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UniProtKB - Q9NZE8 (RM35_HUMAN)

Entry version 154 (10 Feb 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

39S ribosomal protein L35, mitochondrial

Gene

MRPL35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NZE8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
39S ribosomal protein L35, mitochondrial
Short name:
L35mt
Short name:
MRP-L35
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL35m1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRPL35
ORF Names:BM-007
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14489, MRPL35

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611841, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NZE8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132313.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51318

Open Targets

More...OpenTargetsi		ENSG00000132313

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30966

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NZE8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MRPL35

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000030525? – 18839S ribosomal protein L35, mitochondrial

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NZE8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NZE8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NZE8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NZE8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NZE8

PeptideAtlas

More...PeptideAtlasi		Q9NZE8

PRoteomics IDEntifications database

More...PRIDEi		Q9NZE8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83381 [Q9NZE8-1]
83382 [Q9NZE8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NZE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NZE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132313, Expressed in heart and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NZE8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NZE8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132313, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119469, 56 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5226, 39S mitochondrial large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NZE8

Protein interaction database and analysis system

More...IntActi		Q9NZE8, 48 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338389

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NZE8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NZE8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bacterial ribosomal protein bL35 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4316, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007547

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_123951_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NZE8

Identification of Orthologs from Complete Genome Data

More...OMAi		MYHDRTN

Database of Orthologous Groups

More...OrthoDBi		1333597at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NZE8

TreeFam database of animal gene trees

More...TreeFami		TF317642

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019338, Ribosomal-L35_mit
IPR021137, Ribosomal_L35
IPR037229, Ribosomal_L35_sf

The PANTHER Classification System

More...PANTHERi		PTHR15909, PTHR15909, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01632, Ribosomal_L35p, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143034, SSF143034, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ 
        60         70         80         90        100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR 
       110        120        130        140        150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC 
       160        170        180 
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV
Length:188
Mass (Da):21,514
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A44076927C5A54B
GO
Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-188: Missing.

Show »
Length:170
Mass (Da):19,192
Checksum:iDF3B4AEF300F91D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTC1D3YTC1_HUMAN
39S ribosomal protein L35, mitochon...
MRPL35
177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R348S4R348_HUMAN
39S ribosomal protein L35, mitochon...
MRPL35
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64263 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03001019P → S1 PublicationCorresponds to variant dbSNP:rs10901Ensembl.1
Natural variantiVAR_05463224A → T1 PublicationCorresponds to variant dbSNP:rs17851803Ensembl.1
Natural variantiVAR_05463329R → H. Corresponds to variant dbSNP:rs1051949Ensembl.1
Natural variantiVAR_03446380A → P. Corresponds to variant dbSNP:rs34044771Ensembl.1
Natural variantiVAR_05180381P → L. Corresponds to variant dbSNP:rs3192352Ensembl.1
Natural variantiVAR_054634180Y → C. Corresponds to variant dbSNP:rs1052065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036507171 – 188Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF208849 mRNA Translation: AAF64263.1 Frameshift.
AK314555 mRNA Translation: BAG37140.1
AK314577 mRNA Translation: BAG37154.1
AL832982 mRNA Translation: CAH56349.1
AC009309 Genomic DNA No translation available.
BC020651 mRNA Translation: AAH20651.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1987.1 [Q9NZE8-2]
CCDS1988.1 [Q9NZE8-1]

NCBI Reference Sequences

More...RefSeqi		NP_057706.2, NM_016622.3 [Q9NZE8-1]
NP_663619.1, NM_145644.2 [Q9NZE8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51318

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51318

UCSC genome browser

More...UCSCi		uc002srg.5, human [Q9NZE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208849 mRNA Translation: AAF64263.1 Frameshift.
AK314555 mRNA Translation: BAG37140.1
AK314577 mRNA Translation: BAG37154.1
AL832982 mRNA Translation: CAH56349.1
AC009309 Genomic DNA No translation available.
BC020651 mRNA Translation: AAH20651.1
CCDSiCCDS1987.1 [Q9NZE8-2]
CCDS1988.1 [Q9NZE8-1]
RefSeqiNP_057706.2, NM_016622.3 [Q9NZE8-1]
NP_663619.1, NM_145644.2 [Q9NZE8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4031-188[»]
3J9Melectron microscopy3.5031-188[»]
5OOLelectron microscopy3.0631-188[»]
5OOMelectron microscopy3.0331-188[»]
6I9Relectron microscopy3.9031-188[»]
6NU2electron microscopy3.90394-188[»]
6NU3electron microscopy4.4031-188[»]
6VLZelectron microscopy2.9731-188[»]
6VMIelectron microscopy2.9631-188[»]
6ZS9electron microscopy4.0031-188[»]
6ZSAelectron microscopy4.0031-188[»]
6ZSBelectron microscopy4.5031-188[»]
6ZSCelectron microscopy3.5031-188[»]
6ZSDelectron microscopy3.7031-188[»]
6ZSEelectron microscopy5.0031-188[»]
6ZSGelectron microscopy4.0031-188[»]
SMRiQ9NZE8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119469, 56 interactors
ComplexPortaliCPX-5226, 39S mitochondrial large ribosomal subunit
CORUMiQ9NZE8
IntActiQ9NZE8, 48 interactors
STRINGi9606.ENSP00000338389

PTM databases

iPTMnetiQ9NZE8
PhosphoSitePlusiQ9NZE8

Genetic variation databases

BioMutaiMRPL35

Proteomic databases

EPDiQ9NZE8
jPOSTiQ9NZE8
MassIVEiQ9NZE8
MaxQBiQ9NZE8
PaxDbiQ9NZE8
PeptideAtlasiQ9NZE8
PRIDEiQ9NZE8
ProteomicsDBi83381 [Q9NZE8-1]
83382 [Q9NZE8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51696, 38 antibodies

The DNASU plasmid repository

More...DNASUi		51318

Genome annotation databases

EnsembliENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2]
ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]
GeneIDi51318
KEGGihsa:51318
UCSCiuc002srg.5, human [Q9NZE8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51318
DisGeNETi51318

GeneCards: human genes, protein and diseases

More...GeneCardsi		MRPL35
HGNCiHGNC:14489, MRPL35
HPAiENSG00000132313, Low tissue specificity
MIMi611841, gene
neXtProtiNX_Q9NZE8
OpenTargetsiENSG00000132313
PharmGKBiPA30966
VEuPathDBiHostDB:ENSG00000132313.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4316, Eukaryota
GeneTreeiENSGT00390000007547
HOGENOMiCLU_123951_0_0_1
InParanoidiQ9NZE8
OMAiMYHDRTN
OrthoDBi1333597at2759
PhylomeDBiQ9NZE8
TreeFamiTF317642

Enzyme and pathway databases

PathwayCommonsiQ9NZE8
ReactomeiR-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51318, 377 hits in 856 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MRPL35, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51318
PharosiQ9NZE8, Tdark

Protein Ontology

More...PROi		PR:Q9NZE8
RNActiQ9NZE8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132313, Expressed in heart and 231 other tissues
ExpressionAtlasiQ9NZE8, baseline and differential
GenevisibleiQ9NZE8, HS

Family and domain databases

InterProiView protein in InterPro
IPR019338, Ribosomal-L35_mit
IPR021137, Ribosomal_L35
IPR037229, Ribosomal_L35_sf
PANTHERiPTHR15909, PTHR15909, 1 hit
PfamiView protein in Pfam
PF01632, Ribosomal_L35p, 1 hit
SUPFAMiSSF143034, SSF143034, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRM35_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZE8
Secondary accession number(s): A6NKV6
, B2RB93, Q658U7, Q8WWA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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