MRPL35

Functionⁱ

GO - Molecular functionⁱ

structural constituent of ribosome
Source: UniProtKB
Non-traceable author statementⁱ
- 11543634

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome
translation
Source: UniProtKB
Non-traceable author statementⁱ
- 11543634

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L35, mitochondrial Short name: L35mt Short name: MRP-L35 Alternative name(s): Mitochondrial large ribosomal subunit protein bL35m1 Publication
Gene namesⁱ	Name:MRPL35 ORF Names:BM-007
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132313.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14489 MRPL35
MIMⁱ	611841 gene
neXtProtⁱ	NX_Q9NZE8

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000132313
PharmGKBⁱ	PA30966

Polymorphism and mutation databases

BioMutaⁱ	MRPL35

BioMutaⁱ

MRPL35

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000030525	? – 188	39S ribosomal protein L35, mitochondrial
Transit peptideⁱ	1 – ?	MitochondrionSequence analysis

Proteomic databases

EPDⁱ	Q9NZE8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NZE8
PaxDbⁱ	Q9NZE8
PeptideAtlas More...PeptideAtlasⁱ	Q9NZE8
PRIDEⁱ	Q9NZE8
ProteomicsDBⁱ	83381 83382 [Q9NZE8-2]

PTM databases

iPTMnetⁱ	Q9NZE8
PhosphoSitePlusⁱ	Q9NZE8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000132313 Expressed in 216 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MRPL35
ExpressionAtlasⁱ	Q9NZE8 baseline and differential
Genevisibleⁱ	Q9NZE8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043482

HPAⁱ

HPA043482

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridⁱ	119469, 55 interactors
CORUMⁱ	Q9NZE8
IntActⁱ	Q9NZE8, 9 interactors
STRINGⁱ	9606.ENSP00000338389

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	99 – 101	Combined sources	3
Helixⁱ	108 – 113	Combined sources	6
Beta strandⁱ	114 – 116	Combined sources	3
Beta strandⁱ	122 – 125	Combined sources	4
Turnⁱ	127 – 130	Combined sources	4
Helixⁱ	133 – 135	Combined sources	3
Helixⁱ	138 – 144	Combined sources	7
Beta strandⁱ	145 – 149	Combined sources	5
Helixⁱ	152 – 160	Combined sources	9
Turnⁱ	164 – 167	Combined sources	4
Beta strandⁱ	172 – 174	Combined sources	3
Helixⁱ	178 – 180	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZE8
SMRⁱ	Q9NZE8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bacterial ribosomal protein bL35 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG4316 Eukaryota ENOG4111VAN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007547
HOGENOMⁱ	HOG000293335
HOVERGENⁱ	HBG050017
InParanoidⁱ	Q9NZE8
KEGG Orthology (KO) More...KOⁱ	K02916
OMAⁱ	WKKTAAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UZ0
PhylomeDBⁱ	Q9NZE8
TreeFamⁱ	TF317642

Family and domain databases

InterProⁱ	View protein in InterPro IPR019338 Ribosomal-L35_mit IPR021137 Ribosomal_L35 IPR037229 Ribosomal_L35_sf
PANTHERⁱ	PTHR15909 PTHR15909, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01632 Ribosomal_L35p, 1 hit
SUPFAMⁱ	SSF143034 SSF143034, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NZE8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ 
        60         70         80         90        100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR 
       110        120        130        140        150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC 
       160        170        180 
NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY HDRTNLKV

Length:188

Mass (Da):21,514

Last modified:January 23, 2007 - v3

Checksum:ⁱ3A44076927C5A54B

GO

Isoform 2 (identifier: Q9NZE8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
171-188: Missing.

« Hide

        10         20         30         40         50
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ 
        60         70         80         90        100
TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR 
       110        120        130        140        150
KGKRKTVKAV IDRFLRLHCG LWVRRKAGYK KKLWKKTPAR KKRLREFVFC 
       160        170
NKTQSKLLDK MTTSFWKRRN

Show »

Length:170

Mass (Da):19,192

Checksum:ⁱDF3B4AEF300F91D7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YTC1	D3YTC1_HUMAN	39S ribosomal protein L35, mitochon... 39S ribosomal protein L35, mitochondrial	MRPL35	177	Annotation score:
S4R348	S4R348_HUMAN	39S ribosomal protein L35, mitochon... 39S ribosomal protein L35, mitochondrial	MRPL35	95	Annotation score:

Sequence cautionⁱ

The sequence AAF64263 differs from that shown. Reason: Frameshift at position 122.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030010	19	P → S1 PublicationCorresponds to variant dbSNP:rs10901Ensembl.	1
Natural variantⁱVAR_054632	24	A → T1 PublicationCorresponds to variant dbSNP:rs17851803Ensembl.	1
Natural variantⁱVAR_054633	29	R → H. Corresponds to variant dbSNP:rs1051949Ensembl.	1
Natural variantⁱVAR_034463	80	A → P. Corresponds to variant dbSNP:rs34044771Ensembl.	1
Natural variantⁱVAR_051803	81	P → L. Corresponds to variant dbSNP:rs3192352Ensembl.	1
Natural variantⁱVAR_054634	180	Y → C. Corresponds to variant dbSNP:rs1052065Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036507	171 – 188	Missing in isoform 2. 2 PublicationsAdd BLAST		18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF208849 mRNA Translation: AAF64263.1 Frameshift. AK314555 mRNA Translation: BAG37140.1 AK314577 mRNA Translation: BAG37154.1 AL832982 mRNA Translation: CAH56349.1 AC009309 Genomic DNA No translation available. BC020651 mRNA Translation: AAH20651.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1987.1 [Q9NZE8-2] CCDS1988.1 [Q9NZE8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_057706.2, NM_016622.3 [Q9NZE8-1] NP_663619.1, NM_145644.2 [Q9NZE8-2]
UniGeneⁱ	Hs.433439

Genome annotation databases

Ensemblⁱ	ENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2] ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]
GeneIDⁱ	51318
KEGGⁱ	hsa:51318
UCSC genome browser More...UCSCⁱ	uc002srg.5 human [Q9NZE8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NZE8	39S ribosomal protein L35, mitochondrial		PONAB		188	UniRef90_Q9NZE8
Isoform 2 of 39S ribosomal protein L35, mitochondrial		HUMAN		170
MRPL35 isoform 2		PANTR		188
Uncharacterized protein		PANPA		188
Mitochondrial ribosomal protein L35		GORGO		188
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9NZE8	39S ribosomal protein L35, mitochondrial		PONAB		188	UniRef50_Q9NZE8
39S ribosomal protein L35, mitochondrial		BOVIN		188
Isoform 2 of 39S ribosomal protein L35, mitochondrial		HUMAN		170
MRPL35 isoform 2		PANTR		188
Uncharacterized protein		PANPA		188
+79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF208849 mRNA Translation: AAF64263.1 Frameshift. AK314555 mRNA Translation: BAG37140.1 AK314577 mRNA Translation: BAG37154.1 AL832982 mRNA Translation: CAH56349.1 AC009309 Genomic DNA No translation available. BC020651 mRNA Translation: AAH20651.1
CCDSⁱ	CCDS1987.1 [Q9NZE8-2] CCDS1988.1 [Q9NZE8-1]
RefSeqⁱ	NP_057706.2, NM_016622.3 [Q9NZE8-1] NP_663619.1, NM_145644.2 [Q9NZE8-2]
UniGeneⁱ	Hs.433439

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J7Y	electron microscopy	3.40	3	1-188	[»]
	3J9M	electron microscopy	3.50	3	1-188	[»]
	5OOL	electron microscopy	3.06	3	1-188	[»]
	5OOM	electron microscopy	3.03	3	1-188	[»]
ProteinModelPortalⁱ	Q9NZE8
SMRⁱ	Q9NZE8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119469, 55 interactors
CORUMⁱ	Q9NZE8
IntActⁱ	Q9NZE8, 9 interactors
STRINGⁱ	9606.ENSP00000338389

PTM databases

iPTMnetⁱ	Q9NZE8
PhosphoSitePlusⁱ	Q9NZE8

Polymorphism and mutation databases

BioMutaⁱ	MRPL35

BioMutaⁱ

MRPL35

Proteomic databases

EPDⁱ	Q9NZE8
MaxQBⁱ	Q9NZE8
PaxDbⁱ	Q9NZE8
PeptideAtlasⁱ	Q9NZE8
PRIDEⁱ	Q9NZE8
ProteomicsDBⁱ	83381 83382 [Q9NZE8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51318
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000254644; ENSP00000254644; ENSG00000132313 [Q9NZE8-2] ENST00000337109; ENSP00000338389; ENSG00000132313 [Q9NZE8-1]
GeneIDⁱ	51318
KEGGⁱ	hsa:51318
UCSCⁱ	uc002srg.5 human [Q9NZE8-1]

Organism-specific databases

CTDⁱ	51318
EuPathDBⁱ	HostDB:ENSG00000132313.14
GeneCardsⁱ	MRPL35
HGNCⁱ	HGNC:14489 MRPL35
HPAⁱ	HPA043482
MIMⁱ	611841 gene
neXtProtⁱ	NX_Q9NZE8
OpenTargetsⁱ	ENSG00000132313
PharmGKBⁱ	PA30966
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4316 Eukaryota ENOG4111VAN LUCA
GeneTreeⁱ	ENSGT00390000007547
HOGENOMⁱ	HOG000293335
HOVERGENⁱ	HBG050017
InParanoidⁱ	Q9NZE8
KOⁱ	K02916
OMAⁱ	WKKTAAR
OrthoDBⁱ	EOG091G0UZ0
PhylomeDBⁱ	Q9NZE8
TreeFamⁱ	TF317642

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPL35 human
GenomeRNAiⁱ	51318
Protein Ontology More...PROⁱ	PR:Q9NZE8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132313 Expressed in 216 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_MRPL35
ExpressionAtlasⁱ	Q9NZE8 baseline and differential
Genevisibleⁱ	Q9NZE8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019338 Ribosomal-L35_mit IPR021137 Ribosomal_L35 IPR037229 Ribosomal_L35_sf
PANTHERⁱ	PTHR15909 PTHR15909, 1 hit
Pfamⁱ	View protein in Pfam PF01632 Ribosomal_L35p, 1 hit
SUPFAMⁱ	SSF143034 SSF143034, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM35_HUMAN
Accessionⁱ	Q9NZE8Primary (citable) accession number: Q9NZE8 Secondary accession number(s): A6NKV6 , B2RB93, Q658U7, Q8WWA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Ribosomal proteins
Ribosomal proteins families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q9NZE8 (RM35_HUMAN)

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39S ribosomal protein L35, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ