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Protein

Placenta-specific gene 8 protein

Gene

PLAC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta-specific gene 8 protein
Alternative name(s):
Protein C15
Gene namesi
Name:PLAC8
ORF Names:BM-004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145287.10
HGNCiHGNC:19254 PLAC8
MIMi607515 gene
neXtProtiNX_Q9NZF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi51316
OpenTargetsiENSG00000145287
PharmGKBiPA134950814

Polymorphism and mutation databases

BioMutaiPLAC8
DMDMi34922849

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860921 – 115Placenta-specific gene 8 proteinAdd BLAST115

Proteomic databases

PaxDbiQ9NZF1
PeptideAtlasiQ9NZF1
PRIDEiQ9NZF1
ProteomicsDBi83383

PTM databases

PhosphoSitePlusiQ9NZF1

Expressioni

Tissue specificityi

Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.

Gene expression databases

BgeeiENSG00000145287 Expressed in 159 organ(s), highest expression level in colonic mucosa
CleanExiHS_PLAC8
ExpressionAtlasiQ9NZF1 baseline and differential
GenevisibleiQ9NZF1 HS

Organism-specific databases

HPAiHPA040465
HPA077912

Interactioni

Protein-protein interaction databases

BioGridi119467, 5 interactors
IntActiQ9NZF1, 2 interactors
STRINGi9606.ENSP00000309509

Structurei

3D structure databases

ProteinModelPortaliQ9NZF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornifelin family.Curated

Phylogenomic databases

eggNOGiENOG410IZNB Eukaryota
ENOG410YWYC LUCA
GeneTreeiENSGT00390000000694
HOGENOMiHOG000007259
HOVERGENiHBG053607
InParanoidiQ9NZF1
OMAiFVRAPQN
OrthoDBiEOG091G16EA
PhylomeDBiQ9NZF1
TreeFamiTF330308

Family and domain databases

InterProiView protein in InterPro
IPR006461 PLAC_motif_containing
PANTHERiPTHR15907 PTHR15907, 1 hit
PfamiView protein in Pfam
PF04749 PLAC8, 1 hit
TIGRFAMsiTIGR01571 A_thal_Cys_rich, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NZF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAQAPVVVV TQPGVGPGPA PQNSNWQTGM CDCFSDCGVC LCGTFCFPCL
60 70 80 90 100
GCQVAADMNE CCLCGTSVAM RTLYRTRYGI PGSICDDYMA TLCCPHCTLC
110
QIKRDINRRR AMRTF
Length:115
Mass (Da):12,507
Last modified:October 1, 2000 - v1
Checksum:i24B6D7940390C6BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA24D6RA24_HUMAN
Placenta-specific 8, isoform CRA_b
PLAC8 hCG_1782057
58Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422147 mRNA Translation: CAD19530.1
FJ795024 mRNA Translation: ACO37643.1
AF208846 mRNA Translation: AAF64260.1
CH471057 Genomic DNA Translation: EAX05923.1
CCDSiCCDS3601.1
RefSeqiNP_001124187.1, NM_001130715.1
NP_001124188.1, NM_001130716.1
NP_057703.1, NM_016619.2
UniGeneiHs.546392

Genome annotation databases

EnsembliENST00000311507; ENSP00000309509; ENSG00000145287
ENST00000411416; ENSP00000412230; ENSG00000145287
ENST00000426923; ENSP00000399700; ENSG00000145287
ENST00000505406; ENSP00000422526; ENSG00000145287
GeneIDi51316
KEGGihsa:51316

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422147 mRNA Translation: CAD19530.1
FJ795024 mRNA Translation: ACO37643.1
AF208846 mRNA Translation: AAF64260.1
CH471057 Genomic DNA Translation: EAX05923.1
CCDSiCCDS3601.1
RefSeqiNP_001124187.1, NM_001130715.1
NP_001124188.1, NM_001130716.1
NP_057703.1, NM_016619.2
UniGeneiHs.546392

3D structure databases

ProteinModelPortaliQ9NZF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119467, 5 interactors
IntActiQ9NZF1, 2 interactors
STRINGi9606.ENSP00000309509

PTM databases

PhosphoSitePlusiQ9NZF1

Polymorphism and mutation databases

BioMutaiPLAC8
DMDMi34922849

Proteomic databases

PaxDbiQ9NZF1
PeptideAtlasiQ9NZF1
PRIDEiQ9NZF1
ProteomicsDBi83383

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311507; ENSP00000309509; ENSG00000145287
ENST00000411416; ENSP00000412230; ENSG00000145287
ENST00000426923; ENSP00000399700; ENSG00000145287
ENST00000505406; ENSP00000422526; ENSG00000145287
GeneIDi51316
KEGGihsa:51316

Organism-specific databases

CTDi51316
DisGeNETi51316
EuPathDBiHostDB:ENSG00000145287.10
GeneCardsiPLAC8
HGNCiHGNC:19254 PLAC8
HPAiHPA040465
HPA077912
MIMi607515 gene
neXtProtiNX_Q9NZF1
OpenTargetsiENSG00000145287
PharmGKBiPA134950814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZNB Eukaryota
ENOG410YWYC LUCA
GeneTreeiENSGT00390000000694
HOGENOMiHOG000007259
HOVERGENiHBG053607
InParanoidiQ9NZF1
OMAiFVRAPQN
OrthoDBiEOG091G16EA
PhylomeDBiQ9NZF1
TreeFamiTF330308

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiPLAC8 human
GenomeRNAii51316
PROiPR:Q9NZF1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145287 Expressed in 159 organ(s), highest expression level in colonic mucosa
CleanExiHS_PLAC8
ExpressionAtlasiQ9NZF1 baseline and differential
GenevisibleiQ9NZF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006461 PLAC_motif_containing
PANTHERiPTHR15907 PTHR15907, 1 hit
PfamiView protein in Pfam
PF04749 PLAC8, 1 hit
TIGRFAMsiTIGR01571 A_thal_Cys_rich, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLAC8_HUMAN
AccessioniPrimary (citable) accession number: Q9NZF1
Secondary accession number(s): C1K3N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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