UniProtKB - Q9NZI2 (KCIP1_HUMAN)
Kv channel-interacting protein 1
KCNIP1
Functioni
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
4 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 146 | Calcium 1PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 148 | Calcium 1PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 150 | Calcium 1PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 152 | Calcium 1PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 157 | Calcium 1PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 194 | Calcium 2PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 196 | Calcium 2PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 198 | Calcium 2PROSITE-ProRule annotation2 Publications | 1 | |
Metal bindingi | 205 | Calcium 2PROSITE-ProRule annotation2 Publications | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- potassium channel activity Source: UniProtKB-KW
- potassium channel regulator activity Source: UniProtKB
- transmembrane transporter binding Source: GO_Central
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- regulation of potassium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Calcium, Metal-binding, Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q9NZI2 |
Reactomei | R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
SignaLinki | Q9NZI2 |
Protein family/group databases
TCDBi | 8.A.82.2.6, the calmodulin calcium binding protein (calmodulin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Kv channel-interacting protein 1Short name: KChIP11 Publication Alternative name(s): A-type potassium channel modulatory protein 1 Potassium channel-interacting protein 1 Vesicle APC-binding protein |
Gene namesi | Name:KCNIP1 Synonyms:KCHIP1, VABP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15521, KCNIP1 |
MIMi | 604660, gene |
neXtProti | NX_Q9NZI2 |
VEuPathDBi | HostDB:ENSG00000182132 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- dendrite By similarity
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 30820 |
OpenTargetsi | ENSG00000182132 |
PharmGKBi | PA30041 |
Miscellaneous databases
Pharosi | Q9NZI2, Tbio |
Genetic variation databases
BioMutai | KCNIP1 |
DMDMi | 73621122 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073818 | 1 – 227 | Kv channel-interacting protein 1Add BLAST | 227 |
Proteomic databases
EPDi | Q9NZI2 |
MassIVEi | Q9NZI2 |
PaxDbi | Q9NZI2 |
PeptideAtlasi | Q9NZI2 |
PRIDEi | Q9NZI2 |
ProteomicsDBi | 61890 83400 [Q9NZI2-1] 83401 [Q9NZI2-2] 83402 [Q9NZI2-3] 83403 [Q9NZI2-4] |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182132, Expressed in nucleus accumbens and 123 other tissues |
ExpressionAtlasi | Q9NZI2, baseline and differential |
Genevisiblei | Q9NZI2, HS |
Organism-specific databases
HPAi | ENSG00000182132, Tissue enhanced (brain, choroid plexus, epididymis) |
Interactioni
Subunit structurei
Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity).
Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains.
Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers.
Interacts with KCNIP2 isoform 3 in a calcium-dependent manner.
Interacts with Naja atra venom CTX3.
By similarity6 PublicationsBinary interactionsi
Q9NZI2
Isoform 2 [Q9NZI2-2]
GO - Molecular functioni
- transmembrane transporter binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119044, 25 interactors |
ComplexPortali | CPX-3256, Kv4.3-KChIP1 channel complex |
DIPi | DIP-29246N |
IntActi | Q9NZI2, 18 interactors |
MINTi | Q9NZI2 |
Miscellaneous databases
RNActi | Q9NZI2, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9NZI2 |
SMRi | Q9NZI2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NZI2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 94 | EF-hand 1; degenerateCuratedAdd BLAST | 57 | |
Domaini | 97 – 132 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 133 – 168 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 181 – 216 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 214 – 227 | Interaction with KCND2By similarityAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
GeneTreei | ENSGT00940000158048 |
HOGENOMi | CLU_072366_2_2_1 |
InParanoidi | Q9NZI2 |
OMAi | IHEKLRW |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q9NZI2 |
TreeFami | TF318560 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL
60 70 80 90 100
EQLEAQTNFT KRELQVLYRG FKNECPSGVV NEDTFKQIYA QFFPHGDAST
110 120 130 140 150
YAHYLFNAFD TTQTGSVKFE DFVTALSILL RGTVHEKLRW TFNLYDINKD
160 170 180 190 200
GYINKEEMMD IVKAIYDMMG KYTYPVLKED TPRQHVDVFF QKMDKNKDGI
210 220
VTLDEFLESC QEDDNIMRSL QLFQNVM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MS16 | A0A0A0MS16_HUMAN | Kv channel-interacting protein 1 | KCNIP1 | 220 | Annotation score: | ||
A0A087WTU8 | A0A087WTU8_HUMAN | Kv channel-interacting protein 1 | KCNIP1 | 207 | Annotation score: | ||
A0A1B0GTZ7 | A0A1B0GTZ7_HUMAN | Kv channel-interacting protein 1 | KCNIP1 | 232 | Annotation score: | ||
E5RJY5 | E5RJY5_HUMAN | Kv channel-interacting protein 1 | KCNIP1 | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 116 | S → P in BAH13550 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015043 | 1 – 39 | Missing in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_041511 | 1 – 31 | MGAVM…YQYQR → MSGCSKRCKLGFVKFAQTIF KLITGTLSK in isoform 4. 2 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_015044 | 21 – 31 | Missing in isoform 2 and isoform 5. 4 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_047687 | 96 | G → GALPCLEGSPCVEFLPPSPA LLFCLV in isoform 5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF199597 mRNA Translation: AAF33682.1 AY170821 mRNA Translation: AAN77491.1 DQ148476 mRNA Translation: AAZ77793.1 DQ148477 mRNA Translation: AAZ77794.1 DQ148478 mRNA Translation: AAZ77795.1 DQ148479 mRNA Translation: AAZ77796.1 AY780424 mRNA Translation: AAV51968.1 AK301775 mRNA Translation: BAH13550.1 AC008619 Genomic DNA No translation available. AC008719 Genomic DNA No translation available. AC027306 Genomic DNA No translation available. AC027312 Genomic DNA No translation available. AC034199 Genomic DNA No translation available. AC113432 Genomic DNA No translation available. AC134820 Genomic DNA No translation available. KF458055 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61470.1 BC050375 mRNA Translation: AAH50375.1 |
CCDSi | CCDS34285.1 [Q9NZI2-4] CCDS34286.1 [Q9NZI2-1] CCDS4374.1 [Q9NZI2-2] CCDS64312.1 [Q9NZI2-5] CCDS64313.1 [Q9NZI2-3] |
RefSeqi | NP_001030009.1, NM_001034837.2 [Q9NZI2-1] NP_001030010.1, NM_001034838.2 [Q9NZI2-4] NP_001265268.1, NM_001278339.1 [Q9NZI2-5] NP_001265269.1, NM_001278340.1 [Q9NZI2-3] NP_055407.1, NM_014592.3 [Q9NZI2-2] XP_016864896.1, XM_017009407.1 [Q9NZI2-4] |
Genome annotation databases
Ensembli | ENST00000328939.9; ENSP00000329686.4; ENSG00000182132.14 [Q9NZI2-2] ENST00000377360.8; ENSP00000366577.4; ENSG00000182132.14 [Q9NZI2-4] ENST00000411494.5; ENSP00000395323.1; ENSG00000182132.14 ENST00000434108.5; ENSP00000414886.1; ENSG00000182132.14 [Q9NZI2-5] ENST00000520740.5; ENSP00000431102.1; ENSG00000182132.14 [Q9NZI2-3] |
GeneIDi | 30820 |
KEGGi | hsa:30820 |
MANE-Selecti | ENST00000328939.9; ENSP00000329686.4; NM_014592.4; NP_055407.1 [Q9NZI2-2] |
UCSCi | uc003map.5, human [Q9NZI2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF199597 mRNA Translation: AAF33682.1 AY170821 mRNA Translation: AAN77491.1 DQ148476 mRNA Translation: AAZ77793.1 DQ148477 mRNA Translation: AAZ77794.1 DQ148478 mRNA Translation: AAZ77795.1 DQ148479 mRNA Translation: AAZ77796.1 AY780424 mRNA Translation: AAV51968.1 AK301775 mRNA Translation: BAH13550.1 AC008619 Genomic DNA No translation available. AC008719 Genomic DNA No translation available. AC027306 Genomic DNA No translation available. AC027312 Genomic DNA No translation available. AC034199 Genomic DNA No translation available. AC113432 Genomic DNA No translation available. AC134820 Genomic DNA No translation available. KF458055 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61470.1 BC050375 mRNA Translation: AAH50375.1 |
CCDSi | CCDS34285.1 [Q9NZI2-4] CCDS34286.1 [Q9NZI2-1] CCDS4374.1 [Q9NZI2-2] CCDS64312.1 [Q9NZI2-5] CCDS64313.1 [Q9NZI2-3] |
RefSeqi | NP_001030009.1, NM_001034837.2 [Q9NZI2-1] NP_001030010.1, NM_001034838.2 [Q9NZI2-4] NP_001265268.1, NM_001278339.1 [Q9NZI2-5] NP_001265269.1, NM_001278340.1 [Q9NZI2-3] NP_055407.1, NM_014592.3 [Q9NZI2-2] XP_016864896.1, XM_017009407.1 [Q9NZI2-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S1E | X-ray | 2.30 | A | 1-227 | [»] | |
2I2R | X-ray | 3.35 | E/F/G/H/M/N/O/P | 48-227 | [»] | |
2NZ0 | X-ray | 3.20 | A/C | 49-227 | [»] | |
7E83 | electron microscopy | 3.10 | B/E/F/H | 47-227 | [»] | |
7E84 | electron microscopy | 3.10 | E/H/J/L | 47-227 | [»] | |
7F3F | electron microscopy | 3.10 | E/H/J/L | 1-227 | [»] | |
AlphaFoldDBi | Q9NZI2 | |||||
SMRi | Q9NZI2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119044, 25 interactors |
ComplexPortali | CPX-3256, Kv4.3-KChIP1 channel complex |
DIPi | DIP-29246N |
IntActi | Q9NZI2, 18 interactors |
MINTi | Q9NZI2 |
Protein family/group databases
TCDBi | 8.A.82.2.6, the calmodulin calcium binding protein (calmodulin) family |
Genetic variation databases
BioMutai | KCNIP1 |
DMDMi | 73621122 |
Proteomic databases
EPDi | Q9NZI2 |
MassIVEi | Q9NZI2 |
PaxDbi | Q9NZI2 |
PeptideAtlasi | Q9NZI2 |
PRIDEi | Q9NZI2 |
ProteomicsDBi | 61890 83400 [Q9NZI2-1] 83401 [Q9NZI2-2] 83402 [Q9NZI2-3] 83403 [Q9NZI2-4] |
Protocols and materials databases
ABCDi | Q9NZI2, 1 sequenced antibody |
Antibodypediai | 16893, 310 antibodies from 30 providers |
DNASUi | 30820 |
Genome annotation databases
Ensembli | ENST00000328939.9; ENSP00000329686.4; ENSG00000182132.14 [Q9NZI2-2] ENST00000377360.8; ENSP00000366577.4; ENSG00000182132.14 [Q9NZI2-4] ENST00000411494.5; ENSP00000395323.1; ENSG00000182132.14 ENST00000434108.5; ENSP00000414886.1; ENSG00000182132.14 [Q9NZI2-5] ENST00000520740.5; ENSP00000431102.1; ENSG00000182132.14 [Q9NZI2-3] |
GeneIDi | 30820 |
KEGGi | hsa:30820 |
MANE-Selecti | ENST00000328939.9; ENSP00000329686.4; NM_014592.4; NP_055407.1 [Q9NZI2-2] |
UCSCi | uc003map.5, human [Q9NZI2-1] |
Organism-specific databases
CTDi | 30820 |
DisGeNETi | 30820 |
GeneCardsi | KCNIP1 |
HGNCi | HGNC:15521, KCNIP1 |
HPAi | ENSG00000182132, Tissue enhanced (brain, choroid plexus, epididymis) |
MIMi | 604660, gene |
neXtProti | NX_Q9NZI2 |
OpenTargetsi | ENSG00000182132 |
PharmGKBi | PA30041 |
VEuPathDBi | HostDB:ENSG00000182132 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158048 |
HOGENOMi | CLU_072366_2_2_1 |
InParanoidi | Q9NZI2 |
OMAi | IHEKLRW |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q9NZI2 |
TreeFami | TF318560 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZI2 |
Reactomei | R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
SignaLinki | Q9NZI2 |
Miscellaneous databases
BioGRID-ORCSi | 30820, 9 hits in 1072 CRISPR screens |
ChiTaRSi | KCNIP1, human |
EvolutionaryTracei | Q9NZI2 |
GeneWikii | KCNIP1 |
GenomeRNAii | 30820 |
Pharosi | Q9NZI2, Tbio |
PROi | PR:Q9NZI2 |
RNActi | Q9NZI2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182132, Expressed in nucleus accumbens and 123 other tissues |
ExpressionAtlasi | Q9NZI2, baseline and differential |
Genevisiblei | Q9NZI2, HS |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KCIP1_HUMAN | |
Accessioni | Q9NZI2Primary (citable) accession number: Q9NZI2 Secondary accession number(s): A0A0C4DFQ7 Q5U822 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families