ9NZI7
jPOSTiQ9NZI7
MassIVEiQ9NZI7
MaxQBiQ9NZI7
PaxDbiQ9NZI7
PeptideAtlasiQ9NZI7
PRIDEiQ9NZI7
ProteomicsDBi83408 [Q9NZI7-1]
83409 [Q9NZI7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11705, 318 antibodies

The DNASU plasmid repository

More...DNASUi		7342

Genome annotation databases

EnsembliENST00000283628; ENSP00000283628; ENSG00000153560 [Q9NZI7-1]
ENST00000283629; ENSP00000283629; ENSG00000153560 [Q9NZI7-1]
ENST00000447368; ENSP00000395558; ENSG00000153560 [Q9NZI7-4]
GeneIDi7342
KEGGihsa:7342
UCSCiuc003cfq.5, human [Q9NZI7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7342
DisGeNETi7342

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBP1
HGNCiHGNC:12507, UBP1
HPAiENSG00000153560, Low tissue specificity
MIMi609784, gene
neXtProtiNX_Q9NZI7
OpenTargetsiENSG00000153560
PharmGKBiPA37154
VEuPathDBiHostDB:ENSG00000153560.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4091, Eukaryota
GeneTreeiENSGT00940000156148
HOGENOMiCLU_015127_2_0_1
InParanoidiQ9NZI7
OMAiCFLVTTI
PhylomeDBiQ9NZI7
TreeFamiTF314132

Enzyme and pathway databases

PathwayCommonsiQ9NZI7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7342, 10 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7342
PharosiQ9NZI7, Tbio

Protein Ontology

More...PROi		PR:Q9NZI7
RNActiQ9NZI7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000153560, Expressed in forebrain and 237 other tissues
ExpressionAtlasiQ9NZI7, baseline and differential
GenevisibleiQ9NZI7, HS

Family and domain databases

CDDicd09588, SAM_LBP1, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR007604, CP2
IPR013761, SAM/pointed_sf
IPR041418, SAM_3
IPR037600, Ubp1_SAM
PfamiView protein in Pfam
PF04516, CP2, 1 hit
PF18016, SAM_3, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51968, GRH_CP2_DB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZI7
Secondary accession number(s): Q68CT0
, Q86Y57, Q9H8V0, Q9UD76, Q9UD78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: June 2, 2021
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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