UniProtKB - Q9NZH8 (IL36G_HUMAN)
Interleukin-36 gamma
IL36G
Functioni
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
6 PublicationsGO - Molecular functioni
- cytokine activity Source: GO_Central
- interleukin-1 receptor binding Source: InterPro
GO - Biological processi
- cell-cell signaling Source: ProtInc
- cellular response to lipopolysaccharide Source: GO_Central
- cytokine-mediated signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- inflammatory response to antigenic stimulus Source: GO_Central
- innate immune response Source: UniProtKB-KW
- positive regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q9NZH8 |
Reactomei | R-HSA-9014826, Interleukin-36 pathway |
SignaLinki | Q9NZH8 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-36 gammaAlternative name(s): IL-1-related protein 2 Short name: IL-1RP2 Interleukin-1 epsilon Short name: IL-1 epsilon Interleukin-1 family member 9 Short name: IL-1F9 Interleukin-1 homolog 1 Short name: IL-1H1 |
Gene namesi | ORF Names:UNQ2456/PRO5737 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15741, IL36G |
MIMi | 605542, gene |
neXtProti | NX_Q9NZH8 |
VEuPathDBi | HostDB:ENSG00000136688 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 56300 |
OpenTargetsi | ENSG00000136688 |
PharmGKBi | PA38395 |
Miscellaneous databases
Pharosi | Q9NZH8, Tbio |
Genetic variation databases
BioMutai | IL36G |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000430549 | 1 – 17 | 1 PublicationAdd BLAST | 17 | |
ChainiPRO_0000153648 | 18 – 169 | Interleukin-36 gammaAdd BLAST | 152 |
Post-translational modificationi
Proteomic databases
EPDi | Q9NZH8 |
MassIVEi | Q9NZH8 |
PaxDbi | Q9NZH8 |
PeptideAtlasi | Q9NZH8 |
PRIDEi | Q9NZH8 |
ProteomicsDBi | 83397 [Q9NZH8-1] 83398 [Q9NZH8-2] |
PTM databases
iPTMneti | Q9NZH8 |
PhosphoSitePlusi | Q9NZH8 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000136688, Expressed in periodontal ligament and 90 other tissues |
ExpressionAtlasi | Q9NZH8, baseline and differential |
Genevisiblei | Q9NZH8, HS |
Organism-specific databases
HPAi | ENSG00000136688, Group enriched (esophagus, lymphoid tissue, skin) |
Interactioni
Subunit structurei
Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- interleukin-1 receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 121135, 39 interactors |
IntActi | Q9NZH8, 4 interactors |
STRINGi | 9606.ENSP00000259205 |
Miscellaneous databases
RNActi | Q9NZH8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZH8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502STX9, Eukaryota |
GeneTreei | ENSGT00950000182943 |
HOGENOMi | CLU_095373_1_1_1 |
InParanoidi | Q9NZH8 |
OMAi | MCLFCED |
OrthoDBi | 1502484at2759 |
PhylomeDBi | Q9NZH8 |
TreeFami | TF300203 |
Family and domain databases
InterProi | View protein in InterPro IPR000975, IL-1_fam IPR003297, IL-1RA/IL-36 IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 PR01360, INTRLEUKIN1X |
SUPFAMi | SSF50353, SSF50353, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS
60 70 80 90 100
VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK
110 120 130 140 150
EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII
160
LTSELGKSYN TAFELNIND
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J681 | C9J681_HUMAN | Interleukin-36 gamma | IL36G | 38 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024505 | 69 | Q → K. Corresponds to variant dbSNP:rs6707930Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013002 | 19 – 54 | MCKPI…SVTPV → I in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200492 mRNA Translation: AAF69248.1 AF206696 mRNA Translation: AAG35670.1 BN000002 Genomic DNA Translation: CAD29874.1 AY359111 mRNA Translation: AAQ89469.1 AY968311 Genomic DNA Translation: AAX59035.1 AC016724 Genomic DNA Translation: AAY14987.1 BC096721 mRNA Translation: AAH96721.1 BC098130 mRNA Translation: AAH98130.1 BC098155 mRNA Translation: AAH98155.1 BC098337 mRNA Translation: AAH98337.1 |
CCDSi | CCDS2108.1 [Q9NZH8-1] CCDS62992.1 [Q9NZH8-2] |
RefSeqi | NP_001265497.1, NM_001278568.1 [Q9NZH8-2] NP_062564.1, NM_019618.3 [Q9NZH8-1] |
Genome annotation databases
Ensembli | ENST00000259205; ENSP00000259205; ENSG00000136688 ENST00000376489; ENSP00000365672; ENSG00000136688 [Q9NZH8-2] |
GeneIDi | 56300 |
KEGGi | hsa:56300 |
MANE-Selecti | ENST00000259205.5; ENSP00000259205.3; NM_019618.4; NP_062564.1 |
UCSCi | uc002tio.3, human [Q9NZH8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Interleukin-1 entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF200492 mRNA Translation: AAF69248.1 AF206696 mRNA Translation: AAG35670.1 BN000002 Genomic DNA Translation: CAD29874.1 AY359111 mRNA Translation: AAQ89469.1 AY968311 Genomic DNA Translation: AAX59035.1 AC016724 Genomic DNA Translation: AAY14987.1 BC096721 mRNA Translation: AAH96721.1 BC098130 mRNA Translation: AAH98130.1 BC098155 mRNA Translation: AAH98155.1 BC098337 mRNA Translation: AAH98337.1 |
CCDSi | CCDS2108.1 [Q9NZH8-1] CCDS62992.1 [Q9NZH8-2] |
RefSeqi | NP_001265497.1, NM_001278568.1 [Q9NZH8-2] NP_062564.1, NM_019618.3 [Q9NZH8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4IZE | X-ray | 2.00 | A | 18-169 | [»] | |
4P0J | X-ray | 2.30 | A/B | 154-160 | [»] | |
4P0K | X-ray | 1.70 | A | 64-72 | [»] | |
A | 154-160 | [»] | ||||
4P0L | X-ray | 1.55 | A | 64-72 | [»] | |
A | 154-160 | [»] | ||||
6P9E | X-ray | 2.00 | A | 18-169 | [»] | |
SMRi | Q9NZH8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121135, 39 interactors |
IntActi | Q9NZH8, 4 interactors |
STRINGi | 9606.ENSP00000259205 |
PTM databases
iPTMneti | Q9NZH8 |
PhosphoSitePlusi | Q9NZH8 |
Genetic variation databases
BioMutai | IL36G |
Proteomic databases
EPDi | Q9NZH8 |
MassIVEi | Q9NZH8 |
PaxDbi | Q9NZH8 |
PeptideAtlasi | Q9NZH8 |
PRIDEi | Q9NZH8 |
ProteomicsDBi | 83397 [Q9NZH8-1] 83398 [Q9NZH8-2] |
Protocols and materials databases
Antibodypediai | 33310, 329 antibodies from 33 providers |
DNASUi | 56300 |
Genome annotation databases
Ensembli | ENST00000259205; ENSP00000259205; ENSG00000136688 ENST00000376489; ENSP00000365672; ENSG00000136688 [Q9NZH8-2] |
GeneIDi | 56300 |
KEGGi | hsa:56300 |
MANE-Selecti | ENST00000259205.5; ENSP00000259205.3; NM_019618.4; NP_062564.1 |
UCSCi | uc002tio.3, human [Q9NZH8-1] |
Organism-specific databases
CTDi | 56300 |
DisGeNETi | 56300 |
GeneCardsi | IL36G |
HGNCi | HGNC:15741, IL36G |
HPAi | ENSG00000136688, Group enriched (esophagus, lymphoid tissue, skin) |
MIMi | 605542, gene |
neXtProti | NX_Q9NZH8 |
OpenTargetsi | ENSG00000136688 |
PharmGKBi | PA38395 |
VEuPathDBi | HostDB:ENSG00000136688 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502STX9, Eukaryota |
GeneTreei | ENSGT00950000182943 |
HOGENOMi | CLU_095373_1_1_1 |
InParanoidi | Q9NZH8 |
OMAi | MCLFCED |
OrthoDBi | 1502484at2759 |
PhylomeDBi | Q9NZH8 |
TreeFami | TF300203 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZH8 |
Reactomei | R-HSA-9014826, Interleukin-36 pathway |
SignaLinki | Q9NZH8 |
Miscellaneous databases
BioGRID-ORCSi | 56300, 6 hits in 1029 CRISPR screens |
GeneWikii | IL1F9 |
GenomeRNAii | 56300 |
Pharosi | Q9NZH8, Tbio |
PROi | PR:Q9NZH8 |
RNActi | Q9NZH8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136688, Expressed in periodontal ligament and 90 other tissues |
ExpressionAtlasi | Q9NZH8, baseline and differential |
Genevisiblei | Q9NZH8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000975, IL-1_fam IPR003297, IL-1RA/IL-36 IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 PR01360, INTRLEUKIN1X |
SUPFAMi | SSF50353, SSF50353, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL36G_HUMAN | |
Accessioni | Q9NZH8Primary (citable) accession number: Q9NZH8 Secondary accession number(s): Q56B91, Q6UVX7, Q7RTZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families