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Protein

Putative pituitary tumor-transforming gene 3 protein

Gene

PTTG3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pituitary tumor-transforming gene 3 protein
Short name:
hPTTG3
Alternative name(s):
Securin-3
rcPTTG1
Gene namesi
Name:PTTG3P
Synonyms:PTTG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13422 PTTG3P
neXtProtiNX_Q9NZH4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Polymorphism and mutation databases

DMDMi74719651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338601 – 202Putative pituitary tumor-transforming gene 3 proteinAdd BLAST202

Proteomic databases

MaxQBiQ9NZH4
PeptideAtlasiQ9NZH4
PRIDEiQ9NZH4
ProteomicsDBi83387

PTM databases

iPTMnetiQ9NZH4
PhosphoSitePlusiQ9NZH4

Expressioni

Tissue specificityi

Expressed in ovarian tumor and tumor cell lines (SK-OV-3 and PA1).1 Publication

Gene expression databases

CleanExiHS_PTTG3

Organism-specific databases

HPAiHPA008890
HPA045034

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9NZH4
SMRiQ9NZH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 64D-boxBy similarity4
Motifi163 – 173SH3-bindingBy similarityAdd BLAST11

Domaini

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity

Sequence similaritiesi

Belongs to the securin family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

HOVERGENiHBG053264
InParanoidiQ9NZH4
PhylomeDBiQ9NZH4

Family and domain databases

InterProiView protein in InterPro
IPR006940 Securin_separation_inhibitor
PANTHERiPTHR10418 PTHR10418, 1 hit
PfamiView protein in Pfam
PF04856 Securin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NZH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLIYVDKE NEEPGILVAT KDGLKLGSGP SIKALDGRSQ VSISCFGKTF
60 70 80 90 100
DAPTSLPKAT RKALGTVNRA TEKSVKTNGP LKQKQPSFSA KKMTEKTVKA
110 120 130 140 150
KNSVPASDDG YPEIEKLFPF NPLGFESFDL PEEHQIAHLP LSEVPLMILD
160 170 180 190 200
EERELEKLFQ LGPPSPLKMP SPPWKSNLLQ SPLSILLTLD VELPPVCSDI

DI
Length:202
Mass (Da):22,064
Last modified:October 1, 2000 - v1
Checksum:iC19E6E9FE344A539
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198S → C in AAC64411 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200720 Genomic DNA Translation: AAF72580.1
DQ120700 Genomic DNA Translation: ABC40663.1
AF095289 mRNA Translation: AAC64411.1
AY028471 Genomic DNA Translation: AAK40241.1
UniGeneiHs.647156

Similar proteinsi

Entry informationi

Entry nameiPTTG3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZH4
Secondary accession number(s): O95356
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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