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Protein

Interleukin-36 beta

Gene

IL36B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.6 Publications

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 beta
Alternative name(s):
FIL1 eta
Interleukin-1 eta
Short name:
IL-1 eta
Interleukin-1 family member 8
Short name:
IL-1F8
Interleukin-1 homolog 2
Short name:
IL-1H2
Gene namesi
Name:IL36B
Synonyms:IL1F8, IL1H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000136696.10
HGNCiHGNC:15564 IL36B
MIMi605508 gene
neXtProtiNX_Q9NZH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27177
OpenTargetsiENSG00000136696
PharmGKBiPA38391

Polymorphism and mutation databases

DMDMi25008595

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00004305471 – 41 Publication4
ChainiPRO_00001536465 – 164Interleukin-36 betaAdd BLAST160

Post-translational modificationi

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).1 Publication

Proteomic databases

PaxDbiQ9NZH7
PRIDEiQ9NZH7
ProteomicsDBi83395
83396 [Q9NZH7-2]

PTM databases

iPTMnetiQ9NZH7
PhosphoSitePlusiQ9NZH7

Expressioni

Tissue specificityi

Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.2 Publications

Inductioni

By proinflammatory cytokines IL1A, IL1B and TNF in synovial fibroblasts. By IL1A and TNF in keratinocytes. Constitutive in articular chondrocytes.1 Publication

Gene expression databases

BgeeiENSG00000136696 Expressed in 22 organ(s), highest expression level in skin of leg
CleanExiHS_IL1F8
GenevisibleiQ9NZH7 HS

Organism-specific databases

HPAiHPA035664

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118053, 1 interactor
STRINGi9606.ENSP00000259213

Structurei

3D structure databases

ProteinModelPortaliQ9NZH7
SMRiQ9NZH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JCFD Eukaryota
ENOG41118F0 LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9NZH7
KOiK05486
OMAiERGITNN
OrthoDBiEOG091G0NSL
PhylomeDBiQ9NZH7

Family and domain databases

InterProiView protein in InterPro
IPR027172 IL-36_beta
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF24 PTHR10078:SF24, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NZH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD
60 70 80 90 100
TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC
110 120 130 140 150
WKLVGIHTCI NLDVRESCFM GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD
160
FSSMRTNIGM PGRM
Length:164
Mass (Da):18,522
Last modified:October 1, 2000 - v1
Checksum:iF0D2099F4A357A0A
GO
Isoform 2 (identifier: Q9NZH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-164: LQGSQDNIGK...RTNIGMPGRM → EKNIMDLYVE...NTNFYLDSVE

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,702
Checksum:i7A54F3D7557A3EE3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02505736R → C1 PublicationCorresponds to variant dbSNP:rs34754959Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00265788 – 164LQGSQ…MPGRM → EKNIMDLYVEKKAQKPFLFF HNKEGSTSVFQSVSYPGWFI ATSTTSGQPIFLTKERGITN NTNFYLDSVE in isoform 2. 2 PublicationsAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200494 mRNA Translation: AAF69250.1
AF201833 mRNA Translation: AAF25213.1
CH471217 Genomic DNA Translation: EAW73615.1
BC101831 mRNA Translation: AAI01832.1
BC101833 mRNA Translation: AAI01834.1
BN000002 Genomic DNA Translation: CAD29876.1
DQ224343 Genomic DNA Translation: ABA60896.1
AC016724 Genomic DNA Translation: AAY14989.1
CCDSiCCDS2109.1 [Q9NZH7-1]
CCDS2110.1 [Q9NZH7-2]
RefSeqiNP_055253.2, NM_014438.4 [Q9NZH7-1]
NP_775270.1, NM_173178.2 [Q9NZH7-2]
XP_011509264.1, XM_011510962.1 [Q9NZH7-2]
UniGeneiHs.278909

Genome annotation databases

EnsembliENST00000259213; ENSP00000259213; ENSG00000136696 [Q9NZH7-1]
ENST00000327407; ENSP00000328420; ENSG00000136696 [Q9NZH7-2]
GeneIDi27177
KEGGihsa:27177
UCSCiuc002tiq.2 human [Q9NZH7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200494 mRNA Translation: AAF69250.1
AF201833 mRNA Translation: AAF25213.1
CH471217 Genomic DNA Translation: EAW73615.1
BC101831 mRNA Translation: AAI01832.1
BC101833 mRNA Translation: AAI01834.1
BN000002 Genomic DNA Translation: CAD29876.1
DQ224343 Genomic DNA Translation: ABA60896.1
AC016724 Genomic DNA Translation: AAY14989.1
CCDSiCCDS2109.1 [Q9NZH7-1]
CCDS2110.1 [Q9NZH7-2]
RefSeqiNP_055253.2, NM_014438.4 [Q9NZH7-1]
NP_775270.1, NM_173178.2 [Q9NZH7-2]
XP_011509264.1, XM_011510962.1 [Q9NZH7-2]
UniGeneiHs.278909

3D structure databases

ProteinModelPortaliQ9NZH7
SMRiQ9NZH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118053, 1 interactor
STRINGi9606.ENSP00000259213

PTM databases

iPTMnetiQ9NZH7
PhosphoSitePlusiQ9NZH7

Polymorphism and mutation databases

DMDMi25008595

Proteomic databases

PaxDbiQ9NZH7
PRIDEiQ9NZH7
ProteomicsDBi83395
83396 [Q9NZH7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259213; ENSP00000259213; ENSG00000136696 [Q9NZH7-1]
ENST00000327407; ENSP00000328420; ENSG00000136696 [Q9NZH7-2]
GeneIDi27177
KEGGihsa:27177
UCSCiuc002tiq.2 human [Q9NZH7-1]

Organism-specific databases

CTDi27177
DisGeNETi27177
EuPathDBiHostDB:ENSG00000136696.10
GeneCardsiIL36B
HGNCiHGNC:15564 IL36B
HPAiHPA035664
MIMi605508 gene
neXtProtiNX_Q9NZH7
OpenTargetsiENSG00000136696
PharmGKBiPA38391
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCFD Eukaryota
ENOG41118F0 LUCA
GeneTreeiENSGT00900000141014
HOVERGENiHBG052100
InParanoidiQ9NZH7
KOiK05486
OMAiERGITNN
OrthoDBiEOG091G0NSL
PhylomeDBiQ9NZH7

Enzyme and pathway databases

ReactomeiR-HSA-9014826 Interleukin-36 pathway

Miscellaneous databases

ChiTaRSiIL36B human
GeneWikiiIL1F8
GenomeRNAii27177
PROiPR:Q9NZH7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136696 Expressed in 22 organ(s), highest expression level in skin of leg
CleanExiHS_IL1F8
GenevisibleiQ9NZH7 HS

Family and domain databases

InterProiView protein in InterPro
IPR027172 IL-36_beta
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF24 PTHR10078:SF24, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL36B_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH7
Secondary accession number(s): Q3MIH0
, Q53SR6, Q7RTZ7, Q9UHA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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