UniProtKB - Q9NZE8 (RM35_HUMAN)
39S ribosomal protein L35, mitochondrial
MRPL35
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
- translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q9NZE8 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L35, mitochondrialShort name: L35mt Short name: MRP-L35 Alternative name(s): Mitochondrial large ribosomal subunit protein bL35m1 Publication |
Gene namesi | Name:MRPL35 ORF Names:BM-007 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132313.14 |
HGNCi | HGNC:14489, MRPL35 |
MIMi | 611841, gene |
neXtProti | NX_Q9NZE8 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrial ribosome Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 51318 |
OpenTargetsi | ENSG00000132313 |
PharmGKBi | PA30966 |
Miscellaneous databases
Pharosi | Q9NZE8, Tdark |
Polymorphism and mutation databases
BioMutai | MRPL35 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000030525 | ? – 188 | 39S ribosomal protein L35, mitochondrial |
Proteomic databases
EPDi | Q9NZE8 |
jPOSTi | Q9NZE8 |
MassIVEi | Q9NZE8 |
MaxQBi | Q9NZE8 |
PaxDbi | Q9NZE8 |
PeptideAtlasi | Q9NZE8 |
PRIDEi | Q9NZE8 |
ProteomicsDBi | 83381 [Q9NZE8-1] 83382 [Q9NZE8-2] |
PTM databases
iPTMneti | Q9NZE8 |
PhosphoSitePlusi | Q9NZE8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000132313, Expressed in heart and 231 other tissues |
ExpressionAtlasi | Q9NZE8, baseline and differential |
Genevisiblei | Q9NZE8, HS |
Organism-specific databases
HPAi | ENSG00000132313, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
3 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 119469, 56 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q9NZE8 |
IntActi | Q9NZE8, 48 interactors |
STRINGi | 9606.ENSP00000338389 |
Miscellaneous databases
RNActi | Q9NZE8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NZE8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4316, Eukaryota |
GeneTreei | ENSGT00390000007547 |
HOGENOMi | CLU_123951_0_0_1 |
InParanoidi | Q9NZE8 |
OMAi | MYHDRTN |
OrthoDBi | 1333597at2759 |
PhylomeDBi | Q9NZE8 |
TreeFami | TF317642 |
Family and domain databases
InterProi | View protein in InterPro IPR019338, Ribosomal-L35_mit IPR021137, Ribosomal_L35 IPR037229, Ribosomal_L35_sf |
PANTHERi | PTHR15909, PTHR15909, 1 hit |
Pfami | View protein in Pfam PF01632, Ribosomal_L35p, 1 hit |
SUPFAMi | SSF143034, SSF143034, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ
60 70 80 90 100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR
110 120 130 140 150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC
160 170 180
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YTC1 | D3YTC1_HUMAN | 39S ribosomal protein L35, mitochon... | MRPL35 | 177 | Annotation score: | ||
S4R348 | S4R348_HUMAN | 39S ribosomal protein L35, mitochon... | MRPL35 | 95 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030010 | 19 | P → S1 PublicationCorresponds to variant dbSNP:rs10901Ensembl. | 1 | |
Natural variantiVAR_054632 | 24 | A → T1 PublicationCorresponds to variant dbSNP:rs17851803Ensembl. | 1 | |
Natural variantiVAR_054633 | 29 | R → H. Corresponds to variant dbSNP:rs1051949Ensembl. | 1 | |
Natural variantiVAR_034463 | 80 | A → P. Corresponds to variant dbSNP:rs34044771Ensembl. | 1 | |
Natural variantiVAR_051803 | 81 | P → L. Corresponds to variant dbSNP:rs3192352Ensembl. | 1 | |
Natural variantiVAR_054634 | 180 | Y → C. Corresponds to variant dbSNP:rs1052065Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036507 | 171 – 188 | Missing in isoform 2. 2 PublicationsAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF208849 mRNA Translation: AAF64263.1 Frameshift. AK314555 mRNA Translation: BAG37140.1 AK314577 mRNA Translation: BAG37154.1 AL832982 mRNA Translation: CAH56349.1 AC009309 Genomic DNA No translation available. BC020651 mRNA Translation: AAH20651.1 |
CCDSi | CCDS1987.1 [Q9NZE8-2] CCDS1988.1 [Q9NZE8-1] |
RefSeqi | NP_057706.2, NM_016622.3 [Q9NZE8-1] NP_663619.1, NM_145644.2 [Q9NZE8-2] |
Genome annotation databases
Ensembli | ENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2] ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1] |
GeneIDi | 51318 |
KEGGi | hsa:51318 |
UCSCi | uc002srg.5, human [Q9NZE8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF208849 mRNA Translation: AAF64263.1 Frameshift. AK314555 mRNA Translation: BAG37140.1 AK314577 mRNA Translation: BAG37154.1 AL832982 mRNA Translation: CAH56349.1 AC009309 Genomic DNA No translation available. BC020651 mRNA Translation: AAH20651.1 |
CCDSi | CCDS1987.1 [Q9NZE8-2] CCDS1988.1 [Q9NZE8-1] |
RefSeqi | NP_057706.2, NM_016622.3 [Q9NZE8-1] NP_663619.1, NM_145644.2 [Q9NZE8-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | 3 | 1-188 | [»] | |
3J9M | electron microscopy | 3.50 | 3 | 1-188 | [»] | |
5OOL | electron microscopy | 3.06 | 3 | 1-188 | [»] | |
5OOM | electron microscopy | 3.03 | 3 | 1-188 | [»] | |
6I9R | electron microscopy | 3.90 | 3 | 1-188 | [»] | |
6NU2 | electron microscopy | 3.90 | 3 | 94-188 | [»] | |
6NU3 | electron microscopy | 4.40 | 3 | 1-188 | [»] | |
6VLZ | electron microscopy | 2.97 | 3 | 1-188 | [»] | |
6VMI | electron microscopy | 2.96 | 3 | 1-188 | [»] | |
SMRi | Q9NZE8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119469, 56 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q9NZE8 |
IntActi | Q9NZE8, 48 interactors |
STRINGi | 9606.ENSP00000338389 |
PTM databases
iPTMneti | Q9NZE8 |
PhosphoSitePlusi | Q9NZE8 |
Polymorphism and mutation databases
BioMutai | MRPL35 |
Proteomic databases
EPDi | Q9NZE8 |
jPOSTi | Q9NZE8 |
MassIVEi | Q9NZE8 |
MaxQBi | Q9NZE8 |
PaxDbi | Q9NZE8 |
PeptideAtlasi | Q9NZE8 |
PRIDEi | Q9NZE8 |
ProteomicsDBi | 83381 [Q9NZE8-1] 83382 [Q9NZE8-2] |
Protocols and materials databases
Antibodypediai | 51696, 38 antibodies |
DNASUi | 51318 |
Genome annotation databases
Ensembli | ENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2] ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1] |
GeneIDi | 51318 |
KEGGi | hsa:51318 |
UCSCi | uc002srg.5, human [Q9NZE8-1] |
Organism-specific databases
CTDi | 51318 |
DisGeNETi | 51318 |
EuPathDBi | HostDB:ENSG00000132313.14 |
GeneCardsi | MRPL35 |
HGNCi | HGNC:14489, MRPL35 |
HPAi | ENSG00000132313, Low tissue specificity |
MIMi | 611841, gene |
neXtProti | NX_Q9NZE8 |
OpenTargetsi | ENSG00000132313 |
PharmGKBi | PA30966 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4316, Eukaryota |
GeneTreei | ENSGT00390000007547 |
HOGENOMi | CLU_123951_0_0_1 |
InParanoidi | Q9NZE8 |
OMAi | MYHDRTN |
OrthoDBi | 1333597at2759 |
PhylomeDBi | Q9NZE8 |
TreeFami | TF317642 |
Enzyme and pathway databases
PathwayCommonsi | Q9NZE8 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Miscellaneous databases
BioGRID-ORCSi | 51318, 375 hits in 825 CRISPR screens |
ChiTaRSi | MRPL35, human |
GenomeRNAii | 51318 |
Pharosi | Q9NZE8, Tdark |
PROi | PR:Q9NZE8 |
RNActi | Q9NZE8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132313, Expressed in heart and 231 other tissues |
ExpressionAtlasi | Q9NZE8, baseline and differential |
Genevisiblei | Q9NZE8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019338, Ribosomal-L35_mit IPR021137, Ribosomal_L35 IPR037229, Ribosomal_L35_sf |
PANTHERi | PTHR15909, PTHR15909, 1 hit |
Pfami | View protein in Pfam PF01632, Ribosomal_L35p, 1 hit |
SUPFAMi | SSF143034, SSF143034, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM35_HUMAN | |
Accessioni | Q9NZE8Primary (citable) accession number: Q9NZE8 Secondary accession number(s): A6NKV6 Q8WWA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Ribosomal proteins
Ribosomal proteins families and list of entries