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Protein

39S ribosomal protein L35, mitochondrial

Gene

MRPL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L35, mitochondrial
Short name:
L35mt
Short name:
MRP-L35
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL35m1 Publication
Gene namesi
Name:MRPL35
ORF Names:BM-007
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000132313.14
HGNCiHGNC:14489 MRPL35
MIMi611841 gene
neXtProtiNX_Q9NZE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132313
PharmGKBiPA30966

Polymorphism and mutation databases

BioMutaiMRPL35

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030525? – 18839S ribosomal protein L35, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9NZE8
MaxQBiQ9NZE8
PaxDbiQ9NZE8
PeptideAtlasiQ9NZE8
PRIDEiQ9NZE8
ProteomicsDBi83381
83382 [Q9NZE8-2]

PTM databases

iPTMnetiQ9NZE8
PhosphoSitePlusiQ9NZE8

Expressioni

Gene expression databases

BgeeiENSG00000132313 Expressed in 216 organ(s), highest expression level in heart left ventricle
CleanExiHS_MRPL35
ExpressionAtlasiQ9NZE8 baseline and differential
GenevisibleiQ9NZE8 HS

Organism-specific databases

HPAiHPA043482

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi119469, 55 interactors
CORUMiQ9NZE8
IntActiQ9NZE8, 9 interactors
STRINGi9606.ENSP00000338389

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZE8
SMRiQ9NZE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4316 Eukaryota
ENOG4111VAN LUCA
GeneTreeiENSGT00390000007547
HOGENOMiHOG000293335
HOVERGENiHBG050017
InParanoidiQ9NZE8
KOiK02916
OMAiWKKTAAR
OrthoDBiEOG091G0UZ0
PhylomeDBiQ9NZE8
TreeFamiTF317642

Family and domain databases

InterProiView protein in InterPro
IPR019338 Ribosomal-L35_mit
IPR021137 Ribosomal_L35
IPR037229 Ribosomal_L35_sf
PANTHERiPTHR15909 PTHR15909, 1 hit
PfamiView protein in Pfam
PF01632 Ribosomal_L35p, 1 hit
SUPFAMiSSF143034 SSF143034, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ
60 70 80 90 100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR
110 120 130 140 150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC
160 170 180
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV
Length:188
Mass (Da):21,514
Last modified:January 23, 2007 - v3
Checksum:i3A44076927C5A54B
GO
Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Show »
Length:170
Mass (Da):19,192
Checksum:iDF3B4AEF300F91D7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTC1D3YTC1_HUMAN
39S ribosomal protein L35, mitochon...
MRPL35
177Annotation score:
S4R348S4R348_HUMAN
39S ribosomal protein L35, mitochon...
MRPL35
95Annotation score:

Sequence cautioni

The sequence AAF64263 differs from that shown. Reason: Frameshift at position 122.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03001019P → S1 PublicationCorresponds to variant dbSNP:rs10901Ensembl.1
Natural variantiVAR_05463224A → T1 PublicationCorresponds to variant dbSNP:rs17851803Ensembl.1
Natural variantiVAR_05463329R → H. Corresponds to variant dbSNP:rs1051949Ensembl.1
Natural variantiVAR_03446380A → P. Corresponds to variant dbSNP:rs34044771Ensembl.1
Natural variantiVAR_05180381P → L. Corresponds to variant dbSNP:rs3192352Ensembl.1
Natural variantiVAR_054634180Y → C. Corresponds to variant dbSNP:rs1052065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036507171 – 188Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208849 mRNA Translation: AAF64263.1 Frameshift.
AK314555 mRNA Translation: BAG37140.1
AK314577 mRNA Translation: BAG37154.1
AL832982 mRNA Translation: CAH56349.1
AC009309 Genomic DNA No translation available.
BC020651 mRNA Translation: AAH20651.1
CCDSiCCDS1987.1 [Q9NZE8-2]
CCDS1988.1 [Q9NZE8-1]
RefSeqiNP_057706.2, NM_016622.3 [Q9NZE8-1]
NP_663619.1, NM_145644.2 [Q9NZE8-2]
UniGeneiHs.433439

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]
GeneIDi51318
KEGGihsa:51318
UCSCiuc002srg.5 human [Q9NZE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208849 mRNA Translation: AAF64263.1 Frameshift.
AK314555 mRNA Translation: BAG37140.1
AK314577 mRNA Translation: BAG37154.1
AL832982 mRNA Translation: CAH56349.1
AC009309 Genomic DNA No translation available.
BC020651 mRNA Translation: AAH20651.1
CCDSiCCDS1987.1 [Q9NZE8-2]
CCDS1988.1 [Q9NZE8-1]
RefSeqiNP_057706.2, NM_016622.3 [Q9NZE8-1]
NP_663619.1, NM_145644.2 [Q9NZE8-2]
UniGeneiHs.433439

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4031-188[»]
3J9Melectron microscopy3.5031-188[»]
5OOLelectron microscopy3.0631-188[»]
5OOMelectron microscopy3.0331-188[»]
ProteinModelPortaliQ9NZE8
SMRiQ9NZE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119469, 55 interactors
CORUMiQ9NZE8
IntActiQ9NZE8, 9 interactors
STRINGi9606.ENSP00000338389

PTM databases

iPTMnetiQ9NZE8
PhosphoSitePlusiQ9NZE8

Polymorphism and mutation databases

BioMutaiMRPL35

Proteomic databases

EPDiQ9NZE8
MaxQBiQ9NZE8
PaxDbiQ9NZE8
PeptideAtlasiQ9NZE8
PRIDEiQ9NZE8
ProteomicsDBi83381
83382 [Q9NZE8-2]

Protocols and materials databases

DNASUi51318
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]
GeneIDi51318
KEGGihsa:51318
UCSCiuc002srg.5 human [Q9NZE8-1]

Organism-specific databases

CTDi51318
EuPathDBiHostDB:ENSG00000132313.14
GeneCardsiMRPL35
HGNCiHGNC:14489 MRPL35
HPAiHPA043482
MIMi611841 gene
neXtProtiNX_Q9NZE8
OpenTargetsiENSG00000132313
PharmGKBiPA30966
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4316 Eukaryota
ENOG4111VAN LUCA
GeneTreeiENSGT00390000007547
HOGENOMiHOG000293335
HOVERGENiHBG050017
InParanoidiQ9NZE8
KOiK02916
OMAiWKKTAAR
OrthoDBiEOG091G0UZ0
PhylomeDBiQ9NZE8
TreeFamiTF317642

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL35 human
GenomeRNAii51318
PROiPR:Q9NZE8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132313 Expressed in 216 organ(s), highest expression level in heart left ventricle
CleanExiHS_MRPL35
ExpressionAtlasiQ9NZE8 baseline and differential
GenevisibleiQ9NZE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR019338 Ribosomal-L35_mit
IPR021137 Ribosomal_L35
IPR037229 Ribosomal_L35_sf
PANTHERiPTHR15909 PTHR15909, 1 hit
PfamiView protein in Pfam
PF01632 Ribosomal_L35p, 1 hit
SUPFAMiSSF143034 SSF143034, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM35_HUMAN
AccessioniPrimary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6
, B2RB93, Q658U7, Q8WWA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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