AHSP

Functionⁱ

Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.1 Publication

GO - Molecular functionⁱ

hemoglobin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189
unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

erythrocyte differentiation Source: InterPro
hemoglobin metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189
hemopoiesis
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189
protein folding Source: InterPro
protein stabilization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

SIGNORⁱ	Q9NZD4

SIGNORⁱ

Q9NZD4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-hemoglobin-stabilizing protein Alternative name(s): Erythroid differentiation-related factor Erythroid-associated factor
Gene namesⁱ	Name:AHSP Synonyms:EDRF, ERAF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169877.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18075 AHSP
MIMⁱ	605821 gene
neXtProtⁱ	NX_Q9NZD4

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51327
Open Targets More...OpenTargetsⁱ	ENSG00000169877
PharmGKBⁱ	PA27842

Polymorphism and mutation databases

BioMutaⁱ	AHSP
DMDMⁱ	23813669

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064509	1 – 102	Alpha-hemoglobin-stabilizing proteinAdd BLAST		102

Proteomic databases

PaxDbⁱ	Q9NZD4
PeptideAtlas More...PeptideAtlasⁱ	Q9NZD4
PRIDEⁱ	Q9NZD4
ProteomicsDBⁱ	83376
TopDownProteomicsⁱ	Q9NZD4

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

By GATA1 during erythroid maturation.

Gene expression databases

Bgeeⁱ	ENSG00000169877 Expressed in 96 organ(s), highest expression level in liver
CleanExⁱ	HS_ERAF
ExpressionAtlasⁱ	Q9NZD4 baseline and differential
Genevisibleⁱ	Q9NZD4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040940

HPAⁱ

HPA040940

Interactionⁱ

Subunit structureⁱ

Monomer. Forms a heterodimer with free alpha-hemoglobin. Does not bind beta-hemoglobin nor alpha₂beta₂ hemoglobin A.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FKBP1A	P62942	3	EBI-720250,EBI-1027571
HBA2	P69905	2	EBI-720250,EBI-714680
UBE3A	Q05086-2	3	EBI-720250,EBI-10175863
ZC3H12A	Q5D1E8	4	EBI-720250,EBI-747793

GO - Molecular functionⁱ

hemoglobin binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189
unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12066189

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119476, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-35198N
IntActⁱ	Q9NZD4, 10 interactors
STRINGⁱ	9606.ENSP00000307199

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 23	Combined sources	19
Helixⁱ	27 – 29	Combined sources	3
Helixⁱ	34 – 52	Combined sources	19
Turnⁱ	53 – 55	Combined sources	3
Helixⁱ	60 – 86	Combined sources	27
Beta strandⁱ	97 – 99	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NZD4
SMRⁱ	Q9NZD4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NZD4

EvolutionaryTraceⁱ

Q9NZD4

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the AHSP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J29P Eukaryota ENOG411196Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003648
HOGENOMⁱ	HOG000030915
HOVERGENⁱ	HBG023495
InParanoidⁱ	Q9NZD4
OMAⁱ	GMKEFNV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14TI
PhylomeDBⁱ	Q9NZD4
TreeFamⁱ	TF337056

Family and domain databases

InterProⁱ	View protein in InterPro IPR015317 A_Hb_stabilising_prot IPR036468 AHSP_sf
PANTHERⁱ	PTHR15914 PTHR15914, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09236 AHSP, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD285427 A_Hb_stabilising_prot, 1 hit
SUPFAMⁱ	SSF109751 SSF109751, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9NZD4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN 
        60         70         80         90        100
YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP 

SS

Length:102

Mass (Da):11,840

Last modified:October 1, 2000 - v1

Checksum:ⁱ275DDF8BC670EF20

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BSK6	H3BSK6_HUMAN		Alpha-hemoglobin-stabilizing protei... Alpha-hemoglobin-stabilizing protein	AHSP	57	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	32	V → A in AAL82894 (Ref. 3) Curated		1
Sequence conflictⁱ	87	D → N in AAL82894 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050650	100	P → T. Corresponds to variant dbSNP:rs36018996Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF364517 mRNA Translation: AAK50856.1 AF208865 mRNA Translation: AAF64279.1 AY072612 Genomic DNA Translation: AAL82894.1 AF485325 Genomic DNA Translation: AAO49381.1 BC035842 mRNA Translation: AAH35842.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10716.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305150.1, NM_001318221.1 NP_001305151.1, NM_001318222.1 NP_057717.1, NM_016633.3
UniGeneⁱ	Hs.274309

Genome annotation databases

Ensemblⁱ	ENST00000302312; ENSP00000307199; ENSG00000169877
GeneIDⁱ	51327
KEGGⁱ	hsa:51327
UCSC genome browser More...UCSCⁱ	uc002ecj.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD4	Erythroid associated factor		HUMAN		102	UniRef100_Q9NZD4
AHSP isoform 1		PANTR		102
Uncharacterized protein		PANPA		102
Alpha-hemoglobin-stabilizing protein (Fragment)		HUMAN		57
AHSP isoform 3 (Fragment)		PANTR		57
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD4	Erythroid associated factor		HUMAN		102	UniRef90_Q9NZD4
AHSP isoform 1		PANTR		102
Uncharacterized protein		PANPA		102
Uncharacterized protein		PAPAN		102
Uncharacterized protein		CHLSB		102
+22

Protein	Similar proteins		Species	Score	Length	Source
Q9NZD4	Alpha-hemoglobin-stabilizing protein		MOUSE		102	UniRef50_Q9NZD4
Erythroid associated factor		HUMAN		102
AHSP isoform 1		PANTR		102
Uncharacterized protein		PANPA		102
Uncharacterized protein		CHLSB		102
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF364517 mRNA Translation: AAK50856.1 AF208865 mRNA Translation: AAF64279.1 AY072612 Genomic DNA Translation: AAL82894.1 AF485325 Genomic DNA Translation: AAO49381.1 BC035842 mRNA Translation: AAH35842.1
CCDSⁱ	CCDS10716.1
RefSeqⁱ	NP_001305150.1, NM_001318221.1 NP_001305151.1, NM_001318222.1 NP_057717.1, NM_016633.3
UniGeneⁱ	Hs.274309

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1W09	NMR	-	A	3-94	[»]
	1W0A	NMR	-	A	3-94	[»]
	1W0B	NMR	-	A	2-102	[»]
	1XZY	NMR	-	A	1-90	[»]
	1Y01	X-ray	2.80	A	1-102	[»]
	1Z8U	X-ray	2.40	A/C	1-102	[»]
	3IA3	X-ray	3.20	A/C	1-91	[»]
	3OVU	X-ray	2.83	A	2-102	[»]
ProteinModelPortalⁱ	Q9NZD4
SMRⁱ	Q9NZD4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119476, 9 interactors
DIPⁱ	DIP-35198N
IntActⁱ	Q9NZD4, 10 interactors
STRINGⁱ	9606.ENSP00000307199

Polymorphism and mutation databases

BioMutaⁱ	AHSP
DMDMⁱ	23813669

Proteomic databases

PaxDbⁱ	Q9NZD4
PeptideAtlasⁱ	Q9NZD4
PRIDEⁱ	Q9NZD4
ProteomicsDBⁱ	83376
TopDownProteomicsⁱ	Q9NZD4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51327
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302312; ENSP00000307199; ENSG00000169877
GeneIDⁱ	51327
KEGGⁱ	hsa:51327
UCSCⁱ	uc002ecj.4 human

Organism-specific databases

CTDⁱ	51327
DisGeNETⁱ	51327
EuPathDBⁱ	HostDB:ENSG00000169877.9
GeneCardsⁱ	AHSP
HGNCⁱ	HGNC:18075 AHSP
HPAⁱ	HPA040940
MIMⁱ	605821 gene
neXtProtⁱ	NX_Q9NZD4
OpenTargetsⁱ	ENSG00000169877
PharmGKBⁱ	PA27842
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J29P Eukaryota ENOG411196Z LUCA
GeneTreeⁱ	ENSGT00390000003648
HOGENOMⁱ	HOG000030915
HOVERGENⁱ	HBG023495
InParanoidⁱ	Q9NZD4
OMAⁱ	GMKEFNV
OrthoDBⁱ	EOG091G14TI
PhylomeDBⁱ	Q9NZD4
TreeFamⁱ	TF337056

Enzyme and pathway databases

SIGNORⁱ	Q9NZD4

SIGNORⁱ

Q9NZD4

Miscellaneous databases

ChiTaRSⁱ	AHSP human
EvolutionaryTraceⁱ	Q9NZD4
GeneWikiⁱ	ERAF
GenomeRNAiⁱ	51327
Protein Ontology More...PROⁱ	PR:Q9NZD4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169877 Expressed in 96 organ(s), highest expression level in liver
CleanExⁱ	HS_ERAF
ExpressionAtlasⁱ	Q9NZD4 baseline and differential
Genevisibleⁱ	Q9NZD4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR015317 A_Hb_stabilising_prot IPR036468 AHSP_sf
PANTHERⁱ	PTHR15914 PTHR15914, 1 hit
Pfamⁱ	View protein in Pfam PF09236 AHSP, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD285427 A_Hb_stabilising_prot, 1 hit
SUPFAMⁱ	SSF109751 SSF109751, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AHSP_HUMAN
Accessionⁱ	Q9NZD4Primary (citable) accession number: Q9NZD4 Secondary accession number(s): Q8TD01
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
	Last sequence update:	October 1, 2000
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniRef

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Supporting data

UniProtKB - Q9NZD4 (AHSP_HUMAN)

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Alpha-hemoglobin-stabilizing protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ