Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-hemoglobin-stabilizing protein

Gene

AHSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.1 Publication

GO - Molecular functioni

  • hemoglobin binding Source: UniProtKB
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

SIGNORiQ9NZD4

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-hemoglobin-stabilizing protein
Alternative name(s):
Erythroid differentiation-related factor
Erythroid-associated factor
Gene namesi
Name:AHSP
Synonyms:EDRF, ERAF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169877.9
HGNCiHGNC:18075 AHSP
MIMi605821 gene
neXtProtiNX_Q9NZD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51327
OpenTargetsiENSG00000169877
PharmGKBiPA27842

Polymorphism and mutation databases

BioMutaiAHSP
DMDMi23813669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645091 – 102Alpha-hemoglobin-stabilizing proteinAdd BLAST102

Proteomic databases

PaxDbiQ9NZD4
PeptideAtlasiQ9NZD4
PRIDEiQ9NZD4
ProteomicsDBi83376
TopDownProteomicsiQ9NZD4

Expressioni

Tissue specificityi

Expressed in blood and bone marrow.2 Publications

Inductioni

By GATA1 during erythroid maturation.

Gene expression databases

BgeeiENSG00000169877 Expressed in 96 organ(s), highest expression level in liver
CleanExiHS_ERAF
ExpressionAtlasiQ9NZD4 baseline and differential
GenevisibleiQ9NZD4 HS

Organism-specific databases

HPAiHPA040940

Interactioni

Subunit structurei

Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha2beta2 hemoglobin A.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119476, 9 interactors
DIPiDIP-35198N
IntActiQ9NZD4, 10 interactors
STRINGi9606.ENSP00000307199

Structurei

Secondary structure

1102
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NZD4
SMRiQ9NZD4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZD4

Family & Domainsi

Sequence similaritiesi

Belongs to the AHSP family.Curated

Phylogenomic databases

eggNOGiENOG410J29P Eukaryota
ENOG411196Z LUCA
GeneTreeiENSGT00390000003648
HOGENOMiHOG000030915
HOVERGENiHBG023495
InParanoidiQ9NZD4
OMAiGMKEFNV
OrthoDBiEOG091G14TI
PhylomeDBiQ9NZD4
TreeFamiTF337056

Family and domain databases

InterProiView protein in InterPro
IPR015317 A_Hb_stabilising_prot
IPR036468 AHSP_sf
PANTHERiPTHR15914 PTHR15914, 1 hit
PfamiView protein in Pfam
PF09236 AHSP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD285427 A_Hb_stabilising_prot, 1 hit
SUPFAMiSSF109751 SSF109751, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NZD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN
60 70 80 90 100
YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP

SS
Length:102
Mass (Da):11,840
Last modified:October 1, 2000 - v1
Checksum:i275DDF8BC670EF20
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSK6H3BSK6_HUMAN
Alpha-hemoglobin-stabilizing protei...
AHSP
57Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32V → A in AAL82894 (Ref. 3) Curated1
Sequence conflicti87D → N in AAL82894 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050650100P → T. Corresponds to variant dbSNP:rs36018996Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364517 mRNA Translation: AAK50856.1
AF208865 mRNA Translation: AAF64279.1
AY072612 Genomic DNA Translation: AAL82894.1
AF485325 Genomic DNA Translation: AAO49381.1
BC035842 mRNA Translation: AAH35842.1
CCDSiCCDS10716.1
RefSeqiNP_001305150.1, NM_001318221.1
NP_001305151.1, NM_001318222.1
NP_057717.1, NM_016633.3
UniGeneiHs.274309

Genome annotation databases

EnsembliENST00000302312; ENSP00000307199; ENSG00000169877
GeneIDi51327
KEGGihsa:51327
UCSCiuc002ecj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364517 mRNA Translation: AAK50856.1
AF208865 mRNA Translation: AAF64279.1
AY072612 Genomic DNA Translation: AAL82894.1
AF485325 Genomic DNA Translation: AAO49381.1
BC035842 mRNA Translation: AAH35842.1
CCDSiCCDS10716.1
RefSeqiNP_001305150.1, NM_001318221.1
NP_001305151.1, NM_001318222.1
NP_057717.1, NM_016633.3
UniGeneiHs.274309

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W09NMR-A3-94[»]
1W0ANMR-A3-94[»]
1W0BNMR-A2-102[»]
1XZYNMR-A1-90[»]
1Y01X-ray2.80A1-102[»]
1Z8UX-ray2.40A/C1-102[»]
3IA3X-ray3.20A/C1-91[»]
3OVUX-ray2.83A2-102[»]
ProteinModelPortaliQ9NZD4
SMRiQ9NZD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119476, 9 interactors
DIPiDIP-35198N
IntActiQ9NZD4, 10 interactors
STRINGi9606.ENSP00000307199

Polymorphism and mutation databases

BioMutaiAHSP
DMDMi23813669

Proteomic databases

PaxDbiQ9NZD4
PeptideAtlasiQ9NZD4
PRIDEiQ9NZD4
ProteomicsDBi83376
TopDownProteomicsiQ9NZD4

Protocols and materials databases

DNASUi51327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302312; ENSP00000307199; ENSG00000169877
GeneIDi51327
KEGGihsa:51327
UCSCiuc002ecj.4 human

Organism-specific databases

CTDi51327
DisGeNETi51327
EuPathDBiHostDB:ENSG00000169877.9
GeneCardsiAHSP
HGNCiHGNC:18075 AHSP
HPAiHPA040940
MIMi605821 gene
neXtProtiNX_Q9NZD4
OpenTargetsiENSG00000169877
PharmGKBiPA27842
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J29P Eukaryota
ENOG411196Z LUCA
GeneTreeiENSGT00390000003648
HOGENOMiHOG000030915
HOVERGENiHBG023495
InParanoidiQ9NZD4
OMAiGMKEFNV
OrthoDBiEOG091G14TI
PhylomeDBiQ9NZD4
TreeFamiTF337056

Enzyme and pathway databases

SIGNORiQ9NZD4

Miscellaneous databases

ChiTaRSiAHSP human
EvolutionaryTraceiQ9NZD4
GeneWikiiERAF
GenomeRNAii51327
PROiPR:Q9NZD4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169877 Expressed in 96 organ(s), highest expression level in liver
CleanExiHS_ERAF
ExpressionAtlasiQ9NZD4 baseline and differential
GenevisibleiQ9NZD4 HS

Family and domain databases

InterProiView protein in InterPro
IPR015317 A_Hb_stabilising_prot
IPR036468 AHSP_sf
PANTHERiPTHR15914 PTHR15914, 1 hit
PfamiView protein in Pfam
PF09236 AHSP, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD285427 A_Hb_stabilising_prot, 1 hit
SUPFAMiSSF109751 SSF109751, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAHSP_HUMAN
AccessioniPrimary (citable) accession number: Q9NZD4
Secondary accession number(s): Q8TD01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again